• Journal of Information Technology Services
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• v.10 no.1
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• pp.191-209
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• 2011

The purpose of this research is to develop a service R&D concept definition and finding service R&D demand in Korea. It is necessary to develop an effective service R&D model to improve the competitiveness of the service industry. A survey model for finding service R&D demands has been developed through extensive discussions with experts. A demand survey for 91 experts in service industry and academia has been conducted to find relative weights of each service R&D category. Several other aspects on service R&D has beed investigated to analyze the relative importance of service R&D subjects. And a benchmarking on previous service R&D research investment has been performed. Past and present service R&D topics are compared as a whole and by each individual domain. A service R&D framework and important funding areas has been suggested. The results of this research can be used for research fund allocation decisions for strengthening service industry competitiveness.

• Bulletin of the Korean Mathematical Society
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• v.61 no.1
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• pp.273-280
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• 2024

Let I be an ideal of a commutative Noetherian semi-local ring R and M be an R-module. It is shown that if dim M ≤ 2 and Supp_R M ⊆ V (I), then M is I-weakly cofinite if (and only if) the R-modules Hom_R(R/I, M) and Ext¹_R(R/I, M) are weakly Laskerian. As a consequence of this result, it is shown that the category of all I-weakly cofinite modules X with dim X ≤ 2, forms an Abelian subcategory of the category of all R-modules. Finally, it is shown that if dim R/I ≤ 2, then for each pair of finitely generated R-modules M and N and each pair of the integers i, j ≥ 0, the R-modules Tor^R_i(N, H^j_I(M)) and Extⁱ_R(N, H^j_I(M)) are I-weakly cofinite.

• Toxicological Research
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• v.8 no.2
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• pp.235-253
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• 1992

A subacute toxicity study of cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II)(SKI 2053R) was carried out to obtain information on its toxicological profiles, and to determine the maximum tolerated dose in beagle dogs. Four groups of beagle dogs (2M and 2F per group, 0,0.5,1.0,2.0mg/kg/day)were given 15 i.v. injections of SKI 2053R. In order to compare the toxic effects of SKI 2053R with those of cisplatin, one group was treated with cisplatin(0.7mg/kg/day)according to the same treatment schedule. The dosing schedule was divided into 3 courses of 5 consecutive days with 23-day dose-free intervals between each course. After completion of the treatments, remaining dogs were necropsied under established guidelines. Three of four dogs in the high dose group and one of four dogs in the middle dose group treated with SKI 2053R died of hypovolemic shock secondary to hemorrhagic and ulcerative enterocolitis. No toxicity-related mortality occurred in the low dose group of SKI 2053R. No survivor was observed in the group of cisplatin. Clinical signs including vomiting, diarrhea, anorexia and loss body weight were apparent in dogs given either cisplatin or high and middle doses of SKI 2053R. Severe thrombocytopenia and leukocytopenia were observed in the high dose group of SKI 2053R and cisplatin-treatment group, while toxicities as bone marrow suppression were reversible. The significant elevation of serum ALP values in group of SKI 2053R(2.0 mg/kg/day and 1.0mg/kg/day) and cisplatin(0.7mg/kg/day)was observed. Slight proteinuria waa observed in high and middle dose level groups of SKI 2053R. In histopathological examinations, pathological alterations of liver, kidney and spleen were noted dose-dependantly in dogs treated with SKI 2053R, and there was no overt sign of toxicity in low dose group of SKI 2053R. Compared to SKI 2053R, more severe durg-related toxicities occurred in dogs treated with cisplatin. It waw estimated that maximum tolerated dose of SKI 2053R in this treatment schedule was 0.5~0.7mg/kg/day. In conclusion, overall toxic potential of SKI 2053R was approximately 3 times lower than that of cisplatin with respect of lethality.

• Food Science of Animal Resources
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• v.24 no.4
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• pp.355-360
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• 2004

In Korean beef market, one of the major problems is mislabeling or fraudulent distribution of Holstein dairy meat or imported beef as domestic Hanwoo meat. Therefore, there has been a great need for a development of technology to identify beef breeds in meat and meat products. This study was carried out to develop the accurate and reliable method for the identification of beef breed using PCR-RFLP marker of MC1R, MGF and TYRPl genes affecting coat colors in cattle. A single base substitution (G\longrightarrowT transition) at the codon for amino acid position 104 of MC1R gene was identified between Hanwoo and Holstein and Angus breeds. The change at this position creates Msp I restriction site in Holstein and Angus, but not in Hanwoo. When the DNA amplified products (537 bp) was digested with Msp I, Hanwoo meat showed a single band of 537bp, while two fragments of 329bp and 208 bp were observed in Holstein meat and Angus breed, respectively. Thus, breed-specific RFLP marker in the MC1R gene can be used to distinguish between Hanwoo meat and Holstein and Angus meats. In the RFLP genotype of MGF gene, the frequency of r/r type was 75％ in Manwoo, whereas the frequency of R/R was 80％ in Hereford breed. Holstein and Angus breeds showed 100％ for R/r type. Therefore, Hanwoo meat showed significant difference in the MGF genotype frequencies compared with those of Holstein meat and imported beef cattle breeds. However, TYRP1 gene showed the same genotype in all breeds examined. Thus, this TYRP1 gene can not be used as a molecular marker for breed identification. As a consequence, we suggest that RFLP markers of the MC1R and MGF coat color genes could be used as DNA marker for identification of Hanwoo meat from Holstein and imported meats.

• IMMUNE NETWORK
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• v.24 no.3
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• pp.21.1-21.16
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• 2024

IL-1, a pleiotropic cytokine with profound effects on various cell types, particularly immune cells, plays a pivotal role in immune responses. The proinflammatory nature of IL-1 necessitates stringent control mechanisms of IL-1-mediated signaling at multiple levels, encompassing transcriptional and translational regulation, precursor processing, as well as the involvement of a receptor accessory protein, a decoy receptor, and a receptor antagonist. In T-cell immunity, IL-1 signaling is crucial during both the priming and effector phases of immune reactions. The fine-tuning of IL-1 signaling hinges upon two distinct receptor types; the functional IL-1 receptor (IL-1R) 1 and the decoy IL-1R2, accompanied by ancillary molecules such as the IL-1R accessory protein (IL-1R3) and IL-1R antagonist. IL-1R1 signaling by IL-1β is critical for the differentiation, expansion, and survival of Th17 cells, essential for defense against extracellular bacteria or fungi, yet implicated in autoimmune disease pathogenesis. Recent investigations emphasize the physiological importance of IL-1R2 expression, particularly in its capacity to modulate IL-1-dependent responses within Tregs. The precise regulation of IL-1R signaling is indispensable for orchestrating appropriate immune responses, as unchecked IL-1 signaling has been implicated in inflammatory disorders, including Th17-mediated autoimmunity. This review provides a thorough exploration of the IL-1R signaling complex and its pivotal roles in immune regulation. Additionally, it highlights recent advancements elucidating the mechanisms governing the expression of IL-1R1 and IL-1R2, underscoring their contributions to fine-tuning IL-1 signaling. Finally, the review briefly touches upon therapeutic strategies targeting IL-1R signaling, with potential clinical applications.

• Microbiology and Biotechnology Letters
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• v.36 no.1
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• pp.28-33
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• 2008

The expression vector (pWHM3-TR1R2) for sprT gene encoding Streptomyces griseus trypsin (SGT) followed by two regulatory genes, sgtR1 and sgtR2, was introduced into Streptomyces lividans TK24 and Streptomyces griseus IFO 13350. Various media with different compositions were used to maximize the productivity of SGT in the recombinant trains. he SGT productivity was best when the transformant of S. lividans TK24 was cultivated in R2YE medium (0.74 unit/mL) at 5 days of cultivation. C5/L (0.66 unit/mL) medium also gave a good productivity, but Livid (0.08 unit/mL) and NDSK (0.06 unit/mL) yielded poor productivities. S. griseus IFO 13350/pWHM3-TR1R2 produced SGT by 1.518 unit/mL (C5/L), 1.284unit/mL (R2YE),0.932 unit/mL (NDSK), and 0.295 unit/mL (Livid) at 7 days of cultivation, which was much higher than those from S. lividans TK24/TR1R2. The SGT protein was purified from the culture broth of S. griseus IFO 13350/pWHM3-TR1R2 in C5/L to homogeneity via ammonium sulfate fractionation, and CM-sepharose and SP-sepharose column chromatographies. The specific activity of purified SGT was 69,252 unit/mg, and the final purification fold and recovery yield were 6.5 and 1.4%, respectively.

• The Journal of the Korea Contents Association
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• v.20 no.9
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• pp.511-519
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• 2020

The aim of this study was to translate and validate the revised Nottingham Sensory Assessment(rNSA) in Republic of Korea. A cross-sectional study was conducted to translate the rNSA into Korean using a modified forward/backward translation procedure. Inter-rater and intra-rater reliability, internal consistency, and concurrent validity were investigated to validate the Korean version rNSA. The Korean version rNSA showed excellent inter-rater reliability (r=0.92-1.00) and intra-rater reliability (r=0.93-1.00). Significant correlations were found between sensory assessment results of the Korean version of the rNSA and the Korean Fugl Meyer Assessment Sensory subscales (r=0.96). The Cronbach α value of internal consistency of Korean version rNSA was ranged from 0.73 to 0.90, the value of K-FMA-S was ranged from 0.70 to 0.88. In these results, psychometric properties of the Korean version of the rNSA achieved the standard level and can be feasible in clinical practice to assess sensory function following stroke in Republic of Korea.

• Archives of Pharmacal Research
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• v.23 no.2
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• pp.151-154
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• 2000

Two sesquiterpene endoperoxides, 1S, 4R, 6R-1, 4-endoperoxy-bisabola-2, 10-diene (1), 1R, 4S, 6R-1, 4-endoperoxy-bisabola-2, 10-diene (II), and a sesquiterpene hydroperoxide, 1$\beta$-hydroperoxygermacra-4 (15), 5, 10 (14)-triene (III) were isolated from the aerial parts of Artemisia stolonifera (Compositae). Their chemical structures were assigned by spectral evidences. Compounds I and II exhibited cytotoxicity against five human tumor cell lines with their $\ED_50 values ranging from 0.20 to 5.43 ${\mu}g/m\ell$ and from <0.1 to 0.87 ${\mu}g/m\ell$, respectively.

• Journal of the Chungcheong Mathematical Society
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• v.23 no.4
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• pp.731-739
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• 2010

In this paper, we prove stability of the reciprocal difference functional equation $$r\(\frac{{\sum}_{i=1}^{m}x_i}{m}\)-r\(\sum_{i=1}^{m}x_i\)=\frac{(m-1){\prod}_{i=1}^{m}r(x_i)}{{\sum}_{i=1}^{m}{\prod}_{k{\neq}i,1{\leq}k{\leq}m}r(x_k)$$ and the reciprocal adjoint functional equation $$r\(\frac{{\sum}_{i=1}^{m}x_i}{m}\)+r\(\sum_{i=1}^{m}x_i\)=\frac{(m+1){\prod}_{i=1}^{m}r(x_i)}{{\sum}_{i=1}^{m}{\prod}_{k{\neq}i,1{\leq}k{\leq}m}r(x_k)$$ in m-variables. Stability of the reciprocal difference functional equation and the reciprocal adjoint functional equation in two variables were proved by K. Ravi, J. M. Rassias and B. V. Senthil Kumar [13]. We extend their result to m-variables in similar types.

• Bulletin of the Korean Chemical Society
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• v.29 no.1
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• pp.43-46
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• 2008

The aim of present study was to examine the inhibitory effects of hydroxamic acid derivatives on the melanogenesis. We found that hydroxamic acid moiety was important for anti-melanogenic activity. Compounds 1a and 1b strongly inhibited melanin synthesis via deactivation of tyrosinase. Hydroxamic acid has metal ion chelating ability which is similar to that kojic acid, however, anti-tyrosinase mechanism of compounds 1a and 1b was different from that of kojic acid. They showed noncompetitive inhibition kinetics