• The Journal of Korean Obstetrics and Gynecology
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• v.32 no.4
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• pp.116-131
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• 2019

Objectives: The aim of this study was to observe the changes of women's postpartum symptoms, the quality of life and depression scale over the first six weeks after childbirth. Methods: Twenty seven mothers who received Korean medical treatment in the outpatient department treatment (from September 27th, 2017 to January 5th, 2018) were evaluated for Verbal numerical rating scale (VNRS), edema index, EuroQol Visual Analogue Scale (EQ-VAS), and Edinburgh Postnatal Depression Scale (EPDS). Results: There were 17 high risk participants (63.0%) and 10 normal participants (37.0%). The VNRS of edema is the highest in the first week, and the VNRS of joint pain is the highest from the second week to the sixth week in all patients. The Extra Cellular Water/Total Body Water (ECW/TBW) of high risk group significantly decreased from $0.403{\pm}0.011$ to $0.387{\pm}0.006$(p<0.05) in the first 2 weeks. The ECW/TBW of normal group significantly decreased from $0.393{\pm}0.070$ to $0.383{\pm}0.011$ (p<0.05) in the first 2 weeks. The EQ-VAS of high risk group increased from $64.12{\pm}13.941$ to $69.35{\pm}18.155$ (p<0.05) in the first 2 weeks. But this difference was not significant statistically (p=0.234). The EQ-VAS of normal group significantly increased from $62.50{\pm}21.763$ to $74.00{\pm}9.661$ (p<0.05) in the first 2 weeks. The difference of EPDS was not statistically significant between the first week and the sixth week in every participants. Conclusions: VNRS was the highest in edema in the first week, joint pain was the highest from the second week to six week. The edema index of high risk groups was higher than that of the normal group in the first week (p<0.05). The EQ-VAS of normal group significantly increased (p<0.05) in the first 2 weeks but high risk group didn't. In the EPDS, the ratio of nine or more points of high risk group was more than twice than normal group in the first 2 weeks.

• Journal of Sasang Constitutional Medicine
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• v.33 no.3
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• pp.54-71
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• 2021

Objectives The purpose of this study was to revise Sasang Digestive Function Inventory (SDFI) and improve its validity and reliability using clinical data. Methods The Sasang type and Cold-Heat pattern differentiation by certified clinical specialist and responses to SDFI items were acquired from 419 hospital patients. The revision of SDFI was performed using item analysis and Explorative Factor Analysis (EFA). Furthermore, the validity and reliability of the revised SDFI (rSDFI) were investigated using Confirmatory Factor Analysis (CFA), Internal Consistency and Item Response Theory (IRT). And, clinical significance of the rSDFI was examined for the differentiation of Sasang types and Cold-Heat patterns. Results The number of the SDFI items were modified from 21 to 15. And, the validity and reliability of the rSDFI subscale structure were found to be acceptable. The scores of rSDFI-total and rSDFI-E significantly decreased in the order of Tae-Eum (TE), So-Yang (SY), So-Eum (SE) types, and the rSDFI score of SE type was significantly lower than that of TE and SY types. The rSDFI-total score could differentiate Cold-Heat pattern in both SY and SE types. And the difference of digestive function between Cold and Heat pattern of SE type could be explained with the rSDFI-D score. The rSDFI-total score in Cold pattern significantly decreased in the order of TE, SY, and SE types, and the rSDFI-total score of TE type is significantly higher than that of SE type in Heat pattern. Conclusions Current results demonstrated the reliability, validity and clinical usefulness of the rSDFI in clinical patients. Therefore, rSDFI can be utilized as an objective clinical measure supporting the differential diagnosis of Sasang typology.

• Journal of Environmental Impact Assessment
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• v.30 no.6
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• pp.380-392
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• 2021

An indoor air quality index for school classrooms based on the Hazard Quotient (HQ) was developed in this study. The current index (IAQI-S) covered PM₁₀, PM_2.5, and CO₂, and breakpoints of IAQI-S were calculated using each HQ value. IAQI-S was applied to the real-time data obtained from 123 classrooms of 46 schools during November 2017 to December 2020. As a result of the comprehensive assessment, 93.1% of PM₁₀ and 94% of PM_2.5 belonged to 'good' and 'moderate', respectively. The IAQI-S based on an 8-hour predicted moving average was compared with Comprehensive Air-quality Index (CAI) and with the IAQI of a foreign reference. The IAQI-S includes CO₂ and consists of more stringent levels comparing to outdoor index (CAI).

• Journal of Sasang Constitutional Medicine
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• v.33 no.3
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• pp.1-15
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• 2021

Introduction The clinical usefulness of Sasang Digestive Function Inventory (SDFI) for analyzing Sasang type-specific pathophysiological symptom was illustrated repeatedly. It was revised to enhance its validity, reliability and clinical usefulness, however its clinical studies supporting these were not sufficient yet. Methods 193 healthy university students responded once to Nepean Dyspepsia Index-Korean (NDIK), Functional Dyspepsia-Related Quality of Life (FDQOL), and Dutch Eating Behavior Questionnaire (DEBQ), and twice to SDFI with four weeks of interval. The Body Mass Index (BMI) and Ponderal Index (PI) were also calculated. The 4-week test-retest reliability and correlation coefficients between NDIK, FDQOL, DEBQ, and SDFI were examined using Pearson's correlation. The significant differences between Sasang types in SDFI and its subscales were examined using ANCOVA with the age as covariate. Results The range of test-retest reliability for SDFI and its subscales was from 0.801 to 0.887. The SDFI-total correlated positively with BMI (r=0.323) and DEBQ-External Eating (r=0.433), while the SDFI-Digestion negatively with NDIK (r=-0.472) and FDQOL-total (r=-0.364). The SDFI-Habit correlated positively with BMI (r=0.310) and DEBQ-total (r=0.481), and the SDFI-Appetite with DEBQ-total (r=0.322). The SDFI-total, SDFI-Digestion, and SDFI-Habit scores of Tae-Eum type (35.6±6.25, 12.38±3.24 and 9.89±3.38, respectively) were significantly bigger than those of So-Eum type (29.84±8.31, 9.93±4.28 and 7.66±3.96). Discussion The SDFI was found to be an objective clinical measure with sufficient concurrent validity for measuring eating behavior and quality of life related to overeating and dyspepsia, and illustrated distinctive differences between Sasang types. It might be useful for the effective medical education and integrative medical practice.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.6
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• pp.403-410
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• 2018

Lifestyle of adolescents cause a lot of health effects in the future. Therefore, in Korea, school health law was enacted and relevant business such as school education program is being carried out. This study was conducted to recognize symptom according to grade. A survey of youth health status was conducted at 19 middle and high schools in Seongnam city from May 2015 to December 2015. The survey made up of 14 questions which was about the health status satisfaction on the adolescent was conducted to investigate frequency by year and the respective health status of 6 grades. A total of 9,584 students responded to the survey, 58.22% answered that they were not free of constipation. 25.69% of respondents had no symptoms of headache, consequently over 70% of respondents had headache. 57.06% of respondents had no symptoms of low back pain and 34.7% had no symptoms of neck & shoulder pain, therefore over 50% of respondents had muscular skeletal symptoms. In menstrual history, only 17.95% of respondents said their period was regular and painless. In respiratory history, except cold, no nasal drop & obstruction has appeared in the group of 54.02%. And 62.97% of respondents had persistent cough usually with cold and 23.41% had cough with cold breeze even if not catch cold. In the third grade of high school students, there were many complaints of pain in various parts such as headache, back pain and shoulder pain, neck pain and menstrual pain, and there was a high rate of complaints of digestive system symptom and defecation symptom. More than half of respondent had constipation discomfort, headache and musculo-skeletal symptoms, menstrual problems and cough. In the third grade of high school students, the rate of complaints of pain complaints, digestive system symptoms, and bowel symptoms was high. Therefore, there is a need for measures and management for continuous health care and health promotion in accordance with students' symptoms and age at each grade level.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.8
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• pp.417-424
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• 2019

Despite its superior ability to show distinct cellular morphology and for long-term storage, conventional tissue fixation by formalin has many drawback, including slower fixation, the exposure to harmful chemicals and extensive protein modification. Herein, we assessed the effects of rapid microwave-assisted tissue fixation on histological examination and on protein integrity by comparing these microwave irradiation fixated tissues with the formalin-fixed tissues. One of the paired mouse tissues (liver and kidney) was fixed in formalin and the other was fixed by using microwave irradiation in phosphate buffered saline. Each slide from the paraffin-embedded tissues was examined by H & E staining for the adequacy of fixation and by immunohistochemical staining for antigenicity in a blinded fashion. Evaluation of protein recovery and the protein quality from the fixed tissues were analyzed by the BCA method and Western blotting, respectively. The results from H & E staining and immunohistochemical staining showed that the sections obtained from microwave-fixed tissues under our experimental conditions were comparable to those of the formalin-fixed tissues except for the integrity of RBCs. Furthermore, proteins were effectively extracted from the microwave-fixed tissues with acceptable preservation of the proteins' quality. Taken together, this microwave-assisted tissue processing yields a quick fixation and better protein recovery in higher amounts, as well as the adequacy of fixation and the antigenicity being comparable to formalin-fixed tissues, and this all suggests that this new fixation technique can be applied in an environment where rapid tissue fixation is required.

• Journal of the korean academy of Pediatric Dentistry
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• v.46 no.3
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• pp.310-317
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• 2019

The purpose of this retrospective study was to evaluate the survival rate of composite resin restorations in permanent first molars in pediatric patients focusing on the influence of risk factors related to patients and teeth. 172 patients (6 - 12 years old) who had their permanent first molars restored with composite resin from July 2010 to July 2012 were investigated. From the dental records, the influence of the risk factors on the survival of restorations was assessed. Location of teeth, classification of cavities, patients' age and caries risk were included as risk factors in this study. The caries risks of patients were evaluated by the value of the decayed-missing-filled teeth index with the records of patients taken at 5 years old. Among 354 restorations, 272 restorations retained and 82 restorations were replaced. The overall cumulative survival rate at 5 years was 73.9%. The main reason for replacement of restorations was secondary caries (81.7%). Patients with older age group and with lower caries risk group showed higher survival rate of restorations. No statistically significant influence was detected between the survival rates and the possible risk factors : location of teeth, patients' age and caries risk. The survival rate of restorations was significantly affected by the classification of the cavities (p = 0.002).

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.4
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• pp.437-445
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• 2018

In this study, we analyzed two components, sulforaphane and PF-3758309 to prove that the mixed composition of them has more effective antioxidant and whitening functions compared to each component. We analyzed the cellular toxicity of each component and also the mixed composition to find the safe concentration level for cell viability. From the single component treatment, we discovered that sulforaphane was safe up to $10{\mu}M$, and PF-3758309 up to 100 nM. Combination treatment of $10{\mu}M$ sulforaphane and 1 nM PF-3758309 did not affect the cell viability. The LPS-stimulated NO generation was significantly reduced by the mixed composition of sulforaphane and PF-3758309. Melanogenesis by ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH) was also inhibited by the mixed composition. In order to confirm the possibility as the cosmetic material, we carried out clinical studies for the mixed composition samples. Skin safety evaluation using patch test was judged to be unstimulated, skin whitening effect was increased, and melanin deposition was suppressed by treatment of mixed composition samples. These results provide us with the opportunity for applying it into the development of new functional cosmetics.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• v.61 no.11
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• pp.573-579
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• 2018

Background and Objectives Cochlear dead region (CDR) is a region in the cochlear where hearing loss has occurred due to damage to the inner hair cells and/or neurons. Recently, a subjective test involving a pure-tone test in the presence of threshold-equalizing noise (TEN) was introduced to identify CDR. However, for uncooperative patients, such a subjective method would be unsuitable and objective methods would be needed instead to detect CDR. The acoustic change complex (ACC) is an evoked potential elicited by changes in the ongoing sound. In this study, we developed an objective method of identifying CDR by combining ACC response with a TEN test, namely the TEN-ACC test, and investigated its feasibility in normal-hearing listeners. Subjects and Method Ten normal-hearing subjects participated in this study. All subjects underwent both behavioral TEN test and electrophysiological TEN-ACC test. The stimuli for the TEN-ACC test consisted of TEN and embedded pure tones with different frequencies/signals to noise ratios (SNRs). To identify the thresholds, the range SNR of stimulation was varied from 0 to 20 dB, in stages of 4 dB. Results The ACC responses of all subjects who participated in this study were well elicited by stimuli developed for the TEN-ACC test. We confirm that the pure-tones embedded in TEN elicited the objective ACC response. Conclusion The results of this study suggest that the novel TEN-ACC test can be applied to evoke ACC in normal-hearing listeners. Future research should incorporate hearing-impaired listeners to determine the feasibility of the TEN-ACC test as an objective method to identify CDR.

• Journal of Biomedical Engineering Research
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• v.39 no.6
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• pp.229-236
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• 2018

Liver cancer is one of the highest incidents in the world, and the mortality rate is the second most common disease after lung cancer. The purpose of this study is to evaluate the diagnostic ability of deep learning in the classification of malignant and benign tumors in CT images of patients with liver tumors. We also tried to identify the best data processing methods and deep learning models for classifying malignant and benign tumors in the liver. In this study, CT data were collected from 92 patients (benign liver tumors: 44, malignant liver tumors: 48) at the Gil Medical Center. The CT data of each patient were used for cross-sectional images of 3,024 liver tumors. In AlexNet and VggNet, the average of the overall accuracy at each image size was calculated: the average of the overall accuracy of the $200{\times}200$ image size is 69.58% (AlexNet), 69.4% (VggNet), $150{\times}150$ image size is 71.54%, 67%, $100{\times}100$ image size is 68.79%, 66.2%. In conclusion, the overall accuracy of each does not exceed 80%, so it does not have a high level of accuracy. In addition, the average accuracy in benign was 90.3% and the accuracy in malignant was 46.2%, which is a significant difference between benign and malignant. Also, the time it takes for AlexNet to learn is about 1.6 times faster than VggNet but statistically no different (p > 0.05). Since both models are less than 90% of the overall accuracy, more research and development are needed, such as learning the liver tumor data using a new model, or the process of pre-processing the data images in other methods. In the future, it will be useful to use specialists for image reading using deep learning.