• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.175-177
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• 2016

Breast cancer is the most common cancer among the population as a whole and among females, yet it is highly curable if diagnosed at an early stage. Different methods are used to diagnose breast cancer. One of these methods features immunological tests using flow cytometry to determine T-lymphocyte (CD4/CD8) ratios in peripheral blood. One hundred patients with breast cancer (50 from Basra, Iraq, and 50 from Baku, Azerbaijan) confirmed to have breast cancer by histopathology were studied. Blood samples were collected from all patients before initiation of treatment and were used for analysis. The mean age of women from Basra was $51.2{\pm}10.7years$ and that of women from Baku was slightly higher at $54.8{\pm}12.2$. The mean CD4/CD8 ratio in Basra was 1.4 and in Baku was 1.8 with P value < 0.05. The percentage of Basra patients who have CD4/CD8 value less than 1 was 50%, while the percentage for Baku patients was 24 % (p < 0.05). While the CD4/CD8 T-lymphocyte ratio might be useful for early diagnosis in patients with breast cancer parallel with other confirmed tests factors involved in explaining variation between countries such as that observed here need to be taken into account.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1163-1167
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• 2008

In this study, cytotoxicity of cadmium on NIH 3T fibroblasts was utilized in order to discover antitoxic compound in methanol extract of Sophora fIavascens Ait. There were treatment groups; control (medium only), $MTT_{50}$ group and five experimental groups. MTT {3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H- tetrazoliumbromide} assay was performed to evaluate the cytotoxicity of cell organelles and $IC_{50}$ was also measured. Accordingly we have examined the detoxification effects of methanol extract of S. flavescens Ait. and leachianone A (LA) on cadmium-treated NIH 3T3 fibroblasts ($IC_{50}=\;12.5{\mu}M$) to observe morphological changes by the light microscopy. Both S. flavescens Ait. methanol extract and LA showed inhibitory effects on cadmium-induced cytotoxicity. Furthermore, LA showed dose-dependency in detoxication. From these results, it is conceivable to suggest that LA from S. flavescens Ait. methanol extract is a potential antitoxic agent.

• Fisheries and Aquatic Sciences
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• v.16 no.3
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• pp.187-194
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• 2013

Microalgae are sensitive indicators of environmental changes, and hence they are widely used in environmental risk assessments and for the development of discharge guidelines. Here we evaluated the toxicity of metals and endocrine-disrupting chemicals (EDCs) to the marine green microalga, Tetraselmis suecica. The toxicants investigated included the metals, Cu, Ni, and Pb; and the EDCs, bisphenol A (BPA), endosulfan (ES), and polychlorinated biphenyl (PCB). The endpoints were variations in cell counts and chlorophyll a levels. T. suecica displayed a varied pattern of sensitivity to the toxicants. Based on the 72-h median effective concentration ($EC_{50}$), ES (0.045 mg/L) was most toxic to T. suecica, followed by PCB (3.96 mg/L) and Pb (9.62 mg/L). Interestingly, T. suecica was relatively tolerant to Cu (43.03 mg/L). The 72-h $EC_{50}$ values of Ni and BPA were approximately 16 mg/L. Our data suggest that this species may be relatively tolerant to most of the chemicals within their permissible limits in the environment.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.358-362
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• 2005

High molecular weight dextran (39% alcohol, v/v), less soluble dextran, eluted from this column between T 500 and T 2000, a commercial linear dextran, Soluble dextran (45% alcohol, v/v) eluted at between T 70 and T 150 dextran. The molecular weight average of total dextran (50% alcohol, v/v) was between 150,000 to 500,000. A few oligosaccharides were detected from hydrolyzates of less soluble dextran. The hydrolyzates of soluble dextran were a family of DP 1 to 6 isomaltooligosaccharides. Compounds greater than DP 4 were branched isomaltooligosaacharides.

• Information and Communications Magazine
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• v.32 no.12
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• pp.45-50
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• 2015

최근 다양한 산업 군에서 ICT 융합 서비스가 활발히 개발되고 있고 사물인터넷(IoT: Internet of Things) 기술이 신성장 동력의 핵심 기술로 주목받고 있다. IoT는 기존에 연결을 고려하지 않았던 생활 속 모든 것들을(daily life objects) 상호 연결시켜주는 기술이다. 가트너는 현재 1% 미만의 사물만이 인터넷에 연결된 상황으로 보고하고 있고 Cisco의 자료에 따르면 2020년에는 연결된 장치 수가 500억 개 이상으로 증가할 것으로 예측하고 있다. 많은 장치가 연결되는 IoT 환경에는 많은 취약점과 보안 위협이 존재할 것이므로 보안과 개인정보 보호 기술은 반드시 제공되어야 하는 핵심기술이다. 본고에서는 IoT 기반 융합 서비스에서 발생했던 침해 사례를 살펴보고, 안전한 서비스 개발을 위한 기본적인 보안 요구사항을 제시한다.

• Journal of Korea Foresty Energy
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• v.19 no.1
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• pp.20-29
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• 2000

This study was carried out to investigate the effects of shading on the growth of 1 -year-old seedlings of Cornus controversa. The height growth was highest in relative light intensities of 100% and 50%, but relative growth rate in 50% was higher than that in 100% treatment. The growth did not occur under 9% relative light intensity. The root collar diameter growth at different light intensities is similar to height growth. The leaf area was highest in 50% relative light intensity, and the leaf area under the light intensity was small compared with the control. SLA and LAI of seedlings increased with decreasing relative light intensity. The LAR and LWR of seedlings increased with decreasing light intensity, but LWR decreased at 9% relative light intensity. The dry weight of root, stem, leaf and branch, and the number of branch and leaf decreased with decreasing relative light intensity. T/R ratio was highest in 17% and 30% relative light intensity. Lateral root growth decreased with decreasing light intensity except for that in 50% light intensity.

• Korean Journal of Microbiology
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• v.40 no.2
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• pp.127-132
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• 2004

We isolated 50 strains from sludge of wastewater treatment aeration tank using selective medium for Thio-bacillus sp. by membrane filtration method. They were identified as Thiobacillus neapolitanus (7), T. tepidarius (4), T. dientrificans (5), T. versutus (23), T. intermedius (2) and T. perometabolis (9). We selected Thiobacillus versutus strain KT51, which had the highest removal efficiency (100％) of hydrogen sulfide and the highest removal efficiency (85％) of dimethyl sulfide for 30 min in screen test. Also Thiobacillus versutus strain KT81 had the highest removal efficiency (26％) of dimethyl disulfide for 30 min in screen test. In applification of lab-scale reactor (closed-biological treatment) using Thiobacillus versutus strain KT51, results were 99.8％ (＜0.02 ppm) removal efficiency of hydrogen sulfide for 15 min.

• Journal of Microbiology and Biotechnology
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• v.30 no.4
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• pp.583-590
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• 2020

Deinococcus actinosclerus BM2^T (GenBank: KT448814) is a radio-resistant bacterium that is newly isolated from the soil of a rocky hillside in Seoul. As an extremophile, D. actinosclerus BM2^T may possess anti-inflammatory properties that may be beneficial to human health. In this study, we evaluated the anti-inflammatory effects of BM2U, an aqueous extract of D. actinosclerus BM2^T, on lipopolysaccharide (LPS)-mediated inflammatory responses in RAW264.7 macrophage cells. BM2U showed antioxidant capacity, as determined by the DPPH radical scavenging (IC₅₀ = 349.3 ㎍/ml) and ORAC (IC₅₀ = 50.24 ㎍/ml) assays. At 20 ㎍/ml, BM2U induced a significant increase in heme oxygenase-1 (HO-1) expression (p < 0.05). BM2U treatment (0.2-20 ㎍/ml) significantly suppressed LPS-induced increase in the mRNA expression of proinflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 (p < 0.05). BM2U treatment also suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), which are involved in the production of inflammatory mediators. BM2U treatment also inhibited the activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs): JNK, ERK, and p-38 (p < 0.05). Collectively, BM2U exhibited anti-inflammatory potential that can be exploited in attenuating inflammatory responses.

• Korean Journal of Digital Imaging in Medicine
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• v.11 no.2
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• pp.51-57
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• 2009

The purpose of this study would evaluate if having clinical effects on diffusion image with quantitative analysis through ADC values of brain's normal tissue and lesions before and after contrast injections using a 3.0T. From November in 2007 until December in 2008, a total of 32 patient was performed on 3.0T(Signa Excite, GE Medical System, USA) with the normal or lesions in the patient who requests diffusion weighted image with 8channel head coil. The pulse sequence was used with spin echo EPI(TR: 10000msec, TE: 72.2 msec, Matrix: 128*128, FOV: 240 mm, NEX: 1, diffusion direction: 3, b-value: 1000). Measurement results of ADC values on lesions, CSF, white matter, gray matter, lesions after contrast injection were measured less 75% than before contrast injection, infarction: 100%, CSF: 78%(high), white matter: 71.4%(low), gray matter: 50%(high, low). The results of paired t-test on the deference of ADC values which statically is significant in three(lesions, CSF, white matter)regions except for white matter(p<0.05). Quantitative analysis of lesions, CSF, white matter, gray matter have difference on all regions. ADC values were low in lesions and white matter, normal CSF after contrast injection commonly is high than before contrast injection, ADC values which white matter were high and low (50:50) after contrast injection. 3.0T diffusion weighted image clinically supposed that performing DWI examination after contrast injection was not desirable because of having effects on brain tissue.

• Fisheries and Aquatic Sciences
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• v.21 no.1
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• pp.1.1-1.12
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• 2018

Pacific bluefin tuna (Thunnus orientalis) is one of the commercially important species in Korea as well as other countries of the North Pacific. Korean offshore large purse seine fisheries targeting small pelagic fishes such as chub mackerel have caught T. orientalis temporarily in the east of Jeju Island. The catch of T. orientalis in March through June occupied approximately 60% of the total. The monthly catch around Jeju Island from 2004 to 2013 showed a negative correlation (r = - 0.755, p < 0.01) with the seawater temperature at 50 m and had a significant positive correlation (r = 0.856, p < 0.01) with the Pacific Decadal Oscillation Index (PDOI). The highest catch and catch per unit effort (CPUE) of T. orientalis around Jeju Island occurred either when the seawater temperature ranged between 15 and $16^{\circ}C$ at 50 m or when the catch was taken near the frontal area where two water masses from offshore and coastal areas collide. The length of T. orientalis caught around Jeju Island from 2004 to 2013 ranged from 19 to 193 cm in fork length (FL). The time series of the monthly mean FL of T. orientalis had a negative correlation (r = - 0.592, p < 0.01) with the seawater temperature at 50 m and had a significant positive correlation (r = 0.668, p < 0.05) with PDOI.