• Title/Summary/Keyword: 고형물질

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약물제제용 나노 입자 제조법

  • 이종휘;김기현;유지연;최지연;이종찬
    • Polymer Science and Technology
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    • v.15 no.4
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    • pp.411-421
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    • 2004
  • Genomics, proteomics, high through-put 기술 등 다양한 기초생물, 의학, 유기화학 분야의 기술 발전을 통하여 신약의 개발 속도는 최근 들어 급격히 가속도가 붙기 시작하고 있다. 그 결과 신약 후보 물질들의 수가 급증하고 있는 추세이다. 현재는 약 3,000-10,000개 정도의 신약 후보 물질 중 약 5-10개 정도의 물질이 임상 phase Ⅰ에 들어가고, 그 중 약 1개 정도의 신약이 최종적으로 얻어지는 것으로 알려져 있다. 스크린이 된 신약 후보 물질이 실질적인 신약으로 탄생하려면 많은 연구과정을 거쳐야 하는데, 고형 경구제제와 같은 제제 연구가 그 중 중요한 부분의 하나이다.(중략)

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Evaluation Physical Characteristics of Coating Materials for Forage Seed Coating by Coating Index (피복지수에 의한 목초종자 피복제의 물리적 특성 평가)

  • 이성운;허삼남;김택림
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.24 no.2
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    • pp.155-162
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    • 2004
  • Different adhesives(CF-clear, arabic gum, cethylmethyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidone, hydroxy propyl cellulose, methyl cellulose) and particulate matters(bentonite, kaolin, calcium carbonate, peatmoss, talcum, vermiculite, zeolite, calcium hydroxide, plaster, calcium phosphate, vermiculite + calcium carbonate, vermiculite + kaolin, vermiculite + talcum) were evaluated by coating index method. According to the weight of single coated seeds, CF-clear and polyvinyl alcohol appeared to be the best coating adhesives for red clover and tall fescue seeds. Both vermiculite and vermiculite + talc(l : 1) for red clover, and vermiculite + talc(l : 1) for tall fescue appeared to be the best particulate matter(P < 0.01). Percent friability showed excellent results for the arabic gum, CF-clear, and polyvinyl alcohol when compared to others(p < 0.01). The coating index showed high with vermiculite and vermiculite + talc(l : 1) in coating red clover seed, and talc, vermiculite, and vermiculite + talc showed good coating index in coating tall fescue seed.

해양수색 위성자료의 검.보정 및 활용 연구

  • ;;B. G. Mitchell
    • Proceedings of the Korean Society of Fisheries Technology Conference
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    • 2000.10a
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    • pp.171-172
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    • 2000
  • 본 연구에서는 ocean color 위성자료의 검ㆍ보정 및 수산활용을 목적으로 6개 OSMI위성 밴드와 동일한 현장 해수 다중 채널 광 측정기, PRR-800 관측자료 및 SeaWiFS 위성 자료, 해양현장의 클로로필 a, 부유성 고형물질 등의 관측자료간 관계식을 도출하고 한국 근해에서 해수의 광학적 특성을 구명하고자 하였다. (중략)

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Characteristics of By-product in Non-thermal Plasma DeSOx and DeNOx Process (플라즈마 탈황탈질 공정의 부산물 특성)

  • 김유석;최석호;유정석;백민수;장길홍
    • Proceedings of the Korea Air Pollution Research Association Conference
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    • 2000.04a
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    • pp.233-234
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    • 2000
  • 저온 플라즈마 탈황탈질 동시처리 공정은 경제적인 장점과 함께 2차 오염물 발생 없이 비료성분을 부산물로 얻을 수 있다는 이점 때문에 국내외적으로 많은 연구가 진행되고 있다 이와 같은 저온 플라즈마 공정은 크게 가스상 물질을 제거하기 위한 플라즈마 반응 공정과 가스상 물질 제거이후 발생하는 고형화된 부산물 제거를 위한 부수 공정으로 구분할 수 있는데, 지금까지의 연구분야는 가스상 오염물질을 제거하는 공정에 초점이 모아져 왔다. (중략)

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Effect of Methane Production from Pig Manure Slurry According to The Solids Concentration and The Crushing Solids of Pig Manure Slurry (돼지분뇨 슬러리중의 고형물 농도수준과 분쇄 처리가 메탄 생성에 미치는 효과)

  • Jeong, Kwang-Hwa;Kim, Jung-Kon;Lee, Dong-Jun;Lee, Dong-Hyun;Cho, Won-Mo
    • Journal of the Korea Organic Resources Recycling Association
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    • v.23 no.4
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    • pp.74-85
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    • 2015
  • Recently, the number of anaerobic digestion facility for livestock manure is on the rise in Korea. All of the livestock manure anaerobic digestion facilities in operation use pig manure slurry as a substrate for anaerobic digestion. Generally, pig manure slurry is composed of 97% water and 3% solids. The particulate matter, such as corn in the form of particles that is undigested by pig is contained in the pig manure slurry. Particulate matter is a factor reducing the effectiveness of biogas production in the anaerobic digestion process. In this study, mechanical grinding treatment was applied to analyze the effect of methane production from pig manure slurry by reducing the particle size of the slurry. On the other hand, the effect of the solid concentration levels on methane production and methane content of the biogas was analyzed. The fine particle concentration in the pig manure slurry was increased by the mechanical grinding treatment. And methane production and methane content of the biogas were higher in grinded pig manure slurry than untreated raw slurry.

Pyrolysis Characteristics of Compressed Municipal Solid Wastes (압축한 도시고형폐기물의 열분해 특성)

  • Kim, Jin-Ho;Shon, Byung-Hyun;Cho, Sang-Won;Lee, Hyup-Hee;Oh, Kwang-Joong
    • Journal of Korean Society of Environmental Engineers
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    • v.22 no.5
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    • pp.907-918
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    • 2000
  • The pyrolysis characteristics of celluloses and plastics, which are the principal materials contributing to the municipal solid wastes(MSWs), was investigated with a thermal gravimetric analysis reaction system. The experiments were carried out in a nitrogen atmosphere in the temperature range of 400~900K at various experimental conditions. Also, a modified pyrolysis model for compressed MSWs has been proposed. Varing the heating rate to 20, 30, 40K/min, reaction orders of MSWs' main component were around 1.1~1.9, activation energies were 117~166kJ/mol for celluloses and 187~239kJ/mol for plastics. Char yield was proportional to the heating rate, particle size, and compressed ratio. The model proposed in this study, which is applying Arrhenius equation and thermodynamics, is closer to the experimental results than the conventional model.

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Investigation of the effect of water chemistry on biologically mediated flocculation in the aquatic environment (수질화학 조성이 수자원환경에서의 미세 부유입자 응집 거동에 미치는 영향 연구)

  • Choi, Jeong Wooa;Lee, Byung Joon
    • Journal of Korea Water Resources Association
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    • v.50 no.11
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    • pp.715-723
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    • 2017
  • Extracellular Polymeric Substances (EPS) in the water environment assemble fine, colloidal particles, such as clays, microorganisms and biomass, in large flocs, which are eventually subject to sedimentation and deposition and determine water/sediment quality and quantity. This study hence aimed to investigate the way that water and colloidal chemistry affects EPS-mediated flocculation of colloidal particles, using a jar-test experiment. Especially, ionic strength, divalent cation and humic substances concentrations were selected as experimental variables in the jar-test experiments, to elucidate their effects on EPS-mediated flocculation. A higher ionic strength increased flocculation capability, reducing electrostatic repulsion between EPS-attached colloidal particles and enhancing particle aggregation. 0.1 M NaCl ionic strength had higher flocculation capability, with 3 times larger floc size and 2.5 times lower suspended solid concentration, than 0.001 M NaCl. Divalent cations, such as $Ca^{2+}$, built divalent cationic bridges between colloidal particles and EPS (i.e., $colloid-Ca^{2+}-EPS$ or $EPS-Ca^{2+}-EPS$) and hence made colloidal particles to build into large, settelable flocs. A small $Ca^{2+}$ concentration enhanced flocculation capability, reducing suspended solid concentration 20 times lower than the initial dosed concentration. However, humic substances, adsorbed on colloidal particles, reduced flocculation, because they blocked EPS adsorption on colloidal particles and increased negative charges and electrostatic repulsion of colloidal particles. Suspended solid concentration in the tests with humic substances remained as high as the initial dosed concentration, indicating stabilization rather than flocculation. Findings about EPS-mediated flocculation in this research will be used for better understanding the fate and transport of colloidal particles in the water environment and for developing the best management practices for water/sediment quality.