• Proceedings of the Optical Society of Korea Conference
• /
• 1991.06a
• /
• pp.22-22
• /
• 1991

광의 병렬처리 능력을 잘 활용한 1$\times$4 매트릭스 스위치의 구조와 전극구조를 설계하고 스위치 특성을 조사하기 위하여 beam propagation method(BPM)를 이용하여 수치계산을 하였다. 기존의 매트릭스 스위치는 대부분의 경우 방향성 결합기를 스위치 element로 이용하여 왔으나 이 결합기는 소자의 길이가 길기 때문에 단일 LinBO3 웨이퍼상에 집적할 수 있는 매트릭스 스위치의 크기가 제한되는 단점이 있다. 본 연구에서는 두 도파로 사이에 세 번째 도파로를 삽입하여 두 도파로를 결합시키는 세 도파로 결합기를 스위치 element로 사용하여 세 개의 스위치 element를 LiNbO3기판위에 직렬로 집적시킨 1$\times$4 매트릭스 스위치를 구성하였다. 스위치 element와 1$\times$4 매트릭스 스위치를 구성하였다. 스위치 element와 1$\times$4 매트릭스 스위치의 특성을 BPM을 사용하여 수치계산할 때 단일 모드 도파로의 유효 굴절을 분포는 n(X) = nm + $\Delta$ncosh-2(2x/w)의 형태로 가정했으며, 사용된 파라미터의 값은 각각 nm=2.1455, $\Delta$n=0.003, W=5$mu extrm{m}$, d=5$\mu\textrm{m}$, λ=1.3$\mu\textrm{m}$ 이고 S-파라메터의 값은 0.95927이므로 단일 모드 도파로가 된다. 계산결과 스위치 element의 결합길이는 3810$\mu\textrm{m}$이며 도파로의 길이가 결합길이와 같을 때 전극에 인가된 전압에 의한 도파로의 굴절을 섭등의 함수로 출력광의 세기를 계산한 결과 스위칭 전압은 14.85volt이고 crosstalk는 -18.9dB였다. 이 스위치 element로 구성된 1$\times$4 매트릭스 스위치는 스위칭 전압을 세 개의 전극에 적절한 조합으로 인가함으로써 한 입력 도파로에 결합된 광이 내개의 출력 도파로중 한 도파로에 스위칭 된다. 한편 수치계산의 결과를 실험적으로 확인하기 위해 스위치 element와 1$\times$4 매트릭스 스위치를 z-cut의 LinbO3 결정에 Ti을 열확산시켜 제작한 소자의 스위칭 특성을 발표할 예정이다.

• The Bulletin of The Korean Astronomical Society
• /
• v.35 no.1
• /
• pp.75.2-75.2
• /
• 2010

We investigate the dependence of occurrence of bar in galaxies on galaxy properties and environment. The environmental conditions considered include the large-scale background density and distance to the nearest neighbor galaxy. We use a volume-limited sample of 33,296 galaxies brighter than $M_r$=-19.5+5logh at $0.02{\leqq}z{\leqq}0.05489$, drawn from the Sloan Digital Sky Survey Data Release 7. We classify the galaxies into early and late types, and identify bars by visual inspection. We find that the fraction of barred galaxies ($f_{bar}$) is 18.2% on average in the case of late-type galaxies, and depends on both u-r color and central velocity dispersion $(\sigma);f_{bar}$ is a monotonically increasing function of u-r color, and has a maximum value at intermediate velocity dispersion (${\sigma}{\simeq}170km\;s^{-1}$). This trend suggests that bars are dominantly hosted by systems having intermediate-mass with no recent interaction or merger history. We also find that $f_{bar}$ does not directly depend on the large-scale background density as its dependence disappears when other physical parameters are fixed. We discover the bar fraction decreases as the separation to the nearest neighbor galaxy becomes smaller than 0.1 times the virial radius of the neighbor regardless of neighbor's morphology. These results imply that it is difficult for bars to be maintained during strong tidal interactions, and that the source for this phenomenon is gravitational and not hydrodynamical.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.14
• /
• pp.5883-5887
• /
• 2015

Despite recent advances in therapeutic strategies for lung cancer, mortality still is increasing. In the present study, we investigated the anti-cancer effects of KMU-193, 2-(4-Ethoxy-phenyl)-N-{5-[2-fluoro-4-(4-methylpiperazine-1-carbonyl)-phenylamino]-1H-indazol-3-yl}-acetamide in a human non-small cell lung cancer cell line A549. KMU-193 strongly inhibited the proliferation of A549 cells, but it did not have anti-proliferative effect in other types of cancer cell lines. KMU-193 further induced apoptosis in association with activation of caspase-3 and cleavage of PLC-${\gamma}1$. However, KMU-193 had no apoptotic effect in untransformed cells such as TMCK-1 and BEAS-2B. Interestingly, pretreatment with z-VAD-fmk, a pan-caspase inhibitor, strongly abrogated KMU-193-induced apoptosis. KMU-193 treatment enhanced the expression levels of p53 and PUMA. Importantly, p53 siRNA transfection attenuated KMU-193-induced apoptosis. Collectively, these results for the first time demonstrate that KMU-193 has strong apoptotic effects on A549 cells and these are largely mediated through caspase-3- and p53-dependent pathways.

• Asian-Australasian Journal of Animal Sciences
• /
• v.12 no.6
• /
• pp.862-867
• /
• 1999

The present study was undertaken to determine the effect of administration of exogenous progesterone early in gestation on uterine levels of IGF-I mRNA and on embryo survival at day 25 of gestation in the pig. Forty-one prepubertal gilts were induced into oestrus with PG600 and artificially inseminated at their subsequent naturally occurring oestrus. Gilts were then randomly assigned to one of three groups. Gilts in the two treatment groups were injected intramuscularly with 50 mg of progesterone either from day 2 to 14 (N=14) or from day 4 to 14 (N=15) after breeding while those in the control group (N=12) were given corn oil (0.5 ml) from day 2 to 14. Between days 25 and 28 of gestation, gilts were slaughtered and reproductive tracts were recovered. Endometrial tissue (1 g) was collected and analysed for IGF-I mRNA levels using a reverse transcription-polymerase chain reaction, Progesterone treatment, starting either on day 2 or 4 after breeding, neither significantly increased embryo survival rate by day 25 of gestation nor altered IGF-I mRNA levels in uterine tissue. However, across all samples, the IGF-I mRNA level in the uterus was highly correlated with embryo survival rate (r=0.8193, p<0.01), supporting the involvement of IGF-I in the regulation of porcine embryo development.

• Korean Journal of Adult Nursing
• /
• v.21 no.4
• /
• pp.403-412
• /
• 2009

Purpose: We analyzed climacteric symptoms, bone mineral density (BMD), serum estradiol ($E_2$) and follicle stimulating hormone (FSH) to identify the health benefits of meridian massage in perimenopausal women. Methods: There were 16 women in the experimental group and 17 people in the control group. Meridian massage was performed for 4 weeks, 3 times a week for 20 minutes each session. The data were collected pre-treatment, posttreatment and 4 weeks after treatment. SPSS/WIN 11.5 was used for data analysis. Results: After meridian massage, there were significant differences in climacteric symptoms (U = 65.50, p = .011) and BMD (U = 65.50, p = .011) between the two groups. The E2 level showed a significant difference between the two groups pre- and posttreatment (U = 75.00, p = .028). FSH showed a significant increase when measured at 4 weeks after the treatment as compared with the amount when measured post-treatment within the control group (z = -2.249, p = .025), experimental group showed a stable change in FSH. but there was no significant difference between the groups. Conclusion: In this study, we confirmed the effects of Meridian massage in decreasing climacteric symptoms, inhibiting the decrease of BMD and stabilizing serum hormone in perimenopausal women. Therefore, it can be considered for use as a nursing intervention for health management in perimenopausal women.

• The korean journal of orthodontics
• /
• v.50 no.2
• /
• pp.75-85
• /
• 2020

Objective: The aim of this study was to evaluate changes in the nasal soft tissues, including movements of landmarks, changes in linear distances, and volumetric changes, using three-dimensional (3D) stereophotogrammetry after microimplant-assisted rapid palatal expansion (MARPE) in adult patients. Methods: Facial data were scanned using a white light scanner before and after MARPE in 30 patients. In total, 7 mm of expansion was achieved over a 4-week expansion period. We determined 10 soft tissue landmarks using reverse engineering software and measured 3D vector changes at those points. In addition, we calculated the distances between points to determine changes in the width of the nasal soft tissues. The volumetric change in the nose was also measured. Results: All landmarks except pronasale and subnasale showed statistically significant movement on the x-axis. Pronasale, subnasale, alar right, and alar left showed significant movement on the y-axis, while all landmarks except subnasale showed significant movement on the z-axis. The alar base width, alar width, and alar curvature width increased by 1.214, 0.932, and 0.987 mm, respectively. The average volumetric change was 993.33 ㎣, and the amount of increase relative to the average initial volume was 2.96%. Conclusions: The majority of soft tissue landmarks around the nasal region show significant positional changes after MARPE in adults. The nose tends to widen and move forward and downward. The post-treatment nasal volume may also exhibit a significant increase relative to the initial volume. Clinicians should thoroughly explain the anticipated changes to patients before MARPE initiation.

• Journal of Korean Academy of Nursing
• /
• v.50 no.2
• /
• pp.271-285
• /
• 2020

Purpose: This study examined the effects of a physical activity promoting program based on the Information-Motivation-Behavioral Skills (IMB) model on physical activity and health outcomes among obese older adults with knee osteoarthritis. Methods: This study utilized a randomized controlled trial with a convenience sample of 75 obese older adults with knee osteoarthritis in a university hospital. The older adults in the intervention group participated in a 12-week program involving weekly group sessions and monitoring calls with education booklets and video clips for exercise dances, while those in the control group received an usual care. Outcomes were measured using self-report questionnaires, anthropometrics, and blood analyses. The intervention effects were analyzed using Mann-Whitney U test and ANCOVA. Results: The mean age of participants was 74.9 years with 84.0% women. The intervention group at 12 weeks showed significantly greater improvements in self-efficacy for physical activity (F=81.92, p<.001), physical activity amounts (Z=-2.21, p=.044), knee joint function (F=15.88, p<.001), and health-related quality of life (F=14.89, p<.001) compared to the control group. Among obese-metabolic outcomes, the intervention group at 12 weeks showed a significant decrease in visceral fat mass (F=7.57, p=.008) and improvement in high-density level cholesterol (F=9.51, p=.003) compared to the control group. Conclusion: Study findings support the need for an IMB based physical activity program for promoting physical activity, knee function and health outcomes in obese older adults with knee osteoarthritis. Longitudinal studies are warranted to confirm the persistence of obese-metabolic effects in clinical settings.

• Restorative Dentistry and Endodontics
• /
• v.25 no.4
• /
• pp.550-560
• /
• 2000

In this study, shear bond strength of two bonding systems were measured and appearance of dentin surfaces were observed with SEM according to the storage time of eugenol on dentin surface, thus evaluated the effect of eugenol on bond strength of two dentin bonding systems. Control groups were directly bonded to dentin surface with One Step, Prime & Bond 2.1. Experimental groups were divided into experimental I and II according to dentin bonding agents. After eugenol application, dentin surfaces were bonded with One Step and Prime & Bond 2.1 according to the each storage time of immediately, 3min, 24hour, 48hour and 1week, and then control and experimental groups were filled with light cured composite resin(Z-100). After 24 hours water storage at $37^{\circ}C$, all samples were subjected to a shear load to fracture at a cross head 1.0mm/min with Instron universal testing machine(No. 4467). Etched dentin surface storaged for each time of immediately, 3min, 24hour, 48hour and 1 week after eugenol application were observed under Scanning Electron Microscope(Hitachi S-2300) at 20kvp. The data were evaluated statistically with two-way ANOVA and Tukey's HSD. The results were as follows; 1. Shear bond strengths were higher in control groups than in the experimental groups. 2. As storage time was increased after eugenol application, the shear bond strengths were decreased in experimental groups. 3. In experimental I, II the shear bond strengths were the lowest in which storage time was 1 week after eugenol application. 4. As storage time was increased after eugenol application, etched dentin surfaces showed obstructed dentinal tubule.

• Restorative Dentistry and Endodontics
• /
• v.19 no.2
• /
• pp.513-533
• /
• 1994

The smooth surface after polishing of composite resin contributes to the patient's comfort, and appearance and longevity of the restoration. This study was performed for the quantitative analysis of the effects of the various finishing and polishing instruments on the surface roughness and reflectivity of the microfill, and hybrid composite resins. Cylindrical specimens 2mm thick and 10mm in diameter of Silux Plus, Durafill VS ; Z100, Prisma TPH, Brilliant, and Herculite XR composite resin were polymerized under the matrix strip. 18 specimens for each composite resin materials were divided into 6 groups ; 5 experimental groups were abraded with # 600 sand paper to remove resin-rich layer, except control. Thereafter, using diamond bur(Mani Dia-Burs), carbide bur(E. T. carbide set 4159), rubber point(Composite polishing kit), aluminum-oxide disk(Sof-Lex disk), polishing paste(Enhance system) ; each specimen was polished to its best achievable surface according to manufacturer's directions. Final polished surfaces were evaluated for the surface roughness with profilometer(${\alpha}$-step 200, Tencor instruments, USA) and for the reflectivity with image analyser(Omniment Image Analyser, Buehler, USA). The results were as follows. 1. Polishing paste or aluminum-oxide disk finish in the microfill, and hybrid composite resins was as smooth as matrix strip finish on the surface roughness test. 2. Polishing paste or aluminum-oxide disk finish in the microfill ; polishing paste finish in the hybrid composite resins was as reflective as matrix strip finish on the refectivity test. 3. For the polishing paste, there were no significant differences between the composite resin materials on the surface roughness and refectivity tests. 4. For the aluminum-oxide disk, the best result was obtained with the microfill composite resin on the surface roughness and reflectivity test. 5. Diamond bur, carbide bur, and rubber point were inappropriate for the final polishing instruments.

• Restorative Dentistry and Endodontics
• /
• v.20 no.1
• /
• pp.214-234
• /
• 1995

The purpose of this work was to study the compatibility of several commercially available dentin adhesives with composite resins. In this study, V-shaped cavity preparations were created on both buccal and lingual surfaces of 60 extracted human premolars($3mm{\times}3mm{\times}2mm$ deep). Preparations were located such that the occlusal margins were on the enamel and the gingival margins were on the cementum(1mm below the CEJ). These specimens were randomly divided into three equal groups. Three dentin adhesives(Scotchbond Multi-Purpose, All Bond 2, Prisma Universal Bond 3)were applied to the cavity in accordance with each manufacturer's instructions. The teeth in each group were restored with four composite resins(Silux plus, Z100, Bisfil, Prisma TPH) in three increments, with each increment light-cured for 40 seconds. All specimens were exposed to 500 cycles of thermal stress. Specimens then placed in a silver nitrate solution(50% by weight) and stored in darkness for 24 hours. They were then immersed for 6 hours in photographic developing solution under flourescent light. Specimens were sectioned buccolingually through the center of the restoration and observed under a binocular stereoscope. To compare the marginal leakage, ANOVA and Dunkan's multiple range tests were used in analysis. Selected samples were further studied using scanning electron microscopy(XL20, Philips, The Netherlands). The results were as follows. 1. In all groups, the enamel margin showed significantly less leakage than the cementum margin. 2. No statistically significant differences were found in microleakage when composite resins were used with their proprietary dentin adhesives. 3. In comparison between dentin adhesives, Prisma Universal Bond 3 showed significantly less leakage at the enamel margin and Scotch bond multi-purpose showed significantly less leakage at the cementum margin than the other groups. 4. In comparison between composite resins, Silux Plus showed significantly more leakage than other groups at the enamel margin and no statistically significant differences were found in microleakage at the cementum margin. 5. According to the backscattered scanning electron microscope, microleakage occurred via gaps at the dentin adhesives/dentin interface.