• The Journal of the Korea Contents Association
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• v.18 no.8
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• pp.255-261
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• 2018

The purpose of this research is to discover the value of experiencing the humanistic spirit of sharing, consideration, sympathy, and communication through the mentoring program between different generations through the . The provides collective mentoring to menti to involuntarily participating mentees, prioritizing traits such as truthfulness, flexibility, and consideration for others. The sharing within the is the sharing of human traits, and displays the characteristics of volunteering. For better mutual connection and interdependence between the mentor and mentee, concentration, sympathy, understanding, and assurance is also needed. Also, sympathy is key trait that both mentors and mentees should possess, along with communication, the lacking of which causes the contradictions within our society and amplification of generational conflicts. Thus, the show the potential to become a unique mentoring program that uses culture and art to experience the humanistic spirit. Also, this program is valuable in that it provides the opportunity for the matured generation to contribute to the local community.

• International journal of thyroidology
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• v.11 no.2
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• pp.123-129
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• 2018

Background and Objectives: Hypermethylation of the tumor suppressor gene RASSF1A and activating mutation of BRAF gene have been recently reported in thyroid cancers. To investigate the role of these two epigenetic and genetic alterations in thyroid tumor progression, methylation of RASSF1A and BRAF mutation were examined in thyroid tumors. Materials and Methods: During 2007 to 2017, 69 papillary carcinomas, 18 nodular hyperplasia, 3 follicular carcinomas, and 13 follicular adenomas were selected. The methylation-specific polymerase chain reaction (MSP) technique was used in detecting RASSF1A methylation and polymerase chain reaction (PCR)-single-stranded conformation polymorphism and sequencing were used for BRAF gene mutation study. Results: The hypermethylation of the RASSF1A gene was found in 84.6%, 100% and 57.9% of follicular adenomas, follicular carcinomas, and papillary carcinomas, respectively. Nodular hyperplasia showed a hypermethylation in 33.3%. The BRAF mutation at V600E was found in 60.7% of papillary carcinoma and 27.0% of nodular hyperplasia, but none of follicular neoplasms. The BRAF mutation was correlated with the lymph node metastasis and MACIS clinical stage. There is an inverse correlation between RASSF1A methylation and BRAF mutation in thyroid lesions. Conclusion: Epigenetic inactivation of RASSF1A through aberrant methylation is considered to be an early step in thyroid tumorigenesis, and the BRAF mutation plays an important role in the carcinogenesis of papillary carcinoma, providing a genetic marker.

• The Journal of Korean Obstetrics and Gynecology
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• v.32 no.2
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• pp.18-28
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• 2019

Objectives: The research is aimed at identifying the necessity of the support project of Korean medical treatment in infertility by analyzing the outcome of those subject and providing data for Korean medical treatment in infertility by analyzing the medical treatment of Korean medical doctors involved in the project. Methods: 98 patients who participated in the support project of Korean medical treatment in infertility in Jeollanamdo and 57 Korean medical doctors who participated as therapists were surveyed. Patients were given four months of treatment at local Korean medical clinics. After the treatment was completed, we analyzed the characteristics of the patients' group. And we sent questionnaires to doctors to answer the message. The content of the questionnaire consisted of infertility treatments, a wish for support project. These data were analyzed by frequency and t-test. Results: Analysis of the answer to the questionnaire obtained data on Korean medical treatment in infertility. The most desired thing for future support program was the introduction of husband and wife care. Conclusions: This survey by Korean medical doctors gave us reference data for Korean medical treatment in infertility and the direction in which therapy business should proceed.

• Journal of The Korean Society of Emergency Medicine
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• v.29 no.6
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• pp.641-648
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• 2018

Objective: This study examined the incidence and amount of air inflow during central venous catheter (CVC) insertion. Methods: This study was an experimental study aimed at designing an apparatus to implement blood vessel and blood flow in the human body. A 1.5-m long core tube with a Teflon tube, suction rubber tube, and polyvinyl chloride tube were made. This core tube was assumed to be the blood vessel of the human body. Blood was replaced with a saline solution. The saline solution was placed higher than the core tube and flowed into the inside of the tube by gravity. The CVC was injected 15-cm deep into the core tube. The air was collected through a 3-way valve into the upper tube. The experiments were carried out by differentiating the pressure in the tube, CVC insertion step, and diameter of the end of the catheter. The experiment was repeated 10 times under the same conditions. Results: The amount of air decreased with increasing pressure applied to the tube. Air was not generated when the syringe needle was injected, and the amount of air increased with increasing size of the distal end catheter. Conclusion: To minimize the possibility of air embolism, it is necessary to close the distal end catheter at the earliest point as soon as possible.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.34 no.2
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• pp.70-79
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• 2021

Objectives : The purpose of this study is to report the effect of korean medical treatments on prurigo nodularis. Methods : We treated a 37-year-old female prurigo nodularis patient who has failed to respond to conventional therapies such as steroids and anti-histamines for 8 years. The patient was admitted to Daejeon University korean medical hospital for 21 days to get korean medical treatments including acupuncture, herbal-medicine, vapor treatment, venesection, pharmacopuncture and herbal-med aerosol therapy. The degree of improvement in prurigo nodularis was determined by the patient's subjective opinions on pruritus, febrile sensation, pain, and sleep disorders. Results : The results of this patient showed distinct improvements on pruritus, febrile sensation, pain, and sleep disorders. Pruritus decreased from 10 to 1, febrile sensation from 10 to 0, pain from 10 to 2, and sleeping hours increased 2 hours to 8 hours according to the patient's subjective opinions. Conclusions : This study shows the possibility that such korean medical treatments can improve prurigo nodularis.

• Journal of Korean Medicine Rehabilitation
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• v.31 no.1
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• pp.59-79
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• 2021

Objectives This study was performed to observe the genotoxic effect of the ChondroT. Methods To evaluate the genotoxicity of ChondroT, an experiment of bacterial reverse mutation test, in vitro mammalian chromosomal aberration test and mammalian erythrocyte micronucleus test in mouse was conducted. Results TA98, TA100 and TA1537 strains in the absence of metabolic activation system (S9 mix), the number of revertant colonies being greater than 2-fold of the respective negative control value. Both in -S9 mix and +S9 mix, the frequencies of aberration cells with structural aberration and numerical aberrations of chromosome were less than 5%. There was no increase of polychromatic erythrocyte with one or more micronuclei at any dose of test substance compared to the negative control group (p<0.05). Conclusions In TA98, TA100 and TA1537 strains in the absence of metabolic activation system (S9 mix), the number of revertant colonies was greater than 2-fold of the respective negative control value, showing positive results. ChondroT was considered to be non-clastogenic to Chinese hamster lung (CHL/IU) cells under the present experimental condition. and ChondroT was determined not to induce an increased frequency of micronuclei in the bone marrow cells of male ICR mice under the present experimental condition.

• Korean Journal of Acupuncture
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• v.38 no.4
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• pp.275-281
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• 2021

Objectives : This study reports changes in liver function test (LFT) after Korean Medicine treatment in patients admitted to Korean Medicine hospital with abnormal LFT. The purpose of this study is to investigate the relationship between the Korean medicine treatment and abonormal LFT to verify safety of Korean medicine treatment by analyzing index of LFT. Methods : From Oct. 2015 to Sep. 2020, the result was analyzed for 91 patients admitted to the Pohang Korean Medicine Hospital and received Korean Medicine treatment. Asparate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TB) were compared at admission and discharge. Results : Comparison between admission and discharge LFT showend AST decreased from 52.72±25.08 to 43.2±19.20, ALT from 70.85±32.40 to 62.13±29.40, and TB from 1.33±0.37 to 0.81±0.29. Conclusions : After Korean medicine treatment, AST, ALT, and TB decreased compared with the values at admission. Further studies on safety of Korean Medicine treatment are warranted.

• Archives of Obesity and Metabolism
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• v.1 no.1
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• pp.14-25
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• 2022

In 1971, Dr. Akira Endo succeeded in isolating a cholesterol synthesis inhibitor, compactin. Later, compactin was renamed mevastatin, meaning that it stops the synthesis of mevalonate, which is considered the first statin. However, mevastatin is not commercially released, whereas lovastatin, developed by Alfred Albert of Merk in 1979, was the first commercially developed statin. After the 4S study, the first largescale clinical trial with statins conducted in Scandinavia showed a dramatic secondary preventive effect against cardiovascular disease, and the effectiveness of statins in patients with dyslipidemia was repeatedly demonstrated. Subsequently, many oral drugs that affect blood lipid concentration; statins and ezetimibe aimed at reducing low-density lipoprotein (LDL)) cholesterol; fibrates and omega 3 formulations aimed at reducing triglycerides were widely developed and used in Korea. In this article, we review the results of clinical studies on representative cardiovascular diseases for four types of oral drugs for dyslipidemia, which are currently the most commonly used in Korea.

• Journal of the Korean Institute of Educational Facilities
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• v.28 no.6
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• pp.3-13
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• 2021

Introduced in 2004 as an 'After-School Academy' policy, the 'After-School Care Class' has become a universal program for elementary schools over time. While the concept of public education service has expanded and changed in various ways including educational welfare, the physical environment of the care classroom has undergone fixed changes within the uniform classroom structure of a standardized school space. The purpose of this study is to identify spatial characteristics of care classroom through chasing and analysing changes in the care class space configuration from 2004 to the present. The findings are as follows. The plan of the early care classroom wasn't much different from the existing common classroom, and it was only in 2007 that the kitchen and floor heating appeared for the first time.From the 2015 standard plan, prominent differentiation of the space between learning activities and resting area was shown, but the spatial characteristics are nothing more than a division that utilizes ready-made furniture. A distinctive feature of the 2018 Seoul care classes are diversity. In the case of the care exclusive classrooms, the division between the support space and the main activity space became more clear using furniture integrated open walls and various floor levels. In the case of a shift classrooms that is used together with common classrooms, it is characterized by flexibility that allows dramatically different classroom configurations for each time period by using a convertible furnishing space.

• Biomolecules & Therapeutics
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• v.5 no.3
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• pp.239-245
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• 1997

Trimetoquinol (TMQ) and its analogs are known to have thromboxane $A_2$ antagonistic action. We also reported that GS389, chemically similar to TMQ, has competitive antagonistic action in rat aorta and human platelets. In the present study, we investigated the pharmacological characteristics of GS283 and GS 386, analogs of GS389, using vascular smooth muscle, human platelets and rat brain homogenates. In isolated pig coronary artery (PCA), both of GS283 and GS386 relaxed U46619-contracted rings in concentration dependent manner. Pretreatment with several concentrations of GS283 and GS386 shifted the dose-response curves to the right, and reduced of maximum contration dose-dependently. Furthermore, GS283 and GS386 strongly inhibited $Ca^{2+}$ -induced contraction in the PCA. In human platelets, U46619- and A23187-induced platelet aggregation was inhibited by GS283 and GS386, concentration-dependently. Anti-platelet aggregation was related to the compound\`s ability to inhibit ATP release at each stimulation. In rat brain homogenates, receptor-binding assay resulted that both GS283 and GS386 have a relative affinity to $\alpha$-adrenergic receptor. Taken together. we concluded that the mechamism of action of GS283 and GS86 is not related with in TXA$_2$ receptor but concerned with calcium antagonistic action and a-blocking action.n.