• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.1
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• pp.83-98
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• 2008

Purpose: This study was performed to determine the inhibitory effect of Soyosangagamhwajae(SYG) on melanin synthesis in B16F10 mouse melanoma cell. Methods: The Inhibitory effects of Soyosangagamhwajae(SYG) on melanin synthesis were determined by in-vitro assay. To elucidate inhibitory effects of SYG on melanin synthesis, we determined the melanin release in B16F10 cell. And to investigate the action mechanism, we assessed the gene expression of tyrosinase, TRP-1, TRP-2. PKA, $PKC{\beta}$ in B16F10 cell. Results: 1. SYG significantly inhibited melanin-release in B16F10 cell. 2. SYG significantly inhibited mushroom tyrosinase activity in vitro. 3. SYG significantly suppressed the expression of tyrosinase in B16F10 cell. 4. SYG significantly suppressed the expression of TRP-1, TRP-2 in B16F10 cell. 5. SYG significantly suppressed the expression of PKA, $PKC{\beta}$ in B16F10 cell. Conclusion: From these results, it may be concluded that SYG has the antimelanogenetic effect.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.21 no.2
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• pp.3-11
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• 2011

Evaluation of cube roots in characteristic three finite fields is required for Tate (or modified Tate) pairing computation. The Hamming weights (the number of nonzero coefficients) in the polynomial representations of $x^{1/3}$ and $x^{2/3}$ determine the efficiency of cube roots computation, where $F_{3^m}$is represented as $F_3[x]/(f)$ and $f(x)=x^m+ax^k+b{\in}F_3[x]$ (a, $b{\in}F_3$) is an irreducible trinomial. O. Ahmadi et al. determined the Hamming weights of $x^{1/3}$ and $x^{2/3}$ for all irreducible trinomials. In this paper, we present formulas for cube roots in $F_{3^m}$ using the shifted polynomial basis(SPB). Moreover, we provide the suitable shifted polynomial basis bring no further modular reduction process.

• Korean Journal of Mathematics
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• v.19 no.4
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• pp.351-365
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• 2011

In the present paper we introduce a new subclass of analytic functions in the unit disc defined by convolution $(f_{\mu})^{(-1)}*f(z)$; where $$f_{\mu}=(1-{\mu})z_2F_1(a,b;c;z)+{\mu}z(z_2F_1(a,b;c;z))^{\prime}$$. Several interesting properties of the class and integral preserving properties of the subclasses are also considered.

• Journal of Ginseng Research
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• v.35 no.1
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• pp.86-91
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• 2011

Ginsenoside (G)-F1 is an enzymatic metabolite generated from G-Rg1. Although this metabolite has been reported to suppress platelet aggregation and to reduce gap junction-mediated intercellular communication, the modulatory activity of G-F1 on the functional role of skin-derived cells has not yet been elucidated. In this study, we evaluated the regulatory role of G-F1 on the cellular responses of B16 melanoma cells. G-F1 strongly suppressed the proliferation of B16 cells up to 60% at 200 ${\mu}g/mL$, while only diminishing the viability of HEK293 cells up to 30%. Furthermore, G-F1 remarkably induced morphological change and clustering of B16 melanoma cells. The melanin production of B16 cells was also significantly blocked by G-F1 up to 70%. Interestingly, intracellular signaling events involved in cell proliferation, migration, and morphological change were up-regulated at 1 h incubation but down-regulated at 12 h. Therefore, our results suggest that G-F1 can be applied as a novel anti-skin cancer drug with anti-proliferative and anti-migration features.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.05
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• pp.43-46
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• 1997

The interfacial bond strength and microstructural analysis of pre-heat treated porcelain-fused-metal (PFM) were investigated using a mechanical three-point bending tester and scanning electron microscope(SEM). Four kinds of heat treated samples were prepared as follows; A: heating $1200^{\circ}F\rightarrow1600^{\circ}F$, holding 1min, reheating $\rightarrow1850^{\circ}F$, hold 3min under vacuum, B: heating $1200^{\circ}F\rightarrow1600^{\circ}F$ holding 1min, reheating $\rightarrow1850^{\circ}F$ under vacuum condition, C: heating $1200^{\circ}F\rightarrow1600^{\circ}F$, holding 1min, reheating $\rightarrow1850^{\circ}F$, holding 3min in the air, repeat same heat treatment process under vacuum condition, D: heating $1200^{\circ}F\rightarrow1600^{\circ}F$, holding 1min, reheating $\rightarrow1850^{\circ}F$, holding 1min in the air. The three-point bending test results shows that the interfacial bond strength of specimen B and C were higher than that of A and B. The SEM study reveals that Specimen C shows the highest surface density.

• YAKHAK HOEJI
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• v.52 no.6
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• pp.488-493
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• 2008

2-Aminothiazole ring as a bioisoster of catechol in dopamine has provided with good oral availability and lipophilic property. 2-Aminoindan, is a rigid form of dopamine, was evaluated as a dopamine D3 agonist with low neurotoxicity. Dopamine D3 agonist was evaluated as selective for the treatment of Parkinson's disease. In order to develop a novel dopamine D3 agonist, we tried to synthesize the aminothiazoloindenoxazine derivative that is a hybrid structure of aminoindenoxazine and thiazole ring. cis-2-Amino-1-indanol (2) was synthesized from 1,2-indandione-2-oxime by catalytic hydrogenation and it was treated with chloroacetyl chloride and NaH in benzene solution to give (${\pm}$)-cis-4,4a,5,9b-tetrahydroindeno[1,2-b][1,4]oxazin-3(2H)-one (6). Nitration of 6 by the mixed acid gave 8-nitro compound (7) and the carbonyl group of 7 was reduced with $LiAlH_4$ to afford compound (8). 8 was reduced to form (${\pm}$)-cis-8-amino-2,3,4,4a,5,9b-hexahydroindeno[1,2-b][1,4]oxazine (9) and finally it was cyclized with KSCN in glacial acetic acid to yield (${\pm}$)-cis-8-amino-2,3,4,4a,5,10b-hexahydrothiazolo[4,5-f]indeno[1,2-b][1,4]oxazine (10).

• The Pure and Applied Mathematics
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• v.30 no.1
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• pp.43-65
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• 2023

In this paper, by using the difference analogue of Nevanlinna's theory, the authors study the shared-value problem concerning two higher order difference operators of a transcendental entire function with finite order. The following conclusion is proved: Let f(z) be a finite order transcendental entire function such that λ(f - a(z)) < ρ(f), where a(z)(∈ S(f)) is an entire function and satisfies ρ(a(z)) < 1, and let 𝜂(∈ ℂ) be a constant such that ∆_𝜂ⁿ⁺¹ f(z) ≢ 0. If ∆_𝜂ⁿ⁺¹ f(z) and ∆_𝜂ⁿ f(z) share ∆_𝜂ⁿ a(z) CM, where ∆_𝜂ⁿ a(z) ∈ S ∆_𝜂ⁿ⁺¹ f(z), then f(z) has a specific expression f(z) = a(z) + Be^Az, where A and B are two non-zero constants and a(z) reduces to a constant.

• Journal of the Korean Magnetics Society
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• v.23 no.5
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• pp.154-158
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• 2013

We have analyzed the magnetization curves measures by using VSM and MOKE in synthetic antiferromagnetic coupled CoB/Ru/CoB thin film. The measured results were compared with calculated ones by Stoner-Wohlfarth model based on the magnetization behavior of two ferromagnetic layers ($M_1$, $M_2$). The calculated total magnetization ($M_{tot}=M_1+M_2$) and single layer magnetization($M_1$) behaviors were compared with measured results by using VSM and MOKE, respectively. The total magnetization curve ($M_{tot}=M_1+M_2$) showed reversible magnetization behavior with flopping field of about 50 Oe. While single layer magnetization ($M_1$) behaviors showed irreversible magnetization behavior in the field range of $H_F$ < H < $H_F$. These magnetization behaviors were explained by the angle difference between magnetization directions of two ferromagnetic layers in SAF sample.

• Communications of the Korean Mathematical Society
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• v.33 no.3
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• pp.889-899
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• 2018

In this paper, we present some upper bounds for unitarily invariant norms inequalities. Among other inequalities, we show some upper bounds for the Hilbert-Schmidt norm. In particular, we prove $${\parallel}f(A)Xg(B){\pm}g(B)Xf(A){\parallel}_2{\leq}{\Large{\parallel}}{\frac{(I+{\mid}A{\mid})X(I+{\mid}B{\mid})+(I+{\mid}B{\mid})X(I+{\mid}A{\mid})}{^dA^dB}}{\Large{\parallel}}_2$$, where A, B, $X{\in}{\mathbb{M}}_n$ such that A, B are Hermitian with ${\sigma}(A){\cup}{\sigma}(B){\subset}{\mathbb{D}}$ and f, g are analytic on the complex unit disk ${\mathbb{D}}$, g(0) = f(0) = 1, Re(f) > 0 and Re(g) > 0.

• The KIPS Transactions:PartB
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• v.15B no.2
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• pp.131-136
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• 2008

L(2,1)-labeling of a graph G is a function f: V(G) $\rightarrow$ {0, 1, 2, ...} such that $|f(u)\;-\;f(\upsilon)|\;{\geq}\;2$ when d(u, v) = 1 and $|f(u)\;-\;f(\upsilon)|\;{\geq}\;1$ when d(u, $\upsilon$) = 2. L(2,1)-labeling number of G, denoted by ${\lambda}(G)$, is the smallest number m such that G has an L(2,1)-labeling with no label greater than m. Since this problem has been proved to be NP-complete, in this article, we develop genetic algorithms for L(2,1)-labeling problem and show that the suggested genetic algorithm peforms very efficiently by applying the algorithms to the class of graphs with known optimum values.