Korean Journal of Clinical Pharmacy (한국임상약학회지)
- Volume 9 Issue 1
- /
- Pages.55-61
- /
- 1999
- /
- 1226-6051(pISSN)
- /
- 2508-786X(eISSN)
Biotransformation of Theophylline in Cirrhotic Rats Induced by Carbon Tetrachloride or N,N-Dimethylnitrosamine
흰쥐에서 사염화탄소 또는 N,N-Dimethylnitrosamine에 의한 간경화시 Theophylline의 생체내변환
- Park, Eun-Jeon (Dept. of Pharmacy, College of Pharmacy, Wonkwang University) ;
- Kim, Jaebaek (Dept. of Pharmacy, College of Pharmacy, Wonkwang University) ;
- Sohn, Dong Hwan (Dept. of Pharmacy, College of Pharmacy, Wonkwang University) ;
- Ko, Geonil (Dept. of Pharmacy, College of Pharmacy, Wonkwang University)
- Published : 1999.05.01
Abstract
The object of this work was to study the pharmacokinetic differences and the cause of these differences in cirrhotic rats induced by N,N-dimethylnitrosamine or carbon tetrachloride treatment when aminophylline (8 mg/kg as theophylline, i.v.) was injected. The concentrations of theophylline and its major metabolite (1,3-dimethyluric acid) in plasma were determined by HPLC. In addition, formation of 1,3-dimethyluric acid from theophylline in microsomes was determined. In cirrhotic rats, the systemic clearance of theophylline was reduced to
Keywords