• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.2
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• pp.553-560
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• 2004

In the present study, we investigated the anti-proliferative effects of aqueous extract of Wikyung-tang(WKT) on the growth of human lung carcinoma cell line A549. WKT treatment declined the cell viability and proliferation of A549 cells in a concentration-dependent manner. The anti-proliferative effects by WKT treatment in A549 cells was associated with morphological changes such as membrane shrinking and cell rounding up. WKT treatment induced an inhibition and/or degradation of apoptotic target proteins such poly(ADP-ribose) polymerase (PARP) and phospholipase C-γ1 (PLC-γ1). WKT treatment did not affect the levels of other Bcl-2 family gene products, such as Bcl-2, Bax and Bad. Western blot analysis and RT-PCT data revealed that the levels of tumor suppressor p53 and cyclin-dependent kinase inhibitor p21 were induced by WKT treatment in A549 cells. Additionally, WKT treatment induced the down-regulation of telomerase reverse transcriptase mRNA (hTERT) expression of A549 cells, however, the levels of other telomere-regulatory gene products were not affected. Taken together, these findings suggest that WKT-induced inhibition of human lung cancer cell proliferation is associated with the induction of apoptotic cell death via regulation of several major growth regulatory gene products and WKT may have therapeutic potential in human lung cancer.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.41 no.2
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• pp.230-235
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• 1996

This study was conducted to investigate the effects of planting densities on sex change and fiber yield in hemp plants, local variety 'Gangweonjong' was planted with various planting densities (40 $\times$ 5, 40 $\times$ 10, 40 $\times$ 20, 60 $\times$ 5, 60 $\times$ 10, 60 $\times$ 20cm), and harvesting dates (June 24, July 9 and 24). The stem length was the longest in the space of 60x20cm(8, 333 plants per l0a). The diameters of stem was the thickest in the planting space of 40 $\times$ 20cm(12, 500 plants per l0a) The ratio of peeled fiber yield was the highest in the planting space of 40$\times$5cm(50, 000 plants per l0a). In general, the condition under denser planting space (40 $\times$ 5cm ; 50, 000 plants per l0a) led to an increase in the number of female plants.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.33 no.1
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• pp.54-58
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• 1988

To define natural embryo growth and germination of the Korean ginseng (Panax ginseng C.A.Meyer) seed, freshly harvested and depulped seeds were seeded on nursery bed at Aug. 5 without stratification. At 100 days after seeding, embryo/endosperm length ratio of the seeds in nursery bed was higher than that of the seeds which were stratified with conventional method for 100 days. And also there was no significant difference between dehiscence ratio of the seeds in nursery bed and that from stratification with sand. The germination ratio of the ginseng seeds seeded without stratification at Aug. 5 was about 57% in average of 2 years and was not significantly lower than that of the seeds seeded after stratification at Nov. 15. And there were also no significant differencies of plant growth after germination between the ginseng seedlings from two seeding methods.

• Korean Journal of Plant Resources
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• v.16 no.2
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• pp.147-154
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• 2003

Agronomic characters of the 361 Korean adzuki beans(Vigna angularis (Willd.) Ohwi & Ohashi) collected in Korea were examined. Korean adzuki beans had predominantly up right growth habit types, followed by the intermediate types (15.3%) and the climbing types (6.9%). Round leaf type was the majority among the collections and followed by elliptical and xiphoid leaf type. Adzuki beans with yellow, light yellow and dark yellow flowers were 89.5％, 9.4％ and 1.1％, respectively. The 60.6% of the collections had red seeds and 26.9% had gray seeds. And collections with green seeds, white seeds mixed with gray spot, brown spots on red seeds, black spots on red seeds and dark gray spots on black seeds were also observed. Korean adzuki beans whose number of days from planting to flowering were 69∼75 days were the majority among 361 Korean adzuki beans. The number of days from flowering to majority were 41∼50 days and the number of days from planting to maturity were 111-120days. Adzuki beans having the stem length of 41-60 cm, the pod number per plant of 16-20 and the 100 seed weight of 8∼10 g were 50.2％, 40.2% and 30.5％ of collections, respectively.

• Journal of Gastric Cancer
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• v.4 no.3
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• pp.164-168
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• 2004

Purpose: The most feared complication of gastrointestinal tract operations is anastomotic leakage, not only because of the presumed individual surgeon's culpability but also because of the assumption that this event is often fatal. We have experienced 32 cases of anastomotic leakage after elective gastric resection during 8 years. The purpose of this study was to evaluate the result of their treatment. Materials and Methods: We evaluated the records of 1335 patients who had undergone elective gastric resection for an adenocarcinoma of stomach from January 1995 to October 2003 and conducted a retrospective, multivariate analysis. Results: Of the 1335 patients, 32 ($2.4\%$) sustained an anastomotic leakage. Anastomotic leakages usually developed on mean postoperative day $9.1\pm3.2$ (range:$1\∼18$ days).Overall, $31.3\%$ (10/32) of patients who sustained an anastomotic leakage died. The anastomotic leakages were identifed by radiological study or by operative finding at the site of the duodenal stump (20 patients), the esophagojejunostomy (7), the gastroduodenostomy (4), and the gastrojejunostomy (1). Fourteen patients ($43.8\%$) underwent a relaparotomy, a drainage procedure in the main, and 18 patients ($56.3\%$) were treated conservatively. The mortality rates were $42.9\%$ (6/14) and $22.2\%$ (4/18), respectively, but this difference was not statistically significant. A cox's proportional hazard analysis showed that a body-mass Index < 24 kg/m2 (odds ratio 5.55, $95\%$ CI: $0.69\∼44.82$) and non-enteral feeding (odds ratio 18.27, $95\%$ CI 2.22.150.69) were independent factors of mortality due to anastomotic leakage. Conclusion: Our observations show that anastomotic leakage after an elective gastric resection has a high risk of being fatal. Moreover, for a patient with a body-mass index lower than $24\;kg/m^{2}$ and/or non-enteral feeding, an anastomotic leakage after an elective gastric resection has a higher risk of being fatal.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.7 no.1
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• pp.78-82
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• 2004

Henoch-$Sch{\ddot{o}}nlein$ purpura (HSP) is a vasculitis of the small vessels in skin, joints, gastrointestinal (GI) tract and kidney. GI symptoms occur in up to 85% of patients and may lead to severe problems such as intussusception, obstruction, and perforation. GI symptoms may not be easily controlled, showing refractoriness to the conventional corticosteroid therapy. Although GI involvements of HSP are acute, and self-limited in most instances, they may cause fatal results in some unusual cases. In such conditions all the possible therapeutic modalities should be considered. We report two cases of severe small bowel involvement of HSP. One case presented with severe abdominal pain showing refractoriness to corticosteroid, but improved with IV immunoglobulin therapy. In the second case, HSP with transmural infarction in the small bowel could be cured with surgical intervention.

• Korean Journal of Plant Resources
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• v.14 no.1
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• pp.48-52
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• 2001

The study was conducted to find effect of irrigation treatment during growth stage on growth and yield of Paeonia lactiflora Pallas L.. In case of top ground part, growth of irrigation treatment at early growing stage(from May 1 to June 12) was larger(stem length of 79.4cm) or thicker(stem diameter of 6.5mm) than stem length of 13.6∼7.4cm and stem diameter of 0.5mm of natural plot and control. The growth of under ground part, root length(34.0cm) and number of root/plant(43.6ea/plant) in irrigation treatment at early growing stage were relatively larger or more number than that of control, and root yield was gained 2,349kg/10a and increased 13% and 8% compare with natural plot and control, respectively. Commercial ratio of root was higher for irrigation treatment at early growing stage, it was increased by 20% than 1,708kg/10a of natural plot.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.50 no.spc1
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• pp.171-174
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• 2005

This study was conducted to know the difference of major characteristics between seed and vegetable perilla varieties. Perilla accessions examined were classified into two groups, i.e., seed perillla variety (saeyeopcildeulkkae, yangsandeulkkae, and younghodeulkkae) and vegetable perilla variety (ipdlkkae 1, namcheondeulkkae, and manbaekdeulkkae). The differences of growth characteristics were observed between two types of perilla varieties. The average flowering date of vegetable perilla varieties (Sep. 28) was 23 days later than that of seed perilla varieties (Sep. 5). Also, the stem height and node numbers of vegetable perilla varieties lower than those of seed perilla varieties. The average 1,000-seed weight, yield, and oil content of seed perilla varieties were higher than those of vegetable perilla varieties. However, as leaf characteristic, the leaf yield (1.8 times) and cyanidin content (2.1 times) were greater than in perilla variety for vegetable. No difference was observed in fatty acids composition between two types of perilla varieties. The average total chlorophyll content in leaves of seed perilla varieties was higher than in that of vegetable perilla varieties.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.35 no.1
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• pp.1-9
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• 1990

This experiment was carried out to understand the effect of pre-sowing seed treatment by GA$_3$ and IAA on flowering and characteristics of yield component in peanuts. Peanut seed was treated by soaking in 10, 50, 100ppm of GA$_3$ solution, and 50, 100, 200ppm of IAA solution. Treatments of GA$_3$ and IAA resulted 7-5 days earlier emergence and 11-17days shorter of the flowering date compared with the untreated control. By soaking treatments with IAA in 100ppm and GA$_3$ in 100ppm, accumulated flowers were increased at early growing stage of 30 days after flowering compared with untreated control. By soaking treatments with IAA in 100ppm and GA$_3$ in 100ppm, main stem length, branch length and internode of main stem showed to flourish at investigation from early growing stage to 3 days before harvesting.

• Journal of Nutrition and Health
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• v.35 no.5
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• pp.512-523
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• 2002

The objective of this study was to investigate the nutritional status, biochemical parameters, lipid and electrolytes concentrations of the enteral nutrition patients according to the duration of enteral nutrition. Eighteen neurosurgery patients in the intensive care unit (ICU) at K University Hospital were subjected in this study. The duration of enteral nutrition was classified into under or over six month of period. Anthropometric, biochemical, clinical, and dietary assessments were performed. Patients' intakes of energy and protein were insufficient, from 82% to 95% of their requirements. Mid-arm muscle circumference (MAMC) and mid-am muscle area (MAMA) were significantly lower in patients over six months of enteral nutrition than those in patients under six months. The subjects were malnourished as indicated by nutrition-related parameters such as hemoglobin, albumin, total lymphocyte count (TLC), tricep skinfold thickness (TSF), mid-arm circumference (MAC), MAMC, and MAMA. Serum chloride level of the patients eve, six months of enteral nutrition was lower (94.7 $\pm$ 3.4 mmo1/1) significantly as compared to that of patients (99.3 $\pm$ 3.5 mmol/ 1) under six months. Urinary sodium and chloride levels were lower in the longer time of enteral nutrition patients than those of shorter period of enteral nutrition patients (p < .05). While serum phospholipid level was higher in the patients over six months of enteral nutrition, other blood biochemical parameters and electrolyte concentrations did not show any differences with the duration of enteral nutrition. Neurosurgery patients in the ICU undergoing long-term enteral nutrition tube-feeding were malnourished and had a variety of metabolic complications. The duration of enteral nutrition could affect the patients' nutritional status, biochemical parameters, and electrolytes balance. The patients who require nutritional support over an extended time need the continuous follow-up care and monitoring by the nutrition support team for laboratory, clinical, and nutritional assessments.