• 대한핵의학회:학술대회논문집
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• 1979.05a
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• pp.7.2-8
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• 1979

• The Monthly Diabetes
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• s.194
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• pp.32-35
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• 2006

고혈당, 고혈압과 같은 위험요인을 적극적으로 개선하고 항혈소판제제의 사용 및 콜레스테롤 강하치료가 필요하다. 그 외에도 체중조절, 금연 등에도 신경을 써야 하며, 고위험 환자를 선별하고 철저히 교육하는 것은 족부궤양을 방지하는 매우 효과적인 방법이다.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.3
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• pp.5-8
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• 2004

• Journal of Preventive Medicine and Public Health
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• v.24 no.4 s.36
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• pp.516-530
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• 1991

A case-control study was conducted to investigate the effect of low-level blood lead on the blood pressure. The plasma renin activity(PRA) was measured also to investigate one of the possible mechanisms by which lead nay play a role to influence on the blood pressure. Seventy-two hypertensive and sixty -nine control study subjects were selected from the workers who had no history of b-related lead exposure, in Ulsan city and it's vicinity, Korea. In addition to measuring blood lead levels and PRA, body mass index(BMI), hematocrit, serum sodium, potassium, creatinine, ionized calcium, and cholesterol were measured. Also, the habits of smoking, alcohol drinking and family history of hypertension were checked. The blood lead level of the hypertensive group was $19.8{\pm}5.5{\mu}g/dl$, which was significantly higher than that of the control group, $12.5{\pm}4.7{\mu}g/dl$(p<0.01). On multiple logistic regression analysis, the odds ratio of blood lead level on the occurence of high blood pressure was 1.38, also statistically significant (p<0.01). There was no significant differences between the hypertensive and the control group in the PRA or In (PRA), but there was a marginally significant linear relationship between blood lead and PRA in the hypertensive group(p<0.1). In conclusion, blood lead level which has been known to be within normal limits may be one of the possible risk factors of hypertension and PRA alteration by lead may act as one of the mechanisms.

• Clinical and Experimental Pediatrics
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• v.51 no.9
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• pp.992-997
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• 2008

Purpose : Hypertension (HTN) is no longer an exclusively adult disease; the prevalence of pediatric HTN is increasing. To understand the evaluation and treatment of childhood HTN in Korea, we investigated, via a questionnaire, how hypertensive children are currently assessed and managed by pediatric cardiologists (CA) and nephrologists (NE). Methods : We surveyed 82 pediatric CA and 77 NE, regarding how they manage hypertensive children in Korea. Results : A total 75 replies were received to our questionnaire request (response rate: 47.15%). Routine blood pressure (BP) checks were more frequently performed by NE (CA: 5.7%, NE: 25%, P=0.03), but most respondents (86%) did not check BP routinely. Mercury sphygmomanometers were the most commonly used devices and ambulatory blood pressure monitoring was not frequently used. The goal BP in treated patients was set at the 95th percentile by 61% of respondents. NE used a lower BP goal in hypertensive children with renal disease (CA: 24%, NE: 64%, P=0.004) or DM (CA: 12.5%, NE: 50%, P=0.003). Angiotensin converting enzyme (ACE) inhibitors were the most commonly used agents (mean: 59%); following ACE inhibitors, CA preferred diuretics for hypertensive children with renal disease or cardiovascular disease, and NE preferred calcium channel blockers, regardless of underlying disease. Self-monitoring was the most frequent method for BP monitoring at home. Conclusion : In Korea, BP measurement is not yet a routine examination in treating hypertension. There are some differences in management strategies vis-$\grave{a}$-vis hypertension, between pediatric cardiologists and nephrologists. For the appropriate management and prevention of secondary disease in long-term studies, standard guidelines and education are needed for pediatricians.

• Bulletin of Food Technology
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• v.12 no.3
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• pp.8-13
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• 1999

키틴/키토산은 지질흡수의 억제, 혈중 콜레스테롤의 저하, 항고혈압활성, 면역활성, 항종양/항암활성 등 다양한 생체기능성을 나타내어 건강지향적인 기능성 식품으로서의 이용가치가 매우 큰것으로 평가되고 있다. 키토산은 성인남자의 혈중 콜레스테롤을 감소시키고 HDL cholesterol은 증가시켜 동맥경화지수를 낮추며 비만환자에게 투여시 체중, 중성지질, LDL cholesterol을 유의하게 낮춤으로서 고지혈증과 비만증의 개선에 유용한 것으로 평가된다. 키토산은 또한 성인의 고염식에 의한 혈압상승을 억제하며 3량체 내외의 키틴/키토산 올리고당은 혈압상승의 중요인자인 angiotensin converting enzyme과 직접 반응하여 활성을 현저히 저하시키고 SHR에서의 혈압을 유의하게 억제하는 특성을 보여 고혈압의 억제 및 치료에도 응용가치가 클 것으로 생각된다. 키틴/키토산 및 그 올리고당은 sarcoma 180, Meth-A solid tumor의 성장을 저해하고 L1210와 같은 negative charge를 갖는 malignant cell을 흡착시키는 등 항종양/항암활성을 보이는데 이는 tumoricidal immunocite의 활성화에 의한 것으로 추정되고 있다. 키틴/키토산의 생체활성은 분자크기, 탈아세틸화도, 유도체의 종류 및 적용방법 등에 따라 차이를 보이기 때문에 키틴/키토산을 기능성 식품으로서 폭넓게 이용하게 위해서는 용도에 맞는 적절한 규격 설정이 요구되고 있다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2018.01a
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• pp.47-50
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• 2018

본 논문에서는 초음파 영상에서 환자 정보를 제거하여 ROI 영역을 추출하고, 추출된 ROI 영역에서 최대 명암도를 임계치로 설정한 이진화 기법을 적용하여 ROI 영역을 이진화 한다. 이진화된 ROI 영역에서 4 방향 윤곽선 추적 기법을 적용하여 상완동맥 혈류 영역이 존재하는 사다리꼴 형태의 영역을 추출한다. 추출된 사다리꼴 형태의 영역에서 상완동맥 혈류영역을 정확히 추출하기 위하여 제안된 무게 중심법을 이용하여 추출된 후보 영역을 양자화 한다. 무게 중심법은 추출된 사다리꼴 영역에서 FCM 기반 무게중심법과 PCM 기반 무게중심법을 각각 계산한 후, 두 중심 간의 차이가 존재 할 경우에는 두 중심의 평균값을 새로운 무게 중심으로 설정하여 각 픽셀들을 클러스터링하여 상완 동맥 영역을 추출한다. 추출된 상완 동맥 영역에는 고혈압 영역인 빨강색 영역과 저혈압이나 혈류가 역류하는 영역인 파란색 영역이 존재한다. 추출된 상완 동맥 영역에서 고혈압 영역만을 추출하기 위해 빨강색 영역을 제외한 그 외의 영역은 제거한다. 전문의가 제공한 상완동맥 혈류 초음파 영상을 대상으로 TPR(True Positive Rate) 검사을 분석한 결과, 제안된 방법이 기존의 방법 보다 TPR 값이 높게 나타나는 것을 확인하였다.

• Journal of Yeungnam Medical Science
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• v.16 no.2
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• pp.333-341
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• 1999

Background and Methods: In order to evaluate characteristics and modulatory factors of blood pressure in peritoneal dialysis(PD), studies were conducted on the 69 patients who had underwent peritoneal equilibration test(PET). Results: The results were as follows; 1) All patients received an antihypertensive drug before PD, but, 15 of 69 patients successfully quit taking the antihypertensive drug after peritoneal dialysis. 2) During peritoneal dialysis, mean arterial pressure(MAP) was significantly decreased for the first 3 months, and this lasted for 1 year, and antihypertensive drug requirements were significantly decreased continuously up to 9 months(p<0.05). 3) After changing the modality from hemodialysis to peritoneal dialysis, MAP(mmHg, from $107.0{\pm}4.5$ to $98.6{\pm}8.8$, p<0.05), antihypertensive drug requirements(from $5.6{\pm}2.6$, to $2.0{\pm}2.5$, p<0.01) and erythropoietin dosages(Uint/week, from $4600{\pm}2660$ to $2000{\pm}1630$, p<0.05) were decreased. 4) Multiple logistic regression analysis showed that MAP(p<0.01) and daily ultrafiltration volume(p<0.05) can contribute to the determination of antihypertensive drug requirements. However the relationship between antihypertensive drug requirements and PET results or dialysis adequacy indices(weekly Kt/V, weekly creatinine clearance) was not revealed. Conclusion: In conclusion, the prescription of antihypertensive drugs should be considered according to daily ultrafiltration volume, especially during first year after initiating PD, and follow-ups for over a year may be needed.

• The Korean Chronic Disease News
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• no.319
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• pp.1-18
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• 2007

복지시대의 첨병-구례군보건의료원 김영락 원장/노인복지시설 통합.개편/비만치료도 건강보험급여 대상/보건소 중심, 만성질환 관리시스템 구축/임의왕진 의료급여비 환수/적절한 운동이 '대장암' 예방한다/모유수유 오래하면 유방암 감소/50대 두통, 어지러움은 중풍 의심/축수산물 항생제 잔류 기준 엄격 적용/담배연기 없는 깨끗한 병원/레이저 이용 암 세포만 선택적 파괴/'주민 삶의 질 적인 개선' 지향-구례구보건의료원/농촌지역 공공보건의료 질적 발전에 정열 쏟아-김영락 원장/동아제약, 유럽 시장 본격진출/LG, 세계 최초 항구토 패치 도입/한미약품, 의약사 금융지원 한다/국내 첫 생약제제 임상시험 지침 마련/암환자 완치율 44.4% 수준/고혈압.당뇨병치료율 2배 증가/혈압 없어도 '코골면' 고혈압 위험 높아/조기위암 전체 위암 절반 넘었다/항암면역세포치료제 NKM 허가/OECD Health Data 2007 보건의료실태분석

• The Korean Journal of Applied Statistics
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• v.18 no.2
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• pp.297-310
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• 2005

In this study we investigate the association between the haplotype block of 4 SNPs in ACE genes and hypertension with a case-control dataset of size of 277 and 40 families data collected from Kangwha studies. To this end we perform a haplotype-based case-control association study and a haplotype-based TDT study. We do the same analysis with tag-SNPs that can identify the haplotype block. Through a cladogram analysis we make the evolution-tree of haplotypes and then classify the haplotypes into a few clades by collecting haplotypes exposed to the disease to the same extent. We also discuss the association between these clades and hypertension.