• Clinical and Experimental Pediatrics
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• 제52권9호
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• pp.984-990
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• 2009

목 적 : 부당경량아는 소아기 저신장의 주요한 이유 중의 하나이다. 유전적 요소는 부당경량아의 성장에 중요한 영향을 끼친다고 알려져 있다. 일반 소아와 유전적 요소사이의 관계에 대한 몇몇 보고가 있다. 하지만 부당경량아와 유전적 요소사이의 관계에 대한 보고는 많지 않다. 그래서 본 논문에서는 부당경량아의 성장과 부모중간키의 측정에 의한 유전적 요소 사이의 관계에 대해 연구하였다. 그리고 IGF-I, IGFBP-3 그리고 유전적 요소가 반영된 출생 후 성장과의 관계에 대해 연구하였다. 방 법 : 1989년부터 2002년까지 한림의대 강동성심병원에서 태어난 신생아로 출생체중이 10백분위수 미만인 부당 경량아 300명 중 추적 관찰이 가능했던 49명을 대상으로 하였다. 대상아의 부모중간키를 최종 평균값으로 하는 새로운 개인별 교정성장곡선을 구해 해당 연령의 표준편차를 적용하여 cHtSDS를 계산하였다. cHtSDS${\geq}0$ (n=35)인 1군, cHtSDS<0 (n=14)인 2군으로 나누고 두 군 간에 IGF-I과 IGFBP-3를 비교하였다. 결 과 : 1군과 2군의 HtSDS와 cHtSDS는 $0.28{\pm}1.05$, $-0.95{\pm}0.85$ (P=0.000), $0.78{\pm}0.93$, $-0.46{\pm}0.67$ (P=0.000)이었다. 또한 IGF-I SDS는 각각 $2.82{\pm}3.69$, $0.23{\pm}2.42$로 1군이 2군에 비하여 유의하게 더 높았다(P=0.012). 전체 cHtSDS ($0.42{\pm}1.03$)는 HtSDS ($-0.22{\pm}1.10$)보다 더 높았고(P=0.000), cHtSDS는 IGF-I SDS와 유의한 양의 상관관계를 가졌다(P=0.016). 결 론 : 본 연구 결과로 볼 때 cHtSDS는 HtSDS와 유의하게 차이가 났다. 현재의 일률적인 표준성장곡선에 의한 성장평가는 유전적 요소를 제대로 반영하지 못할 수 있다. 진정한 성장상태의 평가는 부모중간키 같은 유전적 요소를 반영한 개인별 교정성장곡선의 사용에 의해 가능할 것이다. 비록 cHtSDS를 계산하는 방법론상의 문제가 아직 있지만, cHtSDS는 부당경량아의 성장평가에 유용한 방법이 될 수 있다.

• 한국환경복원기술학회지
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• 제10권3호
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• pp.14-24
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• 2007

The purpose of this study was to investigate how the landscape characteristics and the physical factors of landscape would affect the preference for the Gapcheon in Daejeon Metropolitan City. The Gapcheon was divided in three sections of the outskirts, Expopark areas, and residential complexes. After selecting seven landscape points where the sections could be expressed best, photographs were taken both in the upstream and downstream direction. The questionnaire used to evaluate the river's landscape included 20 items of adverbs that described the form of the river and one item to rate the overall preference. By analyzing the 14 pictures taken, the occupancy rates of the landscape elements in terms of the sky, river, vegetation of the river, mountain, and artificial structures. Image factor analysis was conducted for each of the sections in order to analyze the landscape characteristics of the Gapcheon, and then regression analysis was conducted in order to analyze the relationships among the physical factors influencing the preference of the landscapes. The results were as follows : Factors that compose the visual characters of urban river were classified be the aesthetic factor, the emotional factor and the situation factor. These 3 factors showed a 65.8% total variance. The river landscape with the biggest preference was the one from the Daedeok Grand Bridge as the occupancy area of the mountain, sky, and river was large and distributed evenly and the vegetation of the river was in a good harmony with the surroundings. After carrying out regression analysis to examine the relationships between the visual preference of Gapcheon and the physical factors of landscape(the sky, river, vegetation of the river, mountain, and artificial structure), the following regressions model was made : PRE=5.906+0.017(river)-0.053(artificial structure)-0.060(vegetation of the river) (R-square=0.48).

• Natural Product Sciences
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• 제7권4호
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• pp.95-101
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• 2001

We investigated the effect of aqueous extract of Terminalia chebula (Combretaceae)(TCAE) on the immediate hypersensitivity reaction in vivo and in vivo. TCAE (0.01 to 1 g/kg) dose-dependently inhibited compound 48/80 induced systemic anaphylaxis in mice. When TCAE was pretreated at concentrations ranging from 0.01 to 1 g/kg, the plasma histamine levels were reduced in a dose-dependent manner. TCAE (0.1 and 1 g/kg) significantly inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylactic reaction. TCAE (0.001 to 1 mg/ml) also dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-dinitrophenyl (DNP) IgE. TCAE (0.01 to 1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis $factor-{\alpha}$ production from RPMC. These results indicate that TCAE inhibits immediate hypersensitivity reaction in vivo and in vitro.

• 음성과학
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• 제8권1호
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• pp.143-157
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• 2001

This paper focused on glottal parameters contributing to the perception of loud voices because energy of a voice is not the only effective factor. We used a formant synthesizer to synthesize loud voices. We divided F0 tilt (the tilt of F0 contour), SQ (Speed Quotient), OQ (Open Quotient) and TL (spectral Tilt Level) into three levels to get different combinations with default values for the other synthesizer parameters. Analysis of listening tests indicated that F0 tilt, SQ, OQ and TL in descending order had significant influence on the perception of loud voices. F0 tilt had a far more significant effect than the others. The influence of SQ increased greatly with the exclusion of F0 tilt as a factor. The interaction between parameters was not significant.

• 생명과학회지
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• 제17권8호통권88호
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• pp.1104-1110
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• 2007

2005년 5월부터 2006년 3월까지 안동호와 임하호의 어류상과 서식하는 어종인 끄리(Opsariichthys uncirostris amurensis), 백조어(Culter brevicauda) 그리고 치리(Hemiculter eigenmanni)의 길이-무게 상관관계에 관한 조사 결과를 실시하였으며 결과는 다음과 같다. 조사된 어류는 안동호와 임하호 각각 7과 20종 2,540개체, 4과 11종 850개체였으며, 끄리, 백조어, 치리의 개체수는 안동호에서 총 486개체, 임하호에서는 총 124개 체로 조사되었고, 이들 공서 어류는 길이가 비슷한$({\pm}2.5$ mm) 171개체를 비교하였다. 안동호에 서식하는 끄리, 백조어, 치리의 길이-무게 상관관계식은 각각 TW = $0.000007TL^{3.0543}$, TW = $0.0000009TL^{3.3654}$, TW = $0.000001TL^{3.3872}$로 나타났으며, 임하호에서는 각각 TW = $0.00002TL^{2.8493}$, TW = $0.00001TL^{2.8744}$, TW = $0.000004TL^{3.1082}$로 나타났다. 비대지수에서는 안동호에서는 3종 모두 기울기가 양의 값으로 영양상태가 양호한 것으로 나타났으나, 임하호에서는 치리를 제외한 2종에서 기울기가 음의 값을 나타내어 영양상태가 좋지 않은 것으로 나타났다. 상대적 비대지수를 알아본 결과 끄리와 백조어에서 안동호의 개체가 임하호의 개체보다 비대한 경향을 보였으며, 치리는 임하호의 개체가 더 비대한 것으로 나타났다.

• 대기
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• 제14권3호
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• pp.19-28
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• 2004

In this study, two years Automatic Weather Station (AWS) data observed near the coast and islands are used to evaluate gust factors only when time averaged wind speed is higher than 5 ms. The gust factors are quite different in spatial and temporal domain according to analysis method. As the averaged time is increased, the gust factors are also increased. But the gust factors are decreased when wind speed is increased. It is because each wind speed is averaged one and a maximum wind is the greatest one for each time interval. The result from t-test is shown that all data are included within the 99% significance level. A sample standard deviation of ten minutes and one minute are 0.137~0.197, 0.067~0.142, respectively. Recently, the gust factor provided at the Korea Meteorological Administration (KMA) Homepage is calculated with one-hour averaged method. All though this method is hard to use directly for forecasting the strong wind over sea and coast, the result will be a great help to express Ocean Storm Flash in the Regional Meteorological Offices and the Meteorological Stations.

• Clinical and Experimental Reproductive Medicine
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• 제23권1호
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• pp.33-39
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• 1996

본 연구는 돼지 미성숙난포란의 체외배양시 EGF가 핵성숙의 GVBD와 M II 에 미치는 효과를 조사하였다. 실험 1에서는 EGF를 첨가하였을 때, 난포란의 배양경과 시간 (0, 16, 24, 42시간)에 따른 핵성숙도를 조사하였던바, EGF 10ng/ml이 첨가된 군이 무첨가된 군에 비해서 24시간 이후에 GVBD가 유의하게 높았다 (p < 0.001). 실험 2에서는 난포란의 배양시 EGF 노출시간에 따른 난포란의 핵성숙의 효과를 조사하였던바, 배양 초기 (0-24시간)와 배양 전시간 (0-42시간) 동안 EGF를 배양액내에 첨가한 군의 경우 최종 성숙단계인 M II까지의 핵성숙율은 72.8과 84.8%로써 배양 후기 (24-42시간)에 EGF가 첨가된 군의 53.5%와 배양 전시간 (0-42시간) 동안 무첨가한 군의 26.1%보다 유의하게 높았다 (p < 0.001). 그리고 실험 3에서는 난구세포 부착 난포란과 난구세포가 제거된 난포란에 있어서 EGF의 효과를 조사하였던바, EGF가 첨가된 난구세포 부착 난포란 군의 경우 핵성숙율 (M II)은 84.6%로써 EGF가 첨가된 난구세포 제거군의 53.0%와 무첨가 난구세포 부착군의 27.6%, 난구세포 제거군의 44.2%보다 유의하게 높았다 (p < 0.001). 따라서 이상의 결과로 미루어보아 EGF 단독만으로도 돼지 미성숙난포란의 체외성숙의 핵성숙에 있어서 GVBD와 M II 을 유도할 수 있다고 사료된다.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2003년도 추계학술대회 논문집
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• pp.138-144
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• 2003

Rencentely, the request for the light weight is more incresed in the area of industrial environment and machinery and consistent effort is needed to accomplish high strength of material for the direction of light weight. we got the following characteristic from crack growth test carried out in the range of stress ration of 0.1, 0.3 and 0.6 by means of opening mode displacement. At the content stress ratio, the threshold stress intensity factor crack range ${\Delta}K_{th}$in the early stage of fatigue crack growth (Region I) and dtress intensity factor range ${\Delta}K$ in the stable of fatigue crack growth (Region II) with an increase in ${\Delta}K$. Fatigue life shows more improvement in the Shot-peened material than in the Un-peening material. And compressive residual stress of surface on the Shot peening processed operate resistance force of fatigue. So we can obtain fallowings. (1) The fatigue crack growth rate on stage II is conspicuous with the size of compressive residual stress and is depend on Paris equation. (2) Although the maxium compressive residual stress is deeply and widely formed from surface, fatigue life does not improve than when maxium compressive residual stress is formed in surface. (3) The threshold stress intensity factor range is increased with increasing compressive residual stress.

• Transactions on Electrical and Electronic Materials
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• 제15권4호
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• pp.226-229
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• 2014

In this study, lead-free $(Ba_{0.85}Ca_{0.15})(Ti_{1-x}Zr_x)O_3$ ceramics and a bimorph-type piezoelectric actuator were fabricated using the normal oxide-mixed sintering method, and their dielectric properties, microstructure, and displacement properties were investigated. From the results of X-ray diffraction, the pattern of the specimen has a pure perovskite structure. In addition, no secondary impurity phases were found. The excellent piezoelectric coefficient of $d_{33}=454pC/N$, the electromechanical coupling factor $k_p=0.51$, the dielectric constant ${\varepsilon}_r=3,657$, the mechanical quality factor $Q_m=239$, and $T_c$(Tetragonal-Cubic) =$90^{\circ}C$ were shown at x= 0.085. ${\Delta}k_p/k_p20^{\circ}C$ and ${\Delta}f_r/f_r20^{\circ}C$ showed the maximum value of -0.255 and 0.111 at $-20^{\circ}C$ and $80^{\circ}C$, respectively. The maximum total-displacement was $60{\mu}m$ under the input voltage of 50 V. As a result, it is considered that lead-free $(Ba_{0.85}Ca_{0.15})(Ti_{1-x}Zr_x)O_3$ ceramics is a promising candidate for piezoelectric actuator application for x= 0.085.

• Journal of Periodontal and Implant Science
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• 제26권4호
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• pp.799-821
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• 1996

The ultimate goal of periodontal treatment has been to facilitate regeneration of diseased periodontal tissues, destroyed by inflammatory periodontal disease. For regeneration of the periodontium to occur, all of component tissues must be restored to their original position and architecture. Growth factors which were known to promote the cellular processes, ie, proliferation, migration and matrix synthesis, have been in the spotlight of current periodontics. Platelet-derived growth factor(PDGF) stimulates collagen and non collagen protein synthesis, migration and proliferation of periodontal ligament cells. Insulin-like growth factor(IGF) has potentials to induce collagen and bone matrix synthesis so that it regulates normal bone remodeling. Application of the combination have been known to facilitate formation of bone and cementum, and to synergistically interact to promote coronal migration and proliferation of periodontal ligament cells. These two growth factors have been reported to exhibit positive effect in the periodontally diseased teeth or class m furcation defects. The aim of the present study was to test the hypothesis that PDGF-BB alone or the combination of PDGF-BB and IGF-I can predictably enhance regeneration of the periodontium in the dehiscence defect. Following the resection of premolars, roots were embedded. After 12 weeks of healing period, standardized experimental $4{\times}4mm$ dehiscence defects were created on the mid-facial of the premolar roots in each of 4 young adult dogs. In control group, only methylcellulose gel was inserted in the defects. In experimental group I and II, gel with $2{\mu}g$ of PDGF-BB or $2{\mu}g$ of PDGF-BB and $1{\mu}g$ of IGF-I was inserted in the defects, respectively. At 8 weeks postsurgery, the dogs were sacrificed. The results were observed histologically and analyzed histomorphometrically.The results of this study were as follws. 1. The new cementum formation was $1.26{\pm}0.69mm$ in the control group, $1.80{\pm}0.84mm$ in the experimental group I, $1.93{\pm}0.51mm$ in the experimental group II. The experimental group III, the experimental group I, the control group were in the order of cementum formation without statistically significant differences between control and all experimental groups. 2. The new bone formation was $1.00{\pm}0.53mm$ in the control group, $1.53{\pm}0.63mm$ in the experimental group I, $l.33{\pm}0.45mm$ in the experimental group II. The experimental group I, the experimental group II, the control group were in the order of bone formation without statistically significant differences between control and all experimental groups. 3. The root resorption was $1.12{\pm}0.64mm$ in the control group, $1.34{\pm}0.73mm$ in the experimental group I, $0.79{\pm}0.59mm$ in the experimental group II without statistically significant differences between control and all experimental groups. These results suggested that the use of PDGF-BB alone or PDGF-BB and IGF-I in the dehiscence defects might facilitate periodontal regeneration in some degree, but has not shown statistically significant results.