• Journal of Life Science
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• v.23 no.1
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• pp.131-136
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• 2013

Sirtuin proteins have emerged as important modulators of several age-associated diseases. These include cancer and diabetes, as well as cardiovascular and neurodegenerative diseases. Among the sirtuin family members, SIRT2 mRNA is strongly expressed. To investigate the pathophysiological significance of SIRT2 as a primary regulator of angiogenesis, we focused on the biological role of SIRT2 under hypoxic conditions, examining the gene expression pattern of sirtuin family members in human umbilical vein endothelial cells (HUVECs). SIRT2 was expressed primarily in the cytoplasm, but it was dynamically trans-localized in the nuclear by hypoxia stimuli. Interestingly, both SIRT2 and the pro-angiogenic factor, VEGF, were up- regulated by hypoxia. A Matrigel assay demonstrated that the HUVECs formed a tube-like structure under hypoxia. The SIRT2 inhibitor, AK-1, significantly decreased the tube-forming activity of the HUVECs under either normoxia or hypoxia conditions. These findings suggest that SIRT2 might be a key regulator of angiogenesis.

• KSBB Journal
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• v.24 no.3
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• pp.217-226
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• 2009

p53 undergoes various post-translational modifications, including phosphorylation, ubiquitination, sumoylation, acetylation, methylation, and poly(ADP-ribosyl)ation. Modification of p53 widely affects to various functions of p53. Acetylation and phosphorylation of p53 have been studied for regulating its transcriptional activity which is observed in various stress condition. Otherwise, ubiquitination of p53 by Mdm2 has been well-studied as a canonical ubiquitin-mediated proteasomal degradation pathway. Moreover several investigators have recently reported that ubiquitination of p53 modulates not only its proteasome-dependent degradation by poly-ubiquitination but also its localization and transcriptional activity by mono-ubiquitination which usually does not serve the proteasome dependent degradation. Here we review recent studies on the cellular functions of p53 regulated by post-translational modifications, particularly focusing on mechanisms of ubiquitination.

• Child Health Nursing Research
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• v.20 no.2
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• pp.67-74
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• 2014

Purpose: The purpose of this study was to investigate factors contributing to internet addiction in 4th, 5th, and 6th graders from low income families. Methods: Participants for this study were 201 4th, 5th, and 6th graders from low income families living in Taegu. Data were collected from March, 2 to May, 29, 2013 using self-report structured questionnaires. Data were analyzed using SPSS/Win 20.0 programme. Results: Among the students, 78.6% were regular users, 14.4% were potential users, and 7.0% were high-risk users. The factors influencing internet addiction, in order of importance, were; conversation with family, followed by depression. Conclusion: These results suggest that efforts should make to monitor use of internet by elementary school children from low income families, and preventive strategies should be developed taking into consideration factors that influence internet addiction.

• The Journal of Korean Academy of Sensory Integration
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• v.11 no.1
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• pp.29-37
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• 2013

Objective : The purpose of this study was to investigate the effect of 8 weeks complex exercise program on height, body composition, and physical fitness in elementary school children. Method : The experimental group had 11 children (male=6, female=5) who belong to Seong-Nam Community Welfare Center in Gyeonggi-Do. All children received 50 minutes of complex exercise program 2 times a week for total of 8 weeks. In-body 520 were measured initially to serve as baseline data for height, and body composition. To determine the impact on physical fitness, Primus RS Power Track II commander Sit-up Trunk forward flexion measurement was also done. Repeat measurements of In-body520 Primus RS Power Track II Commander Sit-up Trunk forward flexion were done after 8 weeks. Results : There was significant increase in height, skeletal muscle mass, body fat percentage, lower limbs strength, and muscular endurance after the complex exercise program. There was, however, no significant difference in upper limbs strength, and flexibility after the program. Conclusions : These results indicate that the complex exercise program used in this study was very effective in producing significant benefits in height, body composition, and physical fitness in elementary school children. There would be better objective results if the control group and various environmental factors are considered in the future research.

• Korean Journal of Social Welfare
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• v.58 no.2
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• pp.355-375
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• 2006

The objective of this study examined the effect of job characteristics on the job satisfaction of social worker employed by 1st social agency, hospitals. Data were collected by 240 social workers. Based on Hackman and Oldham's(1975) theory of core job characteristics, this study was to defined other element of job characteristics, in social worker's duties, focused on moderating effect of self-confidence for job satisfaction, and compared to social worker's job characteristics between 1st social agency and hospitals. The results of this study were summarized as follows; first, job autonomy, feedback among Hackman and Oldham's 5 core job characteristics showed positive influence on job satisfaction. The other job characteristics found out significantly effected social worker's job satisfaction than Hackman and Oldham's 5 core job characteristics. Second, identities of social worker's job, cognition of professional level, necessity, and self-confidence variables were found to have a statistically significant strong relationship with job satisfaction of 1st setting social worker. The other side, necessity, self-confidence, sex, social worker's academic career variables positive influenced medical social worker's job satisfaction. Third, the moderating variables which had significant difference among social worker's working conditions. 1st setting social worker's self-confidence partial moderated the effect of job characteristics on social worker's job satisfaction. But, medical social worker's self-confidence not moderated the effect of job characteristics on job satisfaction. As a result, Social worker's job satisfaction depended on job characteristics and self-confidence. Therefore, to assure the job satisfaction, redesign for social worker's job characteristics, reinforced their self-confidence. Staff-development education program, supportive environment, supervision program is strongly recommended.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.26 no.1
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• pp.39-46
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• 2015

In this paper, a gas sensor using a modified $90^{\circ}$ hybrid coupler structure with conducting polymer which operates at 2.4 GHz is represented. Conducting polymers are used to the gas sensing material in proposed sensors. The conducting polymer varies its electrical property, such as work function and conductivity corresponding to the certain gas. To verify this variation of electrical property of conducting polymer at microwave frequencies, the conducting polymer is incorporated with the $90^{\circ}$ hybrid coupler structure, and this proposed sensor operates as reflection type variable attenuator and variable phase shifter. The conducting polymer is employed as impedence-variable transmission lines that cause a impedance mismatching between the general transmission line and conducting polymer. The experiment was conducted with 100 ppm ethanol gas at temperature of $28^{\circ}C$ and relative humidity of 85 %. As a result, the amplitude deviation of $S_{21}$ is 0.13 dB and the frequency satisfying ${\angle}S_{21}=360^{\circ}$ is shifted about 2.875 MHz.

• Applied Microscopy
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• v.26 no.4
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• pp.389-399
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• 1996

In order to understand the morphological differences between two different organic loadings by its upstream, and to compare with other algal groups with references, the fine structure of blue-green algae, Microcystis aeruginosa Kitzing, taken from two branches, Tongbok and Bosung stream of Lake Chuam, Korea pennisula was examined. It showed extinct differences in most physicochemical factors between both branches, except water temperature and pH values. The concentrations of total phosphorus in Tongbok branch were twice as those of Bosung. M. aeruginosa cells were enumerated totally $1.2X10^4cells/ml$ and these individuals in branch of Tongbok were close to two times as much as Bosung. In light and electron microscopy, natural M. aeruginosa colonies formed irregular shape and non-directional array in amorphous matrix. They were consisted of many kinds of cells, youngs or olds in cell division, solitary, and various size of cells. Each cell ranged from 2.61 to $5.40{\mu}m$ in diameter, and averaged as $3.54{\pm}0.19{\mu}m$. In cytoplasm, they contained a number of inclusions in various size, shape and appearances. Among them, polyhedral bodies or carboxysomes, a structured granules, photosynthetic lamellae or thylakoids, and gas vacuoles were prominent and easy to recognize. Although it was failed to find the definable morphological variations in the ultrastructure of M. aeruginosa in terms of algal habitual environments, some useful characters were founded, outer layer of cell wall, polyhedral bodies and gas vacuoles, in blue-green algal classification and taxonomy.

• Journal of the Korean Institute of Landscape Architecture
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• v.45 no.1
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• pp.28-34
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• 2017

This study was carried out to investigate growth characteristics of woody plants that are widely used indoors in accordance with irrigation frequency and to find the optimum irrigation conditions for plants that help to improve the indoor environment. Four woody plants used in this study included Ardisia pusilla, Clusia rosea, Fatsia japonica, and Ficus elastica. They were planted in pots with a diameter of 10cm and cultivated in three different irrigation frequencies: two times per week, one time per week, and one time per two weeks. After 120 days, they were measured by plant height, fresh weight, dry weight, SPAD value, leaf color, leaf water potential, chlorophyll fluorescence (Fv/Fm), and photosynthetic rate. The average soil moisture content was $48.8{\pm}2.1%$ in two times per week, $25.2{\pm}4.4%$ in one time per week, and $10.3{\pm}2.4%$ in one time per two weeks. For A. pusilla, leaf water potential was higher, and Fv/Fm value was 0.731 in two times per week irrigation, showing more wetness. For A. pusilla, F. japonica and F. elastica photosynthetic rate was significantly lower in one time per two weeks irrigation, appearing to be more sensitive to drying than C. rosea. When irrigated one time per week, with the soil's volume average moisture content of 25%, all four woody plants used in this experiment proved to grow smooth. Thus, it was determined to be good for use in indoor landscaping.

• Korean Journal of Agricultural Science
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• v.12 no.1
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• pp.37-46
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• 1985

Several seeded cultivars of Vitis labruscana showing various responses to GA-induced seedlessness were tested to study the effects of streptomycin sulfate on induction of parthenocarpy. The results were summarized as follows. 1. Prebloom dipping of streptomycin sulfate at 200 ppm induced 90~100 % parthenocarpy in 'Schuyler', 'Delaware', 'Ohira-Dela.' and 'Tanored' cultivars and also stimulated maturity but did not show any toxic effects. 2. In most cultivars, the addition of 25 ppm GA to streptomycin tended to increase berry setting and induction of parthenocarpy. 3. Dipping of strepto mycin alone in 'Campbell Early' severely induced berry abscission but the addition of calcium acetate or BA to streptomycin slightly increased setting of berries. 4. In 'Kyoho' and 'Pione' cultivars, streptomycin successfully induced parthenocarpy. Berry setting by streptomycin treatment was variable according to environmental conditions. 5. In 'Campbell Early' and 'Tanored' cultivars, streptomycin severely reduced viability of pollen.

• Journal of Digital Convergence
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• v.10 no.11
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• pp.603-612
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• 2012

When it comes to a country's traditional ideas. that country's geographic setting and religious thought show the people's consciousness, and the characteristics of historic sites and relics show their cultural aspects. Our country has 5000-year cultural history. Especially, the Baekje cultural history created very remarkable relics in our history. With regard to Baekje's own patterns and workmanship, their ornaments were more focused on the beauty of soft and voluptuous curves than that of Goguryeo and Silla This study researched design characteristics of ornaments and symbolic aspects of the patterns by focusing on crowns, crowns' accessories, earrings, necklaces, chignon ornaments of the Baekje's ornaments, To put emphasis on Baekje's ornaments by comparing Baekje's ornaments with Goguryeo's and Silla's. This study collected data on Baekje's ornaments, and reviewed domestic references and specialty publications at the Buyeo National Museum, Gong-ju National Museum, home and abroad, and studied the images of Baekje's metal crafts and patterns through theses. Baekje had splendid and glorious artistic culture, but there are not many historical data and supportive relics left these days. Therefore, a lot of attention, researches and development on Baekje culture are needed. This study found that the ornaments of the Baekje era have not only ornament functions but also the people's creative mind. The culture contents in recent technological development and industrialization change people's recognition, and now they have interest in Baekje culture. Therefore, the purpose of this study is to widely popularize Baekje by studying the patterns of the Baekje era more and developing various and new designs.