• Natural Product Sciences
• /
• v.27 no.4
• /
• pp.264-273
• /
• 2021

Simultaneous quantification of multiple marker compounds in herbal medicine by high performance liquid chromatography (HPLC) analysis is still a challenge due to the complexity in various parameters to be considered and co-existing multi-components. As a case study, a reliable HPLC method for simultaneous quantification of paeoniflorin from Paeoniae Radix and decursin from Angelicae Gigantis Radix in various commercial herbal medicine was developed based on analytical quality by design (AQbD) strategy. As a first step, risk assessment was performed to select the critical method parameters (CMPs) which were decided as organic mobile phase ratio and column oven temperature. In order to evaluate the effect of the CMPs on critical method attributes (CMAs) of peak resolution and tailing, central composite design (CCD) was employed. The final chromatographic conditions were optimized as follows: column- C₁₈, 4.6 × 250 mm, 5 ㎛ particle size; mobile phase- A: acetonitrile, B: 0.1% acetic acid water; detection wavelength- 235 nm for paeoniflorin, 325 nm for decursin; column oven temperature- 25℃; flow rate- 1.0 mL/min; gradient mobile phase system as Time (min) : % A, 0:14, 25:14, 30:50, 60:50, 61:100, 65:100, 66:14, 75:14. The method was successfully validated according to the International Conference on Harmonization (ICH) guidelines and piloted for ten commercial herbal medicines.

• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.21 no.6
• /
• pp.74-80
• /
• 2022

The surface status of a workpiece determines its functionality, product quality, and manufacturing costs. Thus, several finishing technologies have been widely investigated and applied to improve surface characteristics. In this study, rotational electro-magnetic abrasive finishing (REMAF) was suggested as a non-contact finishing process to achieve high geometric precision. To verify the effects of the REMAF process on burr removal on the surface of Al6061, experiments were conducted using the Taguchi method. Based on the experimental results analyzed by the S/N ratio and ANOVA, the optimal conditions were defined as A₃B₂C₃D₃ that corresponded to 1,800 rpm of rotational speed, 1.5 kg of abrasive particle weight, 0.7 mm of abrasive diameter, and 15 min of working time. In addition, the particle weight was a key attribute for deburring, whereas the working time was less effective.

• Advances in aircraft and spacecraft science
• /
• v.9 no.2
• /
• pp.131-148
• /
• 2022

The paper presents the surface-modified NACA 2412 airfoil performance with variable cavity characteristics such as size, shape and orientation, by numerically investigated with the pre-validation study. The study attempts to improve the airfoil aerodynamic performance at 30 m/s with a variable angle of attack (AOA) ranging from 0° to 20° under Reynolds number (R_e) 4.4×10⁵. Through passive surface control techniques, a boundary layer control strategy has been enhanced to improve flow performance. An intense background survey has been carried out over the modifier orientation, shape, and numbers to differentiate the sub-critical and post-critical flow regimes. The wall-bounded flows along with its governing equations are investigated using Reynolds Average Navier Strokes (RANS) solver coupled with one-equational transport Spalart Allmaras model. It was observed that the aerodynamic efficiency of cavity airfoil had been improved by enhancing maximum lift to drag ratio ((l/d) max) with delayed flow separation by keeping the flow attached beyond 0.25C even at a higher angle of attack. Detailed investigation on the cavity distribution pattern reveals that cavity depth and width are essential in degrading the early flow separation characteristics. In this study, overall general performance comparison, all the cavity airfoil models have delayed stalling compared to the original airfoil.

• International conference on construction engineering and project management
• /
• 2015.10a
• /
• pp.405-410
• /
• 2015

Today, the booming construction in Ethiopia is leading to an increased demolition of concrete structures whereby these demolished structures are disposed at landfills. The current practice is creating a huge amount of waste which is environmentally unfriendly and is becoming the main source of pollution in communities. This paper discusses the potential use of demolished concrete from site tested specimens as a recycled aggregate material for new structural concrete. The mechanical, physical and chemical properties of RCA are studied to understand the suitability in the production of recycled concrete. Tests including gradation, unit weight, soundness, density, and abrasion will be conducted to assess RCA properties. Since the percentage of RCA govern the strength of concrete, a C25 concrete is mixed by the ratio of 25%, 50% & 100% RCA with and without water reducing admixture and a control mixture composed of natural aggregate. The output of this study will highly impact the growing construction industry and communities in Ethiopia thereby reducing waste, saving cost, conserving natural aggregates, building capacity and setting quality standards.

• Fisheries and Aquatic Sciences
• /
• v.27 no.5
• /
• pp.283-293
• /
• 2024

Mahseer (Tor soro) growth performance tends to be slow, necessitating further development and intensification of cultivation. One way to develop aquaculture intensification is to manipulate cultivation containers to create optimal environmental conditions for the mahseer to grow. This study aimed to examine the body performance and growth performance of mahseer reared in different colored containers. Experimental research with completely randomized design was employed, with four colored container treatments namely treatment A (transparent), B (green), C (blue), and D (black), with four replications in each treatment. Findings indicate that different rearing media colors had significant effect on absolute length (4.68 ± 0.24 cm), absolute weight (1.58 ± 0.35 g), specific growth rate (2.17 ± 0.38%), feed conversion ratio (2.87 ± 0.04), survival rate (100 ± 0.00%), gross energy (3,816 ± 65.05 cal/g), and body proximate. Physiologically, mahseer fish bred using blue and black containers tend to be more resistant to stress.The best body performance and growth performance were observed in the blue and black colored containers.

• Transactions of Materials Processing
• /
• v.33 no.4
• /
• pp.241-247
• /
• 2024

The triply periodic minimum surface (TPMS) shape with a complex geometry can easily manufactured from additive manufacturing processes. The TPMS shape has a high surface-to-volume ratio. In addition, the TPMS shape increases the possibility of the self-circulation when the fluid flows inside the TPMS structure. Due to these reason, the performance of the fluid flow filter can be greatly improved when the TPMS structure is applied to the filter. The aim of this paper is to investigate the influence of the design of the unit cell for TPMS on self-circulation characteristics of air using computational fluid dynamics (CFD). From the results of the CFD, the effects of the shape and the dimension of the unit cell for TPMS on the self-circulation pattern and the pressure difference are examined. Finally, a proper design of the TPMS is discussed from the viewpoint of self-circulation of air.

• Structural Monitoring and Maintenance
• /
• v.11 no.3
• /
• pp.219-234
• /
• 2024

The strength reduction factor spectrum is traditionally obtained from a single-degree-of-freedom (SDOF) system with a constant damping coefficient. However, according to the principle of Rayleigh damping, the damping coefficient matrix of a system changes with the stiffness matrix, and the damping coefficient of an equivalent SDOF system changes with the tangent stiffness coefficient. In view of that, this study proposes an equivalent SDOF system with an adaptive damping coefficient and derives a standardized reaction balance equation. By iteratively adjusting the strength reduction factor, the corresponding spectrum with an equivalent ductility factor is obtained. In addition, the ratio between the strength reduction factor that considers adaptive damping and the traditional strength reduction factor, denoted by η, is determined, and the η-μ-T relationship is obtained. Seismic records of Classes C, D, and E sites are selected as excitations. Moreover, a nonlinear response time-history analysis is performed to establish the relationship between the η and T values for the equivalent ductility factor μ. Further, by exploring the effects of the site class, ductility factor, second-order stiffness coefficient, and period T on the mean value of η, a simplified calculation equation of mean η is derived, and η is used as a modified value for the traditional strength reduction factor R spectrum.

• Structural Engineering and Mechanics
• /
• v.92 no.2
• /
• pp.207-226
• /
• 2024

Recently, the phenomenon of disproportionate structural failure caused by blast load has grown more common in the field of engineering design. Blast-resistant analyses and designs have been developed by many structural techniques and methodologies to forecast the loads produced by a high explosive charge on structures with complicated geometry. These techniques are based on a good understanding of blast phenomena to analyze structures exposed to blast load. This paper provides a current state-of-the-art review of blast prediction and simulation methods to predict the design blast loads that are used to assess the structural response and damage level to an existing or new building. The damage criteria from the general design approach relevant to civil design applications in forecasting blast loads as well as structural system responses will be provided. Identifying the structures' expected damage class would aid in providing extra reinforcing or strengthening for damaged elements to meet the acceptance criteria or minimize damage by a suitable blast mitigation strategy. Based on identifying the damage class expected of a structure subjected to an explosion, blast mitigation strategies could be used to minimize damage and maximize the ability of the structure to function even after the explosion.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.42 no.2 s.332
• /
• pp.73-82
• /
• 2005

Test data volume and power consumption for scan vectors are two major problems in system-on-a-chip testing. Therefore, this paper proposes a new test data compression/decompression method for low power testing. The method is based on analyzing the factors that influence test parameters: compression ratio, power reduction and hardware overhead. To improve the compression ratio and the power reduction ratio, the proposed method is based on Modified Statistical Coding (MSC), Input Reduction (IR) scheme and the algorithms of reordering scan flip-flops and reordering test pattern sequence in a preprocessing step. Unlike previous approaches using the CSR architecture, the proposed method is to compress original test data, not $T_{diff}$, and decompress the compressed test data without the CSR architecture. Therefore, the proposed method leads to better compression ratio with lower hardware overhead and lower power consumption than previous works. An experimental comparison on ISCAS '89 benchmark circuits validates the proposed method.

• Land and Housing Review
• /
• v.3 no.4
• /
• pp.433-449
• /
• 2012

An experimental investigation was conducted to study the behavior of RC wide beam-column joints with slab subjected to reversed cyclic loads under constant axial load. Six half scale interior wide beam-column assemblies representing a portion of a frame subjected to simulated seismic loading were tested, including three specimens without slab and three specimens with slab. The primary variables were the ratio of column-to-beam flexural capacity ($M_r={\Sigma}M_c/{\Sigma}M_b$ ; 0.77~2.26), ratio of the column-to-beam width (b/H ; 1.54, 1.67). Test results are shown that (1) the current design code and practice for interior joints(type 2) are apply to the wide beam-high strength concrete column. (2) the presence of a slab have an effect on the performance of the wide beam-high strength concrete column interior joints(type 2). therefore in the design of the wide beam-high strength concrete column interior joints(type 2), the width of slab effective as a T beam flange should be considered. It was show that the case of the ratio of column-to-beam flexural capacity is more than 2.0, the effective width of slab are 2 times of an effective depth of wide beam, however if the ratio of column-to-beam flexural capacity is 1.4~2.0, the effective width of slab are not able to be considered.