• Biomolecules & Therapeutics
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• v.29 no.1
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• pp.41-51
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• 2021

Src family kinases (SFKs), an important group of non-receptor tyrosine kinases, are suggested to be excessively activated during various types of tissue fibrosis. The present study investigated the effect of KF-1607, an orally active and a newly synthesized Src kinase inhibitor (SKI) with proposed low toxicity, in preventing the progression of renal interstitial fibrosis. Unilateral ureteral obstruction (UUO) surgery was performed in 6-week-old male C57BL/6 mice to induce renal interstitial fibrosis. Either KF-1607 (30 mg/kg, oral gavage) or PP2 (2 mg/kg, intraperitoneal injection), a common experimental SKI, was administered to mice for seven days, started one day prior to surgery. UUO injury-induced SFK expression, including Src, Fyn, and Lyn kinase. SFK inhibition by KF-1607 prevented the progression of tubular injury in UUO mice, as indicated by decreases in albuminuria, urinary KIM-1 excretion, and kidney NGAL protein expression. Renal tubulointerstitial fibrosis was attenuated in response to KF-1607, as shown by decreases in α-SMA, collagen I and IV protein expression, along with reduced Masson's trichrome and collagen-I staining in kidneys. KF-1607 also inhibited inflammation in the UUO kidney, as exhibited by reductions in F4/80 positive-staining and protein expression of p-NFκB and ICAM. Importantly, the observed effects of KF-1607 were similar to those of PP2. A new pan Src kinase inhibitor, KF-1607, is a potential pharmaceutical agent to prevent the progression of renal interstitial fibrosis.

• Bulletin of the Korean Mathematical Society
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• v.52 no.5
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• pp.1607-1619
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• 2015

We investigate some generalization of a class of Hankel-Clifford transformations having Fox H-function as part of its kernel on a class of Boehmians. The generalized transform is a one-to-one and onto mapping compatible with the classical transform. The inverse Hankel-Clifford transforms are also considered in the sense of Boehmians.

• Bulletin of the Korean Chemical Society
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• v.26 no.10
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• pp.1607-1610
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• 2005

• The Bulletin of The Korean Astronomical Society
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• v.21
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• pp.17.2-18
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• 1996

• Asia Marketing Journal
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• v.25 no.1
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• pp.1-2
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• 2023

• Proceedings of the Korea Information Processing Society Conference
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• 2015.10a
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• pp.1607-1609
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• 2015

정보통신 기술의 발달과 스마트폰의 보급으로 일반 사용자들은 언제, 어디서나 가족 및 주변 사용자들의 모습을 바라보며 통화할 수 있게 되었고, 원하는 영상이나 사진을 감상할 수 있다. 하지만 시각장애인들은 이들을 위한 연구 및 사회적 인프라의 부족으로 인하여 이와 같은 서비스들의 제공 대상에서 늘 제외되어 왔다. 이러한 사항을 개선하기 위하여 본 연구는 시각장애인들을 위한 새로운 방식의 촉각 TV 시스템을 제안한다. 제안하는 시스템은 크게 3D 캡쳐(Capture) 기술, 실시간 전송/스트리밍 기술, 햅틱(Haptic) 장치 및 액츄에이터(Actuator)제어 기술로 구성된다.

• Proceedings of the Korea Information Processing Society Conference
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• 2010.11a
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• pp.1607-1608
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• 2010

본 논문은 통신기반 열차제어방식으로 주목 받고 있는 CBTC 시스템의 지상장치 소프트웨어 기능을 모델기반 개발도구인 SCADE 를 이용하여 설계하는 기법을 제시한다. CBTC 지상장치의 ATO 기능은 모델링 후 다양한 테스트 케이스를 통해서 기능을 검증하였다. 수행된 모델링을 통해서 SCADE 가 CBTC 소프트웨어 시스템을 개발하는데 효과적으로 사용될 수 있음을 제시한다.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2013.05a
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• pp.1607-1608
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• 2013

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2011.06a
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• pp.1607-1608
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• 2011

• Journal of the Korea Institute of Information Security & Cryptology
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• v.25 no.6
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• pp.1607-1620
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• 2015

The server privilege account must be operated through law and regulation. However, due to regulation non-compliance and inadequate operation on financial company server privilege, an incident that every server data being deleted by hacker occur which is later being named as 'NH Bank Cyber Attack'. In this paper, the current operation status on financial company privilege accounts is being analysed to elicit problems and improvement. From the analysis, important evaluation factors will be also selected and applied generating the decision making model for financial company server privilege account operation. The evaluation factor deducted from privilege account status analysis will be used to present and verify the decision making model and formula through AHP(Analytic Hierarchy process).