• Korean Journal of Clinical Pharmacy
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• v.5 no.2
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• pp.75-84
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• 1995

Drug delivery by red cells was established to maintain the release of drugs in the blood. The entrapment method by amphotericin B was re-examined and evaluated for obtaining the suitable entrapping conditions without hemolysis. The amphotericin B treatment below $10{\mu}g/ml$ induced the non-hemolysis to entrap daunorubicin into red cells within 10min. Under these conditions intracellular ATP level was decreased as $18\%$. Membrane fluidity and the shape factor of red cells were maintained. To maintain intracellular ATP, ATP and sodium pyruvate were added during the entrapment procedure because hemolysis during the release test would reflect the loss of intracellular ATP that would be postulate the decrease of the viability invivo. Consequently, the addition of ATP in the reaction solution can raise the intracellular level of ATP.

• The KIPS Transactions:PartA
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• v.9A no.2
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• pp.163-170
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• 2002

Previous buffer cache schemes for continuous media file system only exploited the sequentiality of continuous media accesses and didn't consider looping references. However, in some video applications like foreign language learning, users mark the scene as loop area and then application automatically playbacks the scene several times. In this paper, we propose a novel buffer cache scheme for continuous media file system that sequential and looping references exist together. Proposed scheme increases the cache hit ratio by detecting reference pattern of files and appling an appropriate replacement policy to each file.

• YAKHAK HOEJI
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• v.41 no.2
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• pp.220-224
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• 1997

This study was carried out to investigate the dose dependent antifibrotic effects of polysaccharide from mycelium of Ganoderma lucidum. The experimental hepatic cirrhosis was induced by bile duct ligation/scission (BDL/S) in rats. BDL/S rats in each group were dosed 0.5 mg, 2.0 mg, 5.0 mg or 10.O mg/rat/day orally for 4 weeks after the operation. Antifibrotic effects were evaluated by serum biochemical values, hydroxyproline contents, and light microscopical histology. The results obtained were as follows: 1) Hydroxyproline contents in liver of 5.0 and 10.0mg polysaccharide-treated BDL/S rats were significantly reduced 2) In serum test, ALT, AST, ALP values in polysaccharide from Ganoderma lucidum-treated group were lower than BDL/S control group 3) The hepatic damage such as hepatocellular necrosis, inflammation, bile duct proliferation and fibrosis was less severe in the livers of 2.0 mg and 5.0 mg polysaccharide-treated rats. These results suggest that polysaccharide from mycelium of Ganoderma lucidum to be a promising agent for the inhibition of hepatic cirrhosis.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.7
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• pp.1304-1320
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• 1994

There are two computation techniques in real time systems : precise and imprecise computation. The imprecise computation technique is a means to provide scheduling flexibility in real time systems. The studies on imprecise scheduling using queueing theoretical formulation up to data are to explicitly quantify the costs and benifits in trade-off between the average result quality and the average waiting time of tasks. This paper uses two imprecise scheduling schemes and solves the imprecision probability, the probability of any task being imprecise under two imprecise scheduling schemes and analyzes the dependence of the imprecision probability on several parameters os the monotone imprecise system.

• Journal of Biomedical Engineering Research
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• v.36 no.4
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• pp.128-134
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• 2015

Recently, the structured data format in RDF/OWL has played an increasingly vital role in the semantic web. We converted pediatric and oncologic nuclear medicine imaging reports in free text into RDF/OWL format and evaluated the usefulness of nuclear medicine imaging reports in RDF/OWL by comparing SPARQL query results with the manually retrieved results by physicians from the reports in free text. SPARQL query showed 95% recall for simple queries and 91% recall for dedicated queries. In total, SPARQL query retrieved 93% (51 lesions of 55) recall and 100% precision for 20 clinical query items. All query results missed by SPARQL query were of some inference. Nuclear medicine imaging reports in the format of RDF/OWL were very useful for retrieving simple and dedicated query results using SPARQL query. Further study using more number of cases and knowledge for inference is warranted.

• YAKHAK HOEJI
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• v.41 no.5
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• pp.622-628
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• 1997

Hepatic cirrhosis is a common response to chronic liver injury from many causes and is one of the most common cause of all deaths. This study was carried out to compare experimental hepatic cirrhosis in rats to understand this disease and to apply for the pharmacokinetics in disease state. Following three kinds of experimental models were induced; 1) Bile duct ligation/scission (BDL/S), 2) N, N-dimethylnitrosamine(DMN), 3) Carbon tetrachloride. The hepatic cirrhosis was characterized by examing the liver/body weight ratio, serum biochemical values, hydroxyproline content in liver and histopathological lesions in cirrhotic rat liver. The results are as follows : (1) In BDL/S, the liver was enlarged to 250% of normal liver. In contrast the liver was shrinked to 48% and 78% of the normal liver in DMN and carbon tetrachloride, respectively. (2) In carbon tetrachloride and BDL/S, the serum ALT, AST, ALP and total bilirubin levels were significantly increased to 200~300% of normal level, while ALT and total bilirubin levels were significantly increased in DMN group. (3) Hydroxyproline content in cirrhotic rat liver was significantly 200~500% higher than that of normal liver. (4) Nodular formation with fibrosis was observed in BDL/S, DMN, carbon tetrachloride induced cirrhotic rat liver.

• Journal of Pharmaceutical Investigation
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• v.26 no.1
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• pp.23-28
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• 1996

The dissolution characteristics of DDB were markedly enhanced by preparing solid dispersions of drug with polyethylene glycol 6000. Solid dispersions of various weight fraction were formed by a melting method. And various tablets$(A{\sim}E)$ were prepared from these solid dispersions with excipients (lactose, com starch, Avicel and PVP) by wet granulation method. There were no significant differences in dissolution rates between physical mixture and DDB alone. But dissolution rates of solid dispersions were $1.4{\sim}2.0$ times greater than that of DDB alone and $1.2{\sim}1.8$ times greater than those of a commercial tablet.

• Journal of KIISE:Computer Systems and Theory
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• v.34 no.4
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• pp.138-144
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• 2007

With recent proliferation of video-on-demand services, caching in a multimedia streaming server is becoming increasingly important. Previous studies have shown that request interval based caching and its extension for considering different video popularity performs well in various streaming environments. In this paper, we show that block level refinement of this existing scheme can further improve the performance of streaming servers. Trace driven simulations with real world VOD traces have shown that the proposed scheme improves the cache hit rate and the startup latency.

• Proceedings of the Korean Information Science Society Conference
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• 2003.04d
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• pp.277-279
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• 2003

본 논문에서는 편재 컴퓨팅(ubiquitous and pervasive computing) 환경에 입력 시스템으로 사용하는 센서 네트워크에서 측정한 데이터의 품질 (sampling rate and quantization depth) 을 보증하며 네트워크 트래픽 또는 소모전력과 같은 비용을 최소화하기 위한 방법으로, 휴리스틱 알고리즘에 의한 비주기적 샘플링과 신뢰성 있는 전송규약을 사용하는 비주기적 전송방식을 제안한다. 그리고 제안한 비주기적 전송방식에 핵심기술인 신뢰성 있는 전송 규약의 비용을 최적화하기 위한 방법으로 ACK방식과 NACK방식을 패킷 에러율과 동일한 라우터를 사용하는 이웃 노드의 수와 같은 네트워크 상황에 따라 상보적으로 사용하는 상보적 방식(alternative method)을 제안하고, 전체 통신규약을 설계하며, 해석을 통해 성능을 분석하고, 네트워크 상태에 따라 두 방식의 성능상의 우열이 전환되는 전환점을 유도한다. 제안하는 상보형 신뢰성 있는 전송규약은 전체 센서 네트워크에서 처리되는 패킷의 비트 수를 최소화해, 각 노드의 총 전력 소모의 20-60%를 차지하는 통신모듈의 소비 전력을 줄일 수 있어 전력소모를 크게 개선 할 수 있다. 나아가서 다양한 센서 네트워크에서 설계한 전송규약을 바탕으로 하는 제안하는 비주기적 전송방식을 활용한다면 최적의 비용으로 측정하는 데이터의 품질을 보증할 수 있다.

• Korean Journal of Clinical Pharmacy
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• v.9 no.1
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• pp.55-61
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• 1999

The object of this work was to study the pharmacokinetic differences and the cause of these differences in cirrhotic rats induced by N,N-dimethylnitrosamine or carbon tetrachloride treatment when aminophylline (8 mg/kg as theophylline, i.v.) was injected. The concentrations of theophylline and its major metabolite (1,3-dimethyluric acid) in plasma were determined by HPLC. In addition, formation of 1,3-dimethyluric acid from theophylline in microsomes was determined. In cirrhotic rats, the systemic clearance of theophylline was reduced to $17\%$ of the control value while AUC (area under the plasma concentration-time curve) and $(t_{1/2})_{\beta}$ were increased to about 6 fold and 10 fold, respectively. The formation of 1,3-dimethyluric acid was decreased to $33-41\%$ of the control value in microsomes of cirrhotic rat liver. From these results, it can be concluded that in cirrhotic rats induced by N,N-dimethylnitrosamine or carbon tetrachloride the total body clearance of theophylline is markedly reduced due to a reduced hepatic metabolism.