• YAKHAK HOEJI
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• v.54 no.3
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• pp.180-186
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• 2010

Aldosterone, mineralocorticoid hormone, has important functions related to the regulation of blood pressure and balance of fluids and electrolytes in the distal region of the nephron. By genomic and non-genomic action of aldosterone, the physiological kidney functions are modulated. However, many of them except several kind of sodium channel have not been identified and analyzed yet. In this study, proteomic technologies with two-dimensional gel electrophoresis (2-DE) gel using aldosterone rat model were applied to analyze and identify the aldosterone dependently expressed proteins in rat kidney cortex. As a result, the established aldosterone rat model exhibited the normal physiological responses to aldosterone and modulated proteins were identified, which included 15 increased and 3 decreased proteins on 2-DE analysis. Among them, 11 proteins were identified as changed proteins by LC-MS/MS analysis. These proteins identified as aldosterone induced proteins were involved in several cellular pathways such as cytoskeleton remodeling, energy metabolism, amino acid metabolism, and chaperone process. In conclusion, our data could provide the insights into the new mechanism underlying regulation of kidney functions by aldosterone.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.499-499
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• 2011

Silicon nanowires (Si NWs) have been extensively studied for nanoelectronics owing to their unique optical and electrical properties different from those of bulk silicon. For the development of Si NW devices, better understanding of oxidation behavior in Si NWs would be an important issue. For example, it is widely known that atomic scale roughness at the dielectric (SiOx)/channel (Si) interface can significantly affect the device performance in the nano-scale devices. However, the oxidation process at the atomic-scale is still unknown because of its complexity. In the present work, we investigated the oxidation behavior of Si NW in atomic scale by simulating the dry oxidation process using a reactive molecular dynamics simulation technique. We focused on the residual stress evolution during oxidation to understand the stress effect on oxidation behavior of Si NWs having two different diameters, 5 nm and 10 nm. We calculated the charge distribution according to the oxidation time for 5 and 10 nm Si NWs. Judging from this data, it was observed that the surface oxide layer started to form before it is fully oxidized, i.e., the active diffusion of oxygen in the surface oxide layer. However, it is well-known that the oxide layer formation on the Si NWs results in a compressive stress on the surface which may retard the oxygen diffusion. We focused on the stress evolution of Si NWs during the oxidation process. Since the surface oxidation results in the volume expansion of the outer shell, it shows a compressive stress along the oxide layer. Interestingly, the stress for the 10 nm Si NW exhibits larger compressive stress than that of 5 nm Si NW. The difference of stress level between 5 an 10 anm Si NWs is approximately 1 or 2 GPa. Consequently, the diameter of Si NWs could be a significant factor to determine the self-limiting oxidation behavior of Si NWs when the diameter was very small.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.08a
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• pp.292-292
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• 2011

TFT (Thin Film Transistor)에서 공정을 단순화 시키고, 가격을 하락시키기 위해서는 Poly-Si을 대체할 물질이 필요하다. 이 연구에서는 Chalcogenide Material의 하나인 GeTe 박막을 이용하여 TFT Channel으로 사용 가능한 물질인지 알아보기 위하여 Post-Annealing을 한 뒤, 상 변화에 따른 박막의 저항 변화, Carrier Concentration (cm-3)과 Mobility (cm2V-1s-1)의 변화를 알아보았다. Sputtering을 이용하여 증착한 GeTe 100 nm Thin Film 위에 Sputtering을 이용하여 SiO2 5 nm를 Capping Layer로 증착한 후, Post-Annealing을 200$^{\circ}C$, 300$^{\circ}C$, 400$^{\circ}C$, 500$^{\circ}C$로 온도를 변화 시키며 진행하였고, 이로 인하여 GeTe Thin Film에 외부의 영향을 최소화 하였다. 먼저 GeTe Thin Film의 Sheet Resistance를 측정한 결과는 300$^{\circ}C$ 까지 낮은 Sheet Resistance의 거동을 보이며 반면, 400$^{\circ}C$ 이상이 되면 높은 Sheet Resistance의 거동을 보인다. Hall Measurement를 통해, Carrier Concentration과 Mobility를 알아보았다. Carrier Concentration은 온도가 증가하면 1E+19에서 1E+21 까지 증가하며, Mobility는 감소하는 경향을 보인다. 500$^{\circ}C$ Post-Annealed GeTe Thin Film에서는 Resistivity가 상당히 높아 4 Point Probe (Range : 1 mohm/sq~2 Mohm/sq)로 측정이 불가능하다. XRD로 GeTe Thin Film을 분석한 결과 as-grown, 200$^{\circ}C$, 300$^{\circ}C$에서는 Cubic의 결정 구조를 보이며, Sheet Resistance가 급격히 증가한 400$^{\circ}C$, 500$^{\circ}C$에서는 Rhombohedral의 결정구조를 보인다. GeTe Thin Film은 400$^{\circ}C$ 이상의 Post-Annealing 온도에서 cubic 구조에서 Rhombohedral 구조로 상 변화가 일어난다. 위 결과를 통해, 결정 구조의 변화가 GeTe Thin Film의 저항, Carrier Concentration과 Mobility에 밀접한 영향이 미치는 것을 확인하였다.

• Korean Journal of Acupuncture
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• v.28 no.1
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• pp.1-13
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• 2011

Objectives : The object of this study is to evaluate and develop the system that reflects acupoints electrical properties by the multi-frequency using the SPAC (Single Power Alternative Current) stimulation method based on BIA (Bioelectrical impedance method). Methods : The 12 channel meridian impedance measurement system (MIMS) was designed, which sets multi-frequency with 10 steps (1~10kHz). To check acupoints electrical properties, impedance of acupoints were measured from 11 acupoints selected from the LU and ST meridians. Results : Regarding distribution of measurement values by multi-frequencies, we found the lowest response at 1kHz was in common. But frequency bands which represent the highest response at each acupoint were various. Measurement values of each acupoint by multi-frequencies were expressed similar distribution (P<0.05). Also we could check same frequency band which showed the highest response at left/right equal acupoints (P<0.05). Conclusions : Through change of acupoints electrical properties by multi-frequency stimulation, we checked oriental medical diagnostic possibilities by using this system. We would progress variable clinical trials with this system for oriental medical diagnosis.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.47 no.8
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• pp.13-22
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• 2010

Independent-Gate-Mode Double-Gate(IGM-DG) MOSFET overcomes the limitation of bulk-MOSFET's channel controllability and enables to control the front and back-gate voltages independently. Therefore, circuit designs utilizing the IGM-DG MOSFETs provide the advantage of setting 4-terminal freely, hence achieving not only the performance improvement but also the larger scale integration. This paper presents a 15Gb/s optical receiver with a 1.0V power supply voltage, which consists of a transimpedance amplifier (TIA), a feedforward limiting amplifier (LA), and an output buffer. HSPICE simulations were conducted to confirm the circuit performance, and also to verify the circuit stability issues which may occur from the variations of process and supply voltage.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.464-466
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• 2018

In this paper, a dense cellular network is considered in which each base station equipped with multiple antennas simultaneously communicates with multiple single-antenna users. Based on limited feedback, each user feeds back its quantized channel state information (CSI) to its associated transmitter, and the transmitter broadcasts multiple data streams prepared for the scheduled users using a space-division multiple access scheme. As the amount of CSI is limited at the transmitter, the downlink throughput increases with the number feedback bits. However, the increased number of feedback bits requires the correspondingly increased amount of uplink resources. Thus, an appropriate balance between the downlink throughput and the uplink resource usage should be considered in realistic systems. A net spectral efficiency defined in this context is used in this paper, and the optimal number of feedback bits that maximizes the net spectral efficiency is analyzed. This paper particularly focuses on the case when the received signal power is much smaller than the noise power.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2010.11a
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• pp.231-234
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• 2010

Analysis of conjugated heat transfer has been conducted for the diffuser exposed to hot combustion gas to design the mechanical durability in high temperature. All the heat transfer means, conduction, convection and radiation have been considered to calculate the total heat flux from hot gas to diffuser surface. The calculation has been implemented by two kinds of methods. One thing is one dimensional method based on empirical equations. The other is CFD(Computational Fluid Dynamics) axisymmetric calculation containing ${\kappa}-{\omega}$ SST(Shear Stress Transport) turbulent model and DO(Discrete Ordinate) radiation model. The derived results of two methods have compared and showed similar values. From this result, the amount of cooling water and the dimension of water cooling channel were decided.

• Journal of the Korean Society of Propulsion Engineers
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• v.17 no.5
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• pp.101-112
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• 2013

Large eddy simulation was performed to investigate the effect of linearly increasing wall disturbance on the modification of turbulent characteristics of temperature field in the vicinity of the wall. It was noted that temperature variance increased monotonically whereas temperature dissipation decreased significantly, resulting in a noticeable reduction in both time and length-scales. A sudden drop in turbulent Prandtl number down to around 0.25 in the near-wall region indicated that the similarity between velocity and temperature fields decreases near the wall as a result of linear wall disturbance.

• Journal of Ginseng Research
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• v.36 no.1
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• pp.47-54
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• 2012

Korean red ginseng (KRG) has been used worldwide as a traditional medicine for the treatment of various reproductive diseases. Gonadotropin releasing hormone (GnRH) neurons are the fundamental regulators of pulsatile release of gonadotropin required for fertility. In this study, an extract of KRG (KRGE) was applied to GnRH neurons to identify the receptors activated by KRGE. The brain slice patch clamp technique in whole cell and perforated patch was used to clarify the effect of KRGE on the membrane currents and membrane potentials of GnRH neurons. Application of KRGE (3 ${\mu}g$/${\mu}L$) under whole cell patch induced remarkable inward currents (56.17${\pm}$7.45 pA, n=25) and depolarization (12.91${\pm}$3.80 mV, n=4) in GnRH neurons under high $Cl^-$ pipette solution condition. These inward currents were not only reproducible, but also concentration dependent. In addition, inward currents and depolarization induced by KRGE persisted in the presence of the voltage gated $Na^+$ channel blocker tetrodotoxin (TTX), suggesting that the responses by KRGE were postsynaptic events. Application of KRGE under the gramicidin perforated patch induced depolarization in the presence of TTX suggesting its physiological significance on GnRH response. Further, the KRGE-induced inward currents were partially blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; non-NMDA glutamate receptor antagonist, 10 ${\mu}M$) or picrotoxin (PIC; $GABA_A$ receptor antagonist, 50 ${\mu}M$), and almost blocked by PIC and CNQX mixture. Taken together, these results suggest that KRGE contains ingredients with possible GABA and non-NMDA glutamate receptor mimetic activity, and may play an important role in the endocrine function of reproductive physiology, via activation of $GABA_A$ and non-NMDA glutamate receptors in GnRH neurons.

• Nuclear Engineering and Technology
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• v.5 no.4
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• pp.291-309
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• 1973

Exposure rates due to leakage gamma-rays from operating reactors TRIGA Mark II and III were measured in a horizontal plane by means of scintillation spectrometry using a 3"$\times$3" cylindrical Nal(T1) detector associated with a 400 channel pulse height analyzer under varied conditions of reactor operation. In determining exposure rate due to the leakage gamma-rays at each point of measurement, Moriuchi's spectrum-exposure rate conversion theory was applied instead of using conventional responce matrix method which necessitates very complicated procedures to convert a spectrum into exposure rate. The results show that a basic pattern of "typical" spectrum of the reactor leakage gamma-rays is neither affected by thermal output of the reactor, nor influenced by overall attenuation in radiation intensity. It was indicated that he attenuation of the leakage gamma-rays in air in terms of exposure rate as a whole follows an exponential law, and the total exposure rate due to the leakage gamma-rays at a certain point is nearly proportional to thermal output of the reactor. The complexity in spectrum measured for a movable core reactor, TRIGA Mark III, was analyzed through spectrum resolution, and proper judgement of the leakage gamma-rays in a complex spectrum was discussed.ctrum was discussed.