• Title/Summary/Keyword: $Theta^*$

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Identification of a Novel Human Lysophosphatidic Acid Acyltransferase, LPAAT-theta, Which Activates mTOR Pathway

  • Tang, Wenwen;Yuan, Jian;Chen, Xinya;Gu, Xiuting;Luo, Kuntian;Li, Jie;Wan, Bo;Wang, Yingli;Yu, Long
    • BMB Reports
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    • v.39 no.5
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    • pp.626-635
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    • 2006
  • Lysophosphatidic acid acyltransferase (LPAAT) is an intrinsic membrane protein that catalyzes the synthesis of phosphatidic acid (PA) from lysophosphatidic acid (LPA). It is well known that LPAAT is involved in lipid biosynthesis, while its role in tumour progression has been of emerging interest in the last few years. To date, seven members of the LPAAT gene family have been found in human. Here we report a novel LPAAT member, designated as LPAAT-theta, which was 2728 base pairs in length and contained an open reading frame (ORF) encoding 434 amino acids. The LPAAT-theta gene consisted of 12 exons and 11 introns, and mapped to chromosome 4q21.23. LPAAT-theta was ubiquitously expressed in 18 human tissues by RT-PCR analysis. Subcellular localization of LPAAT-theta-EGFP fusion protein revealed that LPAAT-theta was distributed primarily in the endoplasmic reticulum (ER) of COS-7 cells. Furthermore, we found that the overexpression of LPAAT-theta can induce mTOR-dependent p70S6K phosphorylation on Thr389 and 4EBP1 phosphorylation on Ser65 in HEK293T cells.

Using a Greedy Algorithm for the Improvement of a MapReduce, Theta join, M-Bucket-I Heuristic (그리디 알고리즘을 이용한 맵리듀스 세타조인 M-Bucket-I 휴리스틱의 개선)

  • Kim, Wooyeol;Shim, Kyuseok
    • Journal of KIISE
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    • v.43 no.2
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    • pp.229-236
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    • 2016
  • Theta join is one of the essential and important types of queries in database systems. As the amount of data needs to be processed increases, processing theta joins with a single machine becomes impractical. Therefore, theta join algorithms using distributed computing frameworks have been studied widely. Although one of the state-of-the-art theta-join algorithms uses M-Bucket-I heuristic, it is hard to use since running time of M-Bucket-I heuristic, which computes a mapping from a record to a reducer (i.e., reducer mapping), is O(n) where n is the size of input data. In this paper, we propose MBI-I algorithm which reduces the running time of M-Bucket-I heuristic to $O(r_{max}log\;n)$ and gives the same result as M-Bucket-I heuristic does. We also conducted several experiments to show algorithm and confirmed that our algorithm can improve the performance of a theta join by 10%.

A Study on the Relationship between Psychophysiological Experience and Negative Attitude in Smoking Serious Games (흡연 기능성 게임에서 심리생리학적 경험과 흡연의 부정적 태도와의 관계에 대한 연구)

  • Jang, Han-Jin;Noh, Ghee-Young
    • Journal of Korea Game Society
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    • v.17 no.6
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    • pp.189-198
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    • 2017
  • The purpose of this study is to investigate the relationship between smoking attitudes and psychophysiological variables and to find out whether smoking cessation activities can be helpful for smoking cessation. We set up Negative Attitudes experience as a dependent variable. Several factors including Psychological Resistance, Psychological Distress and brainwave(Left brain ${\theta}$, Right Brain ${\theta}$) as a physiological indicator, which was expected to affect flow, were set up as independent variables to perform regression analysis. As a result, psychological resistance had negative influences on negative attitudes toward smoking in smoking simulation game and psychological distress had positive effect. And left brain ${\theta}$ had negative influences on negative attitudes toward smoking in smoking simulation game and right brain ${\theta}$ had positive effect.

Constant Correlation Factors between Temkin and Langmuir or Frumkin Adsorption Isotherms at Poly-Pt, Re, and Ni/Aqueous Electrolyte Interfaces

  • Chun Jang H.;Jeon Sang K.;Chun Jin Y.
    • Journal of the Korean Electrochemical Society
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    • v.7 no.4
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    • pp.194-200
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    • 2004
  • The constant correlation factors between the Temkin and the Langmuir or the Frumkin adsorption isotherms of over-potentially deposited hydrogen (OPD H) for the cathodic H2 evolution reaction (HER) at poly-Pt and Re/0.5M $H_2SO_4$ and poly-Ni/0.05 M KOH aqueous electrolyte interfaces have been experimentally and consistently found using the phase-shift method. At intermediate values of the fractional surface coverage $(\theta),\;i.e.,\;02<{\theta}<0.8$, the Langmuir and Temkin adsorption isotherms of OPD H for the cathodic HER are correlated to each other even though the adsorption conditions or processes are different from each other. At the same range of $\theta$, correspondingly, the Frumkin and Temkin adsorption isotherms of OPD H for the cathodic HER are correlated to each other. The equilibrium constants $(K_o)$ for the Temkin adsorption isotherms $({\theta}\;vs.\; E)$ are consistently ca. 10 times greater than those (K, Ko) for the corresponding Langmuir or Frumkin adsorption isotherms ($({\theta}\;vs.\; E)$. The interaction parameters (g) for the Temkin adsorption isotherms $({\theta}\;vs.\; E)$ are consistently ra. 4.6 greater than those (g) for the corresponding Langmuir or Frumkin adsorption isotherms $({\theta}\;vs.\; E)$. These numbers (10 times and 4.6) can be taken as constant correlation factors between the corresponding adsolftion isotherms (Temkin, Langmuir, Frumkin) at the interfaces. The Temkin adsorption isotherm corresponding to the Langmuir or the Frumkin adsorption isotherm, and vice versa, can be effectively verified or confirmed using the constant correlation factors. Both the phase-shift methodand constant correlation factors are useful and effective for determining or confirming the suitable adsorption isotherms (Temkin, Langmuir, Frumkin) of intermediates for sequential reactions in electrochemical systems.

Influence of latitude wind pressure distribution on the responses of hyperbolodial cooling tower shell

  • Zhang, Jun-Feng;Ge, Yao-Jun;Zhao, Lin
    • Wind and Structures
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    • v.16 no.6
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    • pp.579-601
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    • 2013
  • Interference effects are of considerable concern for group hyperboloidal cooling towers, but evaluation methods and results are different from each other because of the insufficient understanding on the structure behavior. Therefore, the mechanical performance of hyperboloidal cooling tower shell under wind loads was illustrated according to some basic properties drawn from horizontal rings and cantilever beams. The hyperboloidal cooling tower shell can be regarded as the coupling of horizontal rings and meridian cantilever beams, and this perception is beneficial for understanding the mechanical performance under wind loads. Afterwards, the mean external latitude wind pressure distribution, CP(${\theta}$), was artificially adjusted to pursue the relationship between different CP(${\theta}$) and wind-induced responses. It was found that the maximum responses in hyperboloidal cooling tower shell are primarily dominated by the non-uniformity of CP(${\theta}$) but not the local pressure amplitude CP or overall resistance/drag coefficient CD. In all the internal forces, the maximum amplitude of meridian axial tension shows remarkable sensitivity to the variation of CP(${\theta}$) and it's also the controlling force in structure design, so it was selected as an indicator to evaluate the influence of CP(${\theta}$) on responses. Based on its sensitivity to different adjustment parameters of CP(${\theta}$), an comprehensive response influence factor, RIF, was deduced to assess the meridian axial tension for arbitrary CP(${\theta}$).

A Study on the Natural Convection from the Isothermal Square Beam Attached to an Adiabatic Plate (단열판에 부착된 등온 사각비임에서의 자연대류 열전달에 관한 연구)

  • Park, Jae-Lim;Kwon, Sun-Sok
    • Solar Energy
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    • v.11 no.1
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    • pp.61-68
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    • 1991
  • Steady laminar natural convection heat transfer from the isothermal square beam attached to an adiabatic plate has been studied for various inclination angles of the adiabatic plate and Rayleigh number by using Mach-Zehnder interferometer in air. As the inclination angles change, the different temperature and fluid flow field were obtained by the ascending heated fluid and the adiabatic plate. In this study, the inclination angles were $0^{\circ}$(positive & negative), $45^{\circ}$(positive & negative), and $90^{\circ}$. The maximum total mean Nusselt number value was found at a positive inclination angle ${\theta}=45^{\circ}$.

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Molecular Orbital Theoretical Study on the Conformation and Chemical Reactivity of Insecticidal 0,0-Diethylphenylphosphate Derivatives (살충성(殺蟲性) 0,0-Diethylphenylphosphate 유도체(誘導體)의 형태(形態)와 반응성(反應性)에 관(關)한 분자궤도론적(分子軌度論的) 연구(硏究))

  • Park, Seung-Heui;Sung, Nack-Do;Myung, Pyung-Keun;Jeon, Young-Koo;Lee, Chun-Bae
    • Korean journal of applied entomology
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    • v.24 no.4 s.65
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    • pp.231-238
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    • 1986
  • Molecular orbital theoretical study on the stability of conformations and chemical reactivity of 0,0-diethylphenylphosphate derivatives were carried out by EHT and CNDO/2 molecular orbital calculation method. The results shown that the dipole moment(${\mu}$) and total energies of the ${\theta}=90^{\circ}$ conformer were ${\mu}=3.185D\;&\;E_t=-162.6479(au)$ and also that of the ${\theta}=0^{\circ}$ conformer were ${\mu}=5.596D\;&\;E_t=-162.4013(au)$, respectively. Therefore, the values of ${\mu}\;&\;E_t$ of the ${\theta}=90^{\circ}$ conformer were much smaller than that of the ${\theta}=0^{\circ}$ conformer. The form with angle of rotation ${\theta}=90^{\circ}$ of phenyl ring was shown to be most stable and this was interpreted in terms of electrostatic and steric effect. 0,0-diethylphenylphosphate derivatives are predicted to increase both charge and orbital controlled $SN_2$ reactivity of the electron withdrawing substituent reduces the HOMO & LUMO energy, while the electron withdrawing substituent due to increase in positive charge of phosphorus atom of phosphate molecule.

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Characteristics of the Angular-dependent Exchange Coupling Bias in Multilayer [Pt/Co]N-IrMn with Toward-in Plane Applied Fields (박막수직방향에서 면방향으로 회전하는 인가자기장에 대한 다층박막 [Pt/Co]N-IrMn의 교환바이어스의 각도의존특성)

  • Kim, S.S.;Yim, H.I.;Rhee, J.R.;Lee, S.S.;Hwang, D.G.
    • Journal of the Korean Magnetics Society
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    • v.18 no.4
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    • pp.142-146
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    • 2008
  • The angular dependence of the exchange bias($H_{ex}$) and coercivity($H_c$) in multilayer $[Pt/Co]_N-IrMn$ with applied measuring field rotated toward in-plane at angle $\theta$ from perpendicular-to-plane, has been measured. Multilayer films consisting of $Si/SiO_2/Ta(50)/Pt(4)/[Pt(15)/Co(t_{Co})]_N/IrMn(50)/Ta(50)(in\;{\AA})$ were prepared by magnetron sputtering under typical base pressure below $2{\times}10^{-8}$ Torr at room temperature. Magnetization measurements were performed on a vibrating sample magnetometer and extraordinary Hall voltage measurement systems after cooling from 550 K under a field of 2 kOe applied along the perpendicular to film direction. The hysteresis loop shifts from the origin not only along the field axis but also along the magnetization axis. $H_{ex}$ and $H_c$ show a $1/cos{\theta}$ and $1/|cos{\theta}|$ dependence on the angle($\theta$) between the applied measuring field and the perpendicular-film direction, respectively. This $1/cos{\theta}$ dependence can be accounted for by considering the angular dependence of strong out-of-plane magnetic anisotropy introduced during the field cooling.

The Design of Telecentric Lenses and Fly-eye Lenses by Utilizing fθ Formula (fθ 공식을 활용한 텔레센트릭 렌즈 및 플라이아이 렌즈의 설계)

  • Rim, Cheon-Seog
    • Korean Journal of Optics and Photonics
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    • v.24 no.1
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    • pp.9-16
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    • 2013
  • We try to find the generalized structural equation that gives a perspective understanding for telecentric lenses through paraxial optical algebraic equations and preconditions from a highly experienced design sense. The equation is named the $f{\theta}$ formula and this formula is applied to single lenses, double Gauss lenses, Cooke triplet lenses and the compound lens composed of a Cooke triplet lens and a double Gauss lens step by step. And this formula is also applied to single fly-eye lenses plus a telecentric lens and double fly-eye lenses plus a telecentric lens in sequence. As a result, we can confirm that this $f{\theta}$ formula leads to intuitive optical design with a structural understanding for telecentric lens systems.

Examining the way of presenting reliable information on web page

  • Sohn, Jin-Hun;Lee, Jeong-Mi;Lee, Kyung-Hwa
    • Proceedings of the Korean Society for Emotion and Sensibility Conference
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    • 2001.05a
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    • pp.231-238
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    • 2001
  • Frontal (F3, F4) EEG responses were analyzed and compared during exposure too slides of International Affective Picture System (IAPS) in the study on 42 students. EEG responses during 20 s of exposure to slides intended to elicit happiness (nurturant and erotic), sadness, disgust, surprise, fear or anger emotions were quite similar and were exhibited in theta increase, alpha-blocking and increased beta activity, and frontal asymmetry. However, particular emotions demonstrated variations of the EEG response profiles, enabling to differentiate some pairs of emotions. The profiles showed higher magnitudes of EEG responses in exciting (i.e., erotic happiness) emotion. The most different pairs were exciting -sadness (theta, alpha and alpha asymmetry), exciting-surprise (theta, alpha asymmetry), and exciting-fear (theta, F3 alpha, alpha asymmetry). Nurturant happiness yielded the least differentiation. Differences were found as well within negative emotions, e.g., anger-sadness were differentiated by theta asymmetry, while disgust-fear by beta asymmetry. Obtained results suggest that magnitudes of profiles of EEG variables differentiate emotions elicited by affective pictures.