• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 추계학술대회
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• pp.297-299
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• 2022

악성 뇌교종은 예후가 매우 나쁜 질병으로 평균 생존 기간은 6개월에서 14개월 사이로 보고되어 있다. 따라서 악성 뇌교종을 가진 환자들에게는 정확한 예후 예측이 요구된다. 본 논문에서는 악성 뇌교종을 가진 환자의 예후와 연령을 동시에 예측하는 합성곱 신경망 모델을 제안한다. 악성 뇌교종의 영상 특성을 효과적으로 파악할 수 있는 네 가지 자기공명영상인 T1, T1-contrast enhanced, T2, fluid-attenuated inversion recovery 영상을 입력 데이터로 이용하였다. 예후 예측에 가장 중요한 환자의 연령을 고려함으로써 신경망 모델의 예후 예측 성능이 높아질 것으로 기대된다. 학습된 모델을 검증 데이터에 적용한 결과 환자의 예후와 연령의 피어슨 상관계수가 각각 0.1748, 0.3056으로 나타난 것을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8335-8338
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• 2016

Purpose: To make a comparison of single voxel magnetic resonance spectroscopy (SV-MRS) and dynamic contrast enhancement (DCE) MRI for differentiation of benign and malignant breast lesions in a sample of Iranian women. Materials and Methods: A total of 30 women with abnormal breast lesions detected in mammography, ultrasound, or clinical breast exam were examined with DCE and SV-MRS. tCho (total choline) resonance in MRS spectra was qualitatively evaluated and detection of a visible tCho peak at 3.2 ppm was defined as a positive finding for malignancy. Different types of DCE curves were persistent (type 1), plateau (type 2), and washout (type 3). At first, lesions were classified according to choline findings and types of DCE curve, finally being compared to pathological results as the standard reference. Results: this study included 19 patients with malignant lesions and 11 patients with benign ones. While 63.6 % of benign lesions (7 of 11) showed type 1 DCE curves and 36.4% (4 of 11) showed type 2, 57.9% (11of 19) of malignant lesions were type 3 and 42.1% (8 of 19) type 2. Choline peaks were detected in 18 of 19 malignant lesions and in 3 of 11 benign counterparts. 1 malignant and 8 benign cases did not show any visible resonance at 3.2 ppm so SV-MRS featured 94.7% sensitivity, 72.7 % specificity and 86.7% accuracy.Conclusions: The present findings indicate that a combined approach using MRS and DCE MRI can improve the specificity of MRI for differentiation of benign and malignant breast lesions.

• 말소리와 음성과학
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• 제3권3호
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• pp.27-33
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• 2011

This paper explores two articulatory characteristics of inter-consonantal coordination observed in lingual-lingual (/kt/, /ks/) and labial-lingual (/pt/) sequences. Using electromagnetic articulometry (EMMA), temporal aspects of the lip movement and lingual movement (of the tongue tip and the tongue dorsum) were examined. Three sequences (/ks/, /kt/, /pt/) were investigated in two respects: gestural overlap in C1C2 and formation duration of coronals in C2 (/t/ or /s/). Results are summarized as follows. First, in a sequence of two stop consonants gestural overlap did not vary with order contrast or a low-level motor constraint on lingual articulators. Gestural overlap between two stop consonants was similar in both /kt/ (lingual-lingual; back-to-front) and /pt/ (labial-lingual; front-to-back). Second, gestural overlap was not simply constrained by place of articulation. Two coronals (/s/ and /t/) shared the same articulator, the tongue tip, but they showed a distinctive gestural overlap pattern with respect to /k/ in C1 (/ks/ (less overlap) < /kt/ (more overlap)). Third, temporal duration of the tongue tip gesture varied as a function of manner of articulation of the target segment in C2 (/ks/ (shorter) < /kt/ (longer)) as well as a function of place of articulation of the segmental context in C1 (/pt/ (shorter) < /kt/ (longer)). There are several implications associated with the results from Korean non-assimilating contexts. First, Korean can be better explained in the way of its language-specific gestural pattern; gestural overlap in Korean is not simply attributed to order contrast (front-to-back vs. back-to-front) or a physiological motor constraint on lingual articulators (lingual-lingual vs. nonlingual-lingual). Taking all factors into consideration, inter-gestural coordination is influenced not only by C1 (place of articulation) but also C2 (manner of articulation). Second, the jaw articulator could have been a factor behind a distinctive gestural overlap pattern in different C1C2 sequences (/ks/ (less overlap) vs. /kt/ and /pt/ (more overlap)). A language-specific gestural pattern occurred with reference to a physiological motor constraint on the jaw articulator.

• Journal of Yeungnam Medical Science
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• 제15권2호
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• pp.306-315
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• 1998

1994년 1월에서 1998년 8월까지의 영남대학교 의과대학 부속병원에서 신경베체트병으로 진단받은 9명의 환자를 대상으로 전신적인 임상증상과 자기공명영상소견을 분석한 결과 주된 전신적인 증상은 구강궤양, 안질환, 음부궤양이었으며, 자기공명영상소견에서 병소부위는 중뇌, 내포, 뇌교, 시상, 대뇌기저핵, 중소뇌각, 연수, 그리고 피질하백질 순으로 호발되었다. 이들 병소는 T2강조영상에서 불균질의 고신호강도, T1강조영상에서 저신호 강도로 보였으며, 국소적인 조영증강이 비교적 흔하게 관찰되었다. 추적영상에서 병변의 호전 및 재발이 관찰되었으나 1년이상 추적검사에서 병변이 있던 부위에 뇌조직의 위축이 관찰되었다. 결론적으로 신경베체트병의 전신적인 임상증상과 특징적인 자기공명영상소견을 앎으로서 신경베체트병의 진단에 도움이 되리라 생각한다.

• Investigative Magnetic Resonance Imaging
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• 제20권1호
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• pp.44-52
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• 2016

Purpose: To quantitatively and qualitatively compare fat-suppressed MRI quality using iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) with that using frequency selective fat-suppression (FSFS) T2- and postcontrast T1-weighted fast spin-echo images of the head and neck at 3T. Materials and Methods: The study was approved by our Institutional Review Board. Prospective MR image analysis was performed in 36 individuals at a single-center. Axial fat suppressed T2- and postcontrast T1-weighted images with IDEAL and FSFS were compared. Visual assessment was performed by two independent readers with respect to; 1) metallic artifacts around oral cavity, 2) susceptibility artifacts around upper airway, paranasal sinus, and head-neck junction, 3) homogeneity of fat suppression, 4) image sharpness, 5) tissue contrast of pathologies and lymph nodes. The signal-to-noise ratios (SNR) for each image sequence were assessed. Results: Both IDEAL fat suppressed T2- and T1-weighted images significantly reduced artifacts around airway, paranasal sinus, and head-neck junction, and significantly improved homogeneous fat suppression in compared to those using FSFS (P < 0.05 for all). IDEAL significantly decreased artifacts around oral cavity on T2-weighted images (P < 0.05, respectively) and improved sharpness, lesion-to-tissue, and lymph node-to-tissue contrast on T1-weighted images (P < 0.05 for all). The mean SNRs were significantly improved on both T1- and T2-weighted IDEAL images (P < 0.05 for all). Conclusion: IDEAL technique improves image quality in the head and neck by reducing artifacts with homogeneous fat suppression, while maintaining a high SNR.

• Journal of Yeungnam Medical Science
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• 제27권2호
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• pp.105-112
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• 2010

병리조직학적으로 고환림프종으로 확진된 예들의 초음파검사 및 자기공명영상을 후향적으로 분석하여 다른 고환종양과 구분할 수 있는 소견이 있는지를 알아보기 위하여 본 연구를 시행하였다. 수술적 절제에 의해 확진된 7예와 초음파-유도하 조직생검으로 확진된 1예 등 총 8예를 대상으로 하였다. 종괴의 크기와 위치, 고환 이외에 침범된 장기를 조사하였고, 초음파검사에서는 종괴의 모양과 경계, 종괴 내부의 에코, 균일도와 함께 색도플러검사에서의 혈관분포상태를 조사하였다. 자기공명영상이 시행된 4예를 대상으로 종괴의 모양과 경계, 균일도, T1-및 T2-강조영상에서의 신호강도 및 조영증강 여부와 시간에 따른 조영증강의 변화를 조사하였다. 고환에 국한되어 있었던 경우는 2예에 불과하였고, 4예는 정삭을, 4예는 대동맥주위림프절을 침범하고 있었다. 초음파검사에서 종양의 외연은 6예에서 평활하였고 종괴의 에코는 7예에서 정상 고환 보다 저에코로 보였다. 4예는 균일하였고, 3예는 전반적으로는 균일하였으나 약간 불균일한 부분을 포함하고 있었고, 1예는 불균일하였다. 8예 모두에서 주변의 정상 조직보다는 현저하게 혈관분포상태 (vascularity)가 증가되어 있었다. 자기공명영상 T1-강조영상에서는 정상 고환과 유사한 신호강도로, T2-강조영상에서는 현저한 저신호강도로 관찰되었고 대체로 균일하였다. 조영 후 검사에서는 4예 모두 정상 고환 조직보다는 저신호강도로, 약하게, 균일하게 조영증강되었는데, 역동적 조영증강 검사가 시행된 1예에서는 시간이 감에 따라 점차 조영증강이 증가되는 소견을 관찰할 수 있었다. 이상의 결과를 토대로 50세 이상의 나이가 많은 환자에서 고환 종괴가 관찰되고, 초음파 검사에서 균일한 저에코로, 자기공명영상 T2-강조영상에서 균일한 저신호강도로 관찰될 때에는 고환림프종의 가능성을 가장 먼저 고려하여야할 것으로 생각한다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.4071-4075
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• 2016

Background: FDG PET/CT is at an equivocal stage to recommend for staging of colorectal cancer as compared to contrast-enhanced CT (ceCT). This study was intended to evaluate the value of FDG PET/ceCT in colorectal cancer staging as compared to ceCT alone. Materials and Methods: PET/ceCT was performed for 61 colorectal cancer patients who were prospectively enrolled in the study. Three patients were excluded due to loss to follow-up. PET/ceCT findings and ceCT results alone were read separately. The treatment planning was then determined by tumor board consensus. The criteria for T staging were determined by the findings of ceCT. Nodal positive by PET/ceCT imaging was determined by visual analysis of FDG uptake greater than regional background blood pool activity. The diagnostic accuracy of T and N staging was determined only in patients who received surgery without any neoadjuvant treatment. Results: Of 58 patients, there were 40 with colon cancers including sigmoid cancers and 18 with rectal cancers. PET/ceCT in pre-operative staging detected bone metastasis and metastatic inguinal lymph nodes (M1a) that were undepicted on CT in 2 patients (3%), clearly defined 19 equivocal lesions on ceCT in 18 patients (31%) and excluded 6 metastatic lesions diagnosed by ceCT in 6 patients (10%). These resulted in alteration of management plan in 15 out of the 58 cases (26%) i.e. changing from chemotherapy to surgery (4), changing extent of surgery (9) and avoidance of futile surgery (2). Forty four patients underwent surgery within 45 days after PET/CT. The diagnostic accuracy for N staging with PET/ceCT and ceCT alone was 66% and 48% with false positive rates of 24% (6/25) and 76% (19/25) and false negative rates of 47% (9/19) and 21% (4/19), respectively. All of the false negative lymph nodes from PET/ceCT were less than a centimeter in size and located in peri-lesional regions. The diagnostic accuracy for T staging was 82%. The sensitivity of the peri-lesional fat stranding sign in determining T3 stage was 94% and the specificity was 54%. Conclusions: Our study suggested promising roles of PET/ceCT in initial staging of colorectal cancer with better diagnostic accuracy facilitating management planning.

• 한국안광학회지
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• 제19권4호
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• pp.505-511
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• 2014

목적: 호흡 알코올 농도를 제한한 상태에서 알코올 섭취로 인한 호흡 알코올 농도(breath alcohol concentration, BrAC) 증가가 대비감도에 미치는 영향을 알아보았다. 방법: 20대의 남성 23명(평균연령 $21.17{\pm}2.19$세, body mass index(BMI) $22.09{\pm}2.16$)을 대상으로 Watson 공식을 기반으로 개발된 BAC(blood alcohol concentration) Dosing Software를 이용하여 호흡 알코올 농도 0.05%와 0.08%에 도달하기 위한 알코올 양을 산정하여 투여한 후 다양한 휘도(명소시, 박명시, 박명시 눈부심) 상태에서 대비감도를 측정하여 비교 분석하였다. 결과: 호흡 알코올 농도가 증가할수록 모든 공간주파수에서 대비감도는 감소하였다. 정점대비감도는 명소시 상태에서 6 cycle per degree(cpd), 박명시 상태에서 3 cpd로서 호흡 알코올 농도가 증가하여도 정점이동이 나타나지 않았지만, 박명시 눈부심 상태에서는 0%와 0.05%에서는 6 cpd, 0.08%에서는 3 cpd로서 호흡 알코올 농도 증가에 따른 정점이동이 나타났다. 결론: 음주에 의한 호흡 알코올 농도 증가는 모든 공간주파수에서 대비감도의 감소와 정점대비감도의 이동을 유발함으로써 다양한 시작업에 영향을 미치고 안전사고의 원인이 될 수 있으므로 주의하여야 한다.

• 말소리와 음성과학
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• 제15권4호
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• pp.11-16
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• 2023

The present study examines how a cognitive attention affects Korean learners of English (L2) in perceiving the English stop voicing distinction (/d/-/t/). This study tested the effect of attentional distractor on primary and non-primary acoustic cues, focusing on the role of Voice Onset Time (VOT) and fundamental frequency (F0). Using the dual-task paradigm, 28 Korean adult learners of English participated in the stop identification task carried with (distractor) and without (no-distractor) arithmetic calculation. Results showed that when distracted, Korean learners' sensitivity to VOT decreased as priorly reported with native English speakers. Furthermore, as F0 is a primary cue for a L1 Korean stop laryngeal contrast, its role in L2 English voicing distinction was also affected by a distractor, without compensating for the reduced VOT sensitivity. These findings suggest that flexible use of multiple cues in L1 is not necessarily beneficial for L2 phonological processing when coping with a adverse listening condition.

• 대한수의학회지
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• 제63권2호
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• pp.9.1-9.5
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• 2023

A 5-year-old Labrador Retriever presented with a subcutaneous mass on the right scapular region with localized calor. On magnetic resonance imaging (MRI), a heterogeneously hypointense mass was seen on T1-weighted images (WI) and hyperintense on T2WI and fat-suppressed T2WI with marginal contrast enhancement on postcontrast T1WI and invasion into the surrounding tissue. Histopathological examination of the mass confirmed subcutaneous mast cell tumor (MCT) infiltrating to the adjacent subcutaneous fat. This is the first report to describe the MRI findings of subcutaneous MCT in veterinary medicine. This study suggests that MRI may help evaluate the extent of invasion of subcutaneous MCT.