• Biomedical Science Letters
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• v.22 no.3
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• pp.107-114
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• 2016

Maintenance of fasting blood glucose levels is important for glucose homeostasis. Disruption of feedback mechanisms are a major reason for elevations of glucose level in blood, which is a risk factor for type 2 diabetes mellitus that is mainly caused by malfunction of pancreatic beta-cell and insulin. The fasting blood glucose level has been known to be influenced by genetic and environmental factors. Mitochondria have many functions for cell survival and death: glucose metabolism, fatty acid oxidation, ATP generation, reactive oxygen species (ROS) metabolism, calcium handling, and apoptosis regulation. In addition to these functions, mitochondria change their morphology dynamically in response to multiple signals resulting in fusion and fission. In this study, we aimed to examine association between fasting blood glucose levels and variants of the genes that are reported to have functions in mitochondrial dynamics, fusion and fission, using a cohort study. A total 416 SNPs from 36 mitochondrial dynamics genes were selected to analyze the quantitative association with fasting glucose level. Among the 416 SNPs, 4 SNPs of PRKACB, 13 SNPs of PPP3CA, 6 SNPs of PARK2, and 3 SNPs of GDAP1 were significantly associated. In this study, we were able to confirm an association of mitochondrial dynamics genes with glucose levels. To our knowledge our study is the first to identify specific SNPs related to fasting blood glucose level.

• Journal of Korean Clinical Health Science
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• v.7 no.2
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• pp.1266-1274
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• 2019

Purpose: The purpose of this study was to provide an appropriate direction for effective field practice program by analyzing the influencing factors on satisfaction in ambulance ride practice of paramedic students in Korea. Methods: This study analyzed of 180 paramedic students from 20th to 30th september, 2019. The collected data were analyzed with MedCalc 18.1.0 program. Results: The results of the satisfaction of ambulance riding practice according to the degree of procedure practice are as follows. Satisfaction was high in all groups except the practice time. The lowest satisfaction rate was seen in the category of'There were many cases of applying theories learned at college'within the variable of practice environment(2.82±0.82). The factors affecting the satisfaction of ambulance riding practice were the nurse (β=-0.1472, p=.024) and emergency medical technician(β=-0.3318, p=.002) according to the ambulance worker qualification paramedic, and the practice score (β=0.0048, p<.001). Conclusions: For effective ambulance riding practice, it is necessary to be able to select the practice place where many cases can be experienced, the appropriate selection of the practice leader, and the degree of procedure practice.

• Journal of International Academy of Physical Therapy Research
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• v.7 no.2
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• pp.1031-1036
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• 2016

c-Fos is known to related to synaptic plasticity and apoptosis in damage from ischemia or external injury. The purpose of this study was to investigate whether needle electrode electrical stimulation(NEES) is effective in increasing the number of c-Fos response cells and c-Fos expression in striatum after global ischemia in rats. There were no treatment and occlusion in the control group, global ischemia(GI) group were no treatment after carotid artery occlusion, and needle electrode electrical stimulation(NEES) group were treated with NEES after GI induced. The number of striatum c-Fos response cells and c-Fos protein expression significantly decreased in the NEES group compared to the GI group after 12, 24, 48 hours. The results of the present study suggest that NEES is ineffective in improving global ischemia in rats and may also be ineffective in the globally ischemic human brain.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.38 no.2
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• pp.40-46
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• 2015

The modular assembly system can make it possible for the variety of products to be assembled in a short lead time. In this system, necessary components are assembled to optional components tailor to customers' orders. Budget for inventory investments composed of inventory and purchasing costs are practically limited and the purchasing cost is often paid when an order is arrived. Service cost is assumed to be proportional to service level and it is included in budget constraint. We develop a heuristic procedure to find a good solution for a continuous review inventory system of the modular assembly system with a budget constraint. A regression analysis using a quadratic function based on the exponential function is applied to the cumulative density function of a normal distribution. With the regression result, an efficient heuristics is proposed by using an approximation for some complex functions that are composed of exponential functions only. A simple problem is introduced to illustrate the proposed heuristics.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.37 no.1
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• pp.165-171
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• 2014

We develop an optimization algorithm for a periodic review inventory system under a stochastic budget constraint. While most conventional studies on the periodic review inventory system consider a simple budget limit in terms of the inventory investment being less than a fixed budget, this study adopts more realistic assumption in that purchasing costs are paid at the time an order is arrived. Therefore, probability is employed to express the budget constraint. That is, the probability of total inventory investment to be less than budget must be greater than a certain value assuming that purchasing costs are paid at the time an order is arrived. We express the budget constraint in terms of the Lagrange multiplier and suggest a numerical method to obtain optional values of the cycle time and the safety factor to the system. We also perform the sensitivity analysis in order to investigate the dependence of important quantities on the budget constraint. We find that, as the amount of budget increases, the cycle time and the average inventory level increase, whereas the Lagrange multiplier decreases. In addition, as budget increases, the safety factor increases and reaches to a certain level. In particular, we derive the condition for the maximum safety factor.

• Journal of Korean Physical Therapy Science
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• v.18 no.1
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• pp.69-77
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• 2011

Background: The purpose of this study was to assessment of posture sway on static standing in the elderly. Methods: The participants aged 60 to 90 years, were divided into age such 60s, 70s and 80s and with a history of exercise, arthritis and hang on one's stick. Posture sway were analyzed using the computerized BPM system. Each test was repeated three times. All the data were expressed means and standard deviation by using SPSS 12.0 program. Results: The posture sway test according to sex showed that mean balance, sway number and frequency performance were significantly stable in men than in women. All direction frequency, sway area, sway path and max velocity were significantly unstable in 80s than 70s and 60s. The results of the posture sway test according to exercise group, arthritis and hang on one's stick group were showed that mean balance function was significantly stable in exercise group than arthritis and stick groups. The weight was showed significant correlation by mean balance, sway no, frequency, sway area, sway path and max velocity. Sway area and max velocity were not significant correlation by frequency of lateral and left, right anterior and posterior direction. Conclusion: In this study was showed that posture sway was effected from health condition of elderly.

• Applied Biological Chemistry
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• v.50 no.1
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• pp.1-5
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• 2007

For the purpose of application for biomass of Pleurotus eryngii, the optimum culture condition were tested. It was found that the optimum culture condition for spot culture of pleurotus eryngii were 24$^{\circ}C$ for 18 days with PDA medium. And the optimum culture condition of bioreactor for biomass were pH 5.5, 18$^{\circ}C$ and 27 days with PDMP broth. It was possible to artificial cultivation of mycelial from Pleurotus eryngii using bioreactor for biomass under the optimum conditions, and it was also possible for Pleurotus eryngii biomass because the forming of fruiting body when Pleurotus eryngii was cultivated using mass artificial cultivated mycelial in the bioreactor.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.10a
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• pp.279-281
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• 2017

In the recent years, An attempts have been made to convergence medical technology and IT technology to overcome the limitations of temporal, spatial, and medical technology applications. In this study, we established an environment for emergency information services. The developed smart application for emergency rescue activities support can easily identify emergency situation and First Aid. Then, it can be transmitted to a remote medical guidance doctor so that emergency treatment and hospital response can be performed quickly.

• Proceedings of the Korea Information Processing Society Conference
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• 2002.04b
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• pp.1203-1206
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• 2002

In maned airport, crews may have risks as they manage passenger control system in IPMS in damage situations such as fire in a airport. So the application of unmanned autonomous system can reduce the number of boarding crews and attribute to safe airplane tranportation. PBBC model can be used to obtain control strategy, and airplane and enhance oprators' skill by simulating the airport. The paper suggests an intelligent system of the pbbc control using microprocessor in integrated platform management system which can take measures against passenger situation of a airplane excluding unnecessary warnings with undamaged situations. The system here detected the passenger more accurately and adopted more appriate measures according to airplane status compared with conventional systems.

• Journal of the Korean Institute of Gas
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• v.19 no.6
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• pp.105-109
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• 2015

In this paper is proposed for the oil return device developed to perform efficient emergency operation in the event the sea oil spill. Oil recovery apparatus for spilled oil on marine aims to quickly purged with high recovery. Oil recovery apparatus can prevent secondary pollution which may occur in the purification method using the adhesion agent and chemicals. Also it has excellent properties oil recovery. Adopted by the vapor explosion-proof mechanism to remove the risks that may occur during oil recovery operations.