Korean Journal of Otorhinolaryngology-Head and Neck Surgery

Korean Society of Otolaryngology-Head and Neck Surgery (대한이비인후과학회)
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The Objective Test of Cochlear Dead Region Using Acoustic Change Complex: A Preliminary Report

Acoustic Change Complex에 기반한 와우소실영역 검사의 객관적인 방법 제시를 위한 예비 연구

  • Kang, Soojin (Department of Biomedical Engineering, University of Ulsan) ;
  • Han, Juhyun (Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine) ;
  • Woo, Jihwan (Department of Biomedical Engineering, University of Ulsan) ;
  • Park, Hee Sung (Hearing Research Laboratory, Samsung Medical Center) ;
  • Moon, Il Joon (Hearing Research Laboratory, Samsung Medical Center) ;
  • Choi, Kyusung (Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine) ;
  • Hong, Sung Hwa (Hearing Research Laboratory, Samsung Medical Center)
  • 강수진 (울산대학교 의공학과) ;
  • 한주현 (성균관대학교 의과대학 삼성창원병원 이비인후과학교실) ;
  • 우지환 (울산대학교 의공학과) ;
  • 박희성 (삼성서울병원 청각연구실) ;
  • 문일준 (삼성서울병원 청각연구실) ;
  • 최규성 (성균관대학교 의과대학 삼성창원병원 이비인후과학교실) ;
  • 홍성화 (삼성서울병원 청각연구실)
  • Received : 2017.10.17
  • Accepted : 2017.12.28
  • Published : 2018.11.25
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Abstract

Background and Objectives Cochlear dead region (CDR) is a region in the cochlear where hearing loss has occurred due to damage to the inner hair cells and/or neurons. Recently, a subjective test involving a pure-tone test in the presence of threshold-equalizing noise (TEN) was introduced to identify CDR. However, for uncooperative patients, such a subjective method would be unsuitable and objective methods would be needed instead to detect CDR. The acoustic change complex (ACC) is an evoked potential elicited by changes in the ongoing sound. In this study, we developed an objective method of identifying CDR by combining ACC response with a TEN test, namely the TEN-ACC test, and investigated its feasibility in normal-hearing listeners. Subjects and Method Ten normal-hearing subjects participated in this study. All subjects underwent both behavioral TEN test and electrophysiological TEN-ACC test. The stimuli for the TEN-ACC test consisted of TEN and embedded pure tones with different frequencies/signals to noise ratios (SNRs). To identify the thresholds, the range SNR of stimulation was varied from 0 to 20 dB, in stages of 4 dB. Results The ACC responses of all subjects who participated in this study were well elicited by stimuli developed for the TEN-ACC test. We confirm that the pure-tones embedded in TEN elicited the objective ACC response. Conclusion The results of this study suggest that the novel TEN-ACC test can be applied to evoke ACC in normal-hearing listeners. Future research should incorporate hearing-impaired listeners to determine the feasibility of the TEN-ACC test as an objective method to identify CDR.

Keywords

References

  1. Moore BC. Dead regions in the cochlea: diagnosis, perceptual consequences, and implications for the fitting of hearing AIDS. Trends Amplif 2001;5(1):1-34. https://doi.org/10.1177/108471380100500102
  2. Moore BC. Dead regions in the cochlea: conceptual foundations, diagnosis, and clinical applications. Ear Hear 2004;25(2):98-116.
  3. Vinay, Baer T, Moore BC. Speech recognition in noise as a function of highpass-filter cutoff frequency for people with and without lowfrequency cochlear dead regions. J Acoust Soc Am 2008;123(2):606-9. https://doi.org/10.1121/1.2823497
  4. Vinay, Moore BC. Speech recognition as a function of high-pass filter cutoff frequency for people with and without low-frequency cochlear dead regions. J Acoust Soc Am 2007;122(1):542-53. https://doi.org/10.1121/1.2722055
  5. Cox RM, Johnson JA, Alexander GC. Implications of high-frequency cochlear dead regions for fitting hearing aids to adults with mild to moderately severe hearing loss. Ear Hear 2012;33(5):573-87.
  6. Moore BC, Huss M, Vickers DA, Glasberg BR, Alcantara JI. A test for the diagnosis of dead regions in the cochlea. Br J Audiol 2000;34(4):205-24. https://doi.org/10.3109/03005364000000131
  7. Moore BC, Creeke S, Glasberg BR, Stone MA, Sek A. A version of the TEN test for use with ER-3A insert earphones. Ear Hear 2012;33(4):554-7. https://doi.org/10.1097/AUD.0b013e31824b9e43
  8. Martin BA, Boothroyd A. Cortical, auditory, event-related potentials in response to periodic and aperiodic stimuli with the same spectral envelope. Ear Hear 1999;20(1):33-44. https://doi.org/10.1097/00003446-199902000-00004
  9. Martin BA, Boothroyd A. Cortical, auditory, evoked potentials in response to changes of spectrum and amplitude. J Acoust Soc Am 2000;107(4):2155-61. https://doi.org/10.1121/1.428556
  10. Ostroff JM, Martin BA, Boothroyd A. Cortical evoked response to acoustic change within a syllable. Ear Hear 1998;19(4):290-7. https://doi.org/10.1097/00003446-199808000-00004
  11. He S, Grose JH, Buchman CA. Auditory discrimination: the relationship between psychophysical and electrophysiological measures. Int J Audiol 2012;51(10):771-82. https://doi.org/10.3109/14992027.2012.699198
  12. Martin BA, Tremblay KL, Korczak P. Speech evoked potentials: from the laboratory to the clinic. Ear Hear 2008;29(3):285-313.
  13. Ahadi M, Milani M, Malayeri S. Prevalence of cochlear dead regions in moderate to severe sensorineural hearing impaired children. Int J Pediatr Otorhinolaryngol 2015;79(8):1362-5. https://doi.org/10.1016/j.ijporl.2015.06.013
  14. Choi JE, Lee JJ, Chung WH, Cho YS, Hong SH, Moon IJ. Clinical implication of the threshold equalizing noise test in patients with sudden sensorineural hearing loss. Otol Neurotol 2016;37(10):1503-9. https://doi.org/10.1097/MAO.0000000000001202
  15. Baer T, Moore BC, Kluk K. Effects of low pass filtering on the intelligibility of speech in noise for people with and without dead regions at high frequencies. J Acoust Soc Am 2002;112(3 Pt 1):1133-44. https://doi.org/10.1121/1.1498853
  16. Harris KC, Mills JH, He NJ, Dubno JR. Age-related differences in sensitivity to small changes in frequency assessed with cortical evoked potentials. Hear Res 2008;243(1-2):47-56. https://doi.org/10.1016/j.heares.2008.05.005