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Molecular Basis of Organospecific Carcinogensis by Chemical Carcinogens-Study with Breast Cancer Specific Carcinogens: DMBA as an Indirect-Acting carcinogen and NMU as a Direct-Acting cancinogen. (화학적 발암원의 조직 특이성 암유발기전 - DMBA와 NMU의 선택적 유암 발생기전을 중심으로 )

  • 박종영;김승원;박상철
    • Environmental Mutagens and Carcinogens
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    • v.9 no.1
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    • pp.1-12
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    • 1989
  • To study the selective organospecific carcinogenesis by the specific chemical carcinogens, the breast cancer induction model by oral administration of 7, 12-dimethylbenzanthracene (DMBA) or by intravenous injection of N-methylni-trosourea (NMU) on female rats was analyzed. In the present experiment, we compared the effexts of ages on the chemical mammary carcinogenesis by studying the metabolic system of the carcinogenic activation, detoxification or DNA damage and repair. The breast tumor incidence was significantly higher in the young rats of 50 days old than in those of one year old rats. As an index of organospecific DNA damage or repair, the in vivo covalent binding index(CBI) of the specific organs by the specific chemical carcinogens was monitored. And for the analysis of carcinogenic activation, the quantity of cytochrome P450`s was determined with the respective type-specific monoclonal antibody, while the detoxication capacity was deduced by the activity monitoring of glutathione S-transferase (GST) and peroxidase. The skin tissues of the mammary region had the highest CBI with both of DMBA and NMU at 50 days of age. And there were contrasting differences in the contents of carcinogenic activation and detoxication system: that is, the content of T.C.D.D.-inducible cytochrome P450 was high, while the activities of GST and peroxidase was low in the mammary skin tissues at tumor prevalent age. These results led us to conclude that the molecular organospecific carcinogenesis, as illustrated with mammary carcinoge-nesis by DMBA and NMU, is operated probably through the differential capacity of the target tissues in the high carcinogenic activation, low detoxication and the low DNA repair function.

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Development of Analytical Method for Rutin in Buckwheat Plant using High Performance Liquid Chromatography (메밀 식물체 함유 Rutin의 HPLC 분석방법 개발)

  • Choung Myoung-Gun
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.50 no.spc1
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    • pp.181-186
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    • 2005
  • This experiment was conducted to know the appropriate methods for extraction and determination of rutin contained buckwheat plants. The efficient HPLC analytical condition of rutin contained buckwheat plants was developed. The gradient elution employed a $250mm\times4.6mm$ i.d. Tosoh ODS 120T column. The gradient system was used two mobile phases. A gradient elution was performed with mobile phase A, consisting of $2\%$ Acetic $acid-45\%$ Acetonitrile, and mobile phase B, comprising $2\%$ aqueous acetic acid, and delivered at a flow rate of 1mL/min as follows: 0-18 min, $50-100\%$ A; 18-20 min, $100-50\%$ A; 20-22 min, $50\%$ A. The UV detection wavelength was set at 355 nm. The limit of detection (LOD) for rutin standard compound was 20 ng/mL. And, the higher content of rutin in the extracts was obtained by $80^{\circ}C$ reflex extraction for 120 min. from plants of buckwheat using ethanol.

The Effect of Korean Adult's Mental Health On QOL(Quality Of Life) -The Fifth Korea National Health and Nutrition Examination Survey, 2010 (연령대별 성인의 정신건강이 삶의 질에 미치는 영향 -제5기(2010)국민건강영양조사를 중심으로)

  • Lee, Ye-Jong;Choi, Gum-Ju
    • Journal of Digital Convergence
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    • v.11 no.1
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    • pp.321-327
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    • 2013
  • The purpose of this study is to find out how the adult's mental health in Korea has an impact on the quality of the life. By using '2010 National Health and Nutrition Examination Survey' data, 4,211 people among 20-year-old to 59-year-old adults were enrolled in this study. Frequency and percentage t-test using the SPSS WIN18.0 Multiple regression analysis was conducted and the results of this study are as follows. First, it is showed that in the 20s and 30s the females are a little more sleep than the males regarding the relationship between sleeping hours and the quality of the life of adult men and women. However, there are no differences between the 40s and 50s groups. Second, it is indicated that adult men are higher than women for the subjective health status when it comes to the subjective health status and the usual perceived stress. Although there are no statistical differences according to the gender in the 40s and the 50s, they have a little stress in general. Third, it is confirmed that only the subjective health status and usual stress perception give an beneficial influence on the quality of adult's life in the adult's mental health variations and the quality of life. In summary, this study was found that the adults in the 20s and 50s could increase their satisfaction of their life if they have more positive thinking and less stress from their life. Therefore, the systematical education and programs to manage the health and stress are required.

A Study on the Relation of Adolescent Self-esteem and Labor Participation (청소년의 자존감과 노동참여 간의 관계에 관한 연구)

  • Park, Sang-Jin
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.4
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    • pp.187-192
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    • 2022
  • This research focuses on analyzing the correlation between adolescent self-esteem and labor participation. The findings of this study are as follows: First, when it was analyzed whether there are differences in self-esteem with ages, out of school students were the lowest. and self-esteem level increased with age. Second, when the differences in self-esteem levels between genders were examined, male students showed slighty higher positive self-esteem and total self-esteem, which shows statistically significant difference. Third, the correlation between self-esteem and labor participation is as follows: 50.4% of students experienced part-time jobs in low self-esteem group. And 50.6% of students experienced part-time jobs in high self-esteem group. It shows that self-esteem level doesn't have relation to part-time job experience. Fourth, when the correlation between part-time job intention and self-esteem was analyzed, 50.5% of students in low self-esteem group responded they would have part-time job, but 49.5% of students in high self-esteem group. Also, 50.9% of low self-esteem group students responded they had no intention of getting part-time jobs, but 49.1% in high self-esteem group. It shows self-esteem level doesn't influence the decision to get part-time jobs. Last, the correlation between the reason they get part-time jobs and self-esteem level was analyzed. 68.1% of students in low self-esteem group had part-time jobs voluntarily, while 31.9% had to have jobs involuntarily for economic cause. Also 75.2% of students in high self-esteem group had part-time jobs for voluntary motive and 24.8% for economic cause. So high self-esteem group showed more voluntary cause and low involuntary cause for part-time jobs, but there was no statistically significant value.

UHD 4K end to end broadcast solution over DVB-T2 SFN network using HEVC real time encoding

  • Dimitrakopulos, Nik
    • Broadcasting and Media Magazine
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    • v.19 no.2
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    • pp.36-45
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    • 2014
  • With major sports events such as FIFA World Cup and The Olympic Games coming up, UHDTV technology has been given a major push by broadcasters, test and measurement (T&M), and consumer electronics (TV and set-top box) manufacturers. The increase in picture resolution ($3840{\times}2160$) for 4K and ($7680{\times}4320$) for 8K compared to current HDTV ($1920{\times}1080$), as well as the need to deliver these services in higher frame rates (50/60 up to 100/120fps) translate to a big challenge in UHDTV content delivery to households over terrestrial transmission due to higher data rates. DVB-T2 has been favored by many countries across the world as it is proven to give the best spectral efficiency for terrestrial broadcasting. On the other hand MPEG-4 appears to be the bottleneck for UHDTV since a much higher data rate is needed to deliver such services. Therefore HEVC becomes mandatory for UHDTV delivery over DVB-T2. In this paper, we will give an overview about a complete end-to-end solution for UHDTV delivery over DVB-T2 based on a realistic SFN scenario in Seoul metropolitan area.

The Distribution of C298T Polymorphism in the Oseteocalcin Gene from Korean Male Athletes and its Association with Bone Mineral Density (한국인 남성 운동선수군에서 Osteocalcin 유전자의 C298T 다형성의 분포와 골밀도와의 관계)

  • Jung, In-Geun;Kang, Byung-Yong;Kim, Ji-Young;Oh, Sang-Duk;Ha, Nam-Joo
    • YAKHAK HOEJI
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    • v.50 no.1
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    • pp.26-32
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    • 2006
  • Osteocalcin is a vitamin K dependent and bone specific protein which plays an important role in the regulation of bone and calcium metabolism. In this study, we evaluated the relationship between the C298T polymorphism in the osteocalcin gene and bone mineral density (BMD) in Korean young men and their interaction with physical activity. BMDs of the femoral neck and lumbar spine were measured using dual energy X-ray absorptiometry, and the C298T polymorphism in the osteocalcin gene determined using polymerase chain reaction (PCR)-HindIII restriction fragment length polymorphism (RFLP) method. We did not observe any significant differences in the femoral neck and lumbar spine BMDs across genotypes of this polymorphism in controls, athletes or combined groups, respectively (P>0.05). Therefore, our data suggest that the C298T polymorphism in the osteocalcin gene is not a suitable genetic marker for the susceptibility to BMD.

The Effects of Lessons using Action Learning on Nursing Students (액션러닝을 활용한 수업운영의 효과)

  • Kim, So-Myeong;Park, Sang-Youn
    • The Journal of Korean Academic Society of Nursing Education
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    • v.22 no.1
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    • pp.42-50
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    • 2016
  • Purpose: The purpose of this study was to investigate the effects of action learning on critical thinking disposition, communicative competence, and problem-solving ability in nursing students. Methods: The design for this was a nonequivalent control group pretest-posttest design was used for identification of the effects of lessons using action learning. The consenting participants were 184 fourth-year nursing students in D-city (Experimental group=95, Control group=89). Data was collected and the program was conducted from May 2 to July 19, 2015. Data was analyzed with an ${\chi}^2-test$, a t-test, and a paired t-test and utilized the SPSS win 21.0 program. Results: There were significant differences in critical thinking ability (t=5.00, p<.001), problem-solving ability (t=4.52, p<.001), and communicative competence (t=4.97, p<.001) in the experimental group compared to the control group. Conclusion: The study findings suggest that action-learning programs have proven to be an effective educational program for improving the critical thinking ability, problem solving ability, and communicative competence of nursing students. Action learning can be an effective teaching strategy.

The Removal Rates of the Constituents of Litters in the Littoral Grassland Ecosystems in the Lake Paldangho III.Phosphorus (팔당호 연안대 초지생태계에서 낙엽 구성성분의 유실률 III.인)

  • 홍정림;심규철;장남기
    • Asian Journal of Turfgrass Science
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    • v.10 no.2
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    • pp.159-166
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    • 1996
  • To estimate removal rate of phosphorus in aquatic grassland ecosystems of Paldangho, this investigation was conducted along with the coast of a lake. The experimental results may be summarized on communities of Typha angustata, Miscanthus sacchriflorus Phragmites communis and Scirpus tabernaemontani as follows. The annual production of phosphorus for the litters in T. angustata, M saccharsflorus, P. cam-munis and S. taiernaemontani grasslands were 10.252 g /$m^2$, 3.833 g /$m^2$, , 2.656 g /$m^2$, and 5.210 g /$m^2$, respectively. The ratio of annual production of P accumulated on surface soils in a steady state provides estimates of the removal rate r, The estimated removal rates r of P were 0.58, 0.78, 0.68 and 0.59 in T. angustata, M. sacchariflorus, P. communis and S. tabernaemontani grasslands re- spectively. The removal and accumulation of 50, 95 and of 99% of its steady state level, the estimates for P of T. angustata were 1.195, 5.173 and 8.623 years, in M. sacchariflorus were 0.880, 3.842, and 6.403 years, and in P. cammunis were 1.014, 4.390, and 7.316 years respectively, In S. tabernaemontani grassland required period were 1.178,5.099 and 8.500. Key words:T. angustata, S. tabernaemantani, P. communis, S. tabernaemontani, Paldangho, Removal rate, Phosphorus.

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An investigation on the in si.tu measurement of the oil-concentration

  • Kim, Chang-Nyeun;Park, Young-Moo
    • International Journal of Air-Conditioning and Refrigeration
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    • v.9 no.1
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    • pp.20-28
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    • 2001
  • In order to predict thermodynamic performance of refrigeration system, it is required to know the oil concentration of the refrigerant/oil mixture. The current method is to extract the working mixture and then to measure the oil weight. In this study, oil concentration is measured in si.tu way without any extraction of the working fluid. Based on the measurement, a working equation is presented as follows, C=a +b x t +c x $t^2$ +(d + e x t +f x $t^2$) x SG. C is oil concentration, t is temperature($^{\circ}C). SG Is specific gravity of mixture and a~f is coefficients The oil concentration ranges over 0~l2 wt% and the temperature ranges over 20~50$^{\circ}C. The specific gravity and temperature are measured using the on-line densimeter and thermometer. This working equation enables to predict the oil concentration without any extraction of the mixture. This equation can be applied for R-12/Naphthenic oil and R-134a/P0E oil liquid mixtures.

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Comparison with Importance and Performance in Rehabilitation Nursing Needs Perceived by Stroke Patients Admitted to a Rehabilitation Hospital and Nurses (재활병원에 입원한 뇌졸중 환자와 간호사가 인식하는 재활 간호요구의 중요도와 수행정도 비교)

  • Lee, Eun Hee;Ko, Eun
    • The Korean Journal of Rehabilitation Nursing
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    • v.19 no.1
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    • pp.30-42
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    • 2016
  • Purpose: This study compared the importance and performance of rehabilitation nursing needs perceived by stroke patients and nurses. Methods: A total of 275 subjects were divided into two groups. One group was 136 stroke patients and the other was 139 nurses. Data were collected with the Rehabilitation Nursing Service Inventory. The data were analyzed by t-test and ANOVA using the SPSS/WIN 21.0 program. Results: The degree of importance and performance in rehabilitation nursing needs perceived by the stroke patients were $3.69{\pm}0.47$ and $3.48{\pm}0.50$, respectively, showing a significant difference (t=21.04, p<.001). The degree of importance and performance perceived by nurses were $3.84{\pm}0.42$ and $3.60{\pm}0.45$, respectively, showing a significant difference (t=26.53, p<.001). A significant difference in the degree of importance and performance in rehabilitation nursing needs was also observed between stroke patients and nurses (t=-2.78, p=.006; t=-2.12, p=.035). Conclusion: These findings showed that there was a perception gap between stroke patients and nurses. Therefore, it will necessary to identify methods for reducing this perception gap and developing rehabilitation nursing intervention considering the rehabilitation nursing needs of stroke patients.