• The Korean Journal of Physiology and Pharmacology
• /
• 제3권2호
• /
• pp.137-146
• /
• 1999

Interactions among dexamethasone, dehydroepiandrosterone (DHEA), lipopolysaccharide (LPS), and antimycin A on the glutamate uptake and the polyamine uptake were investigated in primary cultures of rat cerebral cortical astrocytes to examine the effects of dexamethasone and DHEA on the regulatory role of astrocytes in conditions of increased extracellular concentrations of glutamate or polyamines. 1. $[^3H]Glutamate$ uptake: LPS and antimycin A decreased $V_{max},$ but both drugs had little effect on $K_m.$ Dexamethasone also decreased basal $V_{max}$ without any significant effect on $K_m.$ And dexamethasone further decreased the antimycin A-induced decrease of $V_{max}.$ DHEA did not affect the kinetics of basal glutamate uptake and the change by LPS or antimycin A. 2. $[^{14}C]Putrescine$ uptake: LPS increased $V_{max},$ and antimycin A decreased $V_{max}.$ They showed little effect on $K_m.$ Dexamethasone decreased $V_{max}$ of basal uptake and further decreased the antimycin A-induced decrease of $V_{max},$ and also decreased $V_{max}$ to less than control in LPS-treated astrocytes. DHEA did not affect $K_m$ and the change of $V_{max}$ by LPS or antimycin A. 3. $[^{14}C]Spermine$ uptake: Antimycin A decreased $V_{max},$ and LPS might increase $V_{max}.\;K_m$ was little affected by the drugs. Dexamethasone decreased basal $V_{max}$ and might further decrease the antimycin A-induced decrease of $V_{max}.$ And dexamethasone also decreased $V_{max}$ to less than control in LPS-treated astrocytes. DHEA might increase basal $V_{max}$ and $V_{max}$ of LPS-treated astrocytes. 4. $V_{max}$ of glutamate uptake by astrocytes was increased by putrescine (1000 ${\mu}M$ & 2000 ${\mu}M$) and spermidine (200 ${\mu}M,$ 500 ${\mu}M$ & 2000 ${\mu}M$). Spermine, 200 ${\mu}M$ (and 100 ${\mu}M$), also increased $V_{max},$ but a higher dose of 2000 ${\mu}M$ decreased $V_{max}.\;K_m$ of glutamate uptake was not significantly changed by these polyamines, except that higher doses of spermine showed tendency to decrease $K_m$ of glutamate uptake. In astrocytes, dexamethasone inhibited the glutamate uptake and the polyamine uptake in normal or hypoxic conditions, and the polyamine uptake might be stimulated by LPS and DHEA. Polyamines could aid astrocytes to uptake glutamate.

• 디지털융복합연구
• /
• 제11권3호
• /
• pp.371-380
• /
• 2013

본 연구는 남자 비만 중학생을 대상으로 최대하 방법의 PACER 검사를 통해 최대산소섭취량($\dot{V}O_{2max}$)을 추정할 수 있는 추정식을 개발하고자 중학교 남자 비만 학생 57명을 대상으로 Bruce 프로토콜의 최대운동부하검사와 PACER 검사를 실시하였다. 최대하 수준을 결정하기 위해 PACER 운동 중 목표심박수(75%$HR_{max}$ 이상)가 나타나는 왕복횟수 구간별 대사반응을 측정하였으며, $%HR_{max}$ 구간별(75%, 80%, 85%, 90%, 95%) 대사반응 지표를 단계적 선택법으로 회귀분석을 실시하였다. 그 결과 다음의 모형이 산출되었다. 모형 1(90%$HR_{max}$의 모형): $\dot{V}O_{2max}$(ml/kg/min) = 142.721-0.275(왕복횟수)-0.48(심박수)+0.177(체중)-1.536(연령)[표준오차 3.90ml/kg/min; 2단계까지 운동진행]. 모형 2(95%$HR_{max}$의 모형): $\dot{V}O_{2max}$(ml/kg/min) = 182.851-0.103(왕복횟수)-0.744(심박수)+0.186(체중)-0.324(연령)[표준오차 4.51ml/kg/min; 3단계까지 운동진행]. 모형 1의 추정된 $\dot{V}O_{2max}$와 실측 $\dot{V}O_{2max}$간 차이 평균은 $3.25{\pm}6.32ml/kg/min$(%error=6.84%), 모형 2는 $3.16{\pm}4.54ml/kg/min$(%error=5.75%). 비만인 대상자들에게 최대하 운동방법으로는 심박수와 운동지속시간이 짧았던 모형 1이 모형 2보다 적합한 형태로 생각된다.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2009년도 춘계학술대회 논문집 에너지변화시스템부문
• /
• pp.143-145
• /
• 2009

본 논문에서는 AC-AC 직접 변환 방식인 매트릭스 컨버터의 진압 변조 방법 중 하나인 $V_{max}-V_{mid}$ PWM 변조 방법을 간략화한 Simple $V_{max}-V_{mid}$ 전압 변조 방법에 대해 소개한다. $V_{max}-V_{mid}$ 전압 변조 방법은 실행 전에 입력전압 위상각$(\theta_E)$을 판별하는 PLL(Phase Looked Loop)과정을 거친 후, 얻은 위상 정보를 사용하석 게이트 신호를 만들어 낸다. 하지만 PLL의 사용이 연산 시간의 딜레이를 발생시키고, 처리과정을 복잡하게 만드는 단점으로, PLL과정을 생략하여 입력 전압의 크기 정보만으로 섹터를 판별하고 게이트 신호를 발생시켜 스위치를 조작하는 변조 방범을 사용하였다. 이로 인해 연산시간의 단축과 처리 과정의 축소 등의 이점을 취하고, 이를 시뮬레이션으로 검증한다.

• 대한화학회지
• /
• 제24권6호
• /
• pp.426-433
• /
• 1980

컬럼 단면적에 대한 $V_{max}$ 와 $V_{HWB}$ 크기의 의존성이 기대했던 것과 같이 직선적인 함수 관계에 있음을 알 수 있었다. 이 의존성은 일반적으로 가장 굵은 입자 크기인 20∼50 mesh의 이온교환수지를 사용한 지름 3 mm의 컬럼에 의하여 증명되었다. 유속의 영향은 $V_{max}$값에 대해서는 거의 효과가 없었으나, $V_{HWB}$값에 대해서는 강한 영향을 주는 긍정적 항으로서 작용한다는 것을 알 수 있었다. 유속이 빠르면 Bandenverbreitung은 급격히 증가되었다. 이와 같은 사실은 분리곤란한 물질의 분리 문제엔 느린 유속이 유익하다는 것을 보여 준다. 흡착량은 $V_{max}$ 와 $V_{HWB}$값에 부가적으로 영향을 주었다. 분리효과가 더 이상 이루어 질 수 없도록 많은 양의 방사성핵 (Co 와 Mn)을 사용했을 때는 $V_{max}$값의 차이는 미소하였다. Co($K_D$=68.2)와 Mn($K_D$=71.8)의 분리를 통하여, 만들어 낸 공식을 검증하였고 또한 그것이 잘 적용될 수 있음을 증명할 수 있었다.

• 전기학회논문지
• /
• 제58권2호
• /
• pp.285-291
• /
• 2009

In this paper, comparative analysis of offset voltage PWM method and $V_{max}-V_{mid}$ PWM method for three-phase matrix converter is addressed by using a simple analytical and graphical method. Offset voltage PWM method calculates PWM patterns in terms of offset voltage and variable slope of carrier, and it simplifies matrix converter modulation algorithm significantly. $V_{max}-V_{mid}$ PWM method generates patterns by using two phases and maintaining a remaining phase to base phase, and it is implemented in the industrial products. The most important performance criterion of modulation method is a magnitude of current ripples and it is analytically modelled. The graphical illustration of theses complex multivariable functions make per-carrier cycle and per fundamental cycle behavior of two PWM methods understood. Two modulation methods are analysed with the analytical formulas and graphics, and the analysis shows offset voltage PWM method is superior to $V_{max}-V_{mid}$ PWM method with respect to input current ripples and output voltage ripples.

• The Korean Journal of Physiology
• /
• 제27권2호
• /
• pp.209-215
• /
• 1993

The aim of the present study was to derive regression equations for $\dot{V}o_{2max}\;vs.\;\dot{V}o_{2peak},\;and\;\dot{V}o_2\;vs.$ heart rate, exercise time, and other variables from maximal exercise tests on a treadmill using the Bruce and inclined protocols. Twelve male and 10 female Korean college students aged between 19 and 23 years voIunteered for this study. After the resting measurements, the subjects performed a maximal exercise on a treadmill according to the Bruce protocol. When the resting conditions were restored, the subjects performed another maximal exercise according to an inclined protocol where the speed was fixed at 8.05 $km{\cdot}h^{-1}$ and the grade was incremented starting from 09t by 2.5% for every 2 min. Peak $\dot{V}o_2$ observed during the Bruce exercise $(\dot{V}o_{2peak})$ was $37.7{\pm}2.4\;and\;31.7{\pm}1.8\;ml\;kg^{-1}\;min^{-1}$ in the male and female groups, respectively. Peak $\dot{V}o_2$ observed during the inclined exercise was higher than $\dot{V}o_{2peak}$ during the Bruce exercise. Maximum $\dot{V}o_2$ value observed during the tyro exercises $(\dot{V}o_{2max})$ was $43.0{\pm}2.8\;and\;36.2{\pm}1.4\;ml\;kg^{-1}\;min^{-1}$ in the male and female groups, respectively. Thus, $\dot{V}o_{2peak}$ by the Bruce protocol was about 12% (male) or 13% (female) lower than $\dot{V}o_{2max}$, and a linear relationship was found between $\dot{V}o_{2peak}$ and $\dot{V}o_{2max}$. The peak values of % $\dot{V}o_{max}$ with the Bruce protocol were $89.2{\pm}3.3\;and\;87.5{\pm}3.6%$ and those with the inclined protocol $97.7{\pm}1.8\;and\;96.9{\pm}2.0%$ in the male and female groups, respectively. In the female group, $%\dot{V}o_{2max}$ at a given workload was higher than in the male group, while $\dot{V}o_{2}$ per kg body weight was the same. Maximum HR observed during the two exercises was $204{\pm}2\;and\;195{\pm}3\;beat\;min^{-1}$ in the male and female groups, respectively. Linear relationships were found, excluding the last points, between 1) $\dot{V}o_{2}$ and exercise time, 2) $\dot{V}o_{2}$ and $%\dot{V}o_{2max}\;and\;%HR_{max}$.

• The Journal of Korean Physical Therapy
• /
• 제22권4호
• /
• pp.15-20
• /
• 2010

Purpose: The purpose of this study was to measure changes in the H-reflex and V wave under loading conditions (e.g. prone and standing position) and to investigate whether postural change would affect the H-reflex and V wave in post stroke hemiplegic patients. Methods: Thirty persons with hemiplegia resulting from stroke (20 males, 10 females) participated in this study. Electromyography (EMG) was used to electrically stimulate and record the soleus H-reflexes and V waves under various loading conditions. The normality of the distribution of each variable (H latency, $H_{max}/M_{max}$ ratio, $V_{max}/M_{max}$ ratio) was tested using the Kolmogorov-Smirnov test. The means of normally distributed continuous data were assessed by independent t-test (${\alpha}$=0.05). Results: There were statistically significant differences in $H_{max}/M_{max}$ ratio (p<0.01), $V_{max}/M_{max}$ ratio (p<0.01), H latency (p<0.01) among the prone and standing position. Conclusion: We found that the H-reflex and V wave in standing position was more active to weight bearing load than prone position.

• Journal of Astronomy and Space Sciences
• /
• 제19권1호
• /
• pp.1-6
• /
• 2002

Recently, one interesting possibility is proposed that a magnetar can be a progenitor of short and hard gamma-ray bursts (GRBs). If this is true, one may expect that the short and hard GRBs, at least some of GRBs in this class, are distributed in the Euclidean space and that the angular position of these GRBs is correlated with galaxy clusters. Even though it is reported that the correlation is statistically marginal, the observed value of < $V/V_{max}$ > deviates from the Euclidean value. The latter fact is often used as evidence against a local extragalactic origin for short GRB class. We demonstrate that GRB sample of which the value of < $V/V_{max}$ > deviates from the Euclidean value can be spatially confined within the low value of z. We select very short bursts (TgO < 0.3 sec) from the BATSE 4B catalog. The value of < $V/V_{max}$ > of the short bursts is 0.4459. Considering a conic-beam and a cylindrical beam for the luminosity function, we deduce the corresponding spatial distribution of the GRB sources. We also calculate the fraction of bursts whose redshifts are larger than a certain redshift z', i.e. f>z'. We find that GRBs may be distributed near to us, despite the non-Euclidean value of < $V/V_{max}$ >. A broad and uniform beam pattern seems compatible with the magnetar model in that the magnetar model requires a small $z_{max}$.

• Tuberculosis and Respiratory Diseases
• /
• 제42권6호
• /
• pp.900-912
• /
• 1995

연구배경: 최대운동부하 검사는 심폐기능의 종합적인 평가를 위하여 널리 이용되고 있으나 아직 우리나라에는 최대운동시의 호흡성 가스교환이나 폐기능의 정상치가 제대로 확립되어 있지 않은 설정이다. 본 연구의 목적은 한국성인에서 최대운동시의 이들 지표의 연령과 성별에 따른 정상치 내지 참고치를 마련하는 동시에 이들 중 일부지표의 추정정상치를 산출하는 회귀방정식을 구하는데 있다. 방법: 건강한 성인 남성 603명, 여성 397명, 합계 1,000명(20~66세)을 대상으로 Bruce법으로 증상제한성 최대운동부하 검사를 실시하였으며, 이중 885명에서는 VC, $FEV_1$ 및 MVV도 측정하였다 대상자들은 모두 전문체육인이 아닌 스포츠센터의 회원이었으며, 운동부하검사 중에는 안전상의 문제 때문에 부득이 트레드밀의 손잡이를 잡는 것을 허용하였다. 곁과: $VO_2\;max/m^2$, $VCO_2\;max/m^2$ 및 VE max/$m^2$는 모두 남성에서 뚜렷이 컸으며, 남녀에서 모두 연령의 증가에 따라 감소하였다. 한편 RR max는 성별에 따른 차이는 없었으나, 연령의 증가에 따라 약간씩 감소하였으며, $V_T$ max는 남성에서 월등히 많았으나 남녀에서 다같이 연령에 따른 일정한 경향의 변화는 없었다. 그리고 $V_T$ max/VC, $V_E$ max/MVV 및 BR의 평균은 최대운동시에 나이가 많은 여성에서도 상당한 환기예비가 있음을 보여주었다. 저자들은 성적을 토대로 운동시간(분), 나이(세), 시장(cm), 체중(kg), 성별(남=0, 여=1), VC(L), $FEV_1$(L) 및 VE max(L) 등을 변수로 해서 구한 주요 지표들의 회귀방정식은 다음과 같다. $VO_2\;max/m^2(L/min)=1.449+0.073{\times}$운동시간-$0.007{\times}$연령+$0.010{\times}$체중-$0.006{\times}$신장-$0.209{\times}$성별, $VCO_2\;max/m^2(L/min)=1.672+0.063{\times}$운동시간-$0.008{\times}$연령+$0.010{\times}$체중-$0.005{\times}$신장-$0.319{\times}$성별, $V_E\;max/m^2(L/min)=58.161+1.503{\times}$운동시간-$0.315{\times}$연령-$9.871{\times}$성별 또는 $V_E\;max/m^2(L/min)=47.873+6.458{\times}FEV_1-5.715{\times}$성별 및 $V_T\;max(L)=1.497+0.223{\times}VC-0.493{\times}$성별. 결론: 본 연구에서 얻은 최대운동시의 호흡성 가스 교환 및 환기기능에 관한 성적은 건강과 체력에 대해서 일반인보다 관심이 높을 것으로 생각되는 스포츠센터 회원들을 대상으로 한 것이기 때문에, 안전상의 문제로 트레드밀의 손잡이를 잡고 검사를 해야하는 환자나 건강인을 위한 이상적인 목표치 내지 정상치를 제공한 것으로 생각된다. Background: Although graded exercise stress tests are widely used for the evaluation of cardiorespiratory performance, normal standards on respiratory gas exchange and ventilatory functions at maximal exercise in Koreans have not been well established. The purpose of this study is to provide reference values on these by sex and age, along with derivation of some of their prediction equations. Method: Symptom-limited maximal exercise test was carried out by Bruce protocol in 1,000 healthy adults consisting of 603 males and 397 females, aged 20~66 years. Among them VC, $FEV_1$ and MVV were also determined in 885 cases. All the subjects were members of a health center, excluding athletes. During the exercise, subjects were allowed to hold on to front hand rail of the treadmill for safety purpose. Results: The $VO_2\;max/m^2$, $VCO_2\;max/m^2$ and $V_E\;max/m^2$ were greater in males than in females and decreased with age. The RR max in men and women was similar but decreased slightly with age. The $V_T$ max was markedly greater in men but showed no significant changes with age in either gender. The mean of $V_T$ max/VC, $V_E$ max/MVV and BR revealed that there were considerable ventilatory reserves at maximal exercise even in older females. The regression equations of the cardinal parameters obtained using exercise time(ET, min), age(A, yr), height(Ht, cm), weight(W, kg), sex(S, 0=male; 1=female), VC(L), $FEV_1$(L) and $V_E$ max(L) as variables are as follows: $VO_2\;max/m^2$(L/min)=1.449+0.073 ET-0.007A+0.010W-0.006Ht-0.209S, $VCO_2\;max/m^2$(L/min)=1.672+0.063ET-0.008A+0.010W-0.005Ht-0.319S, VE max/$m^2$(L/min)=58.161+1.503ET-0.315A-9.871S or VE max/$m^2$(L/min)=47.873+6.548 $FEV_1$-5.715 S, and VT max(L)=1.497+0.223VC-0.493S. Conclusion: Respiratory gas exchange and ventilatory variables at maximal exercise were studied in 1,000 non-athletes by Bruce protocol. During exercise, the subjects were allowed to hold on to hand rail of the treadmill for safety purpose. We feel that our results would provide ideal target values for patients and healthy individuals to be achieved, since our study subjects were members of a health center whose physical fitness levels were presumably higher than ordinary population.

• 한국광학회:학술대회논문집
• /
• 한국광학회 2007년도 동계학술발표회 논문집
• /
• pp.319-320
• /
• 2007