• 대한본초학회지
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• 제28권3호
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• pp.53-60
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• 2013

Objectives : DojukSan is known to be effective for treating a urinary diseases and stomatitis. However, there has been a lack of studies regarding the effects of Dojuksan on the inflammatory activities and effector inflammatory disease mechanism about macrophage before is not known. To elucidate the molecular mechanisms of Dojuksan water extract (DJS) on pharmacological and biochemical actions in inflammation, we examined the effect of DJS on pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated macrophages. Methods : In the present study, pro-inflammatory cytokine production was determined by performing enzyme-linked immunosorbent assay, reverse transcription polymerase chain reaction, and western blot analysis to measure the activation of MAPKs. Cells were treated with 200 ng/mL of LPS 1 h prior to the addition of DJS. Cell viability was measured by MTS assay. The investigation focused on whether DJS inhibited nitric oxide (NO) and prostaglandin E2 ($PGE_2$) productions, as well as the expressions of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6) and mitogen-activated protein kinases (MAPKs) in LPS-stimulated RAW 264.7 cells. Results : We found that DJS inhibited LPS-induced NO, $PGE_2$ and IL-6 productions as well as the expressions of iNOS and COX-2. Furthermore, DJS suppressed the LPS-induced phosphorylation of p38 MAPK and c-Jun NH2-protein kinase (JNK). Conclusions : These results suggest that DJS has inhibitory effects on LPS-induced $PGE_2$, NO, and IL-6 production, as well as the expressions of iNOS and COX-2 in the murine macrophage. These inhibitory effects occur through blockades on the MAPKs phosphorylation.

• 대한기관윤리심의기구협의회지
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• 제4권1호
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• pp.16-22
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• 2022

Purpose: The traditional ethical study only suggests a blurred insight on the research using medical big data, especially in this rapid-changing and demanding environment which is called "4th Industry Revolution." Current institutional/ethical issues in big data research need to approach with the thoughtful insight of past ethical study reflecting the understanding of present conditions of this study. This study aims to examine the ethical issues that are emerging in recent health care big data research. So, this study aims to survey the public perceptions on of health care big data as part of the process of public discourse and the acceptance of the utility and provision of big data research as a subject of health care information. In addition, the emerging ethical challenges and how to comply with ethical principles in accordance with principles of the Belmont report will be discussed. Methods: Survey was conducted from June 3th August to 6th September 2020. The online survey was conducted through voluntary participation through Internet users. A total of 319 people who completed the survey (±5.49%P [95% confidence level] were analyzed. Results: In the area of the public's perspective, the survey showed that the medical information is useful for new medical development, but it is also necessary to obtain consents from subjects in order to use that medical information for various research purposes. In addition, many people were more concerned about the possibility of re-identifying personal information in medical big data. Therefore, they mentioned the necessity of transparency and privacy protection in the use of medical information. Conclusion: Big data on medical care is a core resource for the development of medicine directly related to human life, and it is necessary to open up medical data in order to realize the public good. But the ethical principles should not be overlooked. The right to self-determination must be guaranteed by means of clear, diverse consent or withdrawal of subjects, and processed in a lawful, fair and transparent manner in the processing of personal information. In addition, scientific and ethical validity of medical big data research is indispensable. Such ethical healthcare data is the only key that will lead to innovation in the future.

• 한국가금학회지
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• 제49권3호
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• pp.157-165
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• 2022

RGB 조건에서 하나의 픽셀은 255의 세제곱 개 이상의 색상을 표현할 수 있다. 현재까지의 컴퓨터 비전 연구는 조류에서 나타나는 다양한 깃털색 표현형에 대해 세밀히 분석하여 종을 구분하였지만, GWAS에 이용될 목적을 위해 다양하게 유전되는 색상을 단순화하지 못하였다고 판단된다. 본 연구는 연산오계(YO)와 백색레그혼(WL) 상호역교배 F₂ 집단을 이용하였으며 이미지 양자화를 통하여 이미지의 크기를 줄이고 저장을 용이하게 하였으며 깃털색의 원인 유전자 탐색을 위한 기초 자료를 제공하기 위하여 육안으로 결정하였던 다양한 깃털색을 단순화하였다. 특히, GWAS 연구에 필요한 수치화된 표현형을 제시하였다는 측면에서 가치가 있다고 판단된다.

• 한국엔터테인먼트산업학회논문지
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• 제13권4호
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• pp.229-240
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• 2019

우리나라는 자연재난 및 인위적인 재난 등 다양한 재난을 겪고 있다. 본 연구는 재난관리 단계 중 대응 단계에서 활동하는 소방 구급 대원의 재난대응 능력에 대한 인식을 파악하기 위한 서술적 조사연구이다. 연구 대상자는 G도 소재 소방서 구급 대원 중 현장 경험 2년 이상의 1급 응급구조사를 대상으로 하였으며, 현장대응 능력의 하위 요소에 대한 문항이 포함된 설문지를 작성하여 최종 수집된 설문지 161건을 SPSS Program을 이용하여 분석하였다. 연구 결과 대상자의 환자분류 능력, 환자처치 능력, 환자이송 능력, 재난지원 능력 및 재난대응 신속성의 평균은 각각 3.53점, 3.68점, 3.66점, 2.95점 및 3.44점이었으며, 다중회귀 분석의 결과로 재난대응 신속성에 영향을 미치는 변수는 환자처치 능력, 환자이송 능력, 재난 지원 능력 순으로 나타났다. 결론적으로, 소방 구급 대원은 재난대응 신속성을 향상시키기 위해서는 환자처치 능력, 환자이송 능력, 재난지원 능력을 우선적으로 고려해야 하겠으며, 궁극적으로 재난대응 능력을 향상시키기 위한 재난대응 지침을 마련해야 하겠다.

• 한국노년학
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• 제29권1호
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• pp.243-258
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• 2009

배경: 낙상은 노인의 가장 일반적이고 심각한 건강문제로 대두되고 있다. 낙상은 중요한 신체적 심리적 영향을 주며 결과적으로 신체적 행동약화나 기능의 위축, 사회적 기능 약화 등을 야기시킨다. 하지만, 상대적으로 낙상 후의 심리적, 정신적 부분은 간과되어져왔다. 낙상 후 노인들이 심리적 또는 정신적으로 보고하는 대표적인 증상으로는 다시 낙상을 할 것이라는 두려움으로 나타났다. 목표: 이 논문은 노인의 낙상에 대한 두려움에 영향을 주는 요인에 대한 모델을 테스트하는데 있다. 또한, 낙상에 대한 두려움에 영향을 주는 중요한 요인 중 하나인 노인의 운동과 운동에 대한 신념, 운동에 대한 기대감의 관계를 연구함에 있다. 방법: 미국 메릴랜드주 볼티모어시 지역에 거주하는 노인149명을 대상으로 2004 11월부터 2005년 3월까지 수집된 2차 자료를 이용해서 결과가 분석되었다. 참가 가능 노인으로는 본 연구에 참여하기로 동의한 노인을 대상으로, 노인요양시설에 거주하며, 인지적으로 이상이 없고 (MMSE>20), 65세 이상의 나이를 가진 노인을 대상으로 한다. 자료 수집은 구조화된 설문지를 통해서 이루어졌다. 자료 분석을 위해, SPSS 12.0을 통해 빈도분석과 상관분석 등이 사용되었고, 모델 평가를 하기 위해서 AMOS프로그램을 통해 path analysis를 시행하였다. 결과: 모델 내 49개의 path중에 13개의 path가 유의하게 나타났고 모델의 22%가 설명되어졌다. 모델의 확실성은 chi-square를 통해서 조사되었고 결과 모델의 확실성이 입증되었다. 또한, CFI 는 0.99 RMSEA는 0.00으로 모델을 지지하는 결과가 나타났다. 특히, 성별, 과거 낙상경험, 운동은 노인의 낙상에 대한 두려움을 설명하는 중요한 변수로 나타났다. 논의: 본 연구는 노인의 낙상에 대한 두려움을 총체적으로 설명하기 위한 모델을 제시한다. 또한, 운동에 대한 신념과 결과에 대한 기대치가 노인의 운동을 설명하는 직접적 변수로, 낙상에 대한 두려움을 설명하는 간접적인 변수로 나타났다. 이 연구는 노인들이 낙상의 두려움을 줄이기 위해 적극적으로 운동에 참여하도록 하는데 중요한 이론적 근거를 제공한다.

• 한국환경보건학회지
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• 제49권6호
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• pp.305-311
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• 2023

Background: The National Institute of Environmental Research (NIER)'s classification of and airborne fraction ratio for consumer chemical products (CCP) does not reflect the characteristics of various product classifications. Objectives: The purpose of this study was to reclassify the types of spray products according to the diverse spray characteristics of CCPs to evaluate the airborne fraction ratio of representative spray types and to compare them with previous CCPs types and airborne fraction ratios. Methods: One thousand seven hundred two products were selected through market research, and 932 newly reported products were selected. After that, 200 were selected to evaluate products with potential inhalation exposure. After classifying six product types that are expected to show differences in the airborne fraction ratio according to the type of product, a final 38 products were selected for use in the airborne fraction ratio through random sampling. Results: CCP has been reclassified from two to six types so that the characteristics of all products are well-reflected. The NIER simply had two airborne fraction ratios, but the results of experiments with six types of products showed a significant difference in values (p<0.01). Airborne fraction ratios of propellant general foam, pump general aerosol, and pump trigger foam in spray type, which were not previously present in NIER, were 7.1%, 24.4%, and 3.5%, respectively. Conclusions: For the diversified types of CCPs, the newly proposed classification was more appropriate than the existing NIER classification. The airborne fraction ratio was also different for each type, so a new value was suggested.

• Journal of Korean Neurosurgical Society
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• 제66권6호
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• pp.681-689
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• 2023

Objective : Subarachnoid hemorrhage (SAH) is a condition characterized by bleeding in the subarachnoid space, often resulting from the rupture of a cerebral aneurysm. Delayed cerebral ischemia caused by vasospasm is a significant cause of mortality and morbidity in SAH patients, and inflammatory markers such as systemic inflammatory response index (SIRI), systemic inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), and derived NLR (dNLR) have shown potential in predicting clinical vasospasm and outcomes in SAH patients. This article aims to investigate the relationship between inflammatory markers and cerebral vasospasm after aneurysmatic SAH (aSAH) and evaluate the predictive value of various indices, including SIRI, SII, NLR, and dNLR, in predicting clinical vasospasm. Methods : A retrospective analysis was performed on a cohort of 96 patients who met the inclusion criteria out of a total of 139 patients admitted Trakya University Hospital with a confirmed diagnosis of aSAH between January 2013 and December 2021. Diagnostic procedures, neurological examinations, and laboratory tests were performed to assess the patients' condition. The Student's t-test compared age variables, while the chi-square test compared categorical variables between the non-vasospasm (NVS) and vasospasm (VS) groups. Receiver operating characteristic (ROC) curve analyses were used to evaluate the diagnostic accuracy of laboratory parameters, calculating the area under the ROC curve, cut-off values, sensitivity, and specificity. A significance level of p<0.05 was considered statistically significant. Results : The study included 96 patients divided into two groups : NVS and VS. Various laboratory parameters, such as NLR, SII, and dNLR, were measured daily for 15 days, and statistically significant differences were found in NLR on 7 days, with specific cut-off values identified for each day. SII showed a significant difference on day 9, while dNLR had significant differences on days 2, 4, and 9. Graphs depicting the values of these markers for each day are provided. Conclusion : Neuroinflammatory biomarkers, when used alongside radiology and scoring scales, can aid in predicting prognosis, determining severity and treatment decisions for aSAH, and further studies with larger patient groups are needed to gain more insights.

• Animal Bioscience
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• 제36권12호
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• pp.1831-1841
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• 2023

Objective: This study was realized to evaluate the effects of supplementation with blends of water and fat-soluble vitamins on animal performance and carcass traits of young Nellore bulls. Methods: Forty-three Nellore bulls, with an initial weight of 261±27.3 kg and a mean age of 8±1.0 months, were used. Five animals were slaughtered at the beginning of the experiment (reference group), to determine the initial empty body weight of the bulls that remained in the experiment. The remaining 38 bulls were fed ad libitum and distributed in a completely randomized design in a 2×2 factorial scheme, with or without supplementation of water-soluble (B-blend+ or B-blend-) and fat-soluble (ADE+ or ADE-) vitamin blends. Diets were isonitrogenous (120 g of crude protein/kg dry matter [DM] of total mixed ration) and consisted of a roughage:concentrate rate of 30:70 based on total DM of diet. The experiment lasted 170 days, with 30 days of adaptation and 140 days for data collection. At the beginning and end of the experimental period, the bulls were weighed to determine the average daily gain. To estimate the apparent digestibility of nutrients and microbial efficiency, spot collections of feces and urine were performed for five consecutive days. Results: DM, ashes, organic matter, crude protein, ethereal extract, neutral detergent fiber corrected for residual ash and residual nitrogenous, and N intake and apparent digestibility were not influenced by vitamin supplementation, but total digestible nutrients intake and non-fibrous carbohydrates digestibility were influenced by B complex vitamin supplementation. Nitrogen balance, microbial efficiency, and performance data were not influenced (p>0.05) by vitamin supplementation. Conclusion: Vitamin supplementation (a blend of water-soluble and fat-soluble vitamins or their combinations) does not influence the animal performance and carcass traits of young Nellore bulls.

• 한국과학교육학회지
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• 제28권5호
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• pp.482-494
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• 2008

본 연구에서는 창의적 사고력은 협의의 측면으로 정의하여 제시하였고 그리고 비판적 사고력은 강한 의미의 측면으로 정의하여 제시하였으며, 이를 토대로 하여 현행 탐구 교수 전략을 수정 보완하는데 활용할 수 있는 창의적 사고력과 비판적 사고력 신장 모델을 개발하였다. 이 모델은 교사가 물어보는 인과적 질문에 대하여 학생들로 하여금 발산적 사고력을 활용하면서 조별 토론에 의하여 잠정적 설명들을 적어도 세 가지로 응답들을 하게 한 후에, 이어서 조 별 토론하면서 보다 더 나은 하나의 설명(가설)을 선택하도록 하는 가설을 제안하는 과정이다. 발산적인 사고로 다양한 가설들을 만들어 내기 위해서도 조 별 협동학습 활동이 필수적이며, 또한 학생들로 하여금 강한 의미의 비판적 사고를 형성하게 하기 위해서도 반드시 협동 학습에서 조 별 토론에 의하여 얻어진 사고의 결과들을 만들어 내도록 하여야 한다. 이러한 과정을 경험하면서 학생들은 창의적인 사고와 비판적인 수렴적 사고를 작동하게 되는 것이다. 이 창의적 사고력과 비판적 사고력 신장 모델을 적용한 수업 전략에는 기존 수업 전략에 비하여 아주 조그마한 차이만을 보여주나, 이와 같은 창의적 사고력과 비판적 사고력을 활용한 탐구 교수 전략을 중학교 2학년 학생들과 대학교 1학년 학생들에게 적용한 결과에 의하면 비교반과 비교하였을 때 유의미하게 창의력이 신장되었다. 창의적 사고력과 비판적 사고력 신장 모델을 활용한 다양한 여덟 개의 실례들을 개발하였다. 이 여덟 개의 결과들은 기존의 탐구 교수 전략에 들어 있는 인과적 질문에 대하여 설명들(가설들)을 하고 있는 형태들을 갖추고 있다.

• 한국간담췌외과학회지
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• 제28권2호
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• pp.134-143
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• 2024

Backgrounds/Aims: The hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is classified as the advanced stage (BCLC stage C) with extremely poor prognosis, and in current guidelines is recommended for systemic therapy. This study aimed to evaluate the surgical outcomes and long-term prognosis after hepatic resection (HR) for patients who have HCC combined with PVTT. Methods: We retrospectively analyzed 332 patients who underwent HR for HCC with PVTT at ten tertiary referral hospitals in South Korea. Results: The median overall and recurrence-free survival after HR were 32.4 and 8.6 months, while the 1-, 3-, and 5-year overall survival rates were 75%, 48%, and 39%, respectively. In multivariate analysis, tumor number, tumor size, AFP, PIVKA-II, neutrophil-to-lymphocyte ratio, and albumin-bilirubin (ALBI) grade were significant prognostic factors. The risk scoring was developed using these seven factors-tumor, inflammation and hepatic function (TIF), to predict patient prognosis. The prognosis of the patients was well stratified according to the scores (log-rank test, p < 0.001). Conclusions: HR for patients who have HCC combined with PVTT provided favorable survival outcomes. The risk scoring was useful in predicting prognosis, and determining the appropriate treatment strategy for those patients who have HCC with PVTT.