• Title/Summary/Keyword: 고정벽

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A Study on the Pan-Jang in the Joseon Dynasty (조선시대 판장(板墻)에 관한 연구)

  • Oh, Jun-young;Kim, Young-mo
    • Korean Journal of Heritage: History & Science
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    • v.49 no.1
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    • pp.68-83
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    • 2016
  • Pan-jang(板墻) has become the lost facility, and the examples of its original form can be found no more due to its variable material characteristics. In order to study panjang as a lost facility, the following are needed: - To bring to light its usage and examples. - To investigate its components and structure. Panjang refers to the wall made of wooden plate and is classified as a special wall according to its material characteristics. In addition, Chinese mokyeongbyuk(木影壁) and Japanese panbyeong(板?) are similar to Korean panjang in terms of the materials, but there are clear differences in their structures. Panjang was also transformed into various types according to their materials or forms. As the wooden elements of panjang, sinbang(信防), pillars, do-ri(道里), jungbang(中枋), inbang(引枋), parn(板), dae(帶), choyeop(草葉), bangyeon(方椽), gaeparn(蓋板), pyeonggodae(平高臺), and yeonharm(椽檻) were selectively used, and they are similar, in particular, to the components of ilgakmoon(一角門). The stylobate of panjang is largely classified into three according to the kinds and structures of the wooden elements; and its frame into two according to whether sanginbang(上引枋) is used or not. The materials for the roof area include planks(蓋板) and tiles and have the distinct structural differences according to each material.

A method of wall absorption treatment for enhancing the speech intelligibility at a directional microphone array in a room (실내 공간 내 지향성 마이크 어레이에서의 음성 명료도 개선을 위한 벽면 흡음 처리 방법)

  • Ko, Byeong-Yun;Ih, Jeong-Guon;Cho, Wan-Ho
    • The Journal of the Acoustical Society of Korea
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    • v.40 no.6
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    • pp.649-659
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    • 2021
  • Wall absorption treatment effectively reduces reverberation, but requires a large area for a live room and each wall absorption affects speech intelligibility differently. In this study, we try to find the most effective wall for the absorption treatment using the beamforming array microphone in terms of speech intelligibility. The absorption importance factor is defined by using the collision number of reflected sounds on each wall. It allows estimating how much the speech signal will be enhanced by the absorption treatment. A cuboid room with a size of 107 m3 and a reverberation time of 1.1 s is selected for the simulation. When a Helmholtz-type absorption is treated on the wall with the most significant importance factor, the modified clarity for 500 and 1k Hz is improved by 5.1 dB and 4.8 dB respectively, and the speech transmission index is enhanced by 0.06. The difference in results between the proposed method and commercial simulation code is less than a Just-Noticeable Difference (JND). The absorption treatment on the wall with the most significant importance factor shows improvement greater than the wall with the largest area, and its difference is larger than a JND value.

Development of Software-Defined Perimeter-based Access Control System for Security of Cloud and IoT System (Cloud 및 IoT 시스템의 보안을 위한 소프트웨어 정의 경계기반의 접근제어시스템 개발)

  • Park, Seung-Kyu
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.21 no.2
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    • pp.15-26
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    • 2021
  • Recently, as the introduction of cloud, mobile, and IoT has become active, there is a growing need for technology development that can supplement the limitations of traditional security solutions based on fixed perimeters such as firewalls and Network Access Control (NAC). In response to this, SDP (Software Defined Perimeter) has recently emerged as a new base technology. Unlike existing security technologies, SDP can sets security boundaries (install Gateway S/W) regardless of the location of the protected resources (servers, IoT gateways, etc.) and neutralize most of the network-based hacking attacks that are becoming increasingly sofiscated. In particular, SDP is regarded as a security technology suitable for the cloud and IoT fields. In this study, a new access control system was proposed by combining SDP and hash tree-based large-scale data high-speed signature technology. Through the process authentication function using large-scale data high-speed signature technology, it prevents the threat of unknown malware intruding into the endpoint in advance, and implements a kernel-level security technology that makes it impossible for user-level attacks during the backup and recovery of major data. As a result, endpoint security, which is a weak part of SDP, has been strengthened. The proposed system was developed as a prototype, and the performance test was completed through a test of an authorized testing agency (TTA V&V Test). The SDP-based access control solution is a technology with high potential that can be used in smart car security.

A Study on Transport Robot for Autonomous Driving to a Destination Based on QR Code in an Indoor Environment (실내 환경에서 QR 코드 기반 목적지 자율주행을 위한 운반 로봇에 관한 연구)

  • Se-Jun Park
    • Journal of Platform Technology
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    • v.11 no.2
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    • pp.26-38
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    • 2023
  • This paper is a study on a transport robot capable of autonomously driving to a destination using a QR code in an indoor environment. The transport robot was designed and manufactured by attaching a lidar sensor so that the robot can maintain a certain distance during movement by detecting the distance between the camera for recognizing the QR code and the left and right walls. For the location information of the delivery robot, the QR code image was enlarged with Lanczos resampling interpolation, then binarized with Otsu Algorithm, and detection and analysis were performed using the Zbar library. The QR code recognition experiment was performed while changing the size of the QR code and the traveling speed of the transport robot while the camera position of the transport robot and the height of the QR code were fixed at 192cm. When the QR code size was 9cm × 9cm The recognition rate was 99.7% and almost 100% when the traveling speed of the transport robot was less than about 0.5m/s. Based on the QR code recognition rate, an experiment was conducted on the case where the destination is only going straight and the destination is going straight and turning in the absence of obstacles for autonomous driving to the destination. When the destination was only going straight, it was possible to reach the destination quickly because there was little need for position correction. However, when the destination included a turn, the time to arrive at the destination was relatively delayed due to the need for position correction. As a result of the experiment, it was found that the delivery robot arrived at the destination relatively accurately, although a slight positional error occurred while driving, and the applicability of the QR code-based destination self-driving delivery robot was confirmed.

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Simultaneous Removal of Cd and Cr(VI) in the Subsurface Using Permeable Reactive Barrier Filled with Fe-loaded Zeolite: Soil Box Experiment (Fe-loaded zeolite로 충진된 투수성 반응벽체를 이용한 지반 내 Cd과 Cr(VI)의 동시제거: 모형 토조 실험)

  • Rhee, Sung-Su;Lee, Seung-Hak;Park, Jun-Boum
    • Journal of the Korean Geotechnical Society
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    • v.26 no.10
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    • pp.61-68
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    • 2010
  • A pilot-scale model test was performed to estimate the availability of new material, Fe-loaded zeolite, as the filling material in permeable reactive barrier (PRB) against the contaminated groundwater with both Cd and Cr(VI). Aquifer was simulated by filling up a large scale soil tank with sands, and mobilizing the water flow by the head difference of water level in both ends of the tank. Then, the mixture of concentrated Cd and Cr(VI) solution was injected into the aquifer to form a contaminant plume, and its behavior through Fe-loaded zeolite barrier was monitored. The test results showed that Fe-loaded zeolite barrier successfully treated the contaminant plume containing both Cd and Cr(VI) and that the immobilized contaminants in the barrier were not desorbed or released. The results indicated that the Fe-loaded zeolite could be a promising material in PRBs against the multiple contaminants with different ionic forms like Cr(VI) and Cd.

Antibacterial Properties of Poly-butylene Adipate Terephthalate With Zinc Pyrithione Composites (Zinc pyrithione을 함유한 poly-butylene adipate terephthalate 복합체의 항균 특성)

  • Tae-gyeun Kim;Woo-Suk Jung;Daesuk Bang;Kwang-Hwan Jhee
    • Journal of Life Science
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    • v.34 no.8
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    • pp.540-547
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    • 2024
  • The continuous use of polymer materials has exacerbated waste and environmental challenges, spurring a growing interest in eco-friendly polymers, especially biodegradable polymers. These polymers are gaining attention for their potential as antimicrobial agents, particularly in fields like food packaging a need further underscored by the recent COVID-19 pandemic. This study focuses on the development of an antibacterial polymer by combining poly-butylene adipate terephthalate (PBAT) with zinc pyrithione (ZnPt). The antibacterial properties were assessed through turbidity analysis, the shaking flask method, and the film adhesion method. The antibacterial activities of the composites with varying ZnPt% (w/w) contents (0, 0.1, 0.3, and 0.5) were evaluated against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Results revealed that even at a low concentration of 0.1% (w/w), the composites demonstrated significant antibacterial activity against both Gram-positive bacteria (S. aureus) and Gram-negative bacteria (E. coli). Composites with ZnPt concentrations of 0.3% (w/w) or higher achieved over 99.999% antibacterial efficacy. Field emission scanning electron microscopy (FE-SEM) analysis of the fracture surfaces of the composites confirmed the uniform distribution of ZnPt particles, ranging from 1-4 ㎛. Further FE-SEM analysis of bacterial suspensions exposed to the composite surfaces showed clear evidence of cell wall destruction in both E. coli and S. aureus. As an antimicrobial biodegradable polymer, PBAT-ZnPt composites show great promise for applications in various sectors, including food packaging.

Measurement of Porcine Aortic and Pulmonary Valve Geometry and Design for Implantable Tissue Valve (돼지 대동맥, 폐동맥의 근위부 기하학적 구조 측정을 통한 판막 구조 수치의 계량화와 판막 도안에 관한 연구)

  • Park, Sung-Joon;Kim, Yong-Jin;Nam, Jin-Hae;Kim, Soo-Hwan;Lee, Chang-Ha;Lim, Hong-Gook
    • Journal of Chest Surgery
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    • v.43 no.6
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    • pp.602-613
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    • 2010
  • Background: As life expectancy has been increased, the cardiac valve disease has been increased. In past, mechanical valve for valve replacement surgery was used widely, but it has many weaknesses, such as hemorrhage, teratogenic effect caused by warfarin, acute mechanical failure, taking warfarin during life, etc. So, the tissue valve is used widely and researches for durability of tissue valve are in progress. Tissue valves being used are all imported in Korea, and there is a lack of information on its geometry and design. So, we studied the geometry of porcine aortic and pulmonary valve, and tried to suggest theoretical basis for making the aortic and pulmonary valve. Material and Method: We harvested aortic and pulmonary valves of 25 pigs and measured the geometry of valve at fresh and glutaraldehyde (GA) fixed state. In each group, we measured the diameter of the base, diameter of commissure, valve height, commissural height, etc. Also, for making implantable porcine and bovine pericardial valve, we designed the valve stent form, thickness, height, and leaflet size, form, thickness by different size of valve. Result: The aortic and pulmonary valve geometry and ratio were measured in each group. The right coronary cusp of aortic valve and right facing cusp of pulmonary valve was bigger than other cusps and non coronary cusp was smaller than others (RCC: NCC : LCC=1 : 0.88 : 1). Valve height was correlated to the leaflet size. We designed the outer diameter of stented porcine aortic valve from 19 mm to 33 mm and designed stent height and width, using previous measured ratio of each structure, stent thickness, working thickness (for making valve). Also, we designed the size of stent and form for stented bovine pericardial valve, considering diameter of valve, leaflet length, height and leaflet minimum coaptation area. Conclusion: By measuring of 25 pig's aortic and pulmonary valve geometry and ratio, we can make theoretical basis for making implantable stented porcine valve and bovine pericardial valve in various size. After making implantable valve using these data, it is necessary to do in vivo and in vitro researches, furthermore.

Marginal and internal fitness of three-unit zirconia cores fabricated using several CAD/CAM systems (다양한 CAD/CAM 시스템으로 제작된 3 본 고정성 가공의치 지르코니아 코어의 변연 및 내면 적합도 평가)

  • Huh, Jung-Bo;Kim, U-Sic;Kim, Ha-Young;Kim, Jong-Eun;Lee, Jeong-Yeol;Kim, Young-Su;Jeon, Young-Chan;Shin, Sang-Wan
    • The Journal of Korean Academy of Prosthodontics
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    • v.49 no.3
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    • pp.236-244
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    • 2011
  • Purpose: This study was aimed to compare the margin and internal fitness of 3-unit zirconia bridge cores fabricated by several CAD/CAM systems using replica technique. Materials and methods: Three unit-bridge models in which upper canine and upper second premolar were used as abutments and upper first premolar was missed, were fabricated. Fourty models were classified into 4 groups (Cerasys$^{(R)}$ (Group C), Dentaim$^{(R)}$ (Group D), KaVo Everest$^{(R)}$ (Group K), $Lava^{TM}$ (Group L)), and zirconia cores were fabricated by each company. Sixteen points were measured on each abutment by replica technique. Statistical analysis was accomplished with two way ANOVA and Dunnett T3 (${\alpha}$=.05). Results: In most systems, there was a larger gap on inter margin than outer margin. In the Group K, overall fitness was excellent, but the incisal gap was very large. In the Group C, marginal gap was significantly larger than Group K, but overall internal gap was uniform (P<.05). The axial gap was under $100\;{\mu}m$ in all system. The difference between internal and external gap was small on Group L and C. However, internal gap was significantly larger than external gap in Group D (P<.05). The fitness of canine was better than second premolar among abutments (P<.05). Conclusion: The marginal and internal gap was within the clinically allowed range in all of the three systems. There was a larger gap on second premolar than canine on internal and marginal surface. In most systems, there was a larger gap on occlusal surface than axial surface.

VR media aesthetics due to the evolution of visual media (시각 미디어의 진화에 따른 VR 매체 미학)

  • Lee, Dong-Eun;Son, Chang-Min
    • Cartoon and Animation Studies
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    • s.49
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    • pp.633-649
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    • 2017
  • The purpose of this study is to conceptualize the changing aspects of human freedom of observation and viewing as the visual media evolves from film to 3D stereoscopic film and VR. The purpose of this study is to conceptualize the aspect of freedom and viewing aspect from the viewpoint of genealogy. In addition, I will identify the media aesthetic characteristics of VR and identify the identity and ontology of VR. Media has evolved around the most artificial sense of human being. There is a third visual space called screen at the center of all the reproduction devices centering on visual media such as painting, film, television, and computer. In particular, movies, television, and video screens, which are media that reproduce moving images, pursue perfect fantasy and visual satisfaction while controlling the movement of the audience. A mobilized virtual gaze was secured on the assumption of the floating nature of the so-called viewers. The audience sees a cinematic illusion with a view while seated in a fixed seat in a floating posture. They accept passive, passive, and passively without a doubt the fantasy world beyond the screen. But with the advent of digital paradigm, the evolution of visual media creates a big change in the tradition of reproduction media. 3D stereoscopic film predicted the extinction of the fourth wall, the fourth wall. The audience is no longer sitting in a fixed seat and only staring at the front. The Z-axis appearance of the 3D stereoscopic image reorganizes the space of the story. The viewer's gaze also extends from 'front' to 'top, bottom, left, right' and even 'front and back'. It also transforms the passive audience into an active, interactive, and experiential subject by placing viewers between images. Going one step further, the visual media, which entered the VR era, give freedom to the body of the captive audience. VR secures the possibility of movement of visitors and simultaneously coexists with virtual space and physical space. Therefore, the audience of the VR contents acquires an integrated identity on the premise of participation and movement. It is not a so-called representation but a perfection of the aesthetic system by reconstructing the space of fantasy while inheriting the simulation tradition of the screen.

홍삼 유래 성분들의 면역조절 효능

  • Jo, Jae-Yeol
    • Food preservation and processing industry
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    • v.8 no.2
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    • pp.6-12
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    • 2009
  • 면역반응은 외부 감염원으로부터 신체를 보호하고 외부감염원을 제거하고자 하는 주요항상성 유지기전의 하나이다. 이들 반응은 골수에서 생성되고 비장, 흉선 및 임파절 등에서 성숙되는 면역세포들에 의해 매개된다. 보통 태어나면서부터 얻어진 선천성 면역반응을 매개하는 대식세포, 수지상 세포 등과, 오랜기간 동안 감염된 다양한 면역원에 대한 경험을 토대로 얻어진 획득성 면역을 담당하는 T 임파구 등이 대표적인 면역세포로 알려져 있다. 다양한 면역질환이 최근 주요 사망률의 원인이 되고 있다. 최근, 암, 당뇨 및 뇌혈관질환 등이 생체에서 발생되는 급 만성염증에 의해 발생된다고 보고됨에 따라 면역세포 매개성 염증질환에 대한 치료제 개발을 서두르고 있다. 또한 암환자의 급격한 증가는 암발생의 주요 방어기전인 면역력 증강에 대한 요구들을 가중시키고 있다. 예로부터 사용되어 오던 고려인삼과 홍삼은 기를 보호하고 원기를 회복하는 명약으로 알려진 대표적인 우리나라 천연생약이다. 특별히, 홍삼은 단백질과 핵산의 합성을 촉진시키고, 조혈작용, 간기능 회복, 혈당강하, 운동수행 능력증대, 기억력 개선, 항피로작용 및 면역력 증대에 매우 효과가 좋은 것으로 보고되고 있다. 홍삼에 관한 많은 연구에 비해, 현재까지 홍삼이 면역력 증강에 미치는 효과에 대한 분자적 수준에서의 연구는 매우 미미한 것으로 확인되어져 있다. 홍삼의 투여는 NK 세포나 대식세포의 활성이 증가하고 항암제의 암세포 사멸을 증가시키는 것으로 확인되어졌다. 현재까지 알려진 주요 면역증강 성분은 산성다당류로 보고되었다. 또 한편으로 일부 진세노사이드류에서 항염증 효능이 확인되어졌으며, 이를 통해 피부염증 반응과 관절염에 대한 치료 효과가 있는 것으로 추측되고 있다 [본 연구는 KT&G 연구출연금 (2009-2010) 지원을 받아 이루어졌기에 이에 감사드린다]. 면역반응은 외부 감염물질의 침입으로 유도된 질병환경을 제거하고 수복하는 중요한 생체적 방어작용의 하나이다. 이들 과정은 체내로 유입된 미생물이나 미세화학물질들과 같은 독성물질을 소거하거나 파괴하는 것을 주요 역할로 한다. 외부로 부터 인체에 들어온 이물질에 대한 방어기전은 현재 두 가지 종류의 면역반응으로 구분해서 설명한다. 즉, 선천성 면역 반응 (innate immunity)과 후천성 면역 반응 (adaptive immunity)이 그것이다. 선천성 면역반응은 1) 피부나 점막의 표면과 같은 해부학적인 보호벽 구조와 2) 체온과 낮은 pH 및 chemical mediator (리소자임, collectin류) 등과 같은 생리적 방어구조, 3) phagocyte류 (대식세포, 수지상세포 및 호중구 등)에 의한 phagocytic/endocytic 방어, 그리고 4) 마지막으로 염증반응을 통한 감염에 저항하는 면역반응 등으로 구분된다. 후천성 면역반응은 획득성면역이라고도 불리고 특이성, 다양성, 기억 및 자기/비자기의 인식이라는 네 가지의 특징을 가지고 있으며, 외부 유입물질을 제거하는 반응에 따라 체액성 면역 반응 (humoral immune response)과 세포성 면역반응 (cell-mediated immune response)으로 구분된다. 체액성 면역은 침입한 항원의 구조 특이적으로 생성된 B cell 유래 항체와의 반응과 간이나 대식세포 등에서 합성되어 분비된 혈청내 보체 등에 의해 매개되는 반응으로 구성되어 있다. 세포성 면역반응은 T helper cell (CD4+), cytotoxic T cell (CD8+), B cell 및antigen presenting cell 중개를 통한 세포간 상호 작용에 의해 발생되는 면역반응이다. 선천성 면역반응의 하나인 염증은 우리 몸에서 가장 빈번히 발생되고 있는 방어작용의 하나이다. 예를 들면 감기에 걸렸을 경우, 환자의 편도선내 대식세포나 수지상세포류는 감염된 바이러스 단독 혹은 동시에 감염된 박테리아를 상대로 다양한 염증성 반응을 유도하게 된다. 또한, 상처가 생겼을 경우에도 감염원을 통해 유입된 병원성 세균과 주위조직내 선천성 면역담당 세포들 간의 면역학적 전투가 발생되게 된다. 이들 과정을 통해, 주위 세포나 조직이 손상되면, 즉각적으로 이들 면역세포들 (주로 phagocytes류)은 신속하게 손상을 극소화하고 더 나가서 손상된 부위를 원상으로 회복시키려는 일련의 염증반응을 유도하게 된다. 이들 반응은 우리가 흔히 알고 있는 발적 (redness), 부종 (swelling), 발열 (heat), 통증 (pain) 등의 증상으로 나타나게 된다. 즉, 손상된 부위 주변에 존재하는 모세혈관에 흐르는 혈류의 양이 증가하면서 혈관의 직경이 늘어나게 되고, 이로 인한 조직의 홍반과, 부어 오른 혈관에 의해 발열과 부종이 초래되는 것이다. 확장된 모세혈관의 투과성 증가는 체액과 세포들이 혈관에서 조직으로 이동하게 하는 원동력이 되고, 이를 통해 축적된 삼출물들은 단백질의 농도를 높여, 최종적으로 혈관에 존재하는 체액들이 조직으로 더 많이 이동되도록 유도하여 부종을 형성시킨다. 마지막으로 혈관 내 존재하는 면역세포들은 혈판 내벽에 점착되고 (margination), 혈관벽의 간극을 넓히는 역할을 하는 히스타민 (histamine)이나 일산화질소(nitric oxide : NO), 프로스타그린딘 (prostagladins : PGE2) 및 류코트리엔 (leukotriens) 등과 같은 chemical mediator의 도움으로 인해 혈관벽 사이로 삼출하게 되어 (extravasation), 손상된 부위로 이동하여 직접적인 외부 침입 물질의 파괴나 다른 면역세포들을 모으기 위한 cytokine (tumor necrosis factor [TNF]-$\alpha$, interleukin [IL]-1, IL-6 등) 혹은 chemokine (MIP-l, IL-8, MCP-l등)의 분비 등을 수행함으로써 염증반응을 매개하게 된다. 염증과정시 발생되는 여러 mediator 중 PGE2나 NO 및 TNF-$\alpha$ 등은 실험적 평가가 용이하여 이들 mediator 자체나 생성관련효소 (cyclooxygenase [COX] 및 nitric oxide synthase [NOS] 등)들은 현재항염증 치료제의 개발 연구시 주요 표적으로 연구되고 있다. 염증 반응은 지속기간에 따라 크게 급성염증과 만성염증으로 나뉘며, 삼출물의 종류에 따라서는 장액성, 섬유소성, 화농성 및 출혈성 염증 등으로 구분된다. 급성 염증 (acute inflammation)반응은 수일 내지 수주간 지속되는 일반적인 염증반응이라고 볼 수 있다. 국소반응은 기본징후인 발열과 발적, 부종, 통증 및 기능 상실이 특징적이며, 현미경적 소견으로는 혈관성 변화와 삼출물 형성이 주 작용이므로 일명 삼출성 염증이라고 한다. 만성 염증 (chronic inflammation)은, 급성 염증으로부터 이행되거나 만성으로 시작된다. 염증지속 기간은 보통 4주 이상 장기화 된다. 보통 염증의 경우에는 염증 생성 cytokine인 Th1 cytokine (IL-2, interferone [IFN]-$\gamma$ 및 TNF-$\alpha$ 등)의 생성 후, 거의 즉각적으로 항 염증성 cytokine인 Th2 cytokine(IL-4, IL-6, IL-10 및 transforming growth factor [TGF]-$\beta$ 등)이 생성되어 정상반응으로 회복된다. 그러나, 어떤 원인에서든 면역세포에 의한 염증원 제거 반응이 문제가 되면, 만성염증으로 진행된다. 이 반응에 주로 작용을 하는 염증세포로는 단핵구와 대식세포, 림프구, 형질세포 등이 있다. 암은 전세계적으로 사망률 1위의 원인이 되는 면역질환의 하나이다. 산화적 스트레스나 자외선 조사 혹은 암유발 물질들에 의해 염색체내 protooncogene, tumor-suppressor gene 혹은 DNA repairing gene의 일부 DNA의 돌연변이 혹은 결손 등이 발행되면 정상세포는 암화과정을 시작하게 된다. 양성세포 수준에서 약 5에서 10여년 후 악성수준의 암세포가 생성되게 되면 이들 세포는 새로운 환경을 찾아 전이하게 되는데 이를 통해 암환자들은 다양한 장기에 동인 오리진의 암세포들이 생성한 종양들을 가지게 된다. 이들 종양세포는 정상 장기의 기능을 손상시켜며 결국 생명을 잃게 만든다. 이들 염색체 수준에서의 돌연변이 유래 암세포는 거의 대부분이 체내 면역시스템에 의해 사멸되는 것으로 알려져 있다. 그러나 계속되는 스트레스나 암유발 물질의 노출은 체내 면역체계를 파괴하면서 최후의 방어선을 무너뜨리면서 암발생에 무방비 상태를 만들게 된다. 이런 이유로 체내 면역시스템의 정상적 가동 및 증강을 유도하게 하는 전략이 암예방시 매우 중요한 표적으로 인식되면서 다양한 형태의 면역증강 물질 개발을 시도하고 있다. 인삼은 두릅나무과의 여러해살이 풀로써, 오랜동안 한방 및 민간에서 원기를 회복시키고, 각종 질병을 치료할 수단으로 사용되고 있는 대표적인 전통생약이다. 예로부터 불로(不老), 장생(長生), 익기(益氣), 경신(經身)의 명약으로 구전되어졌는데, 이는 약 2천년 전 중국의 신농본초경(神農本草經)에서 "인삼은 오장(五腸)을 보하고, 정신을 안정시키고, 혼백을 고정하며 경계를 멈추게 하고, 외부로부터 침입하는 병사를 제거하여주며, 눈을 밝게 하고 마음을 열어 더욱 지혜롭게 하고 오랫동안 복용하면 몸이 가벼워지고 장수한다" 라고 기술되어있는 데에서 유래한 것이다. 다양한 연구를 통해 우리나라에서 생산되는 고려인삼 (Panax ginseng)이 효능 면에서 가장 탁월한 것으로 알려져 있으며 특별이 고려인삼으로부터 제조된 고려홍삼은 전세계적으로도 그 효능이 우수한 것으로 보고되어 있다. 대부분의 홍삼 약효는 dammarane계열의 triterpenoid인 ginsenosides라고 불리는 인삼 saponin에 의해 기인된 것으로 알려져 있다. 이들 화합물군의 기본 골격에 따라, protopanaxadiol (PD)계 (22종) 및 protopanaxatriol (PT)계 (10종)으로 구분되고 있다 (표 1). 실험적 접근을 통해 인삼의 약리작용 이해를 위한 다양한 노력들이 경주되고 있으나, 여전히 많은 부분에서 충분히 이해되고 있지 않다. 그러나, 현재까지 연구된 인삼의 약리작용 관련 연구들은 심혈관, 당뇨, 항암 및 항스트레스 등과 같은 분야에서 인삼효능이 우수한 것으로 보고하고 있다. 그러나 면역조절 및 염증현상과 관련된 최근 연구결과들은 많지 않으나, 향후 다양하게 연구될 효능부분으로 인식되고 있다.

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