• The Journal of Korean Medicine
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• v.36 no.1
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• pp.86-92
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• 2015

Objectives: The purpose of this study is to present two treatment cases of psoriasis with insomnia. Methods: We administered Guibi-tang medication to the psoriasis patients with insomnia and tested the results by Psoriasis Area and Severity Index(PASI) and Insomnia Severity Index(ISI) as well. Results: After the treatment both the patients showed improvements in PASI and ISI as well. PASI of Patient 1 changed from 15.2 to 1.2 along with the change of ISI from 27 to 2. In case of Patient 2, PASI changed from 14.6 to 1.8 while ISI changed from 21 to 6. Conclusions: The results suggest that Guibi-tang can be an effective treatment for insomnia and psoriasis as well. Further studies will be needed to demonstrate conclusively the effect of Guibi-tang on psoriasis cure.

• 건강소식
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• v.30 no.2 s.327
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• pp.26-27
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• 2006

우리나라 인구의 약 1~2%가 앓고 있으며 약 100만 명 정도가 건선으로 심한 고통을 받고 있다. 아토피가 주로 어린이∙청소년에게 많다면 건선은 20-30대 성인에게 흔하다. 가장 조심해야 할 연령대는 활동이 왕성한 20대 초반, 특히 면역력이 약해지기 쉬운 여성들이다. 급증하는 젊은 여성들의 음주와 흡연, 불규칙한 수면과 식사 등은 건선을 유발할 위험이 크므로 이에 대한 주의가 필요하다

• Journal of Dental Rehabilitation and Applied Science
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• v.29 no.2
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• pp.203-207
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• 2013

Psoriatic arthritis is a chronic inflammatory form of arthritis that is associated with psoriasis. A 54-yr-old male with chronic psoriatic temporomandibular joint arthritis and myofascial pain was treated using methotrexate and a myofascial pain protocol. Jaw pain improved after 3 weeks, however, tenderness to palpation of muscles remained. Comprehensive evaluation and multidisciplinary clinical treatment is required for the treatment of patients with psoriatic temporomandibular joint arthritis.

• Proceedings of the Korea Information Processing Society Conference
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• 2019.10a
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• pp.657-659
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• 2019

본 논문에서는 피부 이미지에서 건선 병변만을 가장 효과적으로 분할 할 수 있는 분할기법 선별을 목표로 한다. Interactive graph cuts (IGC)와 Level set method (LSM)를 사용하여 건선 영역을 분할한 후 Jaccard Index (JI)와 Dice Similarity Coefficient (DSC)을 사용하여 건선 영역에 효과적인 분할 방법을 제안한다.

• 건강소식
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• v.37 no.1
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• pp.24-26
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• 2013

건선은 신체 면역체계에 이상이 생겨 피부에 염증 반응을 일으키는 질병으로 평소 건강관리를 소홀히 해 면역력이 약해지면 나타나기 쉽다. 보통 바르는 연고로 치료하지만 심할 경우 자외선 치료와 함께 고가의 면역 억제 주사가 필요한 악성 질환이다. 원인과 동반질환, 효과적인 예방법을 알아보았다.

• The Journal of Korean Medicine
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• v.34 no.3
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• pp.160-168
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• 2013

Psoriasis is a chronic, recurrent skin disease without any cure so far. The symptoms of the guttate psoriasis of Soyangins going through tonsillitis and of the psoriasis under the steroid rebound phenomenon are identical to one of yang poison exanthema of a Soyangin. The study administered Yangdokbagho-tang, which is used to cure yang poison exanthema of Soyangins, and, as a result, showed significant treatment results from these two types of four clinical cases. Sasang medicine is considered an effective treatment method to cure psoriasis, an obstinate skin disease.

• Journal of Sasang Constitutional Medicine
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• v.27 no.1
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• pp.171-177
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• 2015

Objectives The purpose of this study is to give an account of the effects of the Traditional Korean herbal medicine therapy which is based on the Sasang constitutional medicine on psoriasis Methods We diagnosed her as Soyangin(少陽人) based on her nature and emotion, physical chracteristics, symptoms. We thought Leaky Gut Syndrome is related to Soyangin Food Stagnation, stuffiness and fullness(食滯痞滿). So we applied Dokhwaljihwang-tang(獨活地黃湯) which is used to Soyangin Food Stagnation, stuffiness and fullness because her symptoms recurred as a result of Food Stagnation(食滯) after eating meat. The improvement of the skin condition was observed by Psoriasis Area and Severity Index (PASI) score Results Psoriasis patient who was treated with Soyangin Dokhwaljihwang-tang showed improvement in Psoriasis symptom. This case study describes the effectivenss on psoriasis symptoms by using Soyangin Dokhwaljihwang-tang. Conclusions The PASI score of the patient reduced from 10.8 to 1.2 after three months of treatment. According to the result, we concluded that Dokhwaljihwang-tang had a good effect on psoriasis.

• Journal of Applied Biological Chemistry
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• v.64 no.2
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• pp.185-192
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• 2021

Psoriasis is a chronic intractable skin disease caused by various inflammatory cytokines such as IL-6, CXCL8, TNF-α, and IFN-γ, as well as IL-17A secreted from Th17 cells and is characterized by hyperkeratosis and chronic inflammation of the epidermis. Brazilin, an active ingredient of Caesalpinia sappan L., is known to exert antioxidant and anti-inflammatory activity, and function in skin barrier improvement. In particular, it was shown as a potential material for treating psoriasis in a tumor necrosis factor (TNF)-α-stimulated HaCaT keratinocyte model. However, the direct regulation of the C-C motif chemokine ligand (CCL) 20, a psoriasis-inducing factor, by brazilin has not been reported. Therefore, in this study, we investigated the suppression of CCL20 and the regulatory mechanism by brazilin using a psoriasis-like model. First, brazilin downregulated CCL20 and CXCL8 in IL-17A-stimulated HaCaT cells in a concentration-dependent manner by inhibiting signal transducer and transcription (STAT)3 phosphorylation. In addition, brazilin significantly inhibited the expression of psoriasis-related genes CXCL8, CCL20, IL-1, IL-6, and TNF-α in TNF-α/IL-17A/IFN-γ-stimulated HaCaT cells. Moreover, brazilin also had a positive effect on improving the skin barrier in TNF-α/IL-17A/IFN-γ-stimulated HaCaT cells. The above results indicated that brazilin ultimately downregulated CCL20 expression by inhibiting STAT3 phosphorylation, and also suppressed the expression of psoriasis-induced cytokines. If the efficacy of brazilin in improving psoriasis is verified through animal models and clinical trials in the future, it may represent a potentially therapeutic substance for psoriasis patients.

• Journal of Applied Biological Chemistry
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• v.63 no.1
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• pp.95-101
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• 2020

Psoriasis is an autoimmune skin disease that is accompanied by hyper proliferation of the epidermis, erythema of various sizes, and ulceration. However, the mechanism of the development of psoriasis dermatitis is unclear. Recently, it is known that the inflammatory cytokines and Th17 cells as well as chemokine (CC motif) ligand 20 (CCL20) are involved in the process of keratinocytes hyper-differentiation, which is common in psoriasis dermatitis. Therefore, we studied the effects of yakuchinone-A, an active ingredient of Alpinia oxyphylla Miquel known for its anti-inflammatory activity, to improve psoriasis dermatitis. First, cytotoxicity of yakuchinone-A was observed in cell counting kit-8 assay and not observed in 10 ㎍/mL concentration on the human keratinocyte HaCaT cells. Yakuchinone-A in the presence of tumor necrosis factor-alpha (TNF-α) on HaCaT cells inhibited mRNA expression of IL-6, IL-8, and TNF-α by up to 61.4±7.5, 23.6±1.5, 46.0±4.8%. CCL20, a chemokine that attracts immune cells such Th17 cells to the inflammation location, was also significantly suppressed by yakuchinone-A. In addition, IκB and STAT3 phosphorylation involved in the CCL20 expression was inhibited by yakuchinone-A in a concentration-dependent manner up to the level of 79.1±5.0, 80.8±2.3%. Furthermore, yakuchinone-A downregulated CCL20 mRNA expression level on IL-17A-activated HaCaT cells as a concentration-dependent manner. Based on these results, yakuchinone-A is expected to be developed as a new material for improving psoriasis dermatitis in the future.

• The Korean Chronic Disease News
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• no.9
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• pp.12-12
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• 1980