• Korean Journal of Clinical Pharmacy
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• v.14 no.2
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• pp.91-95
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• 2004

당뇨환자가 합병증으로 고혈압이 있을 경우 항고혈압약물인 딜티아젬을 투여시 딜티아젬의 동태학적 측면에서 투여계획을 설계하기 위해서 토끼에 알록산을 당뇨병모델을 만들었다. 알록산으로 유도된 급성 및 만성 당뇨 토끼에서 딜티아젬의 약물동태 변화에 대한 결과는 당므과 같다. 1. Alloxan 45 mg/kg을 토끼의 귀정맥에 투여시 혈당농도는 control군에서 $112\pm20.6\;mg/dl$, acute DM군에서는 $260\pm897\;mg/dl$, chronic DM군에서는 $331\pm85\;mg/dl$으로 당뇨가 유발되었음이 확인되었다.. 2. Alloxan에 의한 당뇨병 유발토끼에서 딜티아젬의 혈중농도곡선하면적(AUC)값은 대조군$(21.6\pm2.45\;\mug/ml)$ 보다 chronic DM군$(31.91\pm379\;mg/ml{\cdot}hr)$에서 유의성(p<0.05) 있게 증가하였다. 3. 딜티아젬의 요중누적배설량은 대조군에 비해 acute 및 chronic DM군에서 감소되었으나 유의성은 없었다. 4. 당뇨병 유발 토끼에서 딜티아젬의 토탈바디클리어런스$(CL_t)$ 값과 $\beta$-소실속도정수값이 대조군에 배해서 유의성(p<0.05)있게 감소되었다. 실험적 당뇨 토끼에서 딜티아젬의 생체이용률의 증가는 딜티아젬의 토탈바디클리어런스$(CL_t)$ 값과 베타의 소실속도정수 값이 대조군에 비해서 유의성있게 감소되었기 때문으로 사료된다.

• Journal of the East Asian Society of Dietary Life
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• v.5 no.1
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• pp.67-74
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• 1995

The aim of this study was to investigate the interrelationship among urinary excretion dietary habit of Na, Ca intake and hormonal factors in 22 hypertensive and 30 normotensive hospitalized patients. The results were summarized as follows : 1. Urinary excretion of Na in normotensive patients was not significantly different from that of hypertensive patients, while Ca excretion(as expressed on the basis of mg of creatinine) was significantly higher in hypertensive patients. 2. Habitual dietary intake of Na, Ca in hypertensive patients were not significantly different from those of normotensive patients. 3. There were no significant differences in mean plasma renin activity, aldosterone and parathyroid hormone(PTH) level between two groups. However, systolic pressure significantly correlated with PTH(r=0.2597) and aldosterone level(r=0.24648)(P<0.05). In this study blood pressure did not show any significant relationship between urinary Na excretion and habitual dietary Na intake of Na. It is speculated that individual difference of Na sensitivity might result in heterogenous blood pressure response to dietary Na intake. Higher Ca excretion in hypertensive subjects suggested a future study on the interrelationship between Ca metabolism and aldosterone system in hypertension.

• The Journal of Internal Korean Medicine
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• v.34 no.3
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• pp.267-277
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• 2013

Objectives : The aim of this study was to investigate the correlation between Cold-Heat pattern tendency and demographic traits, physical character, and vital signs in hypertensive patients taking anti-hypertensive agents. Methods : 28 hypertensive patients 30 to 69 years old were recruited. We assessed their general characteristics, physical characteristics (height, weight, waist circumference, etc.), vital signs without respiratory rate (blood pressure, pulse rate, temperature) and administered a Cold-Heat pattern questionnaire. After that, we analyzed statistical data on separate groups according to Cold-Heat characteristics or other criteria. Results : 1. Heat group patients had statistically higher scores in waist, body mass index (BMI), waist circumference and pulse rate. 2. Over weighted group patients had statistically lower scores in cold Pattern Identification. 3. Higher BMI group (above 23/25) patients had statistically significantly higher Heat scores and lower Cold scores, higher waist circumference group patients had lower Cold scores. Conclusions : From the above result in hypertensive patients taking hypertensive agents, Heat group had a obesity tendency and the inverse is also valid. Later, progressed study based on more samples and varied data will contribute to diagnosis the Cold-heat Pattern identification in hypertensive patients.

• Journal of the East Asian Society of Dietary Life
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• v.27 no.4
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• pp.477-490
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• 2017

The objective of this study was to analyze the relationship between blood pressure and serum mineral concentration in hypertension patients subjected to dehydration. The data were collected and analyzed for 7,109 patients who visited a hospital for their health checkup from 2011 till 2015. Respondents were classified into four groups depending upon their state of hypertension and dehydration: control group (no hypertension and no dehydrated), dehydrated group, hypertension group, and dehydrated with hypertension group. Hypertension group was found to have higher levels of serum sodium, calcium, and uric acid than the normal group, whereas the dehydrated group was found to have higher levels of serum sodium and potassium than the normal group. In effect, no significant correlation was directly observed between the hypertension group and dehydration group. However, there were significant negative correlations between dehydration of the old-aged group and their serum mineral concentrations, which are reportedly related to hypertension. Thus, dehydration prevention measures in the elderly over 65 could mitigate hypertension problems.

• Journal of Korean Physical Therapy Science
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• v.28 no.3
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• pp.76-87
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• 2021

Background: The purpose of this study was to evaluate the effects of power walking and square dancing on middle-aged women with hypertension. Design: Randomized controlled Trial. Methods: 30 middle-aged women with hypertension were selected and divided into two groups. 15 cases in the control group received routine treatment, and 15 cases in the intervention group received community vigorous walking and square dancing intervention on the basis of routine treatment. The intervention time was 40-60minutes/day, 5days/week, total 16 weeks. total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), angiotensin II (Ang II), Leptin, blood pressure, and heart rate were measured. Results: Body weight, body mass index (BMI), TC, TG, LOW-density lipoprotein, angiotensin II, leptin, systolic blood pressure and heart rate were significantly reduced after power walking and square dancing (p<0.05). After the experiment, TC and TG in the experimental group were lower than those in the control group (p<0.05), while HDL was higher (p<0.05). Conclusion: The results of this study suggest that power walking exercises and square dances are significant effects on lipid mechanism and heart rate.

• Sleep Medicine and Psychophysiology
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• v.2 no.1
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• pp.55-64
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• 1995

During sleep, relatively major respiratory physiological changes occur in healthy subjects. The contributions and interactions of voluntary and metabolic breathing control systems during waking and sleep are quite different Alterations of ventilatory control occur in chemosensitivity, response to mechanical loads, and stability of ventilation. The activities of intercostal muscles and muscles involved in regulating upper airway size are decreased during sleep. These respiratory physiological changes during sleep compromise the nocturnal ventilatory function, and sleep is an important physiological cause of the nocturnal alveolar hypoventilation. There are several causes of chronic alveolar hypoventilation including cardiopulmonary, neuromuscular diseases. Obstructive sleep apnea syndrome (OSAS) is an important cause of nocturnal hypoventilation and hypoxia. Coexistent cardiopulmonary or neuromuscular disease in patients with OSAS contributes to the development of diurnal alveolar hypoventilation, diurnal hypoxia and hypercapnia. The existing data indicates that nocturnal recurrent hypoxia and fragmentation of sleep in patients with OSAS contributes to the development of systemic hypertension and cardiac bradytachyarrhythmia, and diurnal pulmonary hypertension and cor pulmonale in patients with OSAS is usually present in patients with coexisting cardiac or pulmonary disease. Recent studies reported that untreated patients with OSAS had high long-term mortality rates, cardiovascular complications of OSAS had a major effect on mortality, and effective management of OSAS significantly decreased mortality.

• The Korean Journal of Food And Nutrition
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• v.15 no.2
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• pp.165-172
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• 2002

Studies were carried out to observe the influence of the Aralia continentalis Kitagawa root on blood pressure and blood constituents of the 24 hypertensive elderly(10 men and 14 women aged over 60). Total subjects were divided into three groups according to taking antihypertensive medications(A), antihypertensive medications and mixing beverages with the Aralia continentalis Kitagawa root(B) or mixing beverages with Aralia continentalis Kitagawa root(C). The systolic blood pressure of C group was significantly lower than that of A and B groups. The diastolic blood pressure of C group was lower than A and B groups. The blood glucose level of C group was a little lower than that of A and B groups. The level of TG increased more in A group than C group and decreased in B group. The levels of T-cholesterol and LDL-cholesterol lowered in B and C groups and HDL-cholesterol level was higher in C group. The GOT, GPT and T-bilirubin levels of C group were significantly higher than others. Mixing beverages with Aralia continentalis Kitagawa root did not affect on blood protein and non-protein nitrogens. In conclusion, mixing beverages with Aralia continentalis Kitagawa root had an effect on lowering blood pressure, blood glucose, T-cholesterol and LDL-cholesterol concentrations.

• Journal of Korean Public Health Nursing
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• v.27 no.1
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• pp.190-202
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• 2013

Purpose: To survey relationships between health literacy, disease-related knowledge and compliance to medical recommendations in patients with hypertension. Methods: The subjects were 315 patients conveniently selected from public health centers in Gangwon province. Data were collected through a questionnaire (from January 10, 2013 to February 10, 2013) and analyzed by descriptive statistics, t-test, ANOVA, Duncan test and Pearson's correlation coefficient using the PASW statistics 18.0 program. Results: There were significant differences in health literacy according to age, marital status, monthly family income and education. In regard to disease-related knowledge, there were significant differences according to gender, marital status and monthly family income. There were positive correlations between health literacy and disease-related knowledge (r = .39, p = <.001), disease-related knowledge and compliance to medical recommendations (r = .28, p = <.001). However, there was no correlation between health literacy and compliance to medical recommendations. Conclusion: Health literacy and disease-related knowledge have a significantly positive correlation. Further studies are needed to confirm the effects of health literacy on chronic diseases.

• Journal of Korean Academy of Rural Health Nursing
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• v.1 no.1
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• pp.59-64
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• 2006

Purpose: This study was done to identify the effect of a group walking exercise program on weight, obesity, blood pressure and cholesterol in elderly patients with hypertension. Method: From the population of elderly people in Hwasung city, 80 people with hypertension were selected as participants in this study. Frequencies and paired t-test were used to analyze the data. Results: The group walking exercise program lowered weight, obesity, blood pressure, and cholesterol. And such a change appeared to be effective statistically. Conclusion: Therefore, it is important to develop a program and environment that promotes group walking exercise in elderly patients with hypertension.

• Journal of Korean Neurosurgical Society
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• v.30 no.6
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• pp.705-710
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• 2001

Objective : Postoperative seizure is a well documented complication of aneurysm surgery. The purpose of the present study was to analyze risk factors for postoperative seizure. Methods : Between January 1990 and December 1996, we performed craniotomy for ruptured cerebral aneurysms in 321 patients. Among them 206 patients who could be followed up for more than 1 year(range, 1 to 4.6 years) were enrolled to present study. All patients were treated with anticonvulsants for 3 to 18 months postoperatively. We analyze the incidence of postoperative seizure in different sex and age groups, and risk factors associated with postoperative seizures following aneurysm rupture. For statistical processing chi-square test and Fisher's exact test were used. Results : In the follow-up period of 1 to 4.6 years(mean, 1.8 years) postoperative seizure appeared in 18 out of 206 patients(8.7%). Mean latency between the operation and the first seizure was 6 months(range, 3 weeks to 18 months). The age of the patients has significant influence on the risk of seizure, it occurred more often in younger patients(p =0.0014). Aneurysm location in the MCA was associated with a significantly a higher risk of seizure(p = 0.042). Eight patients(19%) out of 42 patients who suffered delayed ischemic neurologic deficit(DID) developed seizure. Delayed ischemic neurologic deficit was associated with significantly a higher risk of seizure(p =0.019). Infarct and hypertension were associated with significantly a higher risk of seizure(p <0.05). pre- or postoperative intracranial hematoma(intracerebral or epidural hematoma) was associated with significantly a higher risk of seizure(p <0.0001). H-H grade, Fisher grade, Glasgow Outcome Scale of patients and timing of operation after subarachnoid hemorrhage had no significant relation with the risk of seizure. Conclusion : Factors associated with the development of postoperative seizure were middle cerebral artery aneurysm, delayed ischemic neurologic deficit, infarct on late postoperative CT scan, hypertension, pre or postoperative intracranial hematoma(intracerebral or epidural hematoma). Identification of the risk factors may be help to focus the antiepileptic drug threapy in cases prone to develop seizures. Prospective evaluation is indicated.