• Proceedings of the Plant Resources Society of Korea Conference
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• 2011.10a
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• pp.8-8
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• 2011

인류는 자연으로부터 식량과 질병 치료를 위하여 자연스럽게 약초를 얻을 수 있었다. 약 6만 년 전 네안데르탈인의 무덤에서 오늘날 향료로 쓰이는 약초가 발견 될 정도로 인류가 약초를 이용한 역사는 오래 되었다. 약초는 난치병, 노화, 성인병 등 현대의학에서 미비점을 보완하는 대체의약 산업의 원료이자 새로운 생물자원의 보고로서, 그 중요성이 커지고 있다. 새로운 생물자원 소재로 약초는 약용성분을 함유한 식물자원의 확보 및 개발 등 고부가산업의 소재로 선진국에서 연구개발의 경쟁이 치열하며, 약초산업은 천연소재 신약과 기능성 식품, 화장품, 생활용품 등으로 확대되고 있다. 의약품 분야에서는 새로운 시대의 중요한 생명산업으로서 약초는 한약뿐 아니라 신약 개발을 위한 소재로도 부각되고 있으며, 항암제인 택솔, 신종플루 치료제인 타미플루 등 천연물 약의 가능성은 이미 증명되었다. 식품 분야에서는 재배기술 발달과 웰빙 트렌드 속에서 약초는 신선채소와 기능성 식품으로 변신하고 있다. 한약재의 이미지를 벗어난 약초는 음료와 과자, 술 등으로 활용되고, 비빔밥 등 다양한 약선음식으로도 개발되고 있다. 산업소재의 활용분야에서는 약초는 특히 화장품 산업의 소재로 각광받고 있다. 이미 다양한 화장품 회사에서 한방화장품을 출시하여 세계 속으로 진출하고 있다. 또한 약초는 천연 색소이자 생활 용품의 소재로 활용되고 있는데, 약초를 활용한 염색약과 여성 생리대, 샴푸 등의 인기가 높다. 약초산업의 부가가치 증대를 위하여 한약재 위주의 약초산업을 천연물 신약, 기능성 식품, 화장품, 산업 소재 등 고부가가치 시장으로 확장시키고, 우리 약초 산업의 세계화를 추진해야 한다. 연구개발 투자 확대와 빠르게 변화하는 시장을 반영하여 연구 방향을 수립하고, 산학연 및 생산자단체 등과 새로운 약초 산업의 블루오션 창출을 위해 협력을 해야 할 것이다. 또한 약초의 생산기술 안정화를 통해 산업화 기반을 구축하여, 약초 공급의 안정화, 약초 생산 농가 소득 안정화가 필요하며, 마지막으로 변해가는 약초 산업의 트렌드에 부응할 수 있는 품질관리와 유통 질서 확립을 위한 정책과 제도의 선진화가 뒷받침 되어야 할 것이다.

• KSBB Journal
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• v.19 no.1
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• pp.1-11
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• 2004

Chlorella contains a rich source of biochemical products with applications in the feed, food, nutritional, cosmetic, pharmaceutical and even fuels industries. Chlorella is one of unicellular green algae and is mostly grown in fresh water such as pond and lake. It grows in a manner of nonsexual reproduction so that it multiplies 4~16 times overnight. Large-scale culture is conducted by open pond culture or pure culture using fermenter. Chlorella has various efficacies such as heavy metal removal, degradation of toxic materials, control of arteriosclerosis, immunoprotective effects, anticancer activity and growth-stimulating activity of intestinal bacteria. Chlorella can be used as a taste enhancer and foodstuff, as it has a plenty of essential amino acids, polyunsaturated fatty acids, sterols and chlorella growth factor (CGF). Chlorella is a potential organism which can be utilized for CO$_2$ removal and H$_2$ Production in environmental area and energy Production.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.49 no.1
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• pp.17-27
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• 2023

A study was performed to increase skin permeation of tocopheryl acetate, an oil-soluble component among tocopheryl acetate, salicylic acid, and niacinamide, which are the active ingredients of the anti-hair loss toner. As a method of transparently solubilizing tocopheryl acetate while containing salicyl acid and niacinamide, we used a swollen micelle structure that increased the size of the micelle formed by the aggregation of surfactants. The prepared swollen micelle solution contains three kinds of active ingredients, and poloxamer 407 and octyldodeceth-16 were used as surfactants to increase transparent properties and stability. In addition, isostearic acid was used as a co-surfactant to increase the size of micelles. To evaluate the physical properties of the prepared swollen micelles, turbidity at room temperature (25 ℃) was measured. The Franz diffusion cell method was used to evaluate the skin permeation rate of tocopheryl acetate among the hair-loss prevention components contained in swollen micelles. After 24 h, tocopheryl acetate showed a 6-fold improvement in skin permeation compared to the control group. Therefore, it can be seen that the swollen micelles developed in this study can be applied to hair-loss prevention products or solubilized formulations of various functional cosmetics.

• Journal of the Korean Applied Science and Technology
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• v.37 no.6
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• pp.1528-1534
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• 2020

This study examines the trends of the domestic age-friendly industry, examines the ingredients notified by the Ministry of Food and Drug Safety of aging cosmetics, and analyzes the research trends of raw materials other than the notices, and prepares data for the aged-friendly industry to quickly cope with changes in the cosmetics industry environment and aging people. I wanted to. In addition to the ingredients notified by the Ministry of Food and Drug Safety, research trends on the development of ingredients for anti-aging cosmetics are examined, and the anti-aging effects of each ingredient are examined. Through this, 'aging' and 'cosmetics', 'Anti-Aging', 'Anti-Aging', etc. In order to lead the development of anti-aging cosmetics related to the aging industry, research activities on products that are effective in preventing aging by strengthening the skin in addition to the four ingredients notified by the Ministry of Food and Drug Safety are constantly being conducted. In the functional cosmetics field notified by the Minister of Food and Drug Safety, it is believed that various basic research activities should be conducted so that research on anti-aging can be scientifically supported rather than a single research.

• Korean Chemical Engineering Research
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• v.48 no.4
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• pp.413-416
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• 2010

In this research, root extracts of Nelumbo nucifera was tested to see the possibility for functional cosmetic agent. 70-100% ethanol was used as solvent and nuciferin was confirmed as active component. To test cosmetic effect of root extracts of Nelumbo nucifera, safety effect(MTT assay), anti-wrinkle effect(elastase inhibition assay) and antioxidation effect(DPPH free radical scavenging assay) were measured. When 100% ethanol was used as extracting solvent, cell viability was over 80% at $100{\mu}g/ml$, which indicated that root extract of Nelumbo nucifera was suitable for cosmetic agent. Root extract of Nelumbo nucifera showed 40~50% elastase inhibition at $100{\mu}g/ml$ so that it had good anti-wrinkle characteristics. 50% antioxidation capacity($FSC_{50}$) was $5.0{\sim}38{\mu}g/ml$ and root extract of Nelumbo nucifera showed excellent antioxidation effect. From the research, root extracts of Nelumbo nucifera showed strong possibility for anti-wrinkle functional cosmetic agent.

• Korean Journal of Food Science and Technology
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• v.40 no.3
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• pp.277-282
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• 2008

Oriental herbs are reported as having potent functions for preventing many types of diseases. They also appear to have positive effects and potential capabilities for skin care. Among the many oriental herbs that are available, we chose to analyze four medicinal herbs, Korean red ginseng, Artemisia capillaries Thunb, Schizonepeta tenuifolia Briq, and Foeniculum vulgare Mill, because all are popular and considered as favorite medicinal plants in Korea. Extracts of the herbs were obtained by various methods such as using distilled water, ethyl ether, methanol, ethanol, benzene, 1-butanol, and chloroform. Nine phytochemicals were detected in the extracts: maltol, adenosine, b-pinene, menthone, pulegone, limonene, anethole, estragole, and fenchone, which reportedly have multi-functionalities. All phytochemicals were analyzed quantitatively by various chromatographic techniques such as HPLC and gas chromatography-mass (GC-MS) spectrometry. This article also presents the optimum conditions for extracting these 9 targeted phytochemical compounds that were derived from 4 popular oriental herbs, which could be useful for the efficient preparation of each phytochemical.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2023.04a
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• pp.9-9
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• 2023

한국 특산 식물인 미선나무 (Abeliophyllum distichum)는 IUCN Red List의 EN (위기종) 등급에 지정되 어 보호받아 왔다. 미선나무는 국내 자생지 6곳을 포함하는 13개의 서식지에서 생육되고 있다고 알려져 있다. 2017년 이후, 국내에서는 지속적인 보전과 관리하에 법정보호종에서 해제되어 멸종위기종 복원 성 공 사례의 귀감이 되었으나 국내를 제외하면 미선나무의 활용은 아직 어려운 현실이다. 미선나무는 1속 1종이지만 종 내에서 다양성이 존재한다. 꽃의 형태적 특징에 따른 다양한 분류가 이루어지며, 옥황1호을 포함한 분홍, 상아, 연녹색, 흰색 등으로 구분된다. 유전체 연구 및 성분 분석을 통해, 각 표현형마다 유전 정보와 유효 성분의 차이가 존재한다는 것이 알려졌다. 활용 가치를 높이려면, 유전적으로 안정되고 표준화가 가능한 원료가 필요하며, 이는 신품종을 이용하거나 새로운 개발이 필요하다는 것을 내포한다. 일반 식품으로의 활용은 어려우나 기능성 화장품의 원료 등으로 활용되고 있으며, 이러한 활용들은 미선나무의 높은 활용 가치를 투영한다. 활용 가치 평가를 위해 수행된 DNA 손상, 멜라닌 생합성, 항염증, 항산화, 항암 억제 등의 연구를 통해 다양한 약리학적 효능을 가진다는 결과들이 도출되었고, 많은 문헌들이 그 근거를 뒷받침한다. 또한, 유효 성분의 합성경로를 재정립하고 RNA 분석을 통해 그 양상을 예측하기 위한 연구가 진행 중에 있다. 미선나무에서 유래한 식물조직 배양체인 callus의 유도 및 배양이 진행되고 있으며, 옥황1호 유래 callus를 활용하여 다양한 연구를 수행하고 있다. 앞서 언급한 미선나무 연구 및 개발에 대한 한계를 파악하고, 천연 식물 자원으로의 미선나무에 대한 지속적인 관심과 지원을 통해 나고야의정서에 대응하는 전략적 접근이 필요하다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.33 no.1 s.60
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• pp.33-40
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• 2007

Astradalus membranaceus root extract (ARE) contains saponins, flavonoids, and their glycosides. Two flavonoids, calycosin and formononetin, were predominant constituents with the different amount by diverse extraction conditions. ARE showed the anti-oxidative activities, inhibited tyrosinase activity, and increased type I procollagen expression in proportion to calycosin and formononetin contents. The clinical study also showed that skin wrinkles were significantly reduced in the test group treated with a cream formulation containging 0.1% ARE compared with a group treated with a cream formulation without 0.1% ARE (p < 0.05). These results suggest that ARE may have potential as an anti-aging ingredient in cosmetics.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.31 no.4 s.54
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• pp.295-304
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• 2005

Recently, arbutin, oil soluble licorice extact (GLY), ascorbyl glucoside (AA2G), and ethyl ascorbyl ether (EAE) have been widely used as functional whitening ingredients. To Investigate which combination between the above agents could be more effective for whitening effect, tyrosinase activity and MSH-induced melanin production in B-16 melanoma cells were investigated. Both GLY and arbutin dose-dependently inhibited purified tyrosinase activity. The inhibitory effects of GLY with AA2A or EAE on Drosinase activity were more potent than those of GLY alone, whereas that of arbutin with other ingreadients did not show those effects. In MSH-induced melanin production in B-16 melanoma cells, the mixture of Gly and EAE more significantly reduced melanin formation than Gly alone. Stability of mixture of GLY, arbutin, AA2A and EAE exposed at the temperature of $25^{\circ}C\;or\;45^{\circ}C$ for 30 days were also investigated. All of the combinations of whitening agents did not show any critical changes in their composition stability. These data suggest that the combination of GLY and vitamin C derivatives such as AA2G and EAE may be useful for the promotion of whitening effect.

• Korean Journal of Clinical Laboratory Science
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• v.49 no.4
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• pp.329-336
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• 2017

This study examined the effects of polyphenols in grape pruning stem extracts (GPSE) using grape stems discarded after harvest. The inhibitory effects on allergy, proliferation, and apoptosis in UVB-induced HR-1 hairless mice were analyzed. The applicability as a material for functional food and functional cosmetics was evaluated. The contents of the active ingredients of GPSE were analyzed by HPLC. After UVB irradiation on the dermis of HR-1 hairless mice, the number of mast cells was determined by toluidine blue staining to confirm that the skin allergic reaction was caused by GPSE. The results were similar to the normal group in the group applied GPSE, and there was no allergic reaction in the GPSE application group and a significant decreased compared to the sun cream control. PCNA immunohistochemical staining of the epidermal proliferation factor had an inhibitory effect on epidermal epithelial cell proliferation in all concentrations of GPSE and serum base mixture as an average of 42% compared to the control group. The mixture of GPSE and serum base suppressed the apoptosis inhibition rate by 27% on average compared to the control. These results confirmed the inhibitory effects GPSE on the allergic, proliferation, and apoptosis activities by with a serum base on UVB-induced skin damage. GPSE is a functional ingredient with potential skin protection effects, and has a high utilization as an ingredient for functional cosmetics.