• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.7
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• pp.688-698
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• 2017

This study was conducted to identify the conceptual definitions and attributes of fatigue in hemodialysis patients based on the Hybrid Model of concept development. The Hybrid Model was used to investigate the main attributes and indicators of the concept by applying three stages. After a literature review, data were collected through observation and interviews including qualitative research in the field work stage. The participants included 10 patients in hemodialysis center of two hospitals in Gwang-ju, Korea. The attributes of fatigue concept in the hemodialysis patients were divided into four dimensions, physical activity, affective mood, social role, and cognitive reflection. The definition of fatigue by hemodialysis patients was defined as 'subjective feeling usually experienced in four dimensions during the process to recognize and adjust energy deficiency and limited functions caused by uremia and repeated hemodialysis for chronic renal failure'. Considering the dimensions and attributes derived from this study, it may be possible to develop an effective intervention program for fatigue in hemodialysis patients.

• Journal of Digital Convergence
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• v.15 no.10
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• pp.281-291
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• 2017

This purpose of study was to identify variables predicting basic psychological need in hemodialysis patients. The participants were 134 patients from two major general hospitals and two dialysis center located in J city. Data were collected using self-report questionnaires and physiological index. Data analysis was done by using SPSS WIN 18.0 program for one-way ANOVA, independent t-test, Pearson correlation coefficients, and multiple regression. This study showed a negative correlation between basic psychological need and uncertainty(r=--.464, p<.001), depression(r=-.422, p<.001). In addition, relationships and physiological index were Positively correlated. The uncertainty(${\beta}=-.345$), depression(${\beta}=-.279$), physiological index(${\beta}=-.117$) have a 29% explanatory power for the basic psychological need in hemodialysis patients. Physiological index, uncertainty and depression in turn influenced the basic psychological needs of hemodialysis patients. It is necessary to develop nursing strategies and programs to reduce disease uncertainty and depression in order to increase self-deterministic health behavior through autonomy, competence and relationship satisfaction.

• 한국노년학
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• v.38 no.3
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• pp.501-519
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• 2018

The purpose of this study was to explore perception about shared decision making of family caregivers of patients with early dementia (PWED). This study was conducted with a sample of 12 family caregivers (mean age = $71.4{\pm}10.4$) of PWED from three dementia safety centers in Seoul. In-depth interviews were done for each participant about shared decision making and data were analyzed using qualitative content analysis. Six categories and 17 sub-categories identified for participants' perception about shared decision making: means to facilitate communication with patients with dementia, means to secure autonomy of patients, opportunity to facilitate treatment, cause of increasing family caregivers' burden, cause of worsening relationship with patients, and option for choices depending on priority change. The findings of this study can provide a knowledge basis for health care professionals and policy makers to understand how family caregivers of PWED think about shared decision making. It would be of great value to develop educational programs and practical guidelines about shared decision making for PWED and their family, which may contribute to respecting PWED's self-determination right as well as reducing burden of their family.

• Journal of Life Science
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• v.29 no.1
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• pp.105-111
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• 2019

In recent years, progress has been made in the search for the development of new anti-cancer agents by employing specific inhibitors of histone deacetylase (HDAC)-6 to block signal transduction pathways in cancer cells. This study examined the effects of tubastatin A (TubA), an HDAC-6 inhibitor, on the growth and development of immature oocytes in murine ovaries using RNA sequencing analysis. The results from a gene set enrichment analysis (GSEA) indicated that the expression of most of the gene sets involved in the cell cycle and control and progression of meiosis decreased in the TubA-treated group as compared with that in germinal vesicle (GV) stage oocytes. In addition, an ingenuity pathway analysis (IPA) suggested that TubA not only caused increased expression of p53 and pRB and decreased expression of CDK4/6 and cyclin D but also caused elevated expression of genes involved in the control of the DNA check point in G2/M stage oocytes. These results suggest that TubA may induce cell cycle arrest and apoptosis through the induction of changes in the expression of genes involved in signal transduction pathways associated with DNA damage and the cell cycle of immature oocytes in the ovary.

• Journal of the Korean Applied Science and Technology
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• v.37 no.6
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• pp.1687-1697
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• 2020

This study is a comparative descriptive research that identifies the degree and difference of the brain education meditation program from participation stress(physical stress, psychological stress), depression, resilience(self-control ability, interpersonal relationship ability, and positive) for middle-aged women. The subjects were 26 middle-aged women who participated in the brain education meditation program at the D metropolitan city D center for more than a year, 29 middle-aged women did not participate in the brain education meditation program and a total of 55 middle-aged women collected for three weeks from November 4 to 22, 2019. Data analysis fesult that the participating groups in brain education meditation programs differ statistically significantly in physical stress(t=2.549, p=.014), psychological stress(t=2.352, p=.022), self-control ability(t=-2.219, p=.031) and positive(t=-2.387, p=.021), which are higher factors in resilience than non-participating groups. In other words, brain education meditation program participants scored lower physical and psychological stress scores than nonparticipating groups, with higher self-control ability and positive scores. Therefore, it is thought that brain education meditation programs can be used as nursing intervention to reduce stress and improve self-control ability and positive in middle-aged women.

• The Journal of the Korea Contents Association
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• v.22 no.3
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• pp.547-559
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• 2022

This study is a qualitative study to explore caring of a mentally disabled family using mental rehabilitation facilities. As a result of the analysis, the life of a mentally disabled family appeared in 6 topics and 12 sub-themes. Life before the outbreak was warm and comfortable like an electric stove, and a frustrating and difficult life like a parrot in a cage due to family conflicts. The feeling of looking at the child who is starting to develop symptoms is fear and hopelessness that is hard to see ahead, and a sense of guilt for a child trapped in a disease before blooming his life. Forced hospitalization, and my feelings were torn apart, and my thoughts were confused by opaque recovery and worries about future life. The experience I felt as the disease lasted for a long time and hospitalized and discharged repeatedly feared that the mental illness of the family would be known to the people around me, and found that they struggled to cope with repeated recurrence and worsening symptoms. While using mental rehabilitation facilities, the changed life was comforted in a comfortable shelter, and turned out that there was hope for the future and that there was room to smile. The life expected in the future and the theme of hope turned out to be grateful for small changes and determined to be a warm fence for recovery.

• The Journal of the Convergence on Culture Technology
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• v.7 no.2
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• pp.309-316
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• 2021

The purpose of this study is to investigate the level of adaptation to college life and identity the influencing factors on adaptation to college life of college freshmen's. Data were collected from 2088 college freshmen's in B city and analyzed by t-test, ANOVA, Pearson correlation coefficient, and multiple regression using SPSS/WIN 22.0. The degree of adaptation to college life in college freshman was 3.75±0.73. There were significant differences in college life adaptation with respect to gender(t=3.947, p<.001), age(F=3.445, p=.032), major(F=5.539, p=.001), family type(F=6.958, p<.001). There was negative correlation between adaptation to college life and perceived stress(r=-.696, p<.001), depression(r=-.507, p<.001), positive correlation were found between perceived stress and depression(r=.567, p<.001). The factors affecting the adaptation to college life of the study subjects were perceived stress, depression, age, major, family type with an explanatory power of 50.4%. In conclusion, to enhance adaptation to college life of college freshmen's, it is necessary to develop and adopt various program of adaptation to college life.

• The Korea Journal of Herbology
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• v.32 no.2
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• pp.57-64
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• 2017

Objectives : Yam bean (Pachyrhizus erosus) possess various nutrients, it has been widely used as traditional cosmetic material in Indonesia. The aim of this study was to investigate the anti-oxidant activity and the anti-melanogenic effect of Yambean (Pachyrhizus erosus) extract and its fractions. Methods : The anti-oxidant activity of yam bean extract assessed based on total polyphenol, flavonoid contents, DPPH and ABTS radical scavenging assay. To evaluate anti-melanogenic effects and cytotoxicity of Yambean extract and its fractions, B16F10 melanoma cell was used. Results : In results, total polyphenol content of yam bean water extract (YW) and Yambean 70% ethanol extract (YE) were $1.18{\pm}0.03mg/g$ (mg of gallic acid/g of sample), $1.16{\pm}0.01mg/g$. Total flavonoid contents of YW, YE were $3.55{\pm}0.06mg/g$ (mg of naringin/g of sample), $1.78{\pm}0.03mg/g$. Moreover, YE scavenged DPPH and ABTS effectively in $4mg/m{\ell}$ compared to YW. Cytotoxicity of YE and its fractions in B16F10 melanoma cell was measured using MTT assays. It had no cytotoxicity up to $500{\mu}g/m{\ell}$. Melanin accumulation in B16F10 melanoma cell was induced using alpha-melanocyte stimulating hormone (${\alpha}-MSH$) and 3-isobutyl-1-methylxanthine (IBMX). B16F10 melanoma cell treated with $10-500{\mu}g/m{\ell}$ YE and hexane, ethyl acetate, butanol, $H_2O$ fractions for 24h. Non treated B16F10 melanoma cell (Control) markedly increased melanin contents. In contrast, YE ethylacetate fraction effectively suppressed melanin accumulation in a dose-dependent manner. Conclusion : In conclusion, these results suggest that Yambean extract has the potential as a cosmetic material which possess anti-oxidant and anti-melanogenic activities.

• Journal of the Korean Applied Science and Technology
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• v.39 no.2
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• pp.205-219
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• 2022

This study is a descriptive research study to understand the effects of nurses' perception of the disabled, contact experience with the disabled, and human rights sensitivity on attitudes toward the disabled. The subjects of the study were 181 nurses working at two university hospitals in D City and one university hospital in C Special Self-Governing City. Data were collected from September 2, 2021 to October 6, 2021. The collected data wre analyzed using IBM SPSS 26.0 program, and analyzed with t-test, ANOVA, Pearson's Correlation Coefficients, and Multiple Regression Analysis. Factors affecting the subject's attitude toward people with disabilities were perception of people with disabilities(t=-3.96, p<.001), presence or absence of contact with patients with disabilities(t=3.23, p=.001), and the ability to perceive responsibility among human rights sensitivity(t=2.13, p=.035), whether or not they had completed education for improvement the awareness of the disabilities(t=2.90, p=.004), and whether they were recognized of the Act on the Right to Health and Medical Accessibility for the Disabled(t=2.44, p=.016), which showed 30% of explanatory power(F=9.36, p<.001). Accordingly, it is necessary to develop an educational program that can foster nurses' attitudes toward the disabled, including awareness of the disabled, human rights sensitivity, the Health Rights Act for the Disabled, and the experience of contact with the disabled.

• 한국노년학
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• v.31 no.4
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• pp.985-998
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• 2011

This study was conducted to understand current management status of 'day and night care' facilities and to explore the related factors with rates of operation of them. The nationwide mailing survey was conducted with structured questionnaires from July, 14, 2010 to July, 28, 2010. The subjects were 277 facilities (response rate 24.5%). Regarding the types of operating, 79.1% of faculties was run by cooperation, and 17.8% and 3.6% for individuals and national/public institutes respectively. The average of operation rate was 70.15%. National/public institutes showed higher in the rate of operation(79.08%) than 72.49% of cooperations and 57.78% of individuals. The number of manpower was not nearly different by the types of operating bodies, but the number of nurse was significantly different among them. The national/public institutions had 1.07 nurses while individual institutions have only 0.08. We found that facilities run by national/public institutes and founded before 2008 years showed higher rate of operation. In case of providing regular monitoring and evaluation services, and music program for patients showed higher rate of operation. In addition, the number of managers, social workers, and nurses increase the rate of operation. We suggest that quality management and monitoring program for the facilities which run by individuals or established after 2008 years would be developed. We also call for development of programs for facilitating utilization of 'day and night care' facilities such as expanding the family support.