• Journal of Oral Medicine and Pain
• /
• v.25 no.3
• /
• pp.279-289
• /
• 2000

현대에는 날로 복잡해지는 생활양식의 변화에 따라 다양한 스트레스에 노출되고 그로 인한 면역계, 신경계 또는 각종 장기의 기능이상이 점차로 증가되고 있다. 최근 치과에 내원하는 환자들 중 구강건조증을 호소하는 환자들의 다수는 스트레스에 노출되어 있고, 임상적으로도 방사선 타액선 기능 검사에서 타액선, 특히 악하선의 기능이 현저하게 저하되어 있는 소견을 관찰할 수 있 다. 더욱이 이는 타액선 조영술에서 이미 보고된 바 있는 면역성 질환인 $Sj\ddot{o}gren$ 증후군과는 다른 양상으로 관찰되고 있어, 이에 본인은 백서에 스트레스와 관련이 깊은 내분비적 환경 변화를 유도함으로써 이와같은 변화가 악하선 조직의 병리적 변화와 어떠한 연관성을 갖는 지를 관찰하고자 본 실험을 시행하였다. 생후 7주된 Sprague-Dawley계 웅성 백서(165-209g/bw) 40마리를 2 개의 실험군(부신 제거군 : ADX 군, 부신 제거 후 dexamethasone 투여군 : DEX 군)으로 나누어 실험하였다. ADX 군은 외과적으로 부신을 제거한 후 다른 조건을 부여하지 않았고, DEX 군은 외과적으로 부신을 제거한 후 매일 dexamethasone($1.5*10^{-46}mg/g$ I.V./day)을 투여하였으며, 이들을 각각 실험 후 즉시, 1일, 3일, 5일, 7일에 희생시켰다. 그 후에는 즉시 악하선을 적출하여 면역조직화학법으로 Clusterin의 발현 정도 및 부위를 관찰하였다. 그 결과는 다음과 같았다. 1. 광학현미경 하에서, 양 군 모두 유의할만한 조직학적 변화는 관찰되지 않았다. 2. ADX 군에서는 실험기간 전반에 걸쳐 도관세포와 선포세포에서 clusterin이 발현되었다. 3. DEX 군에서는 소수의 선세포에서 국소적으로 clusterin이 관찰되었으나, 전반적으로 도관세포, 선포세포에서 공히 clusterin이 관찰되지 않았다. 부신을 제거한 군에서는 실험기간 전반에 걸쳐 clusterin이 발현되었는데, 이는 clusterin이 스트레스의 생리적 반응의 결과로서 세포보호작용을 한다는 사실에 기초하여 볼 때, 부신을 제거하였을 때도 스트레스를 받았을 때와 같은 영향이 백서의 악하선에 가해졌을 것으로 생각된다. 반면, 부신제거후 glucocorticoid agonist인 dexamethasone을 투여하였을 때, clusterin이 감소 내지 관찰되지 않았던 것은 부신제거에 의해 악하선에 가해졌던 영향을 dexamethasone이 길항하여 나타난 결과로 볼 수 있어, 스트레스에 의해 부신으로부터 분비되는 glucocorticoid가 타액선을 보호하는데 중요한 작용을 하는 것을 시사한다.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2018.05a
• /
• pp.417-418
• /
• 2018

미국 국립가뭄경감센터 (National Drought Mitigation Center, NDMC)는 다양한 가뭄지수를 통합하여 미국 전역의 가뭄진행상황을 모니터링하고 가뭄대응정책 수립을 위한 주요 의사결정정보로 활용하고 있다. 대표적으로 1999년에 개발되어 현재까지 운영 중인 미국가뭄모니터 (United States Drought Monitor, USDM)는 미국 전역에 대하여 가뭄단계를 표시한 지도 (U.S. Drought Monitor map)를 매주 생성하여 제공하고 있다 (http://droughtmonitor.unl.edu/). 가뭄지표(drought index)는 가뭄의 현황과 시공간적인 전개 과정을 분석하고 정량적 가뭄심도 평가 및 가뭄대응계획 수립을 위한 도구로써 다양하게 개발되어 활용되고 있다. 가뭄의 정도를 정량화하기 위하여 개발된 다수의 가뭄지수는 대상과 평가방법에 따라 가뭄을 표현하는 특성이 서로 다르다. 하나의 가뭄지수로는 가뭄특성을 온전히 표현하기 어렵기 때문에, 최근에는 단일 가뭄지수에 의존하기 보다는 다수의 가뭄지수를 이용하되, 여러 가뭄지수 간의 특징을 고려하여 각 가뭄지수가 갖는 장단점을 상호 보완하여 사용하기를 권고하고 있다. USDM은 파머가뭄심도지수 (Palmer Drought Severity Index, PDSI), Soil Moisture Model (NOAA Climate Prediction Center, CPC), 미 지리조사국의 하천유량 주간보고 (USGS Weekly Streamflow), 표준강수지수 (Standardized Precipitation Index, SPI) 등의 주요 가뭄판단지표를 선정하고, 가뭄판단의 기준으로써 각 가뭄지수의 가뭄심도 (drought severity) 및 백분위수 (percentiles)로 등급을 구분하였다. 가뭄등급은 '정상 상태 (none)'를 포함하여 '비정상적인 건조 (abnormally dry, D0)'에서 최악의 가뭄상태를 의미하는 '이례적인 가뭄상태 (exceptional, D4)'에 이르는 6 단계로 구분하고, 정상상태를 제외한 5 단계의 통합가뭄단계로 표시한다. 우리나라에서는 기상청, 수자원공사, 농어촌공사에서 기상/수문/농업관련 가뭄지수의 위험지도를 실시간으로 제공하고 있으며, 각 지표별로 상이한 기준으로 가뭄을 판단하고 있다. 각각의 가뭄지표에 대한 가뭄판단기준은 해당 국가의 장기적으로 축적된 자료를 활용하여 가뭄단계 및 가뭄판단기준의 재설정에 대한 연구가 필요하다. 본 연구에서는 SPI, SC-PDSI, 표준강수증발산지수 (Standardized Precipitation Evapotranspiration Index, SPEI), Evaporative Demand Drought Index (EDDI), 유효가뭄지수 (Effectvie Drought Index, EDI)의 다양한 가뭄지수를 활용하여 USDM의 가뭄심도 및 가뭄판단기준을 적용하고자한다.

• Proceedings of the Plant Resources Society of Korea Conference
• /
• 2019.10a
• /
• pp.82-82
• /
• 2019

황해쑥(Artemisia argyi Lev. et. Vnt)은 국화과의 다년생 초본 식물로서 쑥, 산쑥과 함께 건조한 것이 애엽이라는 생약재로 쓰이며 2016년 기준 전국적으로 81 ha에서 871톤이 생산되고 있다. 주요 유효성분으로 Eupatilin, Jaceosidin 등이 있으며 위궤양에 효과가 있다고 알려져 있어 최근에는 스티렌정 등 신약원료로 각광 받고 있다. 황해쑥은 종자번식 뿐만 아니라 포복경을 이용한 영양번식이 가능하며 현재까지 '섬애' 등 1품종이 개발되어 있으나 농가와 산업체가 요구하고 있는 수량성 또는 Eupatilin 등 성분함량이 높은 품종개발이 필요하다. 국내 연구 결과를 보면 대부분 년 1회 수확을 기준으로 연구되어 왔으나 실제로는 년 2회 수확하는 경우가 더 많다. 따라서 본 실험에서는 년 1회 뿐만 아니라 년 2회로도 수확하여 조사하였다. 시험재료는 AA1801 등 7계통 이며, 시비량은 10 a 당 질소 15.3 kg 인산 20 kg 가리 5 kg이고, 흑색 비닐을 피복한 후 조간 30 cm 주간 15 cm로 하였다. 시험구배치는 난괴법 3반복으로 하였으며 포복경을 5 cm로 잘라 4월 19일에 정식하였다. 1회 수확 시에는 8월 12일, 2회 수확 시에는 6월 17일, 9월 19일에 수확 하였다. 년 1회 수확 시 계통 별 생육특성을 보면, 초장은 202.4~231.5 cm로 평균 213.6 cm 였으며 경경은 10~12.14 mm로 평균 10.9 mm 였다. 분지수는 32.6~37.3개로 평균 35.2개 였으며 엽병장, 엽장, 엽폭은 2.4~4.2 cm, 9.3~12 cm 9.2~12.2 cm로 평균 3.3 cm, 10.7 cm 그리고 10.9 cm 였다. 전초의 생중량과 건중량은 각각 4.9~6.9 kg, 1.8~2.7 kg로 평균 5.5 kg, 2.1 kg 이였다. 특히 AA1902는 다른 계통에 비해 분지수는 적었으나 초장이 크고 경경이 굵었으며 생중량과 건중량도 가장 무거웠다. 년 2회 수확 시 전초의 생중량과 건중량은 각각 5.1~6.2 kg, 1.7~2.0 kg로 평균 5.6 kg, 1.8 kg 이였다. 수량성으로 봤을때는 AA1902는 1회 수확에 적합하며 AA1801, AA1802는 2회 수확 시 생중량과 건중량이 무거웠다. 또한 AA1903의 경우 수확 회수와 상관없이 수량성이 높은 계통으로 판단되었다. 본 자료는 황해쑥 품종육성의 기초자료로 활용하고자 한다.

• Journal of the Korean Regional Science Association
• /
• v.37 no.4
• /
• pp.33-47
• /
• 2021

In urban declining areas, the population is decreasing, and drying environments such as buildings and facilities are aging. Therefore, it is vulnerable in the event of disaster, and recovery takes a lot of time and money. The purpose of this study is to develop an evaluation technique for comprehensively diagnosing disasters in declining areas and to present implications through case analysis. Evaluation indicators were selected to calculate the comprehensive diagnosis index of disasters, and weights were calculated for each class, including disaster types, components, and evaluation indicators, through Analytic Hierarchy Process analysis. The comprehensive diagnoses index for each type of disaster was calculated with the calculated weight, and the risk according to the level of urban decline was analyzed. As a result of analyzing Seoul as a case area, it was analyzed that the overall risk of disasters was high in southern regions such as Seocho-gu, Dongjak-gu, Geumcheon-gu, and Gangseo-gu, and relatively low in downtown and northern Seoul, parks and green areas. The results of this study are of academic significance in that they presented a comprehensive diagnostic index evaluation system and technique for each type of disaster, including natural and social disasters.

• Journal of Dental Rehabilitation and Applied Science
• /
• v.37 no.3
• /
• pp.123-129
• /
• 2021

Purpose: The purpose of this study was to investigate antifungal activity of shiitake mushroom yeast and hyphal type of Candida albicans. Materials and Methods: The extract from shiitake mushroom was collected by drying the supernatant after soaking shiitake mushrooms in water or ethanol. The antifungal activity of the extracts against yeast type of C. albicans was investigated by the susceptibility assay using microplate. C. albicans biofilm was formed on 12-well plate using Ham's F-12 medium in CO₂ incubator and treated with the ethanol extract. Furthermore, C. albicans biofilm was formed on denture base resin disk and treated with or without the ethanol extract in the presence of denture cleanser. Live C. albicans in biofilm was counted by cultured colony forming unit value after inoculated on agar plate. Results: Ethanol extract from shiitake mushroom showed stronger antifungal activity against yeast type of C. albicans compared to its water extract. The ethanol extract significantly reduced count of C. albicans in hyphal biofilm (P < 0.05). Also, the ethanol extract showed synergistically antifungal effect with denture cleanser on candidal biofilm on denture base resin disk (P < 0.05). Conclusion: The ethanol extract of shiitake mushroom may be a candidate for preventing candidal stomatitis as well as denture-related stomatitis.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.4
• /
• pp.264-274
• /
• 2019

This study attempted to analyze the effects of cleansing oil on skin by preferred vegetable base oil. For this, a questionnaire survey was performed against 100 people, and their face washing habit and preferred vegetable base oils were examined. Based on the results, 4 different cleansing oils were prepared and experimented. The experiment was conducted against 10 adult women in their 20-30s, and moisture level, sebum level and trans-epidermal water loss (TEWL) before and after the experiment were measured. After the test, satisfaction was measured, and the results found the followings: When asked what cleansing oil is most preferred by vegetable base oil type, 'rose hip oil' was the highest, followed by 'olive oil', 'apricot kernel oil' and 'camellia oil'. According to the clinical trials, both moisture and sebum levels increased before and after cleansing in all four cleansing oil types by the preferred vegetable base oil (p<0.001, p<0.001). In addition, TEWL decreased with a difference by base oil (p<0.01). According to a subjective satisfaction survey which was performed after the experiment, rose hip oil-contained cleansing oil (RHC) was the highest in terms of cleansing effect and satisfaction level. Consequently, it was confirmed that the cleansing oil by vegetable base oil improved skin conditions by protecting a skin barrier with a positive effect on the improvement of sebum and moisture levels and TEWL. Even though a preferred oil type and a satisfaction level may differ by preferred oil and feeling after use, cleansing oil by vegetable base can be helpful as a skin care product which eases skin dryness and protects a skin barrier.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.11
• /
• pp.96-104
• /
• 2018

Military vessels are complex weapon systems consisting of various integrated onboard equipment. Since their acquisition of military equipment takes a long period of time and a prototype ship is deployed and tested, vessel development has relied on its proprietary process. However, due to the growing complexity of onboard equipment technology, application of systems engineering (SE) process has become indispensable. Nonetheless, an effective design process complementing the existing design with the SE has not yet been developed. As such, we have studied an improved basic design process for submarines based on SE. To do so, we analyzed the processes for the basic design, technical review, and requirement management. Included reviews and requirements are SRR, SFR and PDR, and SSRS, SSS, and SSDD. By combining the results in the SE framework, we built an improved basic design process that can be applied in parallel with the SE-based technical review and requirement management. To assess the process, we applied our proposed model to the submarine development undergoing the basic design phase. It is possible to effectively manage the requirements, design artifacts and improve traceability, and also utilize them as test and evaluation materials. The SE-based basic design process is expected to be useful in other kinds of vessel design.

• Journal of Food Hygiene and Safety
• /
• v.33 no.6
• /
• pp.488-494
• /
• 2018

To ensure food-safety of mushrooms from radioactive contamination, edible mushroom samples distributed in Gyeonggi province in Korea were collected according to species and country of origin. A total of 284 mushrooms, belonging to 10 species (Lentinula edodes, Pleurotus ostreatus, Pleurotus eryngii, Agaricus bisporus, Flammulina velutipes, Phellinus linteus, Inonotus Obliquus (Chaga), Auricularia auricula-judae, Ganoderma lucidum and Tricholoma matsutake) were subjected to radioactivity testing. The concentration of artificial radionuclides, 131I, 134Cs, and 137Cs, was analyzed using gamma-ray spectrometry. 131I and 134Cs were not detected more than MDA value from all samples. Among 204 domestic mushrooms, however, 137Cs were detected in 0.21~2.58 Bq/kg from six cases (3 Lentinula edodes, 1 Ganoderma lucidum and 2 Tricholoma matsutake), whereas 137Cs were detected in 0.21~53.79 Bq/kg from 38 cases (22 Inonotus Obliquus(Chaga), 14 Phellinus linteus, 1 Lentinula edodes and 1 Tricholoma matsutake) among 80 imported mushrooms. In addition, average concentration of 137Cs in 10 Chaga mushroom-processed products was more than twice as much as dried Chaga mushroom, and maximum concentration was 123.79 Bq/kg. Results suggest that radioactivity monitoring system for imported mushrooms and mushroom-processed products should be continuously intensified to secure food-safety in Korea.

• Journal of the Korea Convergence Society
• /
• v.9 no.12
• /
• pp.129-135
• /
• 2018

This study aimed to investigate the contamination rate of microorganisms by times after sterilization in mirrors, dental explorers, and pincettes which are the basic tools used in the dental clinic. 60 samples by each tool were used upon packaging them by 10 units. Contamination rate of microorganisms were tested using dry film media(3M Petrifilm Plates) which is a quick check upon collecting 10 samples right after sterilization, at Week 2, 3, 4, 5, and 6. At Week 0 when was right after sterilization, no microorganism was detected in any tools while they were detected in 2 mirrors, 2 dental explorers, and 2 pincettes at Week 6. 2 to 4 colonies on average were detected in mirrors at Week 2 and 4, 1 to 2 colonies in explorers from Week 5, and no colony was found in pincettes until Week 5 but 1 to 2 colonies at Week 6. Based on these results, the needs of effective periods are suggested for the sterilized tools together with their safe usages.

• The Journal of The Korea Institute of Intelligent Transport Systems
• /
• v.17 no.6
• /
• pp.121-132
• /
• 2018

Weather is an important factor affecting roadway transportation in many aspects such as traffic flow, driver 's driving patterns, and crashes. This study focuses on the relationship between weather and road surface condition and develops a model to estimate the road surface condition using machine learning. A road surface sensor was attached to the probe vehicle to collect road surface condition classified into three categories as 'dry', 'moist' and 'wet'. Road geometry information (curvature, gradient), traffic information (link speed), weather information (rainfall, humidity, temperature, wind speed) are utilized as variables to estimate the road surface condition. A variety of machine learning algorithms examined for predicting the road surface condition, and a two - stage classification model based on 'Random forest' which has the highest accuracy was constructed. 14 days of data were used to train the model and 2 days of data were used to test the accuracy of the model. As a result, a road surface state prediction model with 81.74% accuracy was constructed. The result of this study shows the possibility of estimating the road surface condition using the existing weather and traffic information without installing new equipment or sensors.