• Natural Product Sciences
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• 제13권2호
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• pp.164-168
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• 2007

To investigate natural antibiotics from plant essential oils and to evaluate their synergism with current antimicrobial drugs in inhibiting antibiotic-resistant strains of Streptococcus pneumoniae. The minimal inhibitory concentrations (MICs) of eleven plant essential oils and their main components were established for two antibiotic-susceptible and two antibiotic-resistant strains of S. pneumoniae, using broth microdilution tests. Potential synergism with oxacillin, norfloxacin, or erythromycin was evaluated using a checkerboard microtitre assay. Among the tested oils, Mentha piperita oil and its main component, menthol, exhibited the strongest inhibitory activities against all of the tested strains. The activity of antibiotics against antibiotic-resistant strains of S. pneumoniae was enhanced significantly by combination with Mentha piperita oils and its main component, menthol. In conclusion, the combination Mentha piperita essential oil or menthol with antibiotics could be used to reduce the effective dose of antibiotic and to modulate the resistance of S. pneumoniae strains.

• 생명과학회지
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• 제19권9호
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• pp.1333-1336
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• 2009

식용장미인 로즈차와 야생장미 열매인 로즈힙(rosa spp)을 건조시킨 허브차는 오래 전부터 미국과 유럽 등에서 식용되어 왔고 우리나라에도 수입되어 판매된다. 본 연구는 허브차의 기호성에 영향을 미치는 향기 성분을 동시증류추출(SDE)장치를 사용하여 추출하고 gas chromatography와 GC-mass spectrometry를 사용하여 분석 한 결과, 로즈차와 로즈힙차에서 각각 38 종류와 36종류의 향기성분을 동정하였다. 로즈차의 향기성분으로 중요한 화합물은 phenylethyl alcohol, citronellol, menthol, menthone, linalool 및 geraniol 등이었는데 특히 장미향을 띄는 phenylethyl alcohol과 citronellol은 많은 함량 포함되어 있었다. 한편, 로즈힙차에는 menthol, $\alpha$-anethole, $\alpha$-terpinolene, menthone, linalool 및 6-methyl-5-heptene-2-one등이 포함되어 있었는데. 특히 청량감 있는 페프민트 향인 menthol과 달콤한 아니스와 같은 향인 $\alpha$-anethole은 다소 많은 함량 포함되어 있었다.

• 한국연초학회지
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• 제1권2호
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• pp.149-151
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• 1979

• 한국임상약학회지
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• 제26권3호
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• pp.187-194
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• 2016

Background: Alopecia areata (AA) is a very disturbing and expensive disorder in which the exact etiology is not known and it is yet to be treated completely well. Most alopecia patients exhibit some inflammation in the hair follicles regardless of the causes. The clinical symptoms of alopecia present very diversely while the prime symptom is local intermittent fever which are related to inflamed cells. Methods: This study aimed to evaluate how repetitive intermittent fever can damage the normal human dermal fibroblast (NHDF) cells and investigated the cytotoxic and proliferative effects after application of new candidate drugs (ibuprofen, menthol, cetirizine) for alopecia in comparison to minoxidil. Results: This study demonstrated that ibuprofen, menthol, or/and cetirizine can prevent or slow down the damage of NHDF cells from intermittent fever in early alopecia. Aggressive preventative intervention with those drugs before complete destruction of hair follicle by excessive repetitive fever, is a very important step for alopecia therapy and these drugs are recommended as candidate drugs for alopecia in the future. Conclusion: Aggressive preventative intervention with drugs before complete destruction of hair follicles (NHDF cells) by excessive repetitive fever is a very important step for alopecia therapy or progression.

• 한국잠사곤충학회지
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• 제2권
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• pp.33-39
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• 1962

춘하추 삼기사육에 있어서 연구조사한 결과 본시험에서 다음과 같은 결과를 얻었다. 1. Menthol의 상기첨식시험에서 Menthol의 1%내에서는 잠아의 생리에 하등의 영향이 없다는 결과를 얻었다. 이 결과는 누에의 상기한 실용형질 전면에 걸쳐 무해이며 또 유익하다는 점도 발견치 못하였다. 2. 박하를 상전에 간작하여 지장이 없음이 연명되였으며 박하엽에 거찰된 상엽을 잠아에 결여하여도 누에 생리에 하등영향이 없다. 3. 들깨(荏)에 있어서도 2항과 동일하다. 4. 결과적으로 박하의 상전간작은 무해로운 작물로 사료되며 들깨의 상전간작도 농민들이 기피하는 경향이 있으나 잠아에는 하등영향이 없다.

• Parasites, Hosts and Diseases
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• 제49권3호
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• pp.255-263
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• 2011

The present work evaluated the effects of alcoholic extracts of salvia (Salvia officinalis), thyme (Thymus vulgaris), and 2 pure compounds (thymol and menthol) on the viability of Echinococcus granulosus protoscolices in vitro. Four different concentrations of each extract (2,500, 1,500, 1,000, and 500 ${\mu}g$/ml) and 3 different concentrations each of thymol and menthol (50, 10, and 1 ${\mu}g$/ml) were used. Concentration of 2500 ${\mu}g$/ml of both extracts showed a significant protoscolicidal activity on the 6th day. Complete loss of viability of protoscolices occurred with 500 ${\mu}g$/ml concentration of both extracts at day 6 and day 7 post-treatment (PT), respectively. Pure compounds, i.e., menthol and thymol, showed potent effects with 50 ${\mu}g$/ml concentration at day 2 and day 5 PT, respectively. These effects were compared with those of albendazole sulfoxide (800 ${\mu}g$/ml), a commonly used treatment drug for hydatidosis. Krebs-Ringer solution and the hydatid cystic fluid at a ratio of 4:1 was a good preservative solution which kept the protoscolices viable for 15 days.

• 한국연초학회지
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• 제29권2호
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• pp.98-103
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• 2007

This study compares menthol migration from fillers to filters and mainstream smoke in a type of leaf tobacco and according to the moisture content differences at the range of $11{\sim}15\;%$. The leaf tobacco used in this study consisted of Korea flue cured upper leaves B1O (KFUB1), A40R (KFUA4), lower leaves C1L (KFLC1), CD4L (KFLCD4), burley upper leaves A3T (KBUA3), lower leaves D3W (KBLD3), Orient Basma I/III (OB), Orient Izmir BIG (OI), expanded tobacco (KET), and reconstituted sheet (KRC). Menthol migration to the filter and mainstream was measured under constant conditions for 80 days with intervals of 20 days. In the comparison between flue cured types, there were significant differences in the filter parts, as follows. KFUB1(34.4 %) KFUA4(37.4 %), KFLC1(43 %) and KFLCD4 were 55.7 %. In the comparision between other types of leaf tobaccos, KFUB1 was 34.4 % and KET was 52.6 % at filter parts. In the methol transfer to mainstream smoke was $16.5{\sim}24.2\;%$. The menthol migration to filters was measured based on the moisture content of $11{\sim}15\;%$ for the KFUB1 after storing it for 80 days. The menthol migrations were $36{\sim}40\;%$ at the moisture content of $11{\sim}15\;%$, respectively. The transfers to mainstream smoke were $12.8{\sim}15.8\;%$.

• Advances in materials Research
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• 제2권1호
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• pp.51-64
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• 2013

Enantioselective macromer of trimesic acid was prepared using S(-) menthol with trimesoyl chloride on polyimide (PI) ultrafiltration membrane. The chemical composition of macromer as well as polyimide ultrafiltration membrane was determined by ATR-FTIR Spectroscopy. The optical resolution of chiral alcohols was performed in pressure driven process. The effect of monomer solutions concentration, effect of air-drying time of S(-) menthol solution, effect of reaction time, effect of operating pressure, effect of feed concentration of racemate on the performance of macromer was studied. The synthesised material exhibits separation of chiral alcohols (menthol ~23% and sobrelol ~21%).

• Natural Product Sciences
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• 제16권3호
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• pp.180-184
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• 2010

The simple and accurate method was established for the simultaneous determination of (-)-menthone and (-)-menthol in Menthae herba obtained from Korea and China. A quantitative analysis was performed with a gas chromatography-flame ionization detector and reference compounds were separated on a capillary HP-Innowax column (30 m $\times$ 0.23 mm, 0.50 ${\mu}m$, Agilent, MA, USA). The correlation coefficients of the compounds showed good linearity ($r^2$ > 0.9997) over the linear range. The precision, repeatability and stability showed less than 1.7% of relative standard deviation (RSD) values for two compounds. Recovery rates were within the range of 95.72 - 103.76%. The method was applied successfully to analyze 15 samples of Menthae herba and achieved sufficient and specific separation of reference compounds. The principal component analysis (PCA) exhibited the classification of 15 samples according to their locations of origin.

• KSBB Journal
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• 제8권5호
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• pp.495-503
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• 1993

페퍼민트 세포의 회분배양에 의한 monoterpenoid 풍미성분의 생산 가능성과 세포의 생육 및 정유생산 특성을 알아보기 위해 캘러스로부터 얻은 모배양액 을 기포반응기 형태의 생물반응기에 접종하여 배양 하였다. 회분배양 중 접종량, abiotic stress, yeast elicitor, 그리고 2단 배양 등의 배양조건이 세포생육 과 박하정유 생성 빛 조성에 마치는 영향을 조사하 였으며 배지의 sucrose 농도와 세포생육의 kinetics 를 분석하였다. 접종량을 탈리하여 배양한 결과 2.0 %(PCV)를 접종한 경우가 반응기에서 배양이 가장 적당하였는데 배양 10일 만에 5.8g/P 의 세포생육을 얻었으며 0.109g/P 의 박하정유가 생성되였다. Abi-otic stress의 영향을 보기 위해 16시간은 $27^{\circ}C$ 에서 명상태로,8시간은 암상태로 하고 10'C로 온도를 낮추어 배양한 결과 세포의 생육은 떨어졌으나 박하정유 생성량은 0.546g/P 로 높은 수율을 보여 주었다. 사용한 Lin-Staba 배 지 에 100mg/P 의 yeast extract를 elicitor로 첨가했을 때 세포의 생육과 정유 의 생성량이 높았으며 유일하게 menthol이 정유 중 22.5%의 높은 농도로 생성되었다. 배지의 당농도를 1/2로 줄이고 $27^{\circ}C$ , 명조건으로 6일간 배양한 후 1OOmg/P 의 yeast elicitor를 첨가하여 8시간을 암 상태와 lOoe로 저온처리를 실시하여 6일간 배양한 결과 8일 이후에는 세포의 생육이 감소하였고 정유 생성량은 증가하지 않았으며 menthol도 생생되지 않았다. Dry cell yield는 O.38g dry cell/g sugar이 였으며 specific growth rate은 O.25day-1 이었다. 회분배양에 의해 박하정유가 생성됨을 알 수 있었으 냐 menthol이 생성되지 않고 전구체인 pulegone과 p piperitone이 축적되였다. 그러나 특이하게도 yeast elicitor를 첨가한 경우 menthol이 22.5%로 생성되 었는데 이제까지 박하세포 배양에 의해 생성된 men­t thol 함량으로는 최대치를 보여주는 결과이였다.