• YAKHAK HOEJI
• /
• v.45 no.2
• /
• pp.133-139
• /
• 2001

To improve water solubility of 1,4-dihydroxy-9,10-anthraquinone moiety, 23 of 2-(1-aminoacetylalkyl)-1,4-dihydroxy-9,10-anthraquinone derivatives, which contain nitrogen atom, were synthesized. Of the synthesized compounds, 18 compounds were more cytotoxic on L1210 cells than 2-(1-acetyloxyalkyl)-1,4-dihydroxy-9,10-anthraquinone as comparative structure. This result might be due to the increased hydrophilicity of the compounds.

• Journal of Integrative Natural Science
• /
• v.3 no.2
• /
• pp.107-111
• /
• 2010

Silicon-containing ${\pi}$-conjugated compounds, especially silacyclopentadienes (siloles), have emerged as a new class of electroactive materials with good electron transport properties in OLEDs. 9,9'-spiro-9-silabifluorene compound as well as its starting material 2,2'-dibromobiphenyl have been synthesized with higher yields. Spirosilabifluorene is expected to be an efficient host material for the blue-light emitting diodes. 9,9'-spiro-9-silabifluorene, 1,1-dichloro-1-silafluorene, and 1,1-dimethyl-1-silafluorene were characterized by $^1H$-NMR, UV/Vis and photoluminescence spectroscopy.

• The Journal of the Korean dental association
• /
• v.9 no.12
• /
• pp.837-840
• /
• 1971

The Auther have diagnosed the 9 cases Dentigerous Ameloblastoma from mandible in Korean. 1) All 9 cases were Korean patients. 2) Clinical Diagnosis of 9 cases were cyst but microscopical Diagnos's of all cases were Dentigerous Ameloblastoma. 3) Patients of all cases were sedated with 100mg. Demerol and anesthetized with 2% Lidocain hydrochloride. The surgical procedure was performed in the usual manner.

• Bulletin of the Korean Chemical Society
• /
• v.2 no.3
• /
• pp.114-121
• /
• 1981

Reactions of thioxanthylium ion with dimethyl-, dibenzyl-, diisopropyl-, and diphenylmercury in the air gave 9,9'-methylenedithioxanthene, 9-benzylthioxanthene, 9-acetonylthioxanthene, and 9-phenylthioxanthene, respectively, as a 9-substituted thioxanthene. In contrast with reactions with aromatics with an electron-donating group, large amount of thioxanthene and thioxanthone were obtained. However, only trace amounts of thioxanthene and thioxanthone were obtained from the reaction with dibenzylmercury under nitrogen atmosphere. In order to explain these reactions, one electron transfer between thioxanthylium ion and organomercurials was proposed.

• Proceedings of the KOR-BRONCHOESO Conference
• /
• 1981.05a
• /
• pp.7-8
• /
• 1981

Authors observed clinically 34 cases of the corrosive esophagitis caused by various corrosive agents at Kyung Hee University Hospital from Aug. 1978 to Dec. 1980. The results obtained were as follows; 1. Among the 34 patients, male was 19 (55.9%) and female 15(44.1%). Most frequently found age was 3rd decade. 2. 18 cases(52.9%) came to the hospital within 24 hours after ingestion of the agents, and 13 cases(38.2%) within 2 to 7 days. 3. Seasonal distribution showed most frequently in spring(35.3%). 4. The moment of the accident was suicidal attempt in 27 cases(79.4%) and misdrinking in 7 cases(20.6%). 5. Acetic acid was a most commonly used agent, showing 23 cases(67.6%), lye and insecticides were next in order. 6. Common chief complaints were swallowing difficulty and sore throat. 7. The average hospital days was 14.8 days. 8. Esophagogram was performed between 3 to 7 days after ingestion in 13 cases(38.2 %), findings were constrictions on the 1st narrowing portion in 4 cases(30.8%) and within normal limits in 3 cases(23.1%). 9. Esophagoscopy was performed in 31 cases(91.2%) between 2 to 7 days after ingestion, which revealed edema and coating on entrance of the esophagus in 9 cases (29.0 %). Diffuse edema on entire length of the esophagus and within normal limits were next in order. 10. Laboratory results were as follows: Anemia was in 1 cases(2.9%), leukocytosis. in 21 cases (61.8%), increase ESR in 9 cases (26.5%), markedly increased BUN and creatinine in 3 cases (8.8%), and hypokalemia in 1 cases(2.9%). Proteinuria in 10 cases(29.4%) hematuria in 4 cases(l1.8%), and coca cola urine in 3 cases (8.8%). 11. Associated diseases were 3 cases(8.8%) of cancer, 1 cases (2.9%) of diabetes mellitus, and 1 cases(2.9%) of manic depressive illness. 12. Various treatment was given: Esophageal and gastric washing in 23 cases(67.6%) for the emergent treatment, antibiotics in 32 cases(94.1%), steroids in 30 cases(88.2%), bougienation in 5 cases(14.7%), hemodialysis in 1 case(2.9%), and partial esophagectomy with gastrostomy and gastroileal anastomosis in 1 cases(2.9%). 13. Serious complications were observed in 9 cases (26.5%), consisted of 6 cases(17.6%) of esophageal stricture, 1 cases(2.9%), of aute renal failure, 1 cases (2.9%) of pneu momediastinum with pneumonia, and 1 cases (2.9%) of pneumonia.

• Journal of the Korean Society of Tobacco Science
• /
• v.9 no.1
• /
• pp.57-64
• /
• 1987

The pyrolysis of geometrical isomers of 9-octadecenoic acid were conducted at $600^{\circ}C$ under nitrogen, and its pyrolytic behaviors were investigated. The pyrolytic products of both fatty acids, cis-9-octadecenoic acid(oleic acid) and trans-9-octadecenoic acid(elaidic acid), were analyzed using a gas chromatograph and GC/MS spectrometer. Twenty-seven different compounds were identified from these pyrolyzates, and the chief products of them were ketones, alcohols and aromatic hydrocarbons. And also, the pyrolytic mechanisms of two geometrical isomers of this fatty acid were discussed by a comparison of experimental results.

• Tuberculosis and Respiratory Diseases
• /
• v.72 no.6
• /
• pp.507-510
• /
• 2012

Carbohydrate antigen 19-9 (CA19-9) is a specific tumor marker of the biliary, pancreatic and gastrointestinal tracts. CA19-9 is occasionally elevated in serum in patiens with benign pulmonary diseases such as bronchiectasis, idiopathic interstitial pneumonia or collagen disease-associated pulmonary fibrosis. Intralobar pulmonary sequestration is an uncommon congenital lung anomaly. It is dissociated from the normal tracheobronchial tree and is supplied by an anomalous systemic artery. There have been some reports of elevation of CA19-9 in this lesion. We report a case of intralobar pulmonary sequestration with elevated serum CA19-9 in a 29-year-old man who was diagnosed with bronchiectasia of left lower lung field on general check up. He had no evidence of any malignant disease in pancreatobiliary or gastrointestinal tracts. Elevated serum CA19-9 level might be encountered with benign pulmonary disease such as pulmonary sequestration.

• Journal of Nutrition and Health
• /
• v.39 no.8
• /
• pp.756-761
• /
• 2006

Curcumin has been known for its anti-proliferative and apoptotic effects on several cancer cells. We examined the inhibitory effects of curcumin on cancer cell adhesion, motility, invasion and matrix metalloproteinase-9 (MMP-9) activity in MDA-MB-231 human breast cancer cells. MDA-MB-231 cells were cultured with 0, 5, 10 or $20{\mu}M$ of curcumin. Curcumin significantly inhibited the adhesion of cancer cells to the fibronectin at $20{\mu}M$ and suppressed the motility and invasion of cancer cells at all concentrations. Also, the MMP-9 activity was inhibited by curcumin, but MMP-9 protein amounts were not affected. Our data indicate that curcumin inhibits motility, invasion and MMP-9 activity of MDA-MB-231 cells. Therefore, curcumin may contribute to the potential beneficial food component to prevent the cancer metastasis in human breast cancer.

• 한국정보디스플레이학회:학술대회논문집
• /
• 2003.07a
• /
• pp.1057-1059
• /
• 2003

New polyfluorene derivatives, poly[9,9-bis(4' n-octyloxyphenyl)] fluorene (PAPF-8) and poly[9,9-bis(4'-(2",7"-dimethylocyloxy)phenyl)] fluorene (PAPF-10) were synthesized from the monomers, 2,7-dibromo-9,9-bis[4' (2"-ethylhexyloxy)benzene] fluorene and 2,7-dibromo-9,9-bis[4' (2", 7"-dimethyloctyloxybenzene)] fluorene through the Ni(0) mediated polymerization. The copolymers were characterized using FT-IR spectroscopy, UV-vis spectroscopy, TGA, photoluminescence (PL) & electroluminescence (EL) spectroscopy, elementa analysis, and molecular weight studies. The synthesized POPF-8 and POPF-10 showed a pure blue emission without any spectral change upon thermal annealing and EL device operation.

• Journal of Food Hygiene and Safety
• /
• v.25 no.3
• /
• pp.209-214
• /
• 2010

Metastasis is the primary cause of from breast cancer mortality. Cell migration and invasion play important roles in neoplastic metastasis. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix (ECM), plays an important role in cancer cell invasion. NF-${\kappa}B$ is transcription factor important in the regulation of MMP-9, as the promoter of MMP-9 gene contains binding sites for NF-${\kappa}B$. Brazilin, an active component of sappan wood (Caesalpinia sappan), decreases TPA-induced MMP-9 expression and invasion in MCF-7 cells. Also, brazilin suppressed NF-${\kappa}B$ activation in TPA-treated MCF-7 cells. Taken together, we demonstrated that the inhibition of TPA-induced MMP-9 expression and cell invasion by brazilin is mediated by the suppression of the NF-${\kappa}B$ pathway in MCF-7 cells. This result suggest brazilin provide a potential therapeutic app roach for the treatment of breast cancer.