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AN EXPERIMENT OF ${\gamma}-GLUTAMYL$ TRANSPEPTIDASE ON PERIODONTAL INFLAMMATION (치주염증시 ${\gamma}-Glutamyl$ transpeptidase의 연구)

  • Lee, Seok-Cho;Lim, Jong-Deuk;Yoo, Kang-Rgeol;Oh, Kwi-Ok;Kim, Hyung-Seop
    • Journal of Periodontal and Implant Science
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    • v.23 no.3
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    • pp.517-525
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    • 1993
  • Glutathione(GSH),a tripeptide thiol, found in virtually all cells, functions in metabolism tranasport and cellular protection. It protects cells against the destructive effects of reactive oxygen intermediates and free radicals. Also ${\gamma}-Glutamyl$ transpeptidase(${\gamma}-GTT$), an enzyme of major importance in GSH metabolism, initiates GSH degradation. In order to explore the $GSH-{\gamma}-GTT$ system as periodontal disease activity indicator, we observed the ${\gamma}-GTT$ and arachidonic acid metabolits according to clinical groups(Control, Adult periodontitis, Rapidly progressive Periodontitis). From the experiments, the following results were obtained. 1. When compared with normal, ${\gamma}-GTT$ of A. P. and R. P. P. were increased, and only the change of ${\gamma}-GTT$ of R. P. P. was statistically significant(P<0. 05). 2. The amounts of arachidonic acid metabolites were not different with statistical significance among the clinical groups. 3. ${\gamma}-GTT$ may by useful adjuncts as new cytoprotective indicator and periodontal disease activity indicator in accordance with positive corelation pocket depth, attachment level and ${\gamma}-GTT$.

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Multiple Parallel-Pollard's Rho Discrete Logarithm Algorithm

  • Lee, Sang-Un
    • Journal of the Korea Society of Computer and Information
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    • v.20 no.8
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    • pp.29-33
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    • 2015
  • This paper proposes a discrete logarithm algorithm that remarkably reduces the execution time of Pollard's Rho algorithm. Pollard's Rho algorithm computes congruence or collision of ${\alpha}^a{\beta}^b{\equiv}{\alpha}^A{\beta}^B$ (modp) from the initial value a = b = 0, only to derive ${\gamma}$ from $(a+b{\gamma})=(A+B{\gamma})$, ${\gamma}(B-b)=(a-A)$. The basic Pollard's Rho algorithm computes $x_i=(x_{i-1})^2,{\alpha}x_{i-1},{\beta}x_{i-1}$ given ${\alpha}^a{\beta}^b{\equiv}x$(modp), and the general algorithm computes $x_i=(x_{i-1})^2$, $Mx_{i-1}$, $Nx_{i-1}$ for randomly selected $M={\alpha}^m$, $N={\beta}^n$. This paper proposes 4-model Pollard Rho algorithm that seeks ${\beta}_{\gamma}={\alpha}^{\gamma},{\beta}_{\gamma}={\alpha}^{(p-1)/2+{\gamma}}$, and ${\beta}_{{\gamma}^{-1}}={\alpha}^{(p-1)-{\gamma}}$) from $m=n={\lceil}{\sqrt{n}{\rceil}$, (a,b) = (0,0), (1,1). The proposed algorithm has proven to improve the performance of the (0,0)-basic Pollard's Rho algorithm by 71.70%.

Effect of Gamma Irradiation on the Mechanical and Thermal Properties of Biodegradable Packaging Materials

  • Lim, DaeGyu;Kim, Youngsan;Kwon, Sangwoo;Jang, Hyunho;Park, Su-il
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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    • v.27 no.2
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    • pp.85-90
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    • 2021
  • The gamma irradiation was on to Poly(butylene sebacate-co-terephthalate) (PBSeT), Poly(butylene adipate-co-terephthalate) (PBAT), Poly(lactic acid) (PLA) and casting polypropylene (CPP) at dose levels from 0 to 50 kGy. The properties of gamma irradiated samples were analyzed using DSC, TGA, UTM and FT-IR spectra. The mechanical and thermal properties of PBSeT and PBAT after gamma irradiation were less affected than CPP. The tensile strength and elongation of PBSeT was not affected by gamma irradiation, while these of PBAT, PLA and CPP were significantly decreased at 50 kGy gamma-ray dose. The thermal stability of PBSeT, PBAT, PLA and CPP showed a similar tendency to tensile strength. The glass transition temperature(Tg) and melting temperature(Tm) of PBSeT and PBAT were not altered by increasing gamma-ray dose, while these of PLA and CPP decreased. The chemical composition of all samples was not modified by gamma irradiation, and it was confirmed by FT-IR spectra. Based on mechanical and thermal stability studies of gamma irradiation on bioplastics, tested biodegradable packaging materials showed a potential to be used in sterilization process up to 35 kGy.

The Adjuvant Effect of Subcutaneous Interferon-gamma in the Treatment of Refractory Multidrug-resistant Pulmonary Tuberculosis (난치성 다제내성 폐결핵에서 피하주사 Interferon-gamma 치료의 효과: 예비연구)

  • Kim, Eun Kyung;Shim, Tae Sun;Lee, Jung Yeon;Oh, Yeon-Mok;Lim, Chae-Man;Lee, Sang Do;Koh, Younsuck;Kim, Dong Soon;Kim, Won Dong;Kim, Woo Sung
    • Tuberculosis and Respiratory Diseases
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    • v.57 no.3
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    • pp.226-233
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    • 2004
  • Background : Interferon-gamma (IFN-${\gamma}$) is a critical cytokine in the defense against a Mycobacterium tuberculosis infection. Even though IFN-${\gamma}$ has occasionally been used in the treatment of refractory multidrug-resistant tuberculosis (MDR-TB) with some promising results, there is still some controversy regarding the therapeutic efficacy of IFN-${\gamma}$. This study was performed to examine the effect of subcutaneous IFN-${\gamma}$ in the treatment of MDR-TB patients. Methods : Six patients with refractory MDR-TB were enrolled in this study. Two million IU of IFN-${\gamma}$ was administered subcutaneously three times a week with the concomitant administration of antituberculous drugs for at least for 28 weeks. During the IFN-${\gamma}$ therapy, the sputum smear and culture, radiological and clinical evaluations were performed every 4 weeks throughout the study period. Results : The mean age of the 6 patients was 37 years (ranges, 15-61 years). The drug susceptibility test to standard antituberculous drugs revealed resistance to an average of 6.8 (${\pm}1.2$) agents including isoniazid and rifampicin. An average of 10.8 (${\pm}1.3$) antituberculous drugs were prescribed before IFN-${\gamma}$ therapy. The culture became negative in 2 patients (33%) after initiating IFN-${\gamma}$ therapy; one at 8 weeks, and the other at 24 weeks. Finally, after stopping the IFN-${\gamma}$ therapy after 28 weeks, the culture became positive again in the two patients who were culture-negative. The other 4 patients who failed in the culture conversion are still on antituberculous treatment except for one who died of tuberculosis. Conclusion : Even though 28 weeks of subcutaneous IFN-${\gamma}$ therapy in combination with antituberculous drugs was successful in inducing the culture-negative conversion in some patients with refractory MDR-TB, the culture became positive again after stopping the IFN-${\gamma}$ therapy. This suggests that subcutaneous IFN-${\gamma}$ therapy may have suppressive effect on tuberculosis only during the IFN-${\gamma}$ therapy period in some patients. Further studies will be needed to determine the optimum dose, the administration route, the duration of therapy, and the predicting factors of the response to adjuvant IFN-${\gamma}$ therapy.

The Usefulness of Pleural IFN-$\gamma$ Level in Differential Diagnosis of Tuberculous Pleural Effusion and Malignant Pleural Effusion (결핵성 흉막염과 악성 흉수의 감별진단에 있어서 흉수 IFN-$\gamma$ 측정의 유용성)

  • Kim, Myung-Sun;Yang, Sung-Eun;Chi, Hyun-Sook;Kim, Woo-Sung;Kim, Won-Dong
    • Tuberculosis and Respiratory Diseases
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    • v.45 no.2
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    • pp.280-289
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    • 1998
  • Background: It is sometimes difficult to differentiate tuberculous pleural effusion from malignant pleural effusion by clinical symptoms, signs, by routine tests of pleural fluid, and by pathologic studies. And recently, it was discovered that cytokines such as IL-2, IFN-$\gamma$, TNF-$\alpha$ are elevated in tuberculous pleural fluid, and there have been several attempts to diagnose tuberculous pleural effusion by using these immunological mediators. There are several studies regarding the diagnostic value of IFN-$\gamma$, and there are two studies in Korea. But the diagnostic values of IFN-$\gamma$ in these studies were slightly lower than those in other countries. To compare the diagnostic value of IFN-$\gamma$ with those of CEA and ADA, and to determine the sensitivity and specificity of IFN-$\gamma$ in Korean, we mesured IFN-$\gamma$, CEA level and ADA activity in pleural effusions. Methods: ADA activity, IFN-$\gamma$ level and CEA level as well as cell count, differential count, and biochemical assays such as protein content and lactate dehydrogenase were measured in 40 cases of tuberculous pleuritis and 42 cases of malignant pleural effusion. Results: Tuberculous pleural fluid showed higher levels of IFN-$\gamma$ and ADA ($832.6{\pm}357.2$ pg/ml and $82.5{\pm}25.9$ U/L, respectively) than those of malignant pleural effusion ($2.6{\pm}8.0$ pg/ml and $19.2{\pm}10.9$ U/L, respectively) (p<0.01). Malignant pleural effusions showed higher median value (102.2 ng/ml) than tubercalous pleural effusions (1.8 ng/ml) (p<0.01). The sensitivities of IFN-$\gamma$, ADA, CEA were 0.97, 0.87, 0.67 and the specificities of IFN-$\gamma$, ADA, CEA were 1.0, 0.97, 1.0, respectively. There was no significant correlation between ADA activity and IFN-$\gamma$ level. Conclusion: This study showed that IFN-$\gamma$ test would be a very useful clinical test for differential diagnosis of tuberculous pleuritis and malignant pleural effusion because it is very sensitive and specific, although it is an expensive test.

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ROUGH PRIME IDEALS AND ROUGH FUZZY PRIME IDEALS IN GAMMA-SEMIGROUPS

  • Chinram, Ronnason
    • Communications of the Korean Mathematical Society
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    • v.24 no.3
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    • pp.341-351
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    • 2009
  • The notion of rough sets was introduced by Z. Pawlak in the year 1982. The notion of a $\Gamma$-semigroup was introduced by M. K. Sen in the year 1981. In 2003, Y. B. Jun studied the roughness of sub$\Gamma$-semigroups, ideals and bi-ideals in i-semigroups. In this paper, we study rough prime ideals and rough fuzzy prime ideals in $\Gamma$-semigroups.

ON NONSINGULAR EMBRY QUARTIC MOMENT PROBLEM

  • Li, Chungji;Sun, Xiaoyun
    • Bulletin of the Korean Mathematical Society
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    • v.44 no.2
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    • pp.337-350
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    • 2007
  • Given a collection of complex numbers ${\gamma}{\equiv}\{{\gamma}ij\}$ $(0{\leq}i+j{\leq}2n,\;|i-j|{\leq}n)$ with ${\gamma}00>0\;and\;{\gamma}ji=\bar{\gamma}ij$, we consider the moment problem for ${\gamma}$ in the case of n=2, which is referred to Embry quartic moment problem. In this note we give a partial solution for the nonsingular case of Embry quartic moment problem.

CO-CONTRACTIONS OF GRAPHS AND RIGHT-ANGLED COXETER GROUPS

  • Kim, Jong-Tae;Moon, Myoung-Ho
    • Bulletin of the Korean Mathematical Society
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    • v.49 no.5
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    • pp.1057-1065
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    • 2012
  • We prove that if $\widehat{\Gamma}$ is a co-contraction of ${\Gamma}$, then the right-angled Coxeter group $C(\widehat{\Gamma})$ embeds into $C({\Gamma})$. Further, we provide a graph ${\Gamma}$ without an induced long cycle while $C({\Gamma})$ does not contain a hyperbolic surface group.

ON g·γ-CLOSED SETS AND γ-T* SPACES

  • Park, Jin-Han;Park, Jong-Seo;Kwun, Young-Chel
    • Honam Mathematical Journal
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    • v.29 no.1
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    • pp.41-54
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    • 2007
  • In this paper, we introduce the notion of $g{\cdot}{\gamma}$-closed sets and study its basic properties. Also we introduce the notion of ${\gamma}-T_*$ spaces and investigate relationships among these spaces and ${\gamma}-T_i$ spaces (i = 0,1/2,1) due to Ogata [5].