• Title/Summary/Keyword: 광음향 효과

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Clinically translatable photoacoustic imaging of cancer diagnosis (임상적용이 가능한 광음향 암 진단 기술)

  • Kim, Mi-Ji;Park, Yeon-Seong;Yoon, Changhan
    • The Journal of the Acoustical Society of Korea
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    • v.38 no.4
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    • pp.476-484
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    • 2019
  • Photoacoustic imaging is a hybrid real-time imaging technique that combines high optical contrast and ultrasonic resolution. It has primarily been utilized in pre-clinical research and has evolved into clinical practice. In this paper, we review photoacosutic imaging for detection of primary canccer and metastatis and its limitation in translation from pre-clinical to clinical application.

Photoacoustic Investigation of Carrier Transport and Thermal Diffusivity in GaAs and Si (광음향분광법을 이용한 GaAs와 Si 반도체의 열확산도 측정과 운반자특성 연구)

  • Lim, Jong Tae;Han, Ho Youn;Park, Seung Han;Kim, Ung;Choi, Joong Gill
    • Journal of the Korean Chemical Society
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    • v.41 no.7
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    • pp.329-336
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    • 1997
  • Photoacoustic spectroscopy was utilized to investigate the carrier transport and the thermal diffusivity in GaAs and Si. From the frequency dependence of the photoacoustic signal, it is found that heat source was originated from the instantaneous thermalization process in low frequency region. In high frequency region, however, the heat was generated by the nonradiative bulk recombination and the nonradiative surface recombination processes. It was also shown that the photoacoustic effects in GaAs of a direct band gap were governed by all three processes and those in Si of an indirect band gap were produced by the instantaneous thermalization and the nonradiative bulk recombination only. The phase of the photoacoustic signal showed a minimum value in GaAs. In Si, the phase of the photoacoustic signal was monotonically decreased as the modulation frequency was increased, demonstrating the above-mentioned mechanisms of the generation of heat. By measuring the photoacoustic signal, thermal diffusivities of semiconductors were determined to be ∼0.35 ㎠/s for GaAs and ∼1.24 ㎠/s for Si. In addition, the similar values of thermal diffusivities were obtained from the curve fitting of photoacoustic phase spectra.

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Fabrication of a PMN-PZT needle hydrophone for photoacoustic imaging (광음향 영상화를 위한 PMN-PZT 바늘형 수중청음기 제작)

  • Fan, Xiaofeng;Cao, Yonggang;Ha, Kanglyeol;Kim, Moojoon;Kang, Hyun Wook;Oh, Junghwan
    • The Journal of the Acoustical Society of Korea
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    • v.35 no.3
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    • pp.175-182
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    • 2016
  • For application to several MHz photoacoustic imaging systems, a needle hydrophone was designed and fabricated by using PMN-PZT piezoelectric single crystal, and its characteristics were evaluated through comparison with a commercial PVDF(Polybinylidene Fluoride) hydrophone of which receiving sensitivity is known. The simulation using the KLM model results show that the peak receiving impulse response for $50{\Omega}$ terminating impedance of the fabricated hydrophone is -261.6 dB re $1V/{\mu}Pa$ and the frequency response is relatively flat over 2 ~ 12 MHz with fluctuation less than 5 dB. The measurement results using tone burst signals also show that it has higher (ave. 10.9 dB) sensitivity than the commercial hydrophone in 2 ~ 8 MHz, and the receiving sensitivity of $-255.8{\pm}2.8$ dB re $1V/{\mu}Pa$ was measured for the fabricated hydrophone. In addition, it is known that the photoacoustic signals and the image of a hair obtained by a mechanical scanned photoacoustic imaging system with the fabricated hydrophone were bigger and better than those obtained with the commercial hydrophone.

Optoacoustic Ultrasound Generator Based on Nanostructured Germanium (광음향효과를 이용한 게르마늄 나노구조 기반의 초음파 발생 소자 연구)

  • Yoon, Sang-Hyuk;Heo, Junseok
    • Korean Journal of Optics and Photonics
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    • v.26 no.5
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    • pp.255-260
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    • 2015
  • We have fabricated an optoacoustic ultrasound generator based on nanostructured germanium (Ge). Ge thin films were deposited via e-beam evaporation and then etched using a metal-assisted chemical (MAC) method to form nanostructured Ge films. The measured intensity of ultrasound from the nanostructured Ge covered with PDMS was about 3 times stronger than that of 100-nm-thick chromium (Cr). When the nanostructured Ge was embedded in the PDMS, the intensity of ultrasound became 8.5 times as strong compared to the 100-nm-thick Cr.

Frequency and power stabilization of radio frequency excited CO2 laser using photoacoustic effect (광음향 효과에 의한 고주파 여기식 CO2 레이저의 주파수 및 출력 안정화)

  • Choi, Jong-Woon;Yu, Moon-Jong;Woo, Sam-Yong;Suh, Ho-Suhng
    • Korean Journal of Optics and Photonics
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    • v.15 no.6
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    • pp.569-574
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    • 2004
  • We stabilized the frequency and power of a CW radio-frequency-excited $CO_2$ laser on the peak of the Doppler broadened gain curve using the photoacoustic effect generated from the laser itself. The condenser microphone is installed in the radio frequency discharge chamber to detect a photoacoustic signal. The photoacoustic signal is fed to a lock-in stabilizer as a reference signal for stabilization. The frequency stability is estimated to be better then 5.4${\times}$10$^{-8}$ at the P(20) line. The stabilized output variation was reduced 9.3%, compared to 100% for a free running laser.

An Application of Optoacoustic Technique for the CO Oxidation Reaction Catalyzed by $Gd_{1-x}Sr_xCoO_{3-y}$ (광음향분광법을 이용한 CO 산화반응에서의 $Gd_{1-x}Sr_xCoO_{3-y}$ 촉매효과 연구)

  • Kang Hee-Seok;Oum Ka-Won;Hwang Jin-Soo;Yo Chul-Hyun;Choi Joong-Gill
    • Journal of the Korean Chemical Society
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    • v.37 no.1
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    • pp.55-61
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    • 1993
  • An application of the optoacoustic detection method to investigate the catalytic effect of a perovskite, $Gd_{1-x}Sr_xCoO_{3-y}$ (x = 0.00, 0.25, 0.50, 0.75) system, in the oxidation reaction of CO is described. The optoacoustic signals Of $CO_2$ produced from the oxidation reaction were measured for differing x values in $Gd_{1-x}Sr_xCoO_{3-y}$. By monitoring optoacoustic signals with respect to the time, the concentration ratios of CO and $O_2$, and the temperature, the kinetic information on the catalytic properties of the perovskite for CO oxidation reaction can be obtained. The effect of Sr substitution in $Gd_{1-x}Sr_xCoO_{3-y}$ has been found to show the maximum catalytic effect at x = 0.25 and the substantial increase in catalytic activity at temperatures above 200$^{\circ}C$. It demonstrates that the optoacoustic detection method allows the investigation of the integrated catalytic effect not only for the oxidation reaction of CO, but also for many reactions, in general, by continuously and directly detecting the species associated with the reactions.

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Thermal diffusivity measurement of two-layer ar-coating systems using photoacoustic effects (광음향 효과를 이용한 2층 무반사 코팅막의 열확산도 측정)

  • 권경업;최문호;김석원;한성홍;김종태
    • Korean Journal of Optics and Photonics
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    • v.9 no.6
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    • pp.380-384
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    • 1998
  • As the development of ultrahigh power laser system, the laser mirrors must require high-resistant and effectively cooled. So, the study for the optical multilayer systems having large thermal diffusivity become important. In this study, we designed and fabricated two-layer anti-reflection (AR) optical coating samples, in different evaporation conditions of coating speeds (10, 20 $\AA$/s) and substrate temperatures (50, 100, 150, 20$0^{\circ}C$), using two dielectric materials $MgF_2$ and ZnS which have different refractive indices and measured the through-plane thermal diffusivity by using photoacoustic effect. The optical thicknesses of $MgF_2$ and ZnS layer were fixed as 5/4λ (λ=514.5nm) and λ, respectively, and the thermal diffusivity of the samples fabricated in the different conditions was obtained from the measured amplitude of photoacoustic signals by changing chopping frequency of $Ar^+$ layer beam. The results told us that the thermal diffusivity of the sample fabricated in the condition of 10 $\AA$/s and 15$0^{\circ}C$ showed the largest value.

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Determination of Flow Direction by Using an Acousto-Optic Effect (광음향 변조효과를 이용한 유체의 방향 결정)

  • 김규욱
    • Proceedings of the Optical Society of Korea Conference
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    • 1990.02a
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    • pp.34-36
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    • 1990
  • The flow direction in a glass tube is measured by using a forward scatering dual beam laser Doppler velocimeter with an acousto-optic modulator. We can determine the flow direction by measuring the shifted Doppler frequency which is dependent on the order of modulation of the laser frequency shifting moves only the Doppler signal, enabling complete separation of the Pedestal and Doppler singal.

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