• 우유
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• s.49 summer
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• pp.20-26
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• 1992

• The Journal of the Korea Contents Association
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• v.14 no.11
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• pp.362-369
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• 2014

This study aimed to propose an accurate diagnostic method for osteoporosis by realizing a computer-aided diagnosis system with the application of the statistical analysis of texture features using digital images of lateral lumbar spine of patients with osteoporosis and providing reliable supplementary diagnostic information by model experimental research for early diagnosis of diseases. For these purposes, digital images of lateral lumbar spine of normal individuals and patients with osteoporosis were used in the experiments, and the values of statistical texture features on the set ROI were expressed in six parameters. Among the texture feature values of the six parameters of osteoporosis, the highest and lowest recognition rates of 95 and 80% were shown in average gray level and uniformity, respectively. Moreover, all the six parameters showed recognition rates of over 80% for osteoporosis: 82.5% in average contrast, 90% in smoothness, 87.5% in skewness, and 87.5% in entropy. Therefore, if a program developing into a computer-aided diagnosis system for medical images is coded based on the results of this study, it is considered possible to be applied to preliminary diagnostic data for automatic detection of lesions and disease diagnosis using medical images, to provide information for definite diagnosis of diseases, to diagnose by limited device, and to be used to shorten the time to analyze medical images.

• Journal of Life Science
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• v.25 no.1
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• pp.113-120
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• 2015

Osteoporosis is a major bone disorder defined as having bone mineral density (BMD) of 2.5 standard deviations or more below the peak bone mass. Osteoporosis will increasingly be a major disorder that faces the aging mankind. It is the result of an imbalance in the bone remodeling system, where bone constantly undergoes a cycle of resorption by osteoclasts and formation by osteoblasts. Estrogen deficiency in women following menopause is identified as the predominant reason that causes disparity in this system. Current medical treatments for osteoporosis include hormone replacement therapy (HRT), biphosphonates, and teriparatide, but have various side effects that raise questions concerning their medical safety and practicality. Alternative treatments involving natural product sources are under study to find a safer therapy. Many natural sources including lactoferrin and isoflavones and numerous traditional herbal medicines exhibit anti-resorptive or anabolic effects on bone and thus show promises to provide therapeutic agents in treating osteoporosis. Unfortunately, the majority of natural product treatments are still in its preliminary stages to prove their efficacy even though the development pace of treatment for osteoporosis is astounding in the past few decades. Further progress in pre-clinical studies and the subsequent clinical studies will someday lead to a breakthrough that takes us another step forward in science.

• Applied Microscopy
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• v.32 no.3
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• pp.285-290
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• 2002

The therapeutic effect of safflower seed powder on experimental osteoporosis in the rat induced by ovariectomy was evaluated. Thirty Sprague-Dawley rats were ovariectomized at the age of 12 weeks. Seven weeks postovariectomy, rats were divided into two groups: control and safflower seed powder treated group. Five animals from each group were sacrificed at the following time points: 1, 3, and 5 weeks. Scanning electron microscopic observation and morphometric analysis of the tibiae epiphysis showed that the administration of safflower seed powder significantly prevented reduction of cortical bone width and bone volume compared with the control group. In conclusion, safflower seed powder contains something that prevent bone loss due to estrogen deficiency, and was effective in preventing the osteoporotic decrease of bone mass.

• Journal of Veterinary Clinics
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• v.20 no.3
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• pp.263-273
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• 2003

This study was carried out to investigate the effects of the Korean Safflower (Carthamus inctorius L) seed powder on serum level of hormones and trabecula area during the recovery from osteoporosis induced ovariectomized rats. Four month-old rats were ovariectomized (OVX), remained untreated for 8 weeks, and were subsequently administered safflower seed (0.03 g/kg) every other day 30 for days. We examined the effects of treated safflower seed every 10 days on ovariectomy-related changes in Insulin-like Growth Factors, Insulin-like Growth Factor binding protein-3 (IGFBP-3), Estrogen, Bone-specific alkaline phosphotase, Calcium, and Phospotase in the serum, and also histomorphology of the proximal fibula metaphysis and femur/body weight rate. Ten and 20 days after safflower seed treatment in OVX rats, serum levels of IGF-I, -II and IGFBP-3 were not different from the Sham and OVX groups. In 30 days, serum levels of IGF-I,-II and IGFBP-3 were higher after safflower seed treatment in OVX rats as compared to the other two groups (p<0.05). Bone alkaline phosphatase levels were increased through safflower seed treatment in OVX rats compared to the other two groups in 30 days. There were no differences between OVX and safflower seed treated OVX rats in serum levels of estrogen and femur/body weight rate, but estrogen levels for the sham group were higher than for the other two groups. The safflower seed is increased to serum levels of IGFs, IGFBP-3 and BALP of osteoporosis induced by ovariectomized rats. Thus, we conclude that the safflower seed is a possible role for improvement of osteoporosis induced-ovariectomized rats.

• Journal of radiological science and technology
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• v.28 no.3
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• pp.235-239
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• 2005

The bone mineral density built in adolescence and college term is formed to the highest level between 25 years old and 35 years old and the formed bone mineral density is decreasing in the middle years and senescence. Decrease of the bone mineral density causes Osteopenia and an increase of dangerousness of a bone fracture which become social health problems. This research is to give guidance for the right living style by surveying the relation between the bone mineral density and college students' life. The result is like below. First of all, most objects of the research were insufficient of quantity of motion and the diet they have was consisted of instant food. It was far from the right living habit and exercise and the bone mineral density was also low. Second of all, male students showed more osteopenia than female students in this research and the smokers' bone mineral density was lower than nonsmokers, which proved that smoking in adolescence was related to the bone mineral density. Finally, the opportunistic eating and living style and the excessive diet and unequal caloric intake caused by the notion of preference for a slim person are considered to be the main reasons for the decrease of the bone mineral density.

• Journal of Convergence for Information Technology
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• v.11 no.3
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• pp.54-67
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• 2021

This study is a secondary data study that analyzes the factors affecting the quality of life of the elderly with metabolic syndrome and the elderly with metabolic syndrome with osteoporosis using data from the 7th year of the National Health and Nutrition Survey (2018). The subjects of this study were 639 patients with metabolic syndrome and 161 patients with metabolic syndrome with osteoporosis. For data analysis, the composite sample Rao-Scott χ2 test, general linear model t-test, and regression model were used. As a result of the study, the factors that lowered the quality of life of metabolic syndrome were age, cohabitation, strength training, subjective health status, activity restriction, body mass index and depression, and the explanatory power was 50.4% (F=515.96, p<.001). In metabolic syndrome with osteoporosis, age, subjective health status, activity restriction, and stress were the factors that lowered the quality of life, and the explanatory power was 48.6% (F=10.42, p<.001). Based on these results, it is necessary to develop and provide an intensive multidisciplinary program for the elderly with metabolic syndrome accompanied by osteoporosis to solve the problem of activity restrictions and manage stress reduction through positive acceptance of health status, instrumental and social support, and caring support.

• Journal of the Korean Orthopaedic Association
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• v.55 no.3
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• pp.237-243
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• 2020

Purpose: This study examined the effects of the postoperative administration of parathyroid hormone (PTH) on fracture healing in intertrochanteric fractures accompanied by osteoporosis in elderly females. Materials and Methods: Female patients aged 65 years and more who underwent surgery after a diagnosis of intertrochanteric fractures and osteoporosis during the period from July 2013 to December 2017 were included as subjects. The subjects were divided into two groups: PTH-treated group and non-PTH-treated group. The formation time of the first callus, timing of the bridging callus, and time of bony union for both groups were evaluated. Results: In the PTH-treated group, the mean time of the first callus formation, average time of bridging callus, and the average time of bony union were 32, 58, 83 days, respectively, which were significantly shorter than that of the untreated group. Conclusion: PTH, a treatment for osteoporosis, promotes callus formation and the healing process. Therefore it will be helpful in intertrochanteric fractures accompanied by osteoporosis in elderly females.

• Proceedings of the KSME Conference
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• 2005.11a
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• pp.154.2-154.2
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• 2005

• 가정의 벗
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• v.33 no.3 s.379
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• pp.11-11
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• 2000