• Journal of Life Science
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• v.30 no.6
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• pp.513-521
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• 2020

B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) is a polycomb group protein and a core component of polycomb repressive complex 1. Initial research into Bmi1 has focused on its role in tumorigenesis, and it is generally accepted that it is important for the proliferation and survival of cancer cells. However, more recent studies have revealed that Bmi1 is downregulated in brains with neurodegenerative disease and that it regulates the function of mitochondria and reactive oxygen species levels. In this study, we tested the therapeutic potential of Bmi1 in pilocarpine-induced seizures in Bmi1-knockout mice. Bmi1 expression transiently increased in the hippocampal CA1 and CA3 and the dentate gyrus following pilocarpine-induced status epilepticus (SE). In terms of seizure behavior, SE induction was 43.14% and 53.57% for Bmi1^+/+ and Bmi1^+/- mice, respectively. However, there was no significant difference in mortality or hippocampal damage between the two groups. Two months after SE induction, the frequency of epileptic seizures in the Bmi1^+/- mice was 50% lower than in the control group, although the difference was not statistically significant. In addition, mossy fiber outgrowth in the Bmi1^+/- mice was significantly higher than in their wild-type littermates. Taken together, these data indicate that reduced Bmi1 activity increases pilocarpine-induced seizure probability and mossy fiber outgrowth.

• Information Systems Review
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• v.9 no.3
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• pp.99-132
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• 2007

As customer management rises by important issue in electronic commerce, virtue study about CRM have proceeded much. However, because existent researches were positive researches of most statistical base, There are some limitation that does not show dynamic change with CRM flow by flowing of time, and can not forecast propriety and future result about CRM strategy. Therefore, in order to overcome existent limitation on these CRM study, this study designed dynamic model which draws factors that compose CRM strategy of on-line shopping mall, and do based on technique in system dynamics so that can analyze dynamic change between these factors. Concretely, atomized customer focuses in the on-line shopping mall and does based on Permission marketing theory, and applied CRM of different level to atomized customers and know change of customer satisfaction measurement and discomfort degree accordingly. According to the result of Simulation practice, situation that achieve CRM strategy of different level by atomize customer more increase the customer satisfaction than situation that is not so. Dynamic pattern that presented in this study is expected that can verify validity about CRM achievement strategy of different level at each CRM point of contact & how Internet enterprise including on-line shopping mall is establishing CRM strategy reasonably.

• Journal of Marine Bioscience and Biotechnology
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• v.2 no.1
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• pp.34-39
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• 2007

Penaeidins are members of a special family of antimicrobial peptides existing in several species of shrimp and play a crucial role in the immunological defense of shrimp. In this study, we isolated and characterized one EST clone (penaeidin) from cDNA library of fleshy prawn Fenneropenaeus chinensis hemocytes. Amino acids sequence comparison and phylogenetic analysis with other known penaeidins revealed that our clone was completely identical to F. chinensis Penaeidin 3-2 (Accession no. ABC33920), which composed of 71 amino acids with a putative signal peptide (1-19) and a cysteine-rich domain (C-terminal part). The expression and distribution of Penaeidin 3-2 transcripts in shrimp were detected in hemocytes, hepatopancreas, and muscles, and that Penaeidin 3-2 was constitutively expressed mainly in hemocytes. The artificial infection of white spot syndrome virus to F. chinensis resulted in Penaeidin 3-2 mRNA up-regulation in hemocytes, suggesting that the possible role of Penaeidin 3-2 in host defense system of F. chinensis.

• Food Science of Animal Resources
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• v.28 no.3
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• pp.256-262
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• 2008

To develop a new quality control method for the evaluation of Korean instant noodle soups, the chemical characteristics of roasted red pepper powder (RRP), mixed with lard were investigated while in storage at $65^{\circ}C$ for 6 weeks. The moisture contents of the RRP increased but the crude protein and crude lipid contents decreased up to 4 weeks of storage. The pH value decreased and the acid value increased steadily during storage. Both the American Spice Trade Association (ASTA) value that indicates redness of red pepper, and the CIE L, a, and b values decreased remarkably during storage. The fatty acids of the RRP oil were primarily oleic acid (33.4%), linoleic acid (30.8%), and palmitic acid (21.2%). The composition of fatty acids did not significantly change after 6 weeks of storage (p>0.05). Regarding the free fatty acid (FFA) composition of the RRP oil, palmitic acid (36.5%) was the principal component. The total amount of FFA and the amount of each individual FFA increased remarkably during storage. In addition, the ratio of free unsaturated fatty acids to free saturated fatty acids increased during storage.

• Journal of Gifted/Talented Education
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• v.25 no.4
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• pp.649-667
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• 2015

This study handled underachievement issue of gifted students by developing and validating educational programs as a solution, or relief, of their academic underachievement problems. The proposed educational program was designed to enhancing reading comprehension ability of gifted students with underachievement. Based on comprehensive literature review, this study found that key issues of underachievement have to do with learning strategy, and also that learning strategy was established as 'reading comprehension strategy.' Considering diverse reading comprehension models and strategies suggested by preceding studies, the reading comprehension strategy program in Korean was customized for underachieving gifted students on the middle school level. The effectiveness of the reading comprehension strategy program as a solution to underachievement of gifted students was explored by applying the developed program to 36 identified students after school twice a week for 6 weeks, conducting pre- and post-tests that were selected to measure their reading comprehension abilities, collecting their academic achievement data before and after the intervention by this study, and interviewing students. As the results of this study, reading metacognition ability, reading comprehension skills, and school grades of gifted students with underachievement were meaningfully improved as a group. On the individual level, 12 identified students, exactly one third of the whole group of underachieving gifted students, showed so improved academic achievement as we can say they overcame underachievement based on the Supplee's definition.

• Korean Journal of Food Science and Technology
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• v.31 no.5
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• pp.1188-1195
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• 1999

This study was conducted to determin basic mineral compositions, chemical components, description of particle size distribution and whiteness for 32 items of insoluble mineral substances, i.e., 3 items of diatomaceus earth, 1 item of kaolin, 10 items of bentonite, 13 items of acid clay, 3 items of talc and 2 items of perlite. The chemical components and XRD (X-Ray diffractometer) for insoluble mineral substances, were similar with those of the reported references except kaolin. However, whiteness was determined in 90% level for talc, diatomaceus earth and kaolin. The contents of heavy metals in insoluble mineral substances were determined as follows : Pb, $nd{\sim}23.10$ ppm ; Cd, $nd{\sim}0.67$ ppm ; Hg, $nd{\sim}0.58$ ppm ; As, $nd{\sim}1.42$ ppm ; Cu, $nd{\sim}39.35$ ppm. These data were significanty lower than the references.

• The Journal of Society for e-Business Studies
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• v.24 no.4
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• pp.49-78
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• 2019

In the context of knowledge sharing, network position has been a controversial subject. A central position in the network provides access to non-redundant knowledge, leading to more opportunities of knowledge sharing. On the other hand, as "bridging" relationships, its characteristics as a "weak tie" suggest innate lack of trust and reciprocity which is considered an impediment to share knowledge. This paper attempts to enlighten the underlying dynamic by examining the interaction between network centrality, motivation and ability in knowledge sharing. Furthermore, this paper examines the concept of knowledge sharing ability in depth by operationalizing the construct into three aspects: extensive and diverse knowledge, social media utilization ability and self-efficacy. The results show a partially supported three-way interaction, where the highest level of knowledge provision is reported when the employee has low network centrality, high autonomous motivation and high knowledge sharing ability, i.e. extensive and diverse prior knowledge. Though all models indicate strong associations between network centrality and knowledge sharing, this suggests an even greater power of motivation and ability that gives the strength to overcome unfavorable environments of peripheral position. Therefore, this paper offers an alternative explanation to the existing debate whether network centrality positively or negatively influences knowledge sharing.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.14 no.4
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• pp.40-51
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• 2015

This study analysis traffic phase order alternatives to maximize throughput. According to theoretical analysis alternative2(EW: left turn after through, NS: through after left turn) and alternative5(EW: through after left turn, NS: left turn after through) can minimize the maximum delay. Both alternatives split the phase that have the same destination link under the whole cycle length. This shows that phase order alternative can effect to the fully saturated intersection. In side of simulation analysis by microscopic traffic simulator PTV VISSIM F 7.0, each phase order alternatives can't effect throughput under the non saturated condition. However under the saturated condition, the average controlled delay of the intersection has been changed by phase order alternatives. The simulation analysis shows that alternative2 and alternative5 increase throughput 3.8% to 5.1% under the saturated condition.

• Korean Journal of Childcare and Education
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• v.11 no.3
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• pp.149-167
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• 2015

This study aims to propose the future direction of research of the Nuri-Curriculum, a national level curriculum, analyzing the subjects, the research methods, and the contents of Nuri-Curriculum studies, and current research trends. For these purposes, 102 Nuri-Curriculum articles in major child care-related journals from 2012-2015 are reviewed. PASW 18.0 program was used to calculate frequency and percentage rate. The major findings are as follows. First, a considerable amount of research has been carried out despite a relatively short implementation period. Second, many research topics dealt with include curriculum-related material. Third, 74.5 percent of the articles used quantitative methods, and content-analysis was the most widely used method among them. On the contrary, there was relatively less research which used the experimental method applying the curriculum to real practice, observational or qualitative method. Fourth, most of the research contents focus on the direction of making of the curriculum. Therefore, this paper proposes the necessity of supplementary research including its application to real practice as the research approaches on the Nuri-Curriculum performed so far have been limited.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.10
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• pp.185-190
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• 2007

In this paper, minimum sampling rates and method of nonlinear characterization were suggested for low power, quasi-memoryless PAs. So far, the Nyquist rate of the input signal has been used for nonlinear PA modeling, and it is burdening Analog-to-digital converters for wideband signals. This paper shows that the input Nyquist rate sampling is not a necessary condition for successful modeling of quasi-memoryless PAs. Since this sampling requirement relives the bandwidth requirements for Analog-to-digital converters (ADCs) for feedback paths in digital pre-distortion systems, relatively low-cost ADcs can be used to identify nonlinear PAs for wideband signal transmission, even at severe aliasing conditions. Simulation results show that a generic memoryless nonlinear RF power amplifier with AMAM and AMPM distortion can be successfully identified at any sampling rates. Measurement results show the modeling error variation is less than 0.8dB over any sampling rates.