• Journal of Oral Medicine and Pain
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• v.26 no.3
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• pp.181-187
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• 2001

스트레스가 인체의 항상성에 영향을 미쳐 다양한 질병 및 동통을 일으킬 수 있다는 것은 선학들의 연구에 의해 증명되어 왔다. 특히 정서적으로 중요한 구강안면영역에는 스트레스와 관련된 질병 및 동통이 많이 존재하는데, 이에대한 병리적 기전은 아직 뚜렷하게 밝혀져 있지 않다. 이에 저자는 스트레스와 말초 및 중추신경과의 병리적 관계를 알아보고자, 구속스트레스하에서 구강안면영역의 감각과 운동에 중요한 역할을 하는 삼차신경의 집합체인 삼차신경절과 뇌간조직의 단백질 변화를 western blot을 통해 살펴보았다. 실험동물은 생후 8주된 Sprague-Dawley계 웅성 백서 (323-367 g/bw)를 대조군 3마리, 실험군 15마리로 배정하였고 실험군은 실험 전기간에 걸쳐 구속스트레스를 부여하였다. 실험동물의 삼차신경절과 뇌간은 희생 즉시 적출되었으며, western blot을 시행하여 다음과 같은 결론을 얻었다. 1. 삼차신경절의 모든 군에서 약 18 KDa의 단백질이 균일하게 나타났다. 2. 뇌간의 모든 군에서 약 18 KDa 단백질이 발현되었으며, 정상 대조군, 실험 즉일, 1일, 3일, 7일에서는 뚜렷한 변화가 없었으나 실험 5일군에서는 현저한 감소를 보였다. 구속스트레스에 의해 뇌간의 5일군에서 약 18 KDa의 특수한 단백질이 뚜렷이 감소된 후 7일 군에서 다시 증가되었던 것은 스트레스에 의한 뇌간세포의 반응으로 생각되며, 뇌간에서와 다르게 삼차신경절에서는 그 변화가 나타나지 않았던 것은 스트레스에 대한 조직의 반응 차이라고 생각된다. 따라서 이를 명확하게 확인하기 위해서는 향후 수종의 스트레스와 관련된 단백질 변화에 대한 추가적인 연구가 필요하리라 사료된다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.28 no.3
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• pp.234-238
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• 2002

Photodynamic therapy (PDT) is based on a photochemical reaction which is initiated by light activation of a photosensitizer. The photosensitizer accumulates more in tumor tissues than in normal tissues and is activated with specific wavelength of light, usually laser. The photochemical reaction produces highly reactive oxygen products causing cytotoxiciy and vascular shutdown to the tumor. The advantages of PDT are its relative selective tumor destruction and tissue healing by regeneration, which can maintain important structures with very good functional and esthetic results. Therefore, PDT is considered as an alternative modality for cancers of the head and neck. In this article, we will report three cases of photodynamic therapy for treatment of oral leukoplakia, squamous cell carcinoma, and basal cell carcinoma of head and neck. It was observed that premalignant and malignant lesions responded well to the photodynamic therapy with Aminolevulinic acid (ALA) and $Foscan^{(R)}$. Photodynamic therapy can be considered as a new treatment method for the premalignant and malignant tumors in Oral and Maxillofacial Surgery.

• The Journal of the Korea Contents Association
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• v.19 no.7
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• pp.402-411
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• 2019

The purpose of this study is to determine critical assessments and core competencies, and to determine the competence and discipline of self-assessment. We surveyed 511 students who graduated from 12 universities. Self-efficacy 24 items were measured on a 5-point scale, 8 core competencies and 52 detailed competencies were self - assessed from 0 to a maximum of 10 points. The higher the score, the higher the self - evaluation competency level. Statistical analysis was performed using SPSS 20.0 Ver., And a statistical significance level of 0.05 was considered. The self - evaluation competency level was the highest at 6.7 points in the clinical dentistry area, and the lowest at the evidence - based decision area of 5.7 points. Self-regulation was found to be positively related to the self-evaluation core competence level among self-efficacy sub-factors. As the students' self-efficacy affects subjective academic achievement and self-evaluation, it is necessary to develop and apply relevant programs to enhance critical thinking in curriculum, apply problem-based learning method, improve self-efficacy and leadership, It should be possible to cultivate.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.2
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• pp.381-387
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• 2020

This study investigates the effects of mental health and daily oral habits on temporomandibular joint symptoms. The study was conducted from September 1 to 30, 2019, enrolling a total of 402 young adults. We determined that mental health levels of anxiety, depression, and social maladjustment are significantly different, depending on life satisfaction (p<0.001), subjective health status (p<0.001), and trauma (p<0.01). Treating jaw joints exerted a significant difference in social maladjustment (p<0.05). Temporomandibular joint symptoms are significantly higher among women (p<0.05), drinkers (p<0.01), trauma (p<0.01) and jaw joint treatment patients (p<0.001). Mental health levels (p<0.001), oral habits (p<0.001), and temporomandibular joint symptoms (p<0.001) are all positively correlated. In addition, oral hygiene has the greatest influence on temporomandibular joint symptoms of trauma. Furthermore, factors experienced during treatment of the jaw joints also affect the temporomandibular joint symptoms. We conclude that it is imperative to improve oral health and malpractice in treating jaw joint disorders, and also develop a program that effectively improves jaw joint health, by combining mental health counseling and daily lifestyle improvements.

• Journal of dental hygiene science
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• v.15 no.5
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• pp.594-602
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• 2015

The purpose of this study was to examine the relationship of oral health status and oral health care to life. The subjects in this study were the patients who visited dental hospitals and clinics in several regions for seven months from March 2013. They got dental checkups, and a survey was conducted. The patients who received general treatment scored highest in Oral Health Impact Profile-14. Among the subfactors, the patients who received general treatment scored higher in functional limitation (8.27), physical pain (7.24), physical restrictions (7.90), social restrictions (7.79), physical limitations (8.14) and social difficulties (8.24). The patients who received orthodontic treatment scored higher in handicap (8.78). All the differences were statistically significant. As for gender gaps, the men scored higher in every factor. By age group, the older patients led a worse quality of life. By occupation, the homemakers mostly led a worse quality of life, and the patients who had no systemic diseases lived a better quality of life. All the differences were significant. Concerning self-rated health status and self-rated oral health state, the patients who found themselves to be in better health and in better oral health led a better quality of life. The differences were significant. Regarding oral health care, the patients who didn't get regular dental checkups and who could visit a dental clinic whenever they had a pain lived a better quality of life. The differences were significant. In terms of oral health status, a higher quality of life was found among the patients who had sound teeth, whose teeth received no sealant treatment, whose teeth received no filling therapy, who had no missing tooth, whose teeth received no prosthetic treatment and who had no dental implants teeth.

• Journal of Oral Medicine and Pain
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• v.38 no.2
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• pp.109-114
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• 2013

Chemical burn on the oral mucosa is caused by contact with various chemical products and manifests with localized mucositis, keratotic white lesions, bleeding, and painful tissue surface due to the coagulation of the tissue. Policresulen ($Albothyl^{(R)}$) is a topical antiseptic, commonly used over-the-counter drug for vaginitis, thrush and stomatitis. This drug is highly acidic with pH 0.6, and can act as a strong corrosive agent to oral mucosa. When inadvertently used in oral cavity, it may cause chemical burns of oral mucosa, resulting necrosis and bleeding surface resembling to erythema multifome. A 56 years old female patient presented with the chief complaints of painful ulcerations on the tongue, the upper and lower lips. On intraoral examination, an erythromatous, erosive or ulcerative surface covered with inflammatory exudates or bleeding crust is observed on the anterior half of the tongue and the upper and lower lips. She has occasionally applied the policresulen solution topically on the tongue to relieve pain from recurrent focal glossitis for about 10 years. In this time she applied it broadly and repeatedly to the tongue, the upper and lower lips for the purpose of pain relief by herself without instruction by physician or dentist. After cessation of policresulen application, the oral mucosa was rapidly recovered with use of topical steroids. In 2 weeks the lesions subsided completely. In summary, inadvertent use of $Albothyl^{(R)}$ on oral mucosa may result in chemical burn, causing mucosal erosion, ulceration and inflammation. It can be recovered by topical use of corticosteroid for 2 weeks after cessation of using $Albothyl^{(R)}$.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.19 no.3
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• pp.300-310
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• 1997

In order to make in vivo model of human oral squamous cell cancer, we brought up BALB/C nude mice in specially designed housystem, and maintained some kind of human oral squamous cancer cell lines ; KB, SCC-4, SCC-9, SCC-15, SCC-25. Various concentration of cancer cells were inoculated subcutaneouly into flank area of nude mice. We observed each nude mouse more than 5 weeks after tumor inoculation. We appraised the results, measured the tumor size, and calculated the growing tumor volumes after tumor inoculation according to cancer cell line and concentration of cancer cells in media. Some cancer cell lines were rapidly growing in nude mice, but some cancer cell line couldn't grow in nude mice and resorbed completely. And in some cancer cell line, some nude mice showed continuously growing tumor, but other didn't show any tumor growing. And as a new try, we implanted specially disigned caps on the back of nude mice, and cancer cell lines were brought into the caps with media. We removed the cap after 1 week, and observed over 4 weeks. The shape and size of growing tumor were observed.

• Journal of Dental Rehabilitation and Applied Science
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• v.31 no.4
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• pp.371-377
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• 2015

Oral lichen planus (OLP) is a common mucocutaneous disease, which presents as bilateral or multiple lesions. The several factors are implicated in etiology of OLP such as dental restorations, systemic disease, drugs and stress. Especially the influence of dental restorations and plaque control for OLP has been the interest in dentistry. This case is about OLP patient having poor contoured and ill-fitting metal ceramic restorations. The patient in this study has suffered from OLP for a long time, particularly after restoration of metal ceramic restorations on both posterior teeth of maxilla and mandible. This study reported that OLP lesion recovered effectively by improving the contour and fitness of restorations with plaque control.

• Journal of Oral Medicine and Pain
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• v.36 no.4
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• pp.253-259
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• 2011

Numb chin syndrome, is a rare neuropathy, characterized by facial and oral numbness restricted to the distribution of the mental nerve. Even though this neuropathy is uncommon, but this still has an important clinical meaning because it can be related with a malignancy. Because orofacial symptoms can even present the first clinical feature of a malignancy, dentists should pay careful attention to their meaning and importance to detect the malignant tumor early. Moreover, patients who present with a sudden numbness on chin should be investigated for the undiagnosed malignancy. In this report, we described a patient with stabbing orofacial pain and numbness of chin who was diagnosed with diffuse large B-cell lymphoma and placed the importance on the diagnosis of NCS.

• Journal of dental hygiene science
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• v.10 no.5
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• pp.379-385
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• 2010

The purpose of this study was to examine the oral health knowledge and oral health practice of teachers in early childhood education institutions. The subjects in this study were 169 teachers who worked in early childhood education institutions. After a survey was conducted, the collected data were analyzed with a SPSSWIN 14.0 program. The findings of the study were as follows: 1. Concerning oral health knowledge, they got a mean of 7.97(9), 2.66(3), 2.86(5), 2.42(5) and 1.04(2) respectively in knowledge on dental caries, toothbrushing, periodontitis, fluoride and diet. Overall, they got a mean of 16.98 in 24 items, and the score corresponded to approximately 70 out of 100 points. 2. As for oral health practice, tongue cleaning(4.22) was what they did the most to take care of their oral health, and they just got 2.60 in regular dental checkup. Overall, they got about 3.11 in oral health practice. 3. Regarding relationship between general characteristics and oral health knowledge, the teachers who were in their 30s got 17.47 in overall oral health knowledge, and those with a career of five to less than 10 years got 17.50. The teachers who received college or higher education got 17.27, and the principals got 18.26. Those who had ever received education on oral health got 17.01. But the gaps between them and the others were not statistically significant. 4. As to connections between general characteristics including age and oral health practice, restricted sugar intake, regular dental checkup, the use of oral hygiene supplies, tongue cleaning and overall oral health practice were more prevailing among the older teachers, and the gaps between them and the younger teachers were statistically significant. 5. In terms of relationship between oral health knowledge and oral health practice, there was no statistically significant relationship between the two on the whole, but better oral health knowledge led to better oral health practice in each part. This study shows that various oral health education programs for the kindergarten teachers should be developed and continuous education through the programs is important to improve the knowledge of oral health and to change oral health behavior.