• Animal Bioscience
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• 제35권7호
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• pp.989-998
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• 2022

Objective: This study investigated the effects of intrauterine growth restriction (IUGR) during late pregnancy on the cell growth, proliferation, and differentiation in ovine fetal thymuses. Methods: Eighteen time-mated Mongolian ewes with singleton fetuses were allocated to three groups at d 90 of pregnancy: restricted group 1 (RG1, 0.18 MJ ME/body weight [BW]^0.75/d, n = 6), restricted group 2 (RG2, 0.33 MJ ME/BW^0.75/d, n = 6) and control group (CG, ad libitum, 0.67 MJ ME/BW^0.75/d, n = 6). Fetuses were recovered at slaughter on d 140. Results: The G0/G1 phase cell number in fetal thymus of the RG1 group was increased but the proliferation index and the expression of proliferating cell nuclear antigen (PCNA) were reduced compared with the CG group (p<0.05). Fetuses in the RG1 group exhibited decreased growth hormone receptor (GHR), insulin-like growth factor 2 receptor (IGF-2R), and their mRNA expressions (p<0.05). For the RG2 fetuses, there were no differences in the proliferation index and PCNA expression (p>0.05), but growth hormone (GH) and the mRNA expression of GHR were lower than those of the CG group (p<0.05). The thymic mRNA expressions of cyclin-dependent protein kinases (CDKs including CDK1, CDK2, and CDK4), CCNE, E2-factors (E2F1, E2F2, and E2F5) were reduced in the RG1 and RG2 groups (p<0.05), and decreased mRNA expressions of E2F4, CCNA, CCNB, and CCND were occurred in the RG1 fetuses (p<0.05). The decreased E-cadherin (E-cad) as a marker for epithelial-mesenchymal transition (EMT) was found in the RG1 and RG2 groups (p<0.05), but the OB-cadherin which is a marker for activated fibroblasts was increased in fetal thymus of the RG1 group (p<0.05). Conclusion: These results indicate that weakened GH/IGF signaling system repressed the cell cycle progression in G0/G1 phase in IUGR fetal thymus, but the switch from reduced E-cad to increased OB-cadherin suggests that transdifferentiation process of EMT associated with fibrogenesis was strengthened. The impaired cell growth, retarded proliferation and modified differentiation were responsible for impaired maturation of IUGR fetal thymus.

• 대한바이러스학회지
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• 제27권2호
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• pp.197-207
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• 1997

To investigate the NS4 region of JEV, NS4 cDNA of K94P05 (JEV strain isolated from Korea in 1994) was amplified by RT-PCR and analyzed by sequencing PCR product. Genomic size of NS4 was 1212bp and nucleotide sequence was compared with that of other JEV strains. Nucleotide homology between JaOAr582 and K94P05 was 91.1% and that between Beijing and K94P05 was 89.8%, respectively. But the nucleotide sequence of E region of JaOAr582 and K94P05 showed 97.0% homology and that of Beijing and K94P05 did 95.8% homology. NS4 protein was expressed as a form of fusion protein by a prokaryotic expression system. The induced fusion product showed a lower molecular weight than predicted size and remained insoluble. The NS4 protein might be cleavaged by E. coli protease. Concluding above results, high hydrophobicity of the NS4 protein supported the fact that this protein played a role as a membrane component and the poor nucleotide sequence conservativity among JEV strains suggested that this region might be important to adapt each viral growth environment.

• 동아시아식생활학회지
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• 제25권1호
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• pp.1-11
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• 2015

This research was designed to examine the dietary habits and unbalanced diet of middle school students by gender and region. The survey was conducted using questionnaires on dietary habits and unbalanced diet administered to 726 students (urban: 367, rural: 359). The obesity index using BMI showed that the largest proportion of girls was 'underweight' in both regions, which showed a significant difference by region (p<0.001). Male students in urban areas prefer salty taste more than rural students (p<0.05). In urban areas, problems relating to dietary habits were 'unbalanced diet' and 'overeating' in male students and 'frequent snacks' and 'irregular mealtime' for female students (p<0.01). The frequencies of skipping breakfast (p<0.01), snack intake (p<0.001), eating out (p<0.001) and fast food consumption (p<0.001) were significantly higher in urban students than in rural students, and the reason for eating snacks was 'hungry' in urban students and 'habitually' and 'delicious' in rural students (p<0.01). Unbalanced diet was significantly higher in rural students compared with urban students (p<0.001) and male students compared with female students in urban (p<0.05), and the factors affecting dietary habits were mostly related to family. Male students in urban areas showed a significantly lower intake frequency of 'fish, tofu and beans' (p<0.05) and 'milk and yogurt' (p<0.05), but higher intake frequency of 'vegetables' (p<0.001) compared with female students. Male students in rural areas showed a significantly lower intake frequency of 'meat' (p<0.05) but higher intake frequency of 'milk and yogurt' (p<0.05) compared with female students. Urban students showed a significantly higher intake frequency of food groups compared with rural students. To conclude, desirable nutrition education on meal regularity, snack choice, and problems relating to unbalanced diet should be conducted in schools.

• Journal of Periodontal and Implant Science
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• 제25권1호
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• pp.14-23
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• 1995

Cyclosporin A is a powerful immunosuppressive agent commonly used for patients receiving organ transplants. Like phenytoin and the calcium channel blockers, the drug is associated with gingival overgrowth. The purpose of this study was to compare the correlation with gingival overgrowth score and clinical indices(i.e, : plaque index, papillary bleeding index, probing depth) and correlation with gingival overgrowth score and microorganism distribution in use of phase contrast microscope. After renal tranplant, taking cyclosporin A 40 patients participating in this investigation. Post - transplatation cyclosporin medication period was average $17.53{\pm}15.75$ months. In previous study reported that gingival overgrowth is an adverse side - effects seen in about 25-81% of patient taking cyclosporin A. The results were as follows : 1. Gingival overgrowth prevalence in taking cyclosporin A patients was 77.5%. Prevalence rate of region was anterior region(26 teeth, 55.3%), molar region(14 teeth, 29.8%), premolar region(7 teeth, 14.8%) in turns. Gingival overgrowth score by Angelopoulos & Goaz method was molar region($1.56{\pm}0.81$), anterior region($1.52{\pm}0.75$), premolar region($1.14{\pm}0.90$) in turns. 2. Medication period was not correlation with gingival overgrowth score. 3. Clinical indices and gingival overgrowth score were as follows. 1) Plaque index and gingival overgrowth score was significantly correlated(p

• 한국안광학회지
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• 제12권3호
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• pp.27-33
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• 2007

구면과 비구면 R.G.P 렌즈 착용실태 조사를 인천 경기지역 안경사 374명을 대상으로 착용비율, 관리법, 예비검사법등 여러가지 문항을 설정하여 조사 하였다. 대부분의 안경사들은 비구면 R.G.P 렌즈를 구면보다 7:3의 비율로 많이 판매하고 있었으며 R.G.P 렌즈 핏팅시 반드시 행하여야할 예비검사 항목 Schirmer test, Tear Break up time test, Slit lamp에 의한 Fluorescein검사, Topography에 의한 각막 지형도 검사를 시행하는지 조사하였으나 대부분 시행하지 않고 있었다. 또한 R.G.P 렌즈 핏팅시 가장 많이 나타나는 증상으로는 가벼운 이물감, 충혈, 시력 흐림, 건조감 순으로 나타났다. 본 실태 조사는 이상적인 R.G.P 렌즈를 핏팅을 위하여 반드시 행하여야 할 예비검사 항목을 나열하였으며, 그 중요성을 일깨우고자 하는데 목적이 있다.

• Asian-Australasian Journal of Animal Sciences
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• 제29권4호
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• pp.500-508
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• 2016

This study was conducted to investigate the effects of Momordica charantia saponin (MCS) on ruminal fermentation of maize stover and abundance of selected microbial populations in vitro. Five levels of MCS supplements (0, 0.01, 0.06, 0.30, 0.60 mg/mL) were tested. The pH, $NH_3-N$, and volatile fatty acid were measured at 6, 24, 48 h of in vitro mixed incubation fluids, whilst the selected microbial populations were determined at 6 and 24 h. The high dose of MCS increased the initial fractional rate of degradation at t-value = 0 ($FRD_0$) and the fractional rate of gas production (k), but decreased the theoretical maximum of gas production ($V_F$) and the half-life ($t_{0.5}$) compared with the control. The $NH_3-N$ concentration reached the lowest concentration with 0.01 mg MCS/mL at 6 h. The MSC inclusion increased (p<0.001) the molar proportion of butyrate, isovalerate at 24 h and 48 h, and the molar proportion of acetate at 24 h, but then decreased (p<0.05) them at 48 h. The molar proportion of valerate was increased (p<0.05) at 24 h. The acetate to propionate ratio (A/P; linear, p<0.01) was increased at 24 h, but reached the least value at the level of 0.30 mg/mL MCS. The MCS inclusion decreased (p<0.05) the molar proportion of propionate at 24 h and then increased it at 48 h. The concentration of total volatile fatty acid was decreased (p<0.001) at 24 h, but reached the greatest concentration at the level of 0.01 mg/mL and the least concentration at the level of 0.60 mg/mL. The relative abundance of Ruminococcus albus was increased at 6 h and 24 h, and the relative abundance of Fibrobacter succinogenes was the lowest (p<0.05) at 0.60 mg/mL at 6 h and 24 h. The relative abundance of Butyrivibrio fibrisolvens and fungus reached the greatest value (p<0.05) at low doses of MCS inclusion and the least value (p<0.05) at 0.60 mg/mL at 24 h. The present results demonstrates that a high level of MCS quickly inhibits in vitro fermentation of maize stover, while MCS at low doses has the ability to modulate the ruminal fermentation pattern by regulating the number of functional rumen microbes including cellulolytic bacteria and fungi populations, and may have potential as a feed additive applied in the diets of ruminants.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1992년도 한국자동제어학술회의논문집(국제학술편); KOEX, Seoul; 19-21 Oct. 1992
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• pp.255-260
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• 1992

It is reported on the methodology of signal detection in noise which is based on a comparison of statistical parameters of observation sample from region of frequency-time noise space where a signal may be present and observation sample from region of this noise space and it is known a priori about the latter that the signal is absent in this region.

• Composites Research
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• 제13권6호
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• pp.1-8
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• 2000

무가압함침법에 의한 $Al_2O_{3p}$/AC8A 복합재료의 제조와, 제조법과 관련하여 부가적인 Mg의 첨가와 강화상의 부피분율이 $Al_2O_{3p}$/AC8A복합재료의 기계적 성질과 마모저항에 미치는 영향을 조사하였다. 강화상 입자와 기지재료의 일부를 분말로 조합한 혼합분말 속으로 기지금속을 자발적으로 침투시켜 부피분율이 20~40%인 $Al_2O_{3p}$/AC8A 복합재료를 제조할 수 있었다. 그러나 강화상의 부피분율이 40%인 복합재료의 경우 기공율의 상승으로 복합재료의 강도는 저하하였다. Mg의 첨가량이 5~7wt% 일 때 가장 높은 강도를 나타냈으며, 경도는 Mg 첨가량의 증가에 따라 점진적으로 상승하였다. $Al_2O_{3p}$/AC8A복합재료는 저속에서 기지재료에 비해 내마모성이 저하하였으나, 고속에서는 AC8A합금에 비해 약 5.5배의 우수한 내마모성을 나타냈다. 마모기구의 관찰에 의해 부피분율 20% $Al_2O_{3p}$/AC8A복합재료의 경우 연삭마모가 주된 마모기구임을 알 수 있었으며, 부피분율 40% $Al_2O_{3p}$/AC8A복합재료는 높은 기공율로 인한 마모 가중으로 저속에서도 경미한 응착마모가 관찰됐고 마찰 속도가 증가함에 따라 격심한 마모로 진행되었다.

• Nutrition Research and Practice
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• 제15권2호
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• pp.248-265
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• 2021

BACKGROUND/OBJECTIVES: This study aimed to assess the dietary behaviors of preschool children using the nutrition quotient for preschoolers (NQ-P) and analyzed the difference in the scores of the children's dietary behaviors in regards to the parents' health consciousness. SUBJECTS/METHODS: The subjects were 257 children aged 3-5 years and their parents residing in Seoul and Gyeonggi-do, South Korea. The questionnaire is composed of demographic characteristics, the NQ-P questions, and health consciousness. All data were statistically analyzed by SPSS program (ver. 25.0) and the statistical differences in variables were evaluated by χ2 test, Fisher's exact test, t-test, 1-way analysis of variance and Tukey's multiple comparison test. RESULTS: There was a significant difference on the intake frequency of processed meat by region and fast foods by age, region, and weight status (P < 0.05). There was also a significant difference in not moving around while eating by weight status and parents' effort to have healthy eating habits by sex (P < 0.05). The mean score of NQ-P of the total subjects was 59.47, which was within the medium-low grade. The mean score of balance was 61.62, and the boys were significantly higher than girls (P < 0.05). As the age of children increased, the mean score of the moderation was significantly decreased (P < 0.05). The scores of NQ-P (P < 0.05), balance (P < 0.01), and environment (P < 0.05) were significantly higher in the high group of parents' health consciousness than the low group. CONCLUSIONS: According to the results of the evaluation by NQ-P, the dietary behaviors of preschoolers residing in Seoul and Gyeonggi-do need to be improved. For improving their eating behavior and nutritional health status, parents and children need customized nutrition education programs based on sex, age, region and weight status of preschool children as well as the degree of parents' health consciousness.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제49권3호
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• pp.161-164
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• 2000

A simple methode for calculating the forward voltage drop of IGBTs is presented, on the voltage drops on the p+ body, the reverse biased depletion region between p+body and epi-layer, the epi layer, and the forward biased collector junction. The decrease of the total current density in the epi layer near the p+ body is taken into account. The proposed methode allows a simple but accurate determination of the forward voltage drop in IGBTs, avoiding the complex path taken in the previous model for the forward voltage drops on channel, accumulation region, and epi region. Numerical simulations for 1kV NPT-IGBT with a uniformly doped collector are shown to support the analytical results.