• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.1
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• pp.40-46
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• 2014

We demonstrated that Acanthopanax senticosus fermentation products (FM-5111 and FM-5131) administered to rats functionally protect against DL-ethionine-induced and ethanol-induced fatty liver models. In DL-ethionine-induced fatty liver models, the serum concentrations of aspartate aminotransferase (AST), as well as liver concentrations of triglyceride and total lipid against the control decreased in FM-5111 and FM-5131 treated rats. In ethanol-induced fatty liver models, FM-5111 and FM-5131 treated rats showed a decrease in the liver concentrations of triglyceride and total lipid in ethanol-induced fatty liver models. There were no significant differences in the serum concentrations of AST and alanine aminotransferase in FM-5111 and FM-5131 treated rats. Additionally, FM-5111-, or FM-5131-treated rats showed no significant differences in the body weight gain between the control. These results indicate that Acanthopanax senticosus fermentation products might have protective effects against DL-ethionine-induced and ethanol-induced fatty liver models.

• Korean Journal of Food Science and Technology
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• v.35 no.4
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• pp.702-707
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• 2003

This study was conducted to evaluate the effect of a growth-stimulating material (GSM) containing Eleutherococcus senticosuson on the longitudinal bone growth. The effects of GSM on proliferation zone and IGF-1 mRNA expression in rat growth plate, IGF-1 mRNA expression in MG-63 osteoblast and Hep-G2 hepatocyte, and bone growth of mouse tibia were studied. GSM significantly increased the proliferation zone in growth plate of proximal tibia (P<0.001) and the IGF-1 mRNA expression in growth plate was also increased (P<0.01). Treatment of GSM to MG-63 osteoblast and Hep-G2 hepatocyte also increased IGF-1 mRNA expression more than twice. In addition, bone mineral density of mouse tibia was significantly increased by GSM (P<0.05). Therefore, it was shown that GSM has an activity of bone growth promotion by increasing the expression of IGF-1, a major bone growth factor.

• Korean Journal of Food Science and Technology
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• v.34 no.3
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• pp.518-523
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• 2002

Administration of hot water extracts from Acanthopanax senticosus (GF-2) prophylactically and therapeutically inhibited the systemic anaphylactic shock induced by compound 48/80 in mouse. GF-2 significantly inhibited the production of histamine and eosinophyl in mouse serum through the injection of compound 48/80 in a dose-dependent manner. GF-2 inhibited dose dependently $TNF-{\alpha}$ production of peritoneal exudative cells activated by lipopolysaccharide. Intraperitoneal injection of GF-2 suppressed the production of IgG1 and IgE antibodies in mice immunized with a mixture of ovalbumin and aluminium hydroxide. These results suggest that GF-2 may be beneficial for the treatment of nonspecific and specific anaphylactic reactions and can be potentially applied to the treatment of allergic diseases.

• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.6
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• pp.887-893
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• 2010

This study examined the shelf-life and quality characteristics of the wet noodle added with the Acanthopanax senticosus and Eucommia ulmoides extract (AEE). The wet noodle with AEE reduced total microbial counts and TBARS value compared with the control during storage at $4^{\circ}C$ for 21 days. Moisture content of the wet noodle with AEE and control was not different during the early storage period, but after 9 days of storage, that of the control was decreased about 7%, while that of the noodle with AEE was decreased slightly. Lightness of the wet noodle with AEE showed low value in uncooked and cooked noodles compared with the control and decreased during storage. The pH and texture of the wet noodle with AEE and control did not change during storage at $4^{\circ}C$ for 21 days. In sensory evaluation, texture, soup smell and springiness of the wet noodle with AEE were preferred than the control. These results suggested that the AEE can keep the quality characteristics and increase the shelf-life in the wet noodle.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.12
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• pp.2082-2087
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• 2013

The present study was performed to quantitatively analyze eleutherosides (B and E) and ${\beta}$-glucan in different plant parts of three cultivars (Chungnam, Gangwon, and Jeju) of Acanthopanax senticosus and Acanthopanax koreanum using HPLC and a commercial enzyme kit. Our results showed high linearity in the calibration curves as the coefficients of correlation ($R^2$) were 0.998 (eleutheroside B) and 0.999 (eleutheroside E), respectively. Eleutheroside B and E were found in stem extracts of A. koreanum cultivated in Jeju (1,122 ${\mu}g/g$, eleutheroside B) and A. senticosus cultivated in Chungnam (2,536 ${\mu}g/g$, eleutheroside E), respectively. However, eleutheroside B was not detected in any part of A. senticosus cultivated in Chungnam. For ${\beta}$-glucan contents, stems of A. senticosus and A. koreanum showed higher than other parts. Furthermore, the ${\beta}$-glucan content in stems of A. koreanum cultivated in Gangwon was significantly higher than in those of other cultivars. These results show that the contents of eleutheroside B, E, and ${\beta}$-glucan were higher in stem extracts of A. senticosus and A. koreanum than other parts. Moreover, our results suggest that the contents of eleutheroside B, E, and ${\beta}$-glucan in A. senticosus and A. koreanum are influenced by cultivation area and the selected part.

• The Korean Journal of Food And Nutrition
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• v.23 no.4
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• pp.542-548
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• 2010

This study was conducted to investigate the effects of Acanthopanax senticosus extracts(ASE) on alcohol administered mice. The administration of Acanthopanax senticosus extracts(60 mg/kg) had beneficial actions toward alcohol degradation in acute alcohol treated mice. In the acute alcohol degradation experiment, serum alcohol concentration were lower 3 and 6 hours after taking ethanol(5 g/kg) in ASE treated mice. The oral administration of ASE showed decreased gastric mucous membrane damage produced in ethanol treated mice. In addition, intraperitoneal(i.p.) administration of ASE showed antiinflammatory effects in inhibition tests of vascular permeability produced by acetic acid. ASE also reduced concentrations of nitric oxide(NO), tumor necrosis alpha(TNF)-${\alpha}$ and interleukin(IL)-6 in macrophages that were activated by LPS. These results demonstrate that Acanthopanax senticosus extracts possesses the potential to stimulate alcohol degradation and inhibit inflammatory effects in mice.

• Korean Journal of Pharmacognosy
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• v.38 no.2 s.149
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• pp.152-156
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• 2007

Protein-bound polysaccharide is derived from Acanthopananx senticosus by the cold water extraction. The aim of the study was to evaluate the effects of PS against weight loss and hematological change as a indication of toxicity produced by the treatment of cisplatin. PS protected the weight loss caused by cisplatin (6 mg/kg) and significantly recovered hematological change. Treatment of PS showed the recovery on the weight loss and hematological change as indicators of toxicity of cisplatin treatment. By increasing lymphocyte proliferation and cytokine production, PS may be highly effective in protecting against cisplatin-induced toxicity. The results suggest PS might have a role in reducing toxicity or permitting larger dose of cisplatin to be given.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.555-563
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• 2024

We were selected oriental medicinal herbs known to be effective in strengthening muscles, improving sarcopenia, treating arthritis and osteoporosis. Amino acids have been reported to be associated with the above-mentioned effects. During the manufacturing process of water extracts of ginseng and samchae, the content of arginine, a basic amino acid, was significantly reduced. The decrease was 99.48mg/100ml for steamed red ginseng compared to 114.07mg/100ml for dried white ginseng, and 54.69mg/100ml for steamed samchae compared to 118.90mg/100ml for dried samchae. The extracts of the wild roots of Acanthus apias and the above-ground twigs of Acanthus apias showed significantly higher DPPH and ABTS radical scavenging activities. Meanwhile, DPPH activity was higher in steamed red ginseng and steamed samchae compared to dried white ginseng and dried samche, but ABTS activity increased to 66.88% for steamed red ginseng compared to 41.96% for dried white ginseng, but was 77.48% for dried samchae and 77.52% for steamed samchae.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.40 no.4
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• pp.444-450
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• 1995

It was very hard to gather the seeds of Eleutherococcus senticosus Max. known as a medicinal plant for they tend to drop under the high temperature condition during the summer period in Korea. Therefore, this study was conducted to select seed production site for Eleutherococcus senticosus in Korea, comparing the climate of Hokkaido of Japan, in which the seeds have been produced, with that of various place in this country. It was low that the average maximum temperature during the hottest summer two months (July and August) as a 24.4$^{\circ}C$ in Hokkaido and 21.2$^{\circ}C$ in Daegwanryeong compared with 27.4$^{\circ}C$ in Changsu. Especially in Daegwanryeong, average maximum temperature from June to September remained as low as 21$^{\circ}C$. Effective accumulated temperature(>5$^{\circ}C$) was 807$^{\circ}C$ in Hokkaido and 964$^{\circ}C$ in Daegwanryeong during the ripening period. Monthly sunshined hours from July to August were 121.7~128 hours in Daegwanryeong and 83.5~85.4 hours in Hokkaido. The Eleutherococcus senticosus sprouts at 8.5$^{\circ}C$, comes to flowering season in mid-August, and ripens during late-August and October in Hokkaido, the climate of which is similar to that of Daegwanryeong.

• Journal of Biosystems Engineering
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• v.36 no.6
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• pp.461-466
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• 2011

The purpose of this study is basically for the use of simulations to enhance productivity. In this paper, the optimal number of allocation in a small and medium industry which produces eleutherococcus senticosus sap, is performed using simulations. The simulation model was developed under considerations of production layout, process & operation, process time, total work time, work in process (WIP), utilization, failure rate, and operation efficient as inputs, and was validated with careful comparisons between real behaviors and outputs of the production line. Therefore, we can evaluate effects and changes in productivity when some strategies and/or crucial factors are changed. Although too many workers and machines could decrease productivity, the eleutherococcus senticosus sap production line in this paper has been maintained many machines. To solve this problem, we determined the optimal number of workers and machines that could not cause any interrupt in productions using simulations. This simulation model considers diverse input variables which could influence productivity, and it is very useful not only for the production line of Eleutherococcus Senticosus Sap, but also for other production lines with various purposes, especially, in the small and medium industries.