• 컴퓨터교육학회논문지
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• 제10권5호
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• pp.11-20
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• 2007

본 연구는 중학생을 대상으로, 팀벨의 언플러그드 교재를 사용하여 실험 수업을 실시하고 학습자의 재미와 정보교재로서의 유용성을 평가하였다. 사전 평가를 통해 실험 수업 참가자들의 컴퓨터의 동작 원리에 대한 이해 정도가 매우 낮은 것으로 밝혀졌으나 실험 수업에 대한 학습자의 재미를 기대감, 참여도, 지속성의 관점에서 측정한 결과 긍정적인 반응을 보였고, 실험수업 종료 1개월 후 실시한 사후 평가에서 학습 과정을 대부분 기억하고 있었고, 학습 내용을 정확히 이해하고 있었다. 본 연구를 통해, 팀벨의 교재와 같은 유형의 정보교재를 이용한 컴퓨터 원리 학습은 학습자의 흥미 유발 및 학습 효과 면에서 우수함이 밝혀졌고 연구의 결과에 따라 새로운 정보교육 교육과정에 적용될 수 있는 정보교재의 한 유형으로 제안한다.

• 한국약용작물학회지
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• 제17권6호
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• pp.388-396
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• 2009

The present study investigated an ethanol extract (HS0608) of a mixture of three medicinal plants of Curcuma longae radix, Phellinus linteus, and Scutellariae radix for possible neuroprotective effects on neurotoxicity induced by amyloid $\beta$ protein ($A{\beta}$) (25-35) in cultured rat cortical neurons and antidementia activity in mice. Exposure of cultured cortical neurons to $10\;{\mu}M$ $A{\beta}$ (25-35) for 36 h induced neuronal apoptotic death. At $1-50\;{\mu}g/m{\ell}$, HS0608 inhibited neuronal death, elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), and generation of reactive oxygen species (ROS) induced by $A{\beta}$ (25-35) in primary cultures of rat cortical neurons. Memory loss induced by intracerebroventricular injection of ICR mice with 15 nmol $A{\beta}$ (25-35) was inhibited by chronic treatment with HS0608 (25, 50 and 100 mg/kg, p.o. for 7 days) as measured by a passive avoidance test. From these results, we suggest that the antidementia effect of HS0608 is due to its neuroprotective effect against $A{\beta}$ (25-35)-induced neurotoxicity and that HS0608 may have a therapeutic role in preventing the progression of Alzheimer's disease.

• 한국정보과학회논문지:데이타베이스
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• 제32권1호
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• pp.1-11
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• 2005

군집 질의는 사용자에 의해 명시된 질의 영역 내에서 큐브상의 군집 정보를 계산한다. 프리픽스-섬 기법에 기초한 기존의 방법론은 데이타의 누적된 합을 저장하기 위해 프리픽스-섬 큐브(PC)로 불리는 부가적인 큐브를 사용하므로 높은 저장공간 오버헤드를 초래한다. 이러한 저장공간 오버헤드는 기억장치의 추가적인 비용뿐만 아니라 업데이트의 부가적인 증식(propagation)과 더 많은 물리적 장치로의 접근시간을 유발시킨다. 본 논문에서는 대용량 데이타 웨어하우스에서 PC의 저장공간을 획기적으로 감소시킬 수 있는 'SPEC'으로 불리는 새로운 프리픽스-섬 큐브를 제안한다. SPEC은 PC내 셀들간의 종속에 의한 업데이트 증식을 감소시킨다. 이를 위해 대용량 데이타 큐브로부터 조밀한 서브큐브들을 발견하는 효과적인 알고리즘을 개발한다 다양한 차원의 데이타 큐브와 여러 가지 크기의 질의에 대해 폭 넓은 실험을 행하여 본 논문에서 제안한 방법의 효과와 성능을 조사한다. 실험적인 결과는 SPEC이 적절한 질의 성능을 유지하면서도 PC 저장공간을 상당히 감소시킴을 보여준다.

• 한국약용작물학회지
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• 제20권1호
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• pp.8-15
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• 2012

The present study investigated an ethanol extract of Chaenomeles sinensis fruit (CSF) for possible neuroprotective effects on neurotoxicity induced by amyloid ${\beta}$ protein ($A{\beta}$) (25-35) in cultured rat cortical neurons and also for antidementia activity in mice. Exposure of cultured cortical neurons to $10{\mu}M\;A{\beta}$ (25-35) for 36 h induced neuronal apoptotic death. At $0.1-10{\mu}g/m{\ell}$, CSF inhibited neuronal death, elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), and generation of reactive oxygen species (ROS) induced by $A{\beta}$ (25-35) in primary cultures of rat cortical neurons. Memory loss induced by intracerebroventricular injection of mice with 15 nmol $A{\beta}$ (25-35) was inhibited by chronic treatment with CSF (10, 25 and 50 mg/kg, p.o. for 7 days) as measured by a passive avoidance test. CSF (50 mg/kg) inhibited the increase of cholinesterase activity in $A{\beta}$ (25-35)-injected mice brain. From these results, we suggest that the antidementia effect of CSF is due to its neuroprotective effect against $A{\beta}$ (25-35)-induced neurotoxicity and that CSF may have a therapeutic role for preventing the progression of Alzheimer's disease.

• 한국약용작물학회지
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• 제25권6호
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• pp.353-360
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• 2017

Background: A critical features of Alzheimer's disease (AD) is cognitive dysfunction, which partly arises from decreased in acetylcholine levels. AD afftected brains are characterized by extensive oxidative stress, which is thought to be primarily induced by the amyloid beta ($A{\beta}$) peptide. In a previous study, Cinnamomum loureiroi tincture inhibited acetylcholinesterase (AchE) activity. That study identified AChE inhibitor in the C. loureiroi extract. Furthermore, the C. loureiroi extract enhanced memory in a trimethyltin (TMT)-induced model of cognitive dysfunction, as assessed via two behavioral tests. Rosa laevigata extract protected against oxidative stress-induced cytotoxicity. Administrating R. laevigata extracts to mice significantly reversed $A{\beta}$-induced learning and memory impairment, as shown in behavioral tests. Methods and Results: We conducted behavioral to examine the synergistic effects of C. loureiroi and R. laevigata extracts in inhibiting AChE and counteracting TMT-induced learning and memory losses. We also performed biochemical assays. The biochemical results showed a relationship between increased oxidative stress and cholinergic neurons damage in TMT-treated mice. Conclusions: A diet containing C. loureiroi and R. laevigata extracts ameliorated learning and memory impairments in the Y-maze and passive avoidance tests, and exerted synergistic inhibitory effect against AChE and lipid peroxidation.

• 동의신경정신과학회지
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• 제16권1호
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• pp.119-128
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• 2005

Objective : The purpose of this study was to estimate the effects of Ramulus et Uncus Uncariae DM fraction on memory enhancing in rats Methods : We oral administered Ramulus et Uncus Uncariae DM fraction to rats then executed passive avoidance test and observed figure of pyramidal neuron on CA1 Results : Findings from our experiments have shown that REUD(>1mg/100g/ml) was effective in memorial improvement. and oral administration of REUD(100mg/100g/ml) for 2 weeks was found to induced the figure of pyramidal neuron on CA1 in rat hippocampus injured by scopolamine. Conclusions : As the result of this study, Decrease of memory induced by injection of scopolamine into rat was also attenuted by REUD, based on passive avoidance test, and REUD was found to reduce the activity of AChE and induced about the CA1 in rat hippocampus. Base on these findings, REUD may be beneficial for the treatment of AD.

• 동의생리병리학회지
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• 제32권6호
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• pp.375-383
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• 2018

This study was conducted to investigate the cognitive improvement and memory recovery effects of Korean and Chinese Crataegus pinnatifida ethanolic extracts on scopolamine-induced memory impairment in mice. In vivo studies were carried out with mice treated with Korean Crataegus pinnatifida extracts (KCF) and Chinese Crataegus pinnatifida extracts (CCF) in doses of 5 and 50 mg/kg (p.o.) and scopolamine was injected 30 min before the behavioral testing. Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, and acetylcholinesterase inhibition by Ellman's modified method. The chlorogenic acid and hyperoside as marker compounds of KCF and CCF was quantified by ultra-performance liquid chromatography analysis (UPLC). Results showed that KCF was more contained high content of chlorogenic acid and hyperoside than CCF. In addition, KCF was more exerted free radical (DPPH and ABTS) scavenging activity and blocked AChE activity than CCF. In vivo studies also showed that KCF administration has a further improved the memory of scopolamine-treated mice than CCF in Y-maze test, passive avoidance test and Morris water maze test. These results revealed that KCF more prevents scopolamine-induced memory impairments through antioxidant and acethylcholinesterase inhibition effect compared CCF.

• 대한임상검사과학회지
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• 제50권4호
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• pp.492-500
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• 2018

본 연구는 이중과제 병합 가상현실 프로그램을 경도인지장애 노인에게 적용하여 인지기능, 균형과 뇌파에 미치는 영향을 알아보았다. 이중과제 병합 가상현실 프로그램을 중재한 실험군 집단과 전통적인 작업치료를 중재한 대조군 집단은 1회 30분, 1주일 5회, 총 6주에 걸쳐 실시하였다. 연구 결과는 첫째, 이중과제 병합 가상현실 프로그램을 시행한 실험군이 전통적인 작업치료를 시행한 대조군에 비해 인지기능 중 기억력 항목과 균형 항목에서 유의하게 증가하였다. 둘째, 이중과제 병합 가상현실 프로그램을 시행한 실험군이 전통적인 작업치료를 시행한 대조군에 비해 ${\beta}$파와 SMR파의 세기가 유의하게 증가하였다. 결과를 종합해보면, 이중과제 병합 가상현실 프로그램이 경도인지장애 노인에게 효과적인 치료방법이었고, 다양한 질환을 겪고 있는 대상자들에게 도움이 되는 기초 자료의 초석이 되기를 바란다.

• 동의신경정신과학회지
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• 제29권4호
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• pp.207-221
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• 2018

Objectives: The objective of this study was to observe the anti-amnesic effects of Yukmijihwang-tang (YMJHT), on the scopolamine (Sco)-induced memory impairment in C57BL/6 mice through its favorable acetylcholine (ACh). Also, to observe acetylcholinesterase (AChE) activity, Choline acetyltransferase (ChAT) mRNA expressions, and antioxidant effect. Methods: Six groups, with a total of 20 normal and 100 Sco treated mice were selected based on their body weights after 1 week of acclimatization, were used in this study as follows. Half of the mice in each group were used for passive avoidance task tests and hippocampus ACh content, AChE activity and ChAT mRNA expression measurement, and the remaining half in each group used for Morris water maze test and measurement of cerebral antioxidant defense system. Results: Amnesia due to AChE activations and destroyed cerebral cortex antioxidant defense systems were markedly and dose-dependently inhibited after 28 days of continuous oral pre-treatment with YMJHT 400, 200 and 100 mg/kg, respectively. The overall effects of YMJHT 400 mg/kg were similar to those of tacrine 10 mg/kg. Conclusions: Based on the results, it was established that oral administration of YMJHT favorably alleviates Sco-induced memory impairment, through preservation of ACh, mediated by up-regulation of ChAT mRNA expressions and related AChE inhibition and augmentation of cerebral antioxidant defense system, at least in a condition of this experiment. The overall effects of YMJHT 400 mg/kg were similar to those of tacrine 10 mg/kg.

• 한국융합학회논문지
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• 제12권4호
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• pp.249-258
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• 2021

최근 암호화폐거래소로 투자자들이 몰리면서 비트코인 가격이 급등락하고 있다. 본 연구의 목적은 딥러닝 모형을 이용하여 비트코인의 가격을 예측하고, 투자전략을 통해 비트코인의 수익성이 있는지를 분석하는 것이다. 비선형성과 장기기억 특성을 보이는 비트코인 가격 예측모형으로는 LSTM을 활용하며, 예측 가격을 입력변수로 하는 이동평균선 교차전략의 수익성을 분석하였다. 2013년부터 2021년까지의 LSTM 예측 가격을 이용한 비트코인 이동평균선 교차전략의 투자 성과는 단순 시장가격을 이용한 이동평균선 교차전략과 벤치마크전략 Buy & Hold 보다 각각 5.5%와 46% 이상의 수익률 개선 효과를 보여주었다. 최근 데이터까지 확장하여 분석한 본 연구의 결과는 기존의 연구들과 마찬가지로 암호화폐 시장의 비효율성(inefficiency)을 지지하고 있으며, 비트코인 투자자들에게는 딥러닝 모형을 이용한 투자전략의 실전 활용 가능성을 보여주었다. 향후 연구에서는 다양한 딥러닝 모형들의 성과 비교를 통해 최적의 예측모형을 개발하고 비트코인 투자전략의 수익성을 개선할 필요가 있다.