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Growth in Infants with Cow's Milk Protein Allergy Fed an Amino Acid-Based Formula

  • Vandenplas, Yvan;Dupont, Christophe;Eigenmann, Philippe;Heine, Ralf G.;Host, Arne;Jarvi, Anette;Kuitunen, Mikael;Mukherjee, Rajat;Ribes-Koninckx, Carmen;Szajewska, Hania;Berg, Andrea von;Zhao, Zheng-Yan
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.24 no.4
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    • pp.392-402
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    • 2021
  • Purpose: The present study assessed the role of an amino acid-based formula (AAF) in the growth of infants with cow's milk protein allergy (CMPA). Methods: Non-breastfed, term infants aged 0-6 months with symptoms suggestive of CMPA were recruited from 10 pediatric centers in China. After enrollment, infants were started on AAF for two weeks, followed by an open food challenge (OFC) with cow's milk-based formula (CMF). Infants with confirmed CMPA remained on AAF until 9 months of age, in conjunction with a cow's milk protein-free complementary diet. Body weight, length, and head circumference were measured at enrollment and 9 months of age. Measurements were converted to weight-for-age, length-for-age, and head circumference-for-age Z scores (WAZ, LAZ, HCAZ), based on the World Health Organization growth reference. Results: Of 254 infants (median age 16.1 weeks, 50.9% male), 218 (85.8%) were diagnosed with non-IgE-mediated CMPA, 33 (13.0%) tolerated CMF, and 3 (1.2%) did not complete the OFC. The mean WAZ decreased from 0.119 to -0.029 between birth and enrollment (p=0.067), with significant catch-up growth to 0.178 at 9 months of age (p=0.012) while being fed the AAF. There were no significant changes in LAZ (0.400 vs. 0.552; p=0.214) or HCAZ (-0.356 vs. -0.284; p=0.705) from the time of enrollment to age 9 months, suggesting normal linear and head growth velocity. Conclusion: The amino acid-based study formula, in conjunction with a cow's milk proteinfree complementary diet, supported normal growth till 9 months of age in a cohort of Chinese infants with challenge-confirmed non-IgE-mediated CMPA.

Development of 3D Crop Segmentation Model in Open-field Based on Supervised Machine Learning Algorithm (지도학습 알고리즘 기반 3D 노지 작물 구분 모델 개발)

  • Jeong, Young-Joon;Lee, Jong-Hyuk;Lee, Sang-Ik;Oh, Bu-Yeong;Ahmed, Fawzy;Seo, Byung-Hun;Kim, Dong-Su;Seo, Ye-Jin;Choi, Won
    • Journal of The Korean Society of Agricultural Engineers
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    • v.64 no.1
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    • pp.15-26
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    • 2022
  • 3D open-field farm model developed from UAV (Unmanned Aerial Vehicle) data could make crop monitoring easier, also could be an important dataset for various fields like remote sensing or precision agriculture. It is essential to separate crops from the non-crop area because labeling in a manual way is extremely laborious and not appropriate for continuous monitoring. We, therefore, made a 3D open-field farm model based on UAV images and developed a crop segmentation model using a supervised machine learning algorithm. We compared performances from various models using different data features like color or geographic coordinates, and two supervised learning algorithms which are SVM (Support Vector Machine) and KNN (K-Nearest Neighbors). The best approach was trained with 2-dimensional data, ExGR (Excess of Green minus Excess of Red) and z coordinate value, using KNN algorithm, whose accuracy, precision, recall, F1 score was 97.85, 96.51, 88.54, 92.35% respectively. Also, we compared our model performance with similar previous work. Our approach showed slightly better accuracy, and it detected the actual crop better than the previous approach, while it also classified actual non-crop points (e.g. weeds) as crops.

Pulmonary Functions and Inflammatory Biomarkers in Post-Pulmonary Tuberculosis Sequelae

  • Shanmugasundaram, Kumar;Talwar, Anjana;Madan, Karan;Bade, Geetanjali
    • Tuberculosis and Respiratory Diseases
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    • v.85 no.2
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    • pp.175-184
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    • 2022
  • Background: Post-tuberculosis (TB) sequelae is a commonly encountered clinical entity, especially in high TB burden countries. This may represent chronic anatomic sequelae of previously treated TB, with frequent symptomatic presentation. This pilot study was aimed to investigate the pulmonary functions and systemic inflammatory markers in patients with post-TB sequelae (PTBS) and to compare them with post-TB without sequelae (PTBWS) participants and healthy controls. Methods: A total of 30 participants were enrolled, PTBS (n=10), PTBWS (n=10), and healthy controls (n=10). Pulmonary function tests included spirometry and measurement of airway impedance by impulse oscillometry. Serum levels of matrix metalloproteinase (MMP)-1, transforming growth factor-β, and interferon-γ were estimated. Results: Slow vital capacity (SVC), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC, and peak expiratory flow were significantly lower in PTBS as compared to controls. SVC and FEV1 were significantly less in PTBS as compared to PTBWS. Total airway impedance (Z5), total airway resistance (R5), central airway resistance (R20), area of reactance (Ax), and resonant frequency (Fres) were significantly higher and respiratory reactance at 5 and 20 Hz (X5, X20) were significantly lower in PTBS as compared to PTBWS. Spirometry parameters correlated with impulse oscillometry parameters in PTBS. Serum MMP-1 level was significantly higher in PTBS as compared to other groups. Conclusion: Significant pulmonary function impairment was observed in PTBS, and raised serum MMP-1 levels compared with PTBWS and healthy controls. Follow-up pulmonary function testing is recommended after treatment of TB for early diagnosis and treatment of PTBS.

Investigation of the Influence of Induced Mood on Rehabilitation Engagement: a Study Focusing on Muscle Activity

  • Kim, Jung-Yeon;Jung, Bong-Keun
    • Journal of Biomedical Engineering Research
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    • v.43 no.3
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    • pp.161-169
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    • 2022
  • Engagement is an important factor in the field of rehabilitation as it is a known factor that have a positive influence on functional gaining in people who receive rehabilitation therapy. Although a number of measurements for engagement have been recently developed, investigation of possible factors that may have influence on engagement is not well established. Currently available evidence suggests that engagement is affected by mood and it is hypothesized that a personal factor may contribute to engagement. Therefore, this study aims to test the hypothetical relationship between mood and engagement while performing a manual dexterity task through an experiment in healthy participants prior to investigation on people with medical condition who requires rehabilitation therapy. After inducing target mood (positive or negative mood) for study participants by asking them to recall autobiographical memories, change in muscle activity, which was operationalized as an indicator of engagement, was investigated. Electromyogram (EMG) was recorded from four muscle areas in non-dominant hand side to quantify muscle activity. The results show that the target moods were appropriately induced with the method. Although there were subtle differences in the level of engagement between different moods, certain variables derived from muscle activity were significantly different; mean amplitude for wrist extensor EMG showed significant difference between different moods (Z = -2.023, p < .05) indicating that muscle activities in the wrist extensor are greater for positive mood than negative mood region during manual dexterity task. Meanwhile, performance outcomes of Minnesota Manual Dexterity Test (MMDT), such as mean completion time and number of errors, between moods showed no significant difference in two different moods, resulting in MMDT administration may not be useful task in distinguishing the level of rehabilitation engagement.

Incidence of fistula after primary cleft palate repair: a 25-year assessment of one surgeon's experience

  • Park, Min Suk;Seo, Hyung Joon;Bae, Yong Chan
    • Archives of Plastic Surgery
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    • v.49 no.1
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    • pp.43-49
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    • 2022
  • Background Cleft lip and cleft palate are the most frequent congenital craniofacial deformities, with an incidence of approximately 1 per 700 people. Postoperative palatal fistula is one of the most significant long-term complications. This study investigated the incidence of postoperative palatal fistula and its predictive factors based on 25 years of experience at our hospital. Methods We retrospectively reviewed 636 consecutive palatal repairs performed between January 1996 and October 2020 by a single surgeon. Data from patients' medical records regarding cleft palate repair were analyzed. The preoperative extent of the cleft was evaluated using the Veau classification system, and the cleft palate repair technique was chosen according to the extent of the cleft. SPSS version 25.0 was used for all statistical analyses, and exploratory univariate associations were investigated using the t-test. Results Fistulas occurred in 20 of the 636 patients; thus, the incidence of palatal fistula was 3.1%. The most common fistula location was the hard palate (9/20, 45%), followed by the junction of the hard and soft palate (6/20, 30%) and the soft palate (5/20, 25%). The cleft palate repair technique significantly predicted the incidence of palatal fistula following cleft palate repair (P=0.042). Fistula incidence was significantly higher in patients who underwent surgery using the Furlow double-opposing Z-plasty technique (12.1%) than in cases where the Busan modification (3.0%) or two-flap technique (2.0%) was used. Conclusions The overall incidence of palatal fistulas was 3.1% in this study. Moreover, the technique of cleft palate repair predicted fistula incidence.

On wave dispersion properties of functionally graded plates resting on elastic foundations using quasi-3D and 2D HSDT

  • Bennai, Riadh;Mellal, Fatma;Nebab, Mokhtar;Fourn, Hocine;Benadouda, Mourad;Atmane, Hassen Ait;Tounsi, Abdelouahed;Hussain, Muzamal
    • Earthquakes and Structures
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    • v.22 no.5
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    • pp.447-460
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    • 2022
  • In this article, wave propagation in functional gradation plates (FG) resting on an elastic foundation with two parameters is studied using a new quasi-three-dimensional (3D) higher shear deformation theory (HSDT). The new qausi-3D HSOT has only five variables in fields displacement, which means has few numbers of unknowns compared with others quasi-3D. This higher shear deformation theory (HSDT) includes shear deformation and effect stretching with satisfying the boundary conditions of zero traction on the surfaces of the FG plate without the need for shear correction factors. The FG plates are considered to rest on the Winkler layer, which is interconnected with a Pasternak shear layer. The properties of the material graded for the plates are supposed to vary smoothly, with the power and the exponential law, in the z-direction. By based on Hamilton's principle, we derive the governing equations of FG plates resting on an elastic foundation, which are then solved analytically to obtain the dispersion relations. Numerical results are presented in the form of graphs and tables to demonstrate the effectiveness of the current quasi-3D theory and to analyze the effect of the elastic foundation on wave propagation in FG plates.

Prognostic Impact of Postoperative Complications in High-Risk Operable Non-small Cell Lung Cancer

  • Lee, Seungwook;Roknuggaman, Md;Son, Jung A;Hyun, Seungji;Jung, Joonho;Haam, Seokjin;Yu, Woo Sik
    • Journal of Chest Surgery
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    • v.55 no.1
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    • pp.20-29
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    • 2022
  • Background: Patients with high-risk (HR) operable non-small cell lung cancer (NSCLC) may have unique prognostic factors. This study aimed to evaluate surgical outcomes in HR patients and to investigate prognostic factors in HR patients versus standard-risk (SR) patients. Methods: In total, 471 consecutive patients who underwent curative lung resection for NSCLC between January 2012 and December 2017 were identified and reviewed retrospectively. Patients were classified into HR (n=77) and SR (n=394) groups according to the American College of Surgeons Oncology Group criteria (Z4099 trial). Postoperative complications were defined as those of grade 2 or higher by the Clavien-Dindo classification. Results: The HR group comprised more men and older patients, had poorer lung function, and had more comorbidities than the SR group. The patients in the HR group also experienced more postoperative complications (p≤0.001). More HR patients died without disease recurrence. The postoperative complication rate was the only significant prognostic factor in multivariable Cox regression analysis for HR patients but not SR patients. HR patients without postoperative complications had a survival rate similar to that of SR patients. Conclusion: The overall postoperative survival of HR patients with NSCLC was more strongly affected by postoperative complications than by any other prognostic factor. Care should be taken to minimize postoperative complications, especially in HR patients.

Deep Learning-based Depth Map Estimation: A Review

  • Abdullah, Jan;Safran, Khan;Suyoung, Seo
    • Korean Journal of Remote Sensing
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    • v.39 no.1
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    • pp.1-21
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    • 2023
  • In this technically advanced era, we are surrounded by smartphones, computers, and cameras, which help us to store visual information in 2D image planes. However, such images lack 3D spatial information about the scene, which is very useful for scientists, surveyors, engineers, and even robots. To tackle such problems, depth maps are generated for respective image planes. Depth maps or depth images are single image metric which carries the information in three-dimensional axes, i.e., xyz coordinates, where z is the object's distance from camera axes. For many applications, including augmented reality, object tracking, segmentation, scene reconstruction, distance measurement, autonomous navigation, and autonomous driving, depth estimation is a fundamental task. Much of the work has been done to calculate depth maps. We reviewed the status of depth map estimation using different techniques from several papers, study areas, and models applied over the last 20 years. We surveyed different depth-mapping techniques based on traditional ways and newly developed deep-learning methods. The primary purpose of this study is to present a detailed review of the state-of-the-art traditional depth mapping techniques and recent deep learning methodologies. This study encompasses the critical points of each method from different perspectives, like datasets, procedures performed, types of algorithms, loss functions, and well-known evaluation metrics. Similarly, this paper also discusses the subdomains in each method, like supervised, unsupervised, and semi-supervised methods. We also elaborate on the challenges of different methods. At the conclusion of this study, we discussed new ideas for future research and studies in depth map research.

Effect of Pseudomonas aeruginosa Strain ZK Biofilm on the Mechanical and Corrosion Behavior of 316L Stainless Steel and α-brass

  • Farooq, A.;Zubair, M.;Wadood, H.Z.;Deen, K.M.
    • Journal of Electrochemical Science and Technology
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    • v.12 no.4
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    • pp.431-439
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    • 2021
  • This research work aims to investigate the effect of the aerobic bacterium, Pseudomonas aeruginosa on the mechanical and electrochemical properties of the 316L stainless steel and α-brass. These properties of both the alloys were determined after 7 days of exposure to the controlled and inoculated media at 37℃. The microstructural and electrochemical test results revealed the deleterious effects of Pseudomonas aeruginosa. After exposure to the inoculated medium, the scanning electron microscopy (SEM) results showed the larger pitting and formation of relatively dense biofilm on α-brass compared to 316L stainless steel. The tensile strength and hardness of 316L stainless steel were slightly affected after exposure to the controlled and inoculated media. After exposure to the controlled medium and inoculated media, the tensile strength of the α-brass was least affected but a significant decrease in the hardness (from 165 HV to 124 HV) was observed due to the severe attack induced by the Pseudomonas aeruginosa. Similarly, the open-circuit potential of the 316L stainless steel in the inoculated medium was measured to be less active (-410 mV vs Ag/AgCl) than α-brass (-550 mV vs Ag/AgCl). In the inoculated medium, potentiodynamic polarization curves confirmed the severe attack of Pseudomonas aeruginosa on α-brass (7.15 × 10-2 mm/year) compared to 316L stainless steel which registered a corrosion rate of 5.14 × 10-4 mm/year.

Double burden of malnutrition in ethnic minority school-aged children living in mountainous areas of Vietnam and its association with nutritional behavior

  • Truong, Duong Thuy Thi;Tran, Trang Huyen Thi;Nguyen, Tam Thanh Thi;Tran, Van Hong Thi
    • Nutrition Research and Practice
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    • v.16 no.5
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    • pp.658-672
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    • 2022
  • BACKGROUND/OBJECTIVES: Although children of ethnic minority groups are experiencing a transition from a predominance of undernutrition to overnutrition, there is little evidence of a dual-malnutrition burden. Therefore, this study examined the double burden of malnutrition among school-aged ethnic minority children living in mountainous areas and its association with their diets. SUBJECTS/METHODS: A cross-sectional study was conducted from September 2019 to March 2020 in 3 mountainous areas of Northern Vietnam among 1,556 ethnic minority school-aged children. The prevalence of under-nutrition (stunting and thinness) and over-nutrition (overweight and obesity) were measured using the WHO 2006 child growth standards (height-for-age and BMI-for-age Z-score). Nutritional practices were evaluated by the frequency of food consumption based on a 4-level scale. RESULTS: The percentage of children with stunting and thinness were 14.0% and 5.4%, respectively, while the figure for overweight/obesity was 9.4%. The factors positively associated with stunting were living in a family with more than 2 children or being Muong/other ethnicities compared to the Tay ethnicity. Children who consumed fish/shrimps/crabs or milk weekly/daily were less likely to be undernourished compared to those who never consumed these foods. By contrast, children who never consumed foods rich in vitamin A precursors and vitamin A and fruit or consumed daily snacks/junk food were more likely to be overweight/obese. CONCLUSIONS: Undernutrition remains a common issue among school-aged children and adolescents of ethnic minority groups, while over-nutrition exists simultaneously. Public health nutrition programs promoting adequate diets and positive lifestyle changes related to nutrition are essential to tackle the double burden of malnutrition among ethnic minority children.