• Journal of the Economic Geographical Society of Korea
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• v.17 no.2
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• pp.249-263
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• 2014

Established as the first science park in the world in the late 1950's, the Research Triangle Park(RTP) has not jut grown significantly but also has been successful in the transition from the exogenous development model to the endogenous development model. In this context, this paper attempts to explore the evolutionary path of the RTP by drawing upon the concept of triple-helix spaces of regional innovation. Firstly, the three research universities in the triangle area, as a knowledge space, played a fundamental role for forming the RTP. However, it is difficult to say that the regional universities, as opposed to the Silicon Valley and the Boston area, have had a significant impact on inducing the dynamics of the cluster evolution and the triple helix spaces. Secondly, it can be argued that the North Carolina's Board of Science and Technology, which was formed in 1961 but traced back to the 1950's in its origin, has been a centerpiece of a consensus space that makes a contribution to creating, sustaining and transforming the RTP as a triple-helix-based innovation cluster. Thirdly, there have been a plenty of agents to be an innovation space in the RTP. Particularly, the North Carolina Biotechnology Center(NCBC) and the Microelectronic Center of North Carolina(MCNC) have been the boundary permeable agents to make triple-helix agents interact. Today, the RTP has the triple-helix spaces with the structure that a consensus spaces is centered on out of the three, but all of those are inter-connected and influenced by each other. It can be claimed that the RTP today shows the dynamic structure of cluster evolution in a way in which the existing industry sectors have adapted to the changes in external environment and the new industry sectors have emerged at the same time.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.7
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• pp.743-749
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• 2014

In this study, a noncircular drawing (NCD) sequence for manufacturing high-strength and high-ductility pearlitic steel wires was investigated. Multipass NCD was conducted up to the 12th pass at room temperature with two processing routes (defined as the NCDA and NCDB), and compared with the wire drawing (WD). During the torsion test, delamination fracture in the drawn wire was observed in the 10th pass of the WD whereas it was not observed until the 12th pass of the NCDB. From X-ray diffraction, the circular texture component that increases the likelihood of delamination fracture of the drawn wire was rarely observed in the NCDB. Thus, the improved ability of the multipass NCDB to manufacture high-strength pearlitic steel wires with high torsional ductility compared to the WD (by reducing the likelihood of delamination fracture) was demonstrated.

• Management & Information Systems Review
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• v.38 no.1
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• pp.83-101
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• 2019

Blockchain is considered as an innovative technology along with Artificial Intelligence, Big Data, and Internet of Things. However, since the inception of the genesis of blockchain technology, the cryptocurrency Bitcoin, the technology is not utilized widely, not let alone disruptive applications. Most of the blockchain research deals with the cryptocurrency, general descriptions of the technology such as trend, outlook of the technology, explanation of component technology, and so on. There are no killer applications like Facebook or Google, of course. Reflecting on the slow adoption by businesses, we wanted know about the current status of the research on blockchain in Korea. The main purpose of this paper is to help business practitioners to identify the application of blockchain to enhance the competitiveness of their organization. To do that, we first use the framework by Iansiti et al (2017) and categorize the blockchain related articles published in Korea according to the framework. This is to provide a benchmark or cases of other organizations' adoption of blockchain technology. Second, based on the value proposition of blockchain applications, we suggest evolutionary paths for adopting them. Third, from the demand pull perspective of technology adoption for innovation, we propose applicable areas where blockchain applications can be introduced. Fourth, we use the value chain model to find out the appropriate domains of blockchain applications in the corporate value chains. And the five competitive forces models is adopted to find ways of lowering the power of forces by incorporating blockchain technology.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.1
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• pp.63-71
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• 2004

The human skin is constantly exposed to environmental irritants such as ultraviolet, smoke, chemicals. Free radicals and reactive oxygen species (ROS) caused by these environmental facts play critical roles in cellular damage. These irritants are in themselves damaging to the skin structure but they also participate the immensely complex inflammatory reaction. The purpose of this study was to investigate the skin cell protective effect of Juniperus chinensis xylem extract on the UV and SLS-induced skin cell damages. We tested free radical and superoxide scavenging effect in vitro. We found that Juniperus chinensis xylem extracts had potent radical scavenging effect by 98％ at 100 $\mu\textrm{g}$/mL. Fluorometric assays of the proteolytic activities of matrix metalloproteinase-l(MMP-1, collagenase) were performed using fluorescent collagen substrates. UV A induced MMP-1 synthesis and activity were analyzed by enzyme-linked immunosorbent assay (ELISA) and gelatin-based zymography in skin fibroblasts. The extract of Juniperus chinensis showed strong inhibitory effect on MMP-1 activities by 97％ at 100 $\mu\textrm{g}$/mL and suppressed the UVA induced expression of MMP-1 by 79％ at 25 $\mu\textrm{g}$/mL. This extract also showed strong inhibition on MMP-2 activity in UVA irradiated fibroblast by zymography. We also examined anti-inflammatory effects by the determination test of proinflammatory cytokine, interleukin 6 in HaCaT keratinocytes. In this test Juniperus chinensis decreased expression of interleukin 6 about 30％. Expression of prostaglandin E$_2$, (PGE$_2$) after UVB irradiation was measured by competitive enzyme immunoassay (EIA) using PGE$_2$ monoclonal antibody. At the concentrations of 5-50 $\mu\textrm{g}$/mL of the extracts, the production of PGE$_2$ by HaCaT keratinocytes (24 hours after 10 mJ/$\textrm{cm}^2$ UVB irradiation) was significantly inhibited in culture supernatants (p〈0.05). The viability of cultured HaCaT keratinocytes was significantly reduced at the doses of above 10 mJ/$\textrm{cm}^2$ of UVB irradiation, but the presence of these extracts improved cell viability comparing to control after UVB irradiation. We also investigated the protective effect of this extract in sodium lauryl sulfate (SLS)-induced irritant skin reactions from 24 hour exposure. Twice a day application of the extract for reducing local inflammation in human skin was done. Irritant reactions were assessed by various aspects of skin condition, that is, erythema (skin color reflectance) and transepidermal water loss (TEWL). After 5 days the extract was found to reduce SLS-induced skin erythema and improve barrier regeneration when compared to untreated symmetrical test site. In conclusion, our results suggest that Juniperus chinensis can be effectively used for the prevention of UV and SLS-induced adverse skin reactions such as radical production, inflammation and skin cell damage.