• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.11 no.1
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• pp.28-35
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• 2008

Purpose: The aim of this study is to report the efficacy of infliximab, a monoclonal antibody directed against tumor necrosis factor alpha which is used for both treatment of refractory pediatric Crohn disease (CD) and induction of remission. Methods: Among pediatric patients who were diagnosed with CD at Samsung Medical Center between March 2001 and August 2007, a total of 16 patients were given infliximab to treat conventional therapyresistant refractory CD and severe active CD for induction of remission. Patients needing maintenance therapy were treated with an infliximab infusion every 8 weeks, and fistulizing CD patients occasionally received the infusion upon the condition that a fistula developed. The efficacy of treatment was assessed by comparing the Pediatric Crohn Disease Activity Index (PCDAI), Hct, ESR, CRP, and serum albumin levels using paired t-test. Results: The male/female ratio was 13:3, and the median age was 13 years (range, 21 months~15 years). The patients included 7 cases of therapy-resistant refractory CD, 7 cases of severe active CD, and 2 cases of fistulizing CD. Mean PCDAI before infliximab therapy was 34.19${\pm}$14.96, and mean follow-up PCDAI within 2 to 4 weeks after the last infusion was significantly lower, at 6.88${\pm}$10.31 (p=0.000). Hematological markers such as ESR (p=0.000), serum albumin (p=0.016), and CRP (p=0.009) also improved significantly after infusion. Remission was achieved in 2 of 4 patients refractory to conventional therapy. Among 3 steroid-dependent patients, 2 were able to discontinue steroid therapy, and dose reduction was possible in 1 patient. Remission after top-down therapy without prior use of other immunomodulators was achieved in 6 weeks in all 7 of the patients who had severe CD. Nine of ten refractory fistulizing CD patients also showed improvement after infliximab therapy. Conclusion: Infliximab was effective in pediatric refractory CD for induction of remission and maintenance therapy, as well as in severe CD for top-down induction therapy. Furthermore, infliximab has contributed to steroid cessation and dose reduction. Long-term follow-up evaluation is needed to determine safety and efficacy of infliximab in the future.

• Radiation Oncology Journal
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• v.18 no.4
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• pp.244-250
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• 2000

Purpose : To see the relationship between the response to chemotherapy and the final outcome of neoadiuvant chemotherapy and radiotherapy in patients with mocanry advanced hypopharyngeal cancer. Methods and Materials :A retrospective analysis was done for thirty-two patients with locally advanced hypopharyngeal cancer treated in the Seoul National University Hospital with neoadiuvant chemotherapy and radiotherapy from August 1979 to July 1997. The patients were treated with Co-60 teletherapy unit or 4MV or 6MV photon beam produced by linear accelerator. Daily fractionation was 1.75 to 2 Gy, delivered five times a week. Total dose ranged from 60.8 Gy to 73.8 Gy. Twenty-nine patients received continuous infusion of cisplatin and 5-FU. Other patients were treated with cisplatin combined with bleomycin or vinblastin. Twenty-four (75$\%$) patients received all three prescribed cycles of chemotherapy delivered three weeks apart. Six patients received two cycles, and two patients received only one cycle. Results :The overall 2-year and 5-year survival rates are 65.6$\%$ and 43.0$\%$, respectively. 5-year local control rate is 34$\%$. Organ preservation for more than five years is achieved in 12 patients (38$\%$). After neoadjuvant chemotherapy, 24 patients achieved more than partial remission (PR): the response rate was 75$\%$ (24/32). Five patients had complete remission (CR), 19 patients PR, and 8 patients no response (NR). Among the 19 patients who had PR to chemotherapy, 8 patients achieved CR after radiotherapy. Among the 8 non-responders to chemotherapy, 2 patients achieved CR, and 6 patients achieved PR after radiotherapy. There was no non-responder after radiotherapy. The overall survival rates were 60$\%$ for CR to chemotherapy group, 35.1$\%$ for PR to chemotherapy group, and 50$\%$ for NR to chemotherapy group, respectively (p=0.93). There were significant difference in five-year overall survival rates between the patients with CR and PR after neoadjuvant chemotherapy and radiotherapy (73.3$\%$ vs. 14.7$\%$, p<0.01). The prognostic factor affecting overall survival was the response to overall treatment (CR vs. PR, p<0.01). Conclusion :In this study, there were only five patients who achieved CR after neoadiuvant chemotherapy. Therefore the difference of overall survival rates between CR and PR to chemotherapy group was not statistically significant. Only the response to chemo-radiotherapy was the most important prognostic factor. There needs to be more effort to improve CR rate of neoadjuvant chemotherapy and consideration for future use of concurrent chemoradiotherapy.

• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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• v.5 no.4
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• pp.40-46
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• 1994

Design and microwave absorbing properties of ferrite plate are investigated for the application to the radiowave absorbers used in anechoic chamber. The required frequency-dependence of complex permeability is determined on the basis of wave-impedance-matching relationship. The plate thickness and matchingfrequency are determined from the complex permeability and dielectric constant, and then compared with the directly measured reflection loss. A systematic variation of material constants and their influence on the microwave absorbing properties are demonstrated.

• Proceedings of the Korean Information Science Society Conference
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• 2005.07b
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• pp.640-642
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• 2005

본 논문에서는 온톨로지 기반의 질의-응답을 위한 지능형 웹서비스에 관해 기술하고자 한다. 이 웹서비스는 질의 에이전트와 응답 에이전트 간의 OWL-QL 메시지 교환에 의해서 이루어진다. OWL-QL은 OWL 언어로 표현된 지식베이스를 이용하는 시맨틱 웹 에이전트들 간의 질의-응답 처리를 위한 정형화된 언어이며, 프로토콜이다. OWL-QL에서 응답 에이전트는 질의 에이전트로부터 주어진 질의에 대한 응답처리를 위해 자동화된 추론을 전개한다. 본 논문에서는 시스템을 구성하는 각 에이전트들의 기능과 구조에 관해 설명하고, 질의 에이전트 내에 포함된 그래픽 기반의 OWL-QL 질의 작성기의 유용성에 관해 설명한다.

• Journal of Information Management
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• v.31 no.3
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• pp.35-47
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• 2000

Reviews literature related to several aspects of interlending and document supply. Examines the impact of World Wide Web delivery and the ever-increasing number of periodicals being published electronically. Interlinked with these two factors is the creation of digital libraries. Discusses some of the projects undertaken by higher education institutions to deliver electronic material to researchers and students. Includes articles on various resource sharing activities highlighting the usual access versus owernership issues.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.2
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• pp.61.3-61.3
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• 2021

생명체의 거주가능성(habitability)이란, 천체의 물리적인 성질 및 환경에 따라 얼마나 다양한 수준의 생명체가 생겨날 수 있는가를 보는 것이다. 거주가능성은 주로 액체상태의 물이 고등한 형태의 생명체의 생존에 필수라고 가정하고, 물이 액체 상태에서 안정적으로 존재할 수 있는 항성계의 환경에 관해 연구하게 된다. 본 발표에서는 거주가능성에 관한 해외의 주요 연구 사례에 관해 알아보고, 한국에서는 어떠한 종류의 연구가 가능할지에 관해 논의해 본다. 마지막으로 한국천문연구원의 [우주생명현상탐색] 기획과제에서 제시된 거주가능성 관련 연구 제안을 간략하게 소개한다.

• Clinical and Experimental Pediatrics
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• v.50 no.6
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• pp.556-564
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• 2007

Purpose : We hypothesized that the persisting bronchial hyperresponsiveness (BHR) of adolescents with asthma remission may be controlled mainly by genetic factors, and the BHR of symptomatic asthma by airway inflammation. ${\beta}_2$-adrenoceptor gene is considered to be a candidate gene in the development of BHR. Thus, ${\beta}_2$-adrenoceptor gene polymorphism may be associated with the BHR of adolescents with asthma remission, but not with the BHR of symptomatic asthma. To evaluate this hypothesis, ${\beta}_2$-adrenoceptor gene polymorphism at 2 sites (Arg16-Gly, Gln27-Glu) were examined. Methods : Two hundred two adolescents with BHR ($PC_{20}<18\;mg/mL$) and long term remission (neither asthma-related symptoms nor medication during the previous 2 years) of their asthma (remission group), 182 adolescents with symptomatic asthma (symptomatic group), and 200 healthy adolescents (control group) were studied. Asthma phenotypes were determined using methacholine bronchial provocation test and skin prick test. Genotypes of ${\beta}_2$-adrenoceptor polymorphism were evaluated by PCR-based methods. Results : Gly/Gly allele and Gly16-Gln27 haplotype were more prevalent in the remission group than in the control group (P=0.01, P=0.02), although there was no difference between the symptomatic group and the control group. In the remission group, there was significant difference in geometric mean of $PC_{20}$ among the 3 groups subdivided by the number of Gly16-Gln27 haplotype, showing that the Gly16-Gln27 haplotype was positively associated with BHR. However, no association was found between Gly16-Gln27 haplotype and BHR in the symptomatic group. Conclusion : This study demonstrates that ${\beta}_2$-adrenoceptor polymorphism at amino acid 16 and 27 was associated with BHR persisting in adolescents with asthma remission.

• Radiation Oncology Journal
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• v.10 no.2
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• pp.213-217
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• 1992

Locally advanced cervical carcinoma has shown high rate of local failure and poor survival rate despite the advances in modern radiation therapy techniques. Combination of chemotherapy and radiation therapy demonstrated benefit in improving local control and possibly the overall survival. Twelve patients with advanced stages (Figo stage III, IV) or 11b with bulky tumors (>5 cm in diameter) were treated with combination of radiation therapy and concurrent weekly cisplatin between May of 1988 and September of 1991 at Inje University Paik Hospital. Cisplatin was administered in bolus injections of 50 mg at weekly intervals during the courses of radiation therapy. Median follow-up period was 34 months with ranges from 3 to 53 months. Eleven patients were evaluable for the estimation of response. Response was noted in all the 11 patients: complete response (CR) in 7 ($64\%$), partial response (PR) in 4 ($36\%$). Of the 7 patients with CR, all maintained local control, whereas only 1 of 4 with PR showed local control. Six of 7 with CR are alive disease free on the completion of follow-up. Eight of 11 patients ($73\%$) maintained local control in the pelvis. The median survival for CR patient is 27 months and 9 months for the PR patients. Analysis of survival by stage shows 11 b 4/5, III 2/3 and IV 1/3. Overall survival rate was $61\%$. Three patients recurred: 1 at local, 1 in distant site and 1 with local and distant site. Toxicity for the combination therapy was not excessive. These results are preliminary, but definitely encouraging in view of markedly improved response rate compared with the results of historical control group.

• Optical Science and Technology
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• v.2 no.2
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• pp.44-51
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• 1998

광섬유 브래그 격자(fiber Bragg grating)는 광섬유 코어의 굴절율을 주기적으로 변조하여 특정 파장의 빛을 반사시키는 광섬유 소자로써 광섬유와의 연결 손실이 작고 파장 선택도가 높으며 편광에 무관한 특성 등으로 현재 전세계적으로 광통신용 소자나 광섬유 센서 등으로 활발히 연구되고 있다. 본 기술 해설에서는 이러한 광섬유 격자의 역사, 형성 원리 및 종류 등에 관해 알아보고, 단주기, 장주기 그리고 chirped 광섬유 격자의 특성에 대해 기술하였으며, 또한 광섬유 격자소자의 중요한 응용 분야인 광섬유 센서, 광섬유 레이저, 그리고 광통신에의 응용에 관해 소개하였다.

• Proceedings of the KAIS Fall Conference
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• 2002.05a
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• pp.252-256
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• 2002

정보통신의 발전으로 많은 정보들이 디지털화되면서 각종 시설과 개인영역 등에 대한 보안의 필요성이 커지고 있다. 이와 관련해서 보안을 위한 신원확인과 인증 기술들이 소개되고 있으며 그 중 하나의 방법으로 생체인식이 중요한 기술로 자리 잡고 있다. 본 논문에서는 생체인식에 관해 알아보고 생체인식의 단점을 보완한 다중 생체인식의 기술과 어느 보안수단보다도 적극적인 보안수단으로 가치를 평가받고 있는 ‘무형 인프라’위에서 또 하나의 인프라로 잡아가는 PKI 이 두가지 기술을 결합하여 새로운 보안수단으로서의 방향에 관해 연구하였다.