The Journal of the Acoustical Society of Korea (한국음향학회지)

The Acoustical Society of Korea (한국음향학회)
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Clinically translatable photoacoustic imaging of cancer diagnosis

임상적용이 가능한 광음향 암 진단 기술

  • 김미지 (인제대학교 의료영상 및 치료시스템 연구실) ;
  • 박연성 (인제대학교 의료영상 및 치료시스템 연구실) ;
  • 윤창한 (인제대학교 의료영상 및 치료시스템 연구실)
  • Received : 2019.05.14
  • Accepted : 2019.06.25
  • Published : 2019.07.31
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Abstract

Photoacoustic imaging is a hybrid real-time imaging technique that combines high optical contrast and ultrasonic resolution. It has primarily been utilized in pre-clinical research and has evolved into clinical practice. In this paper, we review photoacosutic imaging for detection of primary canccer and metastatis and its limitation in translation from pre-clinical to clinical application.

광음향 영상 기술은 광학영상 및 초음파영상 기법을 융합한 영상 기술로 높은 공간 해상도 및 대조도의 영상을 실시간으로 제공이 가능하다. 광음향 영상은 전임상 연구에서 많은 연구가 진행되었으며 최근 광음향 영상의 임상적 응용을 위한 연구에 많은 노력을 기울이고 있다. 본 논문은 광음향 영상을 이용한 원발 종양 및 전이 진단 기술 연구 현황에 대해 소개하고 임상적용을 위한 문제점에 대해서 알아보도록 한다.

Keywords

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Fig. 1. Photoacoustic signal generation and imaging process.

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Fig. 2. Illustration of photoacoustic signal detection process. (a) Laser irradiation into biological tissue (b) Photoacoustic signal generation and detection.

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Fig. 3. Photoacoustic imaging result of breast microcalcifications.[16] Reproduced from J. Kang et al. J. Biophotonics 2015, https://doi.org/10.1002/jbio.201 300100,[16] according to the Copyright Clearance Center.

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Fig. 4. Breast imaging with the Twente photoacoustic mammoscope.[20]

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Fig. 5. SBH-PACT of healthy breast image.[17]

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Fig. 6. Detection of sentinel lymph node using photoacoustic imaging. (a) Injection of contrast agent into the primary tumor (b) Detection of photoacoustic signals from a contrast agent flowing to a sentinel lymph node by irradiation with a near-infrared laser.

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Fig. 7. Ultrasound and LAND-localized images of in vivo murine SLN by time.[31] Reproduced from H. Yoon et al. Med Phys 2017, https://doi.org/10.1002/mp.12269[31], according to the Copyright Clearance Center.

Table 1. Features of imaging systems used for sentinel lymph node biopsy.

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