• Journal of The Korean Society of Grassland and Forage Science
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• v.41 no.4
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• pp.250-258
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• 2021

This study was conducted to investigate the effect of feeding systems on feed intake, weight gain, and fawn performance (Cervus canadensis) and estimation of grazing intensity in Elk doe at pasture. A sixteen Elk doe about 236.2 kg were randomly assigned to two feeding treatments. The treatment consisted of a barn feeding system (BF) and grazing at pasture (GR), and pasture was mainly composed of tall fescue, orchard grass, and Kentucky bluegrass. The moisture content of pasture was 19.51~22.61%, which was similar during experimental periods. The crude protein content was significantly higher from June to July (p<0.05). The contents of neutral detergent fiber and acid detergent fiber ranged 53.65~60.18%, and 26.08~29.10%, respectively. There were no significant differences between feeding systems on supplementary feed intake, but the roughage and total dry matter intake showed significant differences between treatment groups (p<0.05), except for May. In August, roughage intake was dramatically decreased in the GR group due to summer environmental changes. On the other hand, the higher intake of roughage in September might be related to nutrient intake for mammals. There was no difference in body weight between treatment groups, but the fawn performance was significantly higher in the GR group (p<0.05). These results might be suggested that grazing elk doe might positively affect fawn growth. However, it is considered that BF might increase the deer weaning rate during the parturition period, since the lower weaning rate in the GR group compared to the BF group. The grazing intensity of Elk doe was increased from May to July and decreased in August, which was influenced by pasture productivity. The average grazing intensity of Elk doe was found to be 15 heads/ha, which might be controlled by supplementary feeding. Further studies needed that mixed sowing methods and fertilization management in old grazing pastures for improved pasture productivity.

• 우유
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• s.54 fall
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• pp.20-30
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• 1993

한국야쿠르트유업은 지난 8월27일 롯데호텔에서 ‘유산균과 건강’이란 주제로 국제학술심포지엄을 개최했다. 이날 심포지엄에서는 암예방을 위한 유산균의 효과(Bandaru S. Reddy 미국 보건연구재단 영양 · 암연구부장), 비피더스균을 이용한 유산균제품의 개발(Denis Roy 캐나다 농업연구소 식품연구개발센터 낙농부장), 유산균의 항암작용에 대한 실험연구(Wilhelm H · Holzapfel 독일 국립 영양연구센터 위생 및 독성연구소장) 등의 주제발표가 있었다. 본지는 이중 ‘암예방을 위한 유산균의 효과’를 전재한다.

• Health Policy and Management
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• v.31 no.1
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• pp.91-99
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• 2021

Background: The Korean government introduced National Cancer Control Program and strengthening national health insurance coverage for cancer patients. Although many positive effects have been observed, there are also many concerns about cancer management such as patient concentration or time-to-treatment. Thus, we investigated the association between the time-to-treatment and survival of cancer patients, and compared regional differences by time trend. Methods: The data used in this study were national health insurance claims data that included patients diagnosed with lung cancer and received surgical treatment between 2005 and 2015. We conducted survival analysis with Cox proportional hazard model for the association between time-to-treatment and survival in lung cancer. Additionally, we compared the regional differences for time-to-treatment by time trend. Results: A total of 842 lung cancer patients were included, and 52.3% of lung cancer patients received surgical treatment within 30 days. Patients who received surgical treatment after 31 days had higher 5-year or 1-year mortality compared to treatment within 30 days (5-year: hazard ratio [HR], 1.566; 1-year: HR, 1.555; p<0.05). There were some regional differences for time-to-treatment, but it was generally reduced after 2010. Conclusion: Delayed surgical treatment after diagnosis can negatively affect patient outcomes in cancer treatment. To improve cancer control strategies, there are needed to analyze the healthcare delivery system for cancer care considering the severity and types of cancer.

• The Korean Journal of Nuclear Medicine Technology
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• v.14 no.2
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• pp.177-180
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• 2010

Purpose: As PET test came to be covered by the pay system of medical insurance (July 1, 2006) and the needs for it becoming increased for laboratory purpose, it became necessary to purchase expensive medical equipments to solve those problems. However, as most of equipments that are operated by cyclotron are very expensive as to amount from tens of millions up to hundreds of millions of won, it is difficult to purchase those equipments from the point of medical organizations. It may be possible to self manufacture those equipments with least costs if their parts functions that meets the operators demands. The Nuclear Medicine department of National Cancer Center (NCC) is trying to manufacture and use equipments that can be made with least costs, including introducing 2 medical equipments that can improves the operator's works. Materials and Methods: Example 1: Self production of radioisotope($^{18}F$) divider was fabricated. The NCC's Nuclear Medicine department acquired one acrylic panel, seven 3-way valve, tubing etc. that can be found in the market to make the main body of divider in cooperation with biomedical engineering, and placed them inside hot cell, and installed switching box outside of hot cell to make it possible to control them from outside. This main body of divider were placed in radioisotope transfer line that are manufactured in the cyclotron. Example 2: Self production of $^{18}F$-FDG automated divider was fabricated. The NCC's Nuclear Medicine department used cavro pump syringe that consists the main body of divider in cooperation with biomedical engineering, biomedical engineering developed programs that divides a certain amount. $^{18}F$-FDG automated divider is placed inside hot cell, and cable chords were used in the equipment, and then it was connected to PC outside hot cell to make it possible to control the $^{18}F$-FDG automated divider. Results: From the NCC's Nuclear Medicine department tests that were carried out from March, 2007 until now, we found out that radioisotope can be sent to radiopharmaceuticals composite module we want, and from the tests that are carried out at NCC's Nuclear Medicine department using $^{18}F$-FDG automated divider since August, 2009 it was possible to distribute radiopharmaceuticals into vial intended. Conclusion: Through the two examples above, we found out that costs can be reduced by self manufacturing expensive equipments from NCC's cyclotron room with least costs. Also, it decreased radiation exposure dose on workers, and set up problem solving processes in cooperation with lots of parties related.

• The Korean Journal of Nuclear Medicine Technology
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• v.27 no.1
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• pp.47-54
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• 2023

Purpose PET-CT imaging require an appropriate quality assurance system to achieve high efficiency and reliability. Quality control is essential for improving the quality of care and patient safety. Currently, there are performance evaluation methods of UN2-1994 and UN2-2001 proposed by NEMA and IEC for PET-CT image evaluation. In this study, we compare phantom images with the same experiments before and after PET-CT 3D normalization and well counter correction and evaluate the usefulness of quality control. Materials and methods Discovery 690 (General Electric Healthcare, USA) PET-CT equiptment was used to perform 3D normalization and well counter correction as recommended by GE Healthcare. Based on the recovery coefficients for the six spheres of the NEMA IEC Body Phantom recommended by the EARL. 20kBq/㎖ of ¹⁸F was injected into the sphere of the phantom and 2kBq/㎖ of ¹⁸F was injected into the body of phantom. PET-CT scan was performed with a radioacitivity ratio of 10:1. Images were reconstructed by appliying TOF+PSF+TOF, OSEM+PSF, OSEM and Gaussian filter 4.0, 4.5, 5.0, 5.5, 6.0, 6,5 mm with matrix size 128×128, slice thickness 3.75 mm, iteration 2, subset 16 conditions. The PET image was attenuation corrected using the CT images and analyzed using software program AW 4.7 (General Electric Healthcare, USA). The ROI was set to fit 6 spheres in the CT image, RC (Recovery Coefficient) was measured after fusion of PET and CT. Statistical analysis was performed wilcoxon signed rank test using R. Results Overall, after the quality control items were performed, the recovery coefficient of the phantom image increased and measured. Recovery coefficient according to the image reconstruction increased in the order TOF+PSF, TOF, OSEM+PSF, before and after quality control, RCmax increased by OSEM 0.13, OSEM+PSF 0.16, TOF 0.16, TOF+PSF 0.15 and RCmean increased by OSEM 0.09, OSEM+PSF 0.09, TOF 0.106, TOF+PSF 0.10. Both groups showed a statistically significant difference in Wilcoxon signed rank test results (P value<0.001). Conclusion PET-CT system require quality assurance to achieve high efficiency and reliability. Standardized intervals and procedures should be followed for quality control. We hope that this study will be a good opportunity to think about the importance of quality control in PET-CT

• Journal of Digestive Cancer Research
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• v.4 no.1
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• pp.21-28
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• 2016

Hepatocellular carcinoma (HCC) is rather unique. Most of HCC patients have underlying chronic liver diseases with or without cirrhosis and the prognosis of HCC depends on the liver function, as well as the tumor extent. Non-invasive diagnosis of HCC can be made with certain risk factors and specific imaging findings (e.g. hypervascularity). Patients with HCC can receive surgical resection, radiotherapy, and systemic chemotherapy as other solid malignancies. HCC has more treatment options such as liver transplantation, transarterial chemoembolization (TACE) and radiofrequency ablation (RFA). A variety of practice guidelines for HCC has been published by many academic societies. Different healthcare systems and availability of resources also affect the practice guidelines; therefore, practice guidelines have similarities and dissimilarities. Herein, we review the current status of practice guidelines for HCC and future perspectives for the improvement of guidelines are also discussed.

• Korean Journal of Head & Neck Oncology
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• v.38 no.1
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• pp.1-9
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• 2022

Thyroid cancer is one of the slow-growing tumors with excellent oncological outcomes. However, a small set of patients with unexpectedly severe outcomes are usually ignored. Anaplastic thyroid cancer (ATC) remains one of the most aggressive and lethal solid tumors. Recently, dabrafenib and trametinib combination therapy or neoadjuvant BRAF induction therapy has shown promising results. In addition, a combination of targeted drugs, immunotherapy, surgery, and radiation therapy can improve overall survival in ATC patients. Another disease for which there is no breakthrough treatment is radioactive iodine-refractory differentiated thyroid cancer (DTC). To date, multikinase inhibitors (sorafenib, lenvatinib) targeting the growth factor signaling pathway have been developed and approved as anticancer agents for patients with advanced DTC. This review includes results from multikinase inhibitors to the emergence of new target molecules, including rearrangements during transformation (RET) and tropomyosin receptor kinase (TRK).

• Journal of Korean Traditional Oncology
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• v.10 no.1
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• pp.47-55
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• 2005

Objectives: The purpose is to advertise the protocol of Best Case Series Programme of National Cancer Institute of USA to korean oriental medical oncologists and researchers Method: We reviewed the submission packet of NCI and related Website and articles. Result and Conclusion: BCS programme is the first step to evaluate the efficacy of complementary and alternative treatment, and to launch the clinical research funded by NCI.

• Korean Journal of Heritage: History & Science
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• v.46 no.4
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• pp.160-173
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• 2013

This research aims to understand the precise character of relics based on literature search and material analysis of the jade excavated from the first buried place of King Jung-jo, and to assess the level of damage through non-destructive diagnosis. Furthermore, scientific conservation treatment was used to restore the original shape of the excavated jade. According to literature search, the excavated jade is known to be jasper, but material analysis showed that it was as a serpentine with the mineral composition of antigorite. Infrared thermography analysis to assess deterioration showed that the internal damage is the result of the interstices developed along the boundary surface of the obtained jade. For conservation treatment of the damaged area on the surface, the jade was filled with a mixture of plaster and glue, and covered with a mixture of acrylic paint and gloss medium for protection, and color was adjusted.

• Journal of Digestive Cancer Research
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• v.8 no.2
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• pp.97-101
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• 2020

Metformin is a widely used first-line anti-diabetic drug worldwide. Epidemiologic studies using the large population-based cohort database have shown the association between metformin uses and reduced risk of various type cancers including gastric cancer. In the gastric cancer prevention, metformin use was associated with the significant reduction of gastric cancer risk, especially for long-term metformin users. However, there is no well-designed randomized controlled clinical trial investigating the effect of metformin as a chemopreventive drug for gastric cancer. Therefore, further well-designed clinical trials will be needed to implement metformin for chemoprevention of gastric cancer.