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Survey on Radiotherpv Protocols for the Rectal Cancers Among the Korean Radiation Oncologists in 2002 for the Development of the Patterns of Care Study of Radiation Therapy (방사선치료 Patterns of Care Study 개발을 위한 2002년 한국 방사선종양학과 전문의들의 직장암 방사선치료 원칙 조사연구)

  • Kim, Jong-Hoon;Kim, Dae-Yong;Kim, Young-Ho;Kim, Woo-Chul;Kim, Chul-Yong;Sung, Jin-Shil;Son, Seung-Chang;Shin, Hyun-Su;An, Young-Chan;Oh, Do-Hum;Oh, One-Yong;Yu, Mi-Ryung;Yu, Hung-Jun
    • Radiation Oncology Journal
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    • v.21 no.1
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    • pp.44-65
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    • 2003
  • Purpose : To conduct nationwide surgery on the principles In radiotherapy for rectal center, and develop the framework of a database of Korean Patterns of Care Study. Materials and Methods : A consensus committee was established to develop a tool for measuring the Patterns in radiotherapy Protocols for rectal cancer. The Panel was composed of radiation oncologists from 18 hospitals in Seoul Wetropolltan area. The committee developed a survey format to analyze radiation oncologist's treatment principles for rectal cancer. The survey items developed for measuring the treatment principles were composed of 1) 8 eliglblllty criteria, 2) 20 Items for staging work-ups and prognostic factors, 3) 7 Items for principles of combined surgery and chemotherapy, 4) 9 patient set-ups, 5) 19 determining radiation fields, 6) S radiotherapy treatment pians, 7) 4 physicalilaboratory examination to monitor a patient's condition during treatment, and 8) 10 follow-up evaluations. These items were sent to radiation oncoioglsts In charge of gastrolntestlnal malignancies in all hospitals (48 hospitals) In Korea to which 30 replies were received (63$\%$). Results : Most of the surrey Items were replied to without no major between the repliers, but with the fellowing items only 50$\%$ of repliers were in agreement : 1) Indications of preoperative radiation, 2) use of endorectal ultrasound, CT scan, and bone scan for staging work-ups, 3) principles of combining chemotherapy with radiotherapy, 4) use of contrast material for small bowel delineation during simulation, 5) determination of field margins, and 6) use of CEA and colonoscopy for follow-up evaluations. Conclusions : The Items where considerable disaggrement was shown among the radiation oncologists seemed to make no serious difference In the treatment outcome, but a practical and reasonable consensus should be reached by the committee, with logical processes of agreement. These Items can be used for a basic database for the Patterns of Care Study, which will survey the practical radiotherapy Patterns for rectal cancer in Korea.

Metamorphic P-T Paths from Devonian Pelitic Schists from the Pelham Dome, Massachusetts, USA (뉴잉글랜드 펠암돔 주변부 데본기 변성 이질암의 변성 온도-압력 경로)

  • 김형수
    • The Journal of the Petrological Society of Korea
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    • v.9 no.4
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    • pp.211-237
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    • 2000
  • Major element zoning has been analyzed in garnet porphroblasts obtained from the Grt-St and Ky-Grt-St grade assemblages in Zones I on the northern flank of the Pelham Dome, north central Massachusetts. These porphyroblasts grew during multiple phases of deformation and meta-morphism revealed by the inclusion trail geometry plus the chemical zoning patterns within garnet porphyroblasts. Unusual zoning patterns, including zoning reversals and gradient changes in XMn, zlgzag patterns in Fe/(Fe +Mg) and staircase-shaped patterns in XCa, are coincident with textural truncations and other changes in microstructure within the garnet porphrublasts. Chemical variations in plagioclase, biotite, muscovite and staurolite combined with inclusion trail geometry and petrography reveal that the garnet zoning patterns are modified by combinations of the following. (1) Uni-and divariant reactions involving garnet consumption(Grt+ Chl+Ms=St+Bt+Qtz + $H_2$O) and production(St+Ms + Qtz= Bt+ Grt +A1$_2$$SiO_{5}$ + $H_2$O). (2) Deformation induced episudic ionit dissolution, preferential diffusion and re-distribution during foliation development. (3) P-T changes during growth of the porphyroblasts. The P-T paths combined with petrographic and inclusion trail morphology observations consist of two pattens; (1) heating/compression during NW-SE shortening; and (2) decompression with cooling during NNW-SSE shortening. Based on temperature-time(T-t) geochronological data and late-Paleozoic tectonic model, Alleghanian metamorphism, which is the result of heterogeneous shearing concentrated along the boundary between the Abalone Terrane(Pelham dome) and cover rocks(Bronson Hill Terrane), has produced Ky-St-Ms mineral assemblage during Pennsylvanian(290-300 Ma) in Shutesbury area. However, temperature of alleghanian metamorphism was not high enough to form garnet and staurolite in the Northfiled syncline area. Alleghanian metamorphism has affected only the matrix due to heterogeneous shearing in the study area.

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Fault reactivation potential during $CO_2$ injection in the Gippsland Basin, Australia (호주 Gippsland Basin에서 $CO_2$ 주입 중 단층 재활성화의 가능성)

  • Ruth, Peter J. van;Nelson, Emma J.;Hillis, Richard R.
    • Geophysics and Geophysical Exploration
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    • v.9 no.1
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    • pp.50-59
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    • 2006
  • The risk of fault reactivation in the Gippsland Basin was calculated using the FAST (Fault Analysis Seal Technology) technique, which determines fault reactivation risk by estimating the increase in pore pressure required to cause reactivation within the present-day stress field. The stress regime in the Gippsland Basin is on the boundary between strike-slip and reverse faulting: maximum horizontal stress $({\sim}\;40.5\;Mpa/km)$ > vertical stress (21 Mpa/km) ${\sim}$ minimum horizontal stress (20 MPa/km). Pore pressure is hydrostatic above the Campanian Volcanics of the Golden Beach Subgroup. The NW-SE maximum horizontal stress orientation $(139^{\circ}N)$ determined herein is broadly consistent with previous estimates, and verifies a NW-SE maximum horizontal stress orientation in the Gippsland Basin. Fault reactivation risk in the Gippsland Basin was calculated using two fault strength scenarios; cohesionless faults $(C=0;{\mu}=0.65)$ and healed faults $(C=5.4;\;{\mu}=0.78)$. The orientations of faults with relatively high and relatively low reactivation potential are almost identical for healed and cohesionless fault strength scenarios. High-angle faults striking NE-SW are unlikely to reactivate in the current stress regime. High-angle faults oriented SSE-NNW and ENE-WSW have the highest fault reactivation risk. Additionally, low-angle faults (thrust faults) striking NE-SW have a relatively high risk of reactivation. The highest reactivation risk for optimally oriented faults corresponds to an estimated pore pressure increase (Delta-P) of 3.8 MPa $({\sim}548\;psi)$ for cohesionless faults and 15.6 MPa $({\sim}2262\;psi)$ for healed faults. The absolute values of pore pressure increase obtained from fault reactivation analysis presented in this paper are subject to large errors because of uncertainties in the geomechanical model (in situ stress and rock strength data). In particular, the maximum horizontal stress magnitude and fault strength data are poorly constrained. Therefore, fault reactivation analysis cannot be used to directly measure the maximum allowable pore pressure increase within a reservoir. We argue that fault reactivation analysis of this type can only be used for assessing the relative risk of fault reactivation and not to determine the maximum allowable pore pressure increase a fault can withstand prior to reactivation.

A Study on Geophysical Characteristics and Regional Geological Structures of the Southwestern Yellow Sea of Korea using Gravity and Magnetic Data (중력 및 자력자료를 이용한 황해 남서부해역의 지구물리학적 특성 및 광역 지구조 연구)

  • Kim, Chang-Hwan;Park, Chan-Hong
    • Journal of the Korean earth science society
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    • v.31 no.3
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    • pp.214-224
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    • 2010
  • Gravity and Magnetic survey data were analyzed to investigate the geophysical characteristics and regional geological structures of the southwestern Yellow Sea. The set of data about the southwestern part of the Yellow Sea in Korea was one collected by the Korea Ocean Research and Development Institute (KORDI) in 2003, 2004, and 2005. The Yellow Sea has a few basins and the study area also includes parts of the Heuksan Basin and the East China Sea Basin. The bathymetry of the study area ranges from about ?40 m southwestward near China to about 150 m northeastward near Korea. The bathymetry has the gentle rise and fall and the smooth slope. The gravity anomalies, from sea surface gravity and satellite gravity data, reflect the basement rocks rather than the smooth bathymetry. The gravity anomalies are higher on Northeastern part of the study area and lower over the South of the Heuksan Basin. The analytic signal from the Bouguer anomaly shows higher anomalous zones near the boundaries of the basins. The magnetic anomalies and the analytic signal, from the magnetic data, suggest that the complex anomalies on the Northern part are attributed to the volcanic intrusions and that the smooth patterns in the Southern part are based on the lack of the intrusions. The power spectrum analysis of the Bouguer anomalies and the magnetic anomalies indicate that the depth to the Moho discontinuity varies from about 30.2 to 28.3 km and that the depths of the basement rocks and the Eocene discontinuity range from about 8.4 to 8 km and from about 1.5 to 1.7 km, respectively. The inversion of the Bouguer anomaly shows that the Moho depth to the Western part of the study area near China is slightly deeper than the Eastern part near Korea. The result of 2-D gravity modeling has a good coherence with the results of the analytic signal, the power spectrum analysis, and the inversion.

Image-Based Assessment and Clinical Significance of Absorbed Radiation Dose to Tumor in Repeated High-Dose $^{131}I$ Anti-CD20 Monoclonal Antibody (Rituximab) Radioimmunotherapy for Non-Hodgkin's Lymphoma (반복적인 $^{131}I$ rituximab 방사면역치료를 시행 받은 비호지킨 림프종 환자 군에서 종양 부위의 영상기반 방사선 흡수선량 평가와 임상적 의의)

  • Byun, Byung-Hyun;Kim, Kyeong-Min;Woo, Sang-Keun;Choi, Tae-Hyun;Kang, Hye-Jin;Oh, Dong-Hyun;Kim, Byeong-Il;Cheon, Gi-Jeong;Choi, Chang-Woon;Lim, Sang-Moo
    • Nuclear Medicine and Molecular Imaging
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    • v.43 no.1
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    • pp.60-71
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    • 2009
  • Purpose: We assessed the absorbed dose to the tumor ($Dose_{tumor}$) by using pretreatment FDG-PET and whole-body (WB) planar images in repeated radioimmunotherapy (RIT) with $^{131}I$ rituximab for NHL. Materials and Methods: Patients with NHL (n=4) were administered a therapeutic dose of $^{131}I$ rituximab. Serial WB planar images alter RIT were acquired and overlaid to the coronal maximum intensity projection (MIP) PET image before RIT. On registered MIP PET and WB planar images, 2D-ROls were drawn on the region of tumor (n=7) and left medial thigh as background, and $Dose_{tumor}$ was calculated. The correlation between $Dose_{tumor}$ and the CT-based tumor volume change alter RIT was analyzed. The differences of $Dose_{tumor}$ and the tumor volume change according to the number of RIT were also assessed. Results: The values of absorbed dose were $397.7{\pm}646.2cGy$ ($53.0{\sim}2853.0cGy$). The values of CT-based tumor volume were $11.3{\pm}9.1\;cc$ ($2.9{\sim}34.2cc$), and the % changes of tumor volume before and alter RIT were $-29.8{\pm}44.3%$ ($-100.0%{\sim}+42.5%$), respectively. $Dose_{tumor}$ and the tumor volume change did not show the linear relationship (p>0.05). $Dose_{tumor}$ and the tumor volume change did not correlate with the number of repeated administration (p>0.05). Conclusion: We could determine the position and contour of viable tumor by MIP PET image. And, registration of PET and gamma camera images was possible to estimate the quantitative values of absorbed dose to tumor.

Habitats Environmental and Population Characteristics of Iris koreana Nakai, a Rare and Endemic Species in Korea (한반도 희귀·특산식물 노랑붓꽃의 자생지 환경 및 개체군 특성)

  • Pi, Jung-Hun;Park, Jeong-Geun;Jung, Ji-Young;Park, Jeong-Seok;Suh, Gang-Uk;Son, Sung-Won
    • Korean Journal of Ecology and Environment
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    • v.49 no.2
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    • pp.102-109
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    • 2016
  • The sustainability of Iris koreana, a rare and endemic plant designated by the Korea Forest Service, is threatened due to artificial factors such as habitats loss and climate change etc. and internal factors such as changes in biological properties of the habitats etc. but conservation biology research has not been performed in South Korea. The objective of this study is to establish the species conservation strategies by analyzing the characteristics of their habitats, including: 1) Population characteristics, and 2) habitat analysis of the vegetation and abiotic environments. From April to May, 2015, population characteristics [density (stems $m^{-2}$), flowering rate (%) and leaf area size ($cm^2$)] in I. koreana habitats such as Buan1~6 (BA1~6), Jangseong1~2 (JS1~2) and vegetation characteristics (phytosociological research and ordination analysis), and abiotic environments [soil temperature ($^{\circ}C$), soil humidity (%), transmitted light ($mol{\cdot}m^{-2}{\cdot}d^{-1}$) and canopy openness (%)] were measured. I. koreana was mainly distributed at elevation 50 to 150 m and 2 to $11^{\circ}$ slope. Slope direction was shown as 90 to $193^{\circ}$. The average degree of canopy openness was 11.9%. It showed the highest at BA2 (17.5) and the lowest at JS1 (7.7). The average degree of transmitted light was $6.3mol{\cdot}m^{-2}{\cdot}d^{-1}$. It showed the highest at BA2 (10.1) and the lowest at JS1 (3.6). Population density showed average 25.8 (stems $m^{-2}$). It showed the highest at JS2 (19.7) and the lowest at JS1 (9.3). flowering stems showed average 16.9 (stems). It showed the highest at BA3 (35) and the lowest at BA5 (4). Leaf area size was average $94.1cm^2$.

Estimation of the Freshwater Advection Speed by Improvement of ADCP Post-Processing Method Near the Surface at the Yeongsan Estuary (ADCP 표층유속 자료처리방법 개선을 통한 영산강 하구 표층 방류수 이류속도 산정)

  • Shin, Hyun-Jung;Kang, Kiryong;Lee, Guan-Hong
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.19 no.3
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    • pp.180-190
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    • 2014
  • It has been customary to exclude top 10-20% of velocity profiles in the Acoustic Doppler Current Profiler (ADCP) measurement due to side lobe effects at the boundary. To better understand the mixing in the Yeongsan estuary, the freshwater advection speed (FAS) was recovered from highly contaminated ADCP data near the surface. The velocity profiles were measured by using ADCP at two stations in the Yeongsan estuary during August 2011: one was located in front of the Yeongsan estuarine dam and the other was deployed near Goha Island. The FAS was recovered from the ADCP data set by applying rigorous post-processing methods and compared with the sediment advection speed (SAS). The SAS was determined by the peak time difference of suspended sediment concentration between two stations in the channel, divided by the distance of two stations. The FAS and the SAS showed very similar value when the freshwater discharge was greater than $2.0{\times}10^7$ ton and the SAS was a bit greater when the freshwater discharge was smaller. Since the FAS was on average about 0.8 m/s greater than the velocity at 0.8 of water depth from the bottom, the net discharge, estimated with recovered FAS and integrated over water depth and tidal cycle, was directed seaward during the high discharge contrary to the onshore direction of the net discharge estimated with 0.8 of water depth from the bottom. Moreover, the velocity shear and Richardson number changed when the FAS was used. Thus, the importance of the true FAS is appreciated in the investigation of the surface layer stability. If currents, temperature and salinity were observed for longer time in the future, it could be possible to more accurately understand the formation and decay of stratification as well as the suspended sediment transport processes.

The effect of guided flapless implant procedure on heat generation from implant drilling (수술가이드를 이용한 무피판 임플란트 술식에서 임플란트 드릴링이 열발생에 미치는 효과)

  • Yoo, Je-Hyeon;Jeong, Seung-Mi;Choi, Byung-Ho;Joo, Sang-Don
    • The Journal of Korean Academy of Prosthodontics
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    • v.51 no.1
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    • pp.11-19
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    • 2013
  • Purpose: The aim of this study was to evaluate the heat generation in bone in vitro during the guided flapless drilling procedure and the effect of drilling methods on the heat generation. Materials and methods: A model that has missing the first and second mandibular molars bilaterally was used. In group A, classical flap implant surgery was performed. In group B, flapless implant surgery using surgical guide was performed. In group C, flapless implant surgery using surgical guide without up-and-down pumping motion was performed. Temperature was measured with k-type thermocouple and a real-time digital thermometer. The thermocouples were placed at 0.5 mm away from the osteotomy area at the depths of 3 mm and 6 mm. The measured values were evaluated with independent t-test. Results: The mean temperature generated was $27.2^{\circ}C$ ($SD{\pm}2.1^{\circ}C$) and $27.5^{\circ}C$ ($SD{\pm}2.3^{\circ}C$) for groups A and B, respectively. These differences were not statistically significant. In group C, the mean temperature was $37.0^{\circ}C$ ($SD{\pm}3.4^{\circ}C$). There were statistically significant differences between groups B and C with respect to the mean temperature. Conclusion: These findings suggest that guided flapless drilling with up-and-down pumping motion may not significantly increase the bone temperature.

The Influence of Attachment Type on the Distribution of Occlusal Force in Implant Supported Overdentures (하악 임플란트 오버덴쳐에서 어태치먼트 종류에 따른 응력분포)

  • Sung, Chai-Ryun;Cho, In-Ho
    • Journal of Dental Rehabilitation and Applied Science
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    • v.25 no.4
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    • pp.375-390
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    • 2009
  • Statement of problem: Implant supported overdenture is accepted widely as a way to restore edentulous ridge providing better retention and support of dentures. Various types of attachment for overdenture have been developed. Purpose: The purpose of this study was to investigate the influence of attachment type in implant overdentures on the biomechanical stress distribution in the surrounding bone, prosthesis and interface between implant and bone. Material and methods: Finite element analysis method was used. Average CT image of mandibular body(Digital $Korea^{(R)}$, KISTI, Korea) was used to produce a mandibular model. Overdentures were placed instead of mandibular teeth and 2mm of mucosa was inserted between the overdenture and mandible. Two implants($USII^{(R)}$, Osstem, Korea) were placed at both cuspid area and 4 types of overdenture were fabricated ; ball and socket, Locator, magnet and bar type. Load was applied on the from second premolar to second molar tooth area. 6 times of finite element analyses were performed according to the direction of the force $90^{\circ}$, $45^{\circ}$, $0^{\circ}$ and unilateral or bilateral force applied. The stress at interface between implants and bone, and prosthesis and the bone around implants ware compared using von Mises stress. The results were explained with color coded graphs based on the equivalent stress to distinguish the force distribution pattern and the site of maximum stress concentration. Results: Unilateral loading showed that connection area between implant fixture and bar generated maximum stress in bar type overdentures. Bar type produced 100 Mpa which means the most among 4 types of attachments. Bilateral loading, however, showed that bar type was more stable than other implants(magnet, ball and socket). 26 Mpa of bar type was about a half of other types on overdenture under $90^{\circ}$ bilateral loading. Conclusions: In any directions of stress, bar type was proved to be the most vulnerable type in both implants and overdentures. Interface stress did not show any significant difference in stress distribution pattern.

Error Analysis of Delivered Dose Reconstruction Using Cone-beam CT and MLC Log Data (콘빔 CT 및 MLC 로그데이터를 이용한 전달 선량 재구성 시 오차 분석)

  • Cheong, Kwang-Ho;Park, So-Ah;Kang, Sei-Kwon;Hwang, Tae-Jin;Lee, Me-Yeon;Kim, Kyoung-Joo;Bae, Hoon-Sik;Oh, Do-Hoon
    • Progress in Medical Physics
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    • v.21 no.4
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    • pp.332-339
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    • 2010
  • We aimed to setup an adaptive radiation therapy platform using cone-beam CT (CBCT) and multileaf collimator (MLC) log data and also intended to analyze a trend of dose calculation errors during the procedure based on a phantom study. We took CT and CBCT images of Catphan-600 (The Phantom Laboratory, USA) phantom, and made a simple step-and-shoot intensity-modulated radiation therapy (IMRT) plan based on the CT. Original plan doses were recalculated based on the CT ($CT_{plan}$) and the CBCT ($CBCT_{plan}$). Delivered monitor unit weights and leaves-positions during beam delivery for each MLC segment were extracted from the MLC log data then we reconstructed delivered doses based on the CT ($CT_{recon}$) and CBCT ($CBCT_{recon}$) respectively using the extracted information. Dose calculation errors were evaluated by two-dimensional dose discrepancies ($CT_{plan}$ was the benchmark), gamma index and dose-volume histograms (DVHs). From the dose differences and DVHs, it was estimated that the delivered dose was slightly greater than the planned dose; however, it was insignificant. Gamma index result showed that dose calculation error on CBCT using planned or reconstructed data were relatively greater than CT based calculation. In addition, there were significant discrepancies on the edge of each beam while those were less than errors due to inconsistency of CT and CBCT. $CBCT_{recon}$ showed coupled effects of above two kinds of errors; however, total error was decreased even though overall uncertainty for the evaluation of delivered dose on the CBCT was increased. Therefore, it is necessary to evaluate dose calculation errors separately as a setup error, dose calculation error due to CBCT image quality and reconstructed dose error which is actually what we want to know.