Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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AN EXPERIMENT OF ${\gamma}-GLUTAMYL$ TRANSPEPTIDASE ON PERIODONTAL INFLAMMATION

치주염증시 ${\gamma}-Glutamyl$ transpeptidase의 연구

  • Lee, Seok-Cho (Dept. of Periodontology, College of Dentistry, Chonbuk National University) ;
  • Lim, Jong-Deuk (Dept. of Periodontology, College of Dentistry, Chonbuk National University) ;
  • Yoo, Kang-Rgeol (Dept. of Phamacology, College of Dentistry, Chonbuk National University) ;
  • Oh, Kwi-Ok (Dept. of Phamacology, College of Dentistry, Chonbuk National University) ;
  • Kim, Hyung-Seop (Dept. of Periodontology, College of Dentistry, Chonbuk National University)
  • 이석초 (전북대학교 치과대학 치주과학교실) ;
  • 임종득 (전북대학교 치과대학 치주과학교실) ;
  • 유광렬 (전북대학교 치과대학 약리학교실) ;
  • 오귀옥 (전북대학교 치과대학 약리학교실) ;
  • 김형섭 (전북대학교 치과대학 치주과학교실)
  • Published : 1993.11.30
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Abstract

Glutathione(GSH),a tripeptide thiol, found in virtually all cells, functions in metabolism tranasport and cellular protection. It protects cells against the destructive effects of reactive oxygen intermediates and free radicals. Also ${\gamma}-Glutamyl$ transpeptidase(${\gamma}-GTT$), an enzyme of major importance in GSH metabolism, initiates GSH degradation. In order to explore the $GSH-{\gamma}-GTT$ system as periodontal disease activity indicator, we observed the ${\gamma}-GTT$ and arachidonic acid metabolits according to clinical groups(Control, Adult periodontitis, Rapidly progressive Periodontitis). From the experiments, the following results were obtained. 1. When compared with normal, ${\gamma}-GTT$ of A. P. and R. P. P. were increased, and only the change of ${\gamma}-GTT$ of R. P. P. was statistically significant(P<0. 05). 2. The amounts of arachidonic acid metabolites were not different with statistical significance among the clinical groups. 3. ${\gamma}-GTT$ may by useful adjuncts as new cytoprotective indicator and periodontal disease activity indicator in accordance with positive corelation pocket depth, attachment level and ${\gamma}-GTT$.

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