• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.30 no.3
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• pp.181-185
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• 2004

Malignant tumor have hypoxic cell fraction, which makes radio-resistant and hypoxia in tumor is a result from the blood flow decrease caused by increase in blood flow resistance. Blood viscosity increase is major factor of increased blood flow resistance and it could be attributed to the decrease in blood deformability index. For the evaluation of the change of blood viscosity and blood deformability in oral squamous cell carcinoma, we perform the test of the change of those factors between the normal control group and oral squamous cell carcinoma cell patient group. Relative viscosity measured against distilled water was $5.25{\pm}0.14$ for normal control group, and $5.78{\pm}0.26$ for the SCC patient group and there was statistical significance between the groups. However, there was no significant difference between the groups in blood viscosity between the groups by tumor size (T1+T2 vs T3+T4). Also, there was no significant difference between the normal control group and SCC patient group in blood deformability index and between the groups by tumor size (T1+T2 vs T3+T4). Increase in blood viscosity was confirmed with this study and it can be postulated that modification blood viscosity might contribute to decrease of hypoxia fraction in oral squamous cell carcinoma, thus improve the effect of radiotherapy and it can be assumed that the main factor of blood viscosity increase is not decrease of blood deformability in oral squamous cell carcinoma.

• Clinical and Experimental Reproductive Medicine
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• v.29 no.4
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• pp.229-236
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• 2002

Objective : The purpose of this study was to evaluate the effect of Cytochalasin B (CCB) on the cytoskeletal stability of mouse oocyte frozen by vitrification. Methods : Mouse oocytes retrieved from cycle stimulated by PMSG and hCG were treated by CCB and then vitrified in EFS-30. These oocytes were placed onto an EM grid and submerged immediately in liquid nitrogen. Thawing of the oocytes was carried out at room temperature for 5 seconds, then the EM grid was placed into 0.75 M, 0.5 M and 0.25 M sucrose at $37^{circ}C$ for 3 minutes, each. These oocytes were fixed in 4% formaldehyde for an hour and then washed in PPB for 15 minutes 3 times, then incubated in PPB containing anti-tubulin monoclonal antibody at $4^{circ}C$ overnight. And then, the oocytes were incubated with FITC-conjugated anti-mouse IgG and propidium iodide (PI) for 45 minutes. Pattern of microtubules and microfilaments of oocytes were evaluated with a confocal microscope. Results: The rate of oocytes containing normal microtubules and microfilaments was significantly decreased after vitrification. The rate of oocyte containing normal microtubules in CCB treated group was higher than those in non-treated group (53.7% vs. 48.9%), but the difference was not significant. The rate of oocyte containing normal microfilaments in CCB treated group was significantly higher than those in non-treated group (64.5% vs. 38.3%, p<0.05). Conclusion: Microfilaments stability could be improved by CCB treatment prior to vitrification. It is suggested that CCB treatment prior to vitrification improve stability of cytoskeleton and then increase success rate in IVF-ET program using vitrification and thawing oocyte.

• Clinical and Experimental Reproductive Medicine
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• v.45 no.1
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• pp.52-55
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• 2018

This study retrospectively assessed whether time-lapse data relating to developmental timing and morphology were associated with clinical outcomes, with the eventual goal of using morphokinetic variables to select embryos prospectively for cryopreservation. In this study, we examined the clinical outcomes of single vitrified-warmed blastocyst transfer cycles that were cultured in a time-lapse incubation system. The morphokinetic variables included uneven pronuclei, an uneven blastomere, multinucleation, and direct, rapid, and irregular division. A total of 164 single vitrified-warmed blastocyst transfer cycles were analyzed (102 cycles of regularly developed blastocysts and 62 cycles of blastocysts with morphokinetic variables). No significant differences in the age of females or the standard blastocyst morphology were found between these two groups. The regularly developed blastocysts showed significantly higher implantation and clinical pregnancy rates than the blastocysts exhibiting morphokinetic variables (30.4% vs. 9.7% and 37.3% vs. 14.5%, respectively; p< 0.01). The blastocysts that exhibited morphokinetic variables showed different mean development times compared with the regularly developed blastocysts. Although morphokinetic variables are known to have fatal impacts on embryonic development, a considerable number of embryos developed to the blastocyst stage. Morphokinetic variables had negative effects on the implantation and clinical pregnancy rates in vitrified-warmed blastocyst transfer cycles. These findings suggest that blastocysts cultured in a time-lapse incubation system should be considered for selective cryopreservation according to morphokinetic variables.

• Korean Journal of Agricultural Science
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• v.45 no.2
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• pp.143-153
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• 2018

Soil characteristics along with various container lengths have an important role in the early survival rate and growth of seedlings by influencing the seedling quality. This experiment was conducted to investigate the effect of container length and different soil mixtures on the growth of poplar in a greenhouse. Two types of soil, homogeneous vs. heterogeneous, were used along with two container lengths (30 vs. 60 cm). The heterogeneous soil was made by dividing 50% vermiculite from a mixture of 25% vermicompost and 25% nursery soil in volume. For the homogeneous soil, the above three soil types were mixed together. Populus euramericana clone cuttings were planted in late April, and then, the growth height, root collar diameter (RCD) and biomass were measured in August. The height of the poplar was not significantly affected by container length and soil type, but the RCD was significantly affected by soil type. Leaf and root biomass was higher at the long container than at the short container for both soil treatments, but stem biomass was lower at the heterogeneous soil than at the homogeneous soil treatment. Root to shoot biomass ratio was higher at the heterogeneous soil treatment than at the homogeneous soil treatment by 12%. In conclusion, heterogeneous soil along with a long container is suitable to increase the carbon allocation into the root.

• Radiation Oncology Journal
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• v.37 no.1
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• pp.30-36
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• 2019

Purpose: This study aimed to identify the feasibility of the maximum standardized uptake value (SUVmax) on baseline 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) as a predictive factor for prognosis in early stage primary lung cancer treated with stereotactic body radiotherapy (SBRT). Materials and Methods: Twenty-seven T1-3N0M0 primary lung cancer patients treated with curative SBRT between 2010 and 2018 were retrospectively evaluated. Four patients (14.8%) treated with SBRT to address residual tumor after wedge resection and one patient (3.7%) with local recurrence after resection were included. The SUVmax at baseline PET/CT was assessed to determine its relationship with prognosis after SBRT. Patients were divided into two groups based on maximum SUVmax on pre-treatment FDG PET/CT, estimated by receiver operating characteristic curve. Results: The median follow-up period was 17.7 months (range, 2.3 to 60.0 months). The actuarial 2-year local control, progression-free survival (PFS), and overall survival were 80.4%, 66.0%, and 78.2%, respectively. With regard to failure patterns, 5 patients exhibited local failure (in-field failure, 18.5%), 1 (3.7%) experienced regional nodal relapse, and other 2 (7.4%) developed distant failure. SUVmax was significantly correlated with progression (p = 0.08, optimal cut-off point SUVmax > 5.1). PFS was significantly influenced by pretreatment SUVmax (SUVmax > 5.1 vs. SUVmax ≤ 5.1; p = 0.012) and T stage (T1 vs. T2-3; p = 0.012). Conclusion: SUVmax at pre-treatment FDG PET/CT demonstrated a predictive value for PFS after SBRT for lung cancer.

• Physical Therapy Korea
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• v.22 no.4
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• pp.71-78
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• 2015

Previous studies have investigated stepping over obstacles in treadmill walking training (TWT-OS) and treadmill walking training (TWT) alone for walking capacity not considering real physical activity. As such, we investigated the effects of TWT-OS on physical activity and changes in different levels of physical activity based on community ambulation in stroke patients. Thirty subjects were randomly assigned to either the experimental group or the control group, with 15 and 15 subjects, respectively. However, one subject from the control group was excluded because of inadequate treatment sessions. All subjects underwent routine physical therapy in the form of treadmill walking. The subjects in the experimental group underwent simultaneous training in obstacle-stepping while walking on the treadmill for 30 min/day, five times/week, for four weeks. Subjects were given a three-axis accelerometer to wear at the hip on a belt for one-week pre- and post-training physical activity. Step counts for seven days, average daily step counts, and the average of minutes spent in sedentary, light, and above moderate activity were chosen as outcome measures of physical activity. No significant differences between the groups were found in terms of step counts for seven days, average daily activity, or daily activity spent at sedentary levels after four-week interventions. However, the average daily activity spent at light levels (-42.60 min vs. -6.71 min) was significantly lower in the experimental group than in the controls. Conversely, average daily activity spent at above moderate levels was higher (19.86 min vs. 11.07 min) (p<.05) after adjusting for each baseline value. Significant pre- and post-training differences were found in all variables of the experimental group (p<.05). Thus, TWT-OS could improve physical levels above moderate activity as a community-oriented task more than simple repetitive waking on a treadmill, and it could provide an opportunity for patients ambulatory after stroke to participate in the community again.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.12 no.1
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• pp.49-56
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• 1982

The purpose of this study was to observe the anatomic variation of condylar head and the positional relationship between condylar head and other anatomic structures of head by means of cephalometry using the submentovertex cephalogram from each person in centric occlusion for producing a good quality of temporomandibular joint radiograph. The 100 submentovertex cephalograms of 100 Korean adults consisted of 50 females ranged from 20 to 24 years age and 50 males ranged from 22 to 30 years age, were studied and analyzed statistically. The results were as follows; 1. The mean of the horizontal angulation of condylar head to the transmeatal line (EE-LA) was 18.5° (S.D. 7.9°), and all measurements that indicate the horizontal angulation of condylar head showed considerable differences among individuals. 2. In the comparison of male vs. female in the measurements, statistically significant differences were found in the majority of measurement items, and with exception of R-LA and LA-LA, the rest of these measurements were larger in male than in female. 3. In the comparison of left vs. right in the measurements, statistically significant differences were found in the majority of measurement items, and with exception of PC-CC, the rest of these measurements were larger in right than in left. As above, because the majority of measurements that involve the horizontal angulation of condylar head varied among individuals, between male and female, and between left and right, the condition of various temporomandibular joint radiography should be determined by means of cephalometry using the submentovertex cephalogram for producing the accurate radiographic image of temporomandibular joint.

• Journal of the Korean Dietetic Association
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• v.23 no.1
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• pp.54-63
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• 2017

Anemia, defined as a reduction in the hemoglobin concentration of blood, is common in diabetes mellitus (DM) patients, can be potentially caused by diabetes complications such as nephropathy. Recent research suggests that diabetes mellitus (DM) itself may be a major risk factor of anemia. However, there are few Korean studies on the relationship between diabetes mellitus (DM) and anemia. This study was performed to investigate the association between anemia and diabetes mellitus (DM) in Korean adults. A total of 10,151 Korean adults over aged 19 years (4,422 male, 5,729 female) were selected from the participants of the Korean National Health and Nutrition Examination Survey VI (KNHANES VI). Korean adults with anemia had a higher prevalence of diabetes mellitus (DM) than the normal adults (11.4% vs. 30.4% in male, 8.8% vs. 9.4% in female). The unadjusted odds ratio (OR) for anemia was greater in adults with DM than in normal male (OR=3.28; 95% CI: 2.27~4.73). After adjusting for other risk factors including age, education, family income, smoking, drinking, and menstrual status, anemia and diabetes were not associated (OR=1.33; 95% CI: 0.84~2.09). Similarly, there was no association between anemia and diabetes in female. In conclusion, this study shows that the prevalence of anemia is similar in diabetic and non-diabetic Korean adults after adjusting for multiple risk factors. Further research is required to elucidate the mechanism of anemia caused as a consequence of diabetes mellitus (DM).

• Korean Journal of Soil Science and Fertilizer
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• v.50 no.5
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• pp.325-335
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• 2017

This study was carried out for 30 days in aeration type and agitation type reactor to characterize organic matter decomposition and ammonia volatilization during the liquid composting of pig slurry, and organic matter and nitrogen removal rate through mass balance analysis was analyzed. In the aeration type reactor, the pH increased from 7.0 to 9.13, and TS 34.5%, VS 33.4%, $BOD_5$ 71.2%, $COD_{Cr}$ 62.3% and TOC 83.2% were removed. In addition, 44.6% of TN and 65.0% of ${NH_4}^+-N$ were removed. In the agitation type reactor, the pH increased from 7.0 to 8.10, and the removal rates of TS 0.9%, VS 0.5%, $COD_{Cr}$ 27.5%, $BOD_5$ 28.9% and TOC 41.3% were obtained. And TN and ${NH_4}^+-N$ showed removal rate of 25.3% and 29.2%, respectively. The first order kinetics constant related to $BOD_5$ degradation was $-0.039day^{-1}$ for aerobic liquid composting and $-0.013day^{-1}$ for agitated reactor. Nitrogen loss in aerobic liquid composting was about 2.3 times higher than that of agitated reactor, whereas FAN/TAN in aerobic liquid composting was about 7.9 times higher than that of agitation type reactor. Therefore, despite the low FAN/TAN in the agitation type reactor, the nitrogen loss rate was relatively high.

• The Journal of the Acoustical Society of Korea
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• v.26 no.1E
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• pp.33-38
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• 2007

Compressional wave velocity and shear wave velocity were measured for gassy sediments collected from Jinhae Bay, Korea. To distinguish inhomogeneities of gassy sediments, Computed Tomography (CT) was carried out for gassy sediment using CT Scanner. The cored sediments are composed of homogeneous and soft mud (greater than $8{\Phi}$ in mean grain size) containing clay content more than 50%. In depth interval of gassy sediments, compressional wave velocity is significantly decreased from 1480m/s to 1360m/s, indicating that the gas greatly affects compressional wave velocity due to a gas and/or degassing cracks. Shear wave velocity shows a slight increasing pattern from ${\sim}55\;m/s$ in the upper part of the core to ${\sim}58\;m/s$ at 320 cm depth, and then decreases to ${\sim}54\;m/s$ in the lower part of the core containing a small amount of gas. But shear wave velocity in the gassy sediments is slightly greater than that of non-gassy sediments in the upper part of the core. Thus, the Vp/Vs ratio is decreased (from 30 to 25) in gas charged zone. The Vp/Vs ratio is well correlated with shear wave velocity, but no correlation with compressional wave velocity. This suggests that low concentrations of gas have little affects on shear wave velocity. By CT images, the gas in the sediments is mostly concentrated around inner edge of core liner due to a long duration after sediment collection.