• Asian Journal of Atmospheric Environment
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• 제8권2호
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• pp.81-88
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• 2014

Noise-barriers on both sides of the roadway (hereafter referred to as double noise-barriers), are a common feature along roads in Korea, and these are expected to have important effects on the near-road air pollution dispersion of vehicle emissions. This study evaluated the double noise-barrier impact on near-road air pollution dispersion, using a FLUENT computational fluid dynamics (CFD) model. The realizable k-${\varepsilon}$ model in FLUENT CFD code was used to simulate vehicle air pollutant dispersion, in around 11 cases of double noise-barriers. The simulated concentration profiles and surface concentrations under no barrier cases were compared with the experimental results. The results of the simulated flows show the following three regimes in this study: isolated roughness (H/W=0.05), wake interface (H/W=0.1), and skimming flow (H/W>0.15). The results also show that the normalized average concentrations at surface (z=1 m) between the barriers increase with increasing double noise-barrier height; however, normalized average concentrations at the top position between the barriers decrease with increasing barrier height. It was found that the double noise-barrier decreases normalized average concentrations of leeward positions, ranging from 0.8 (H/W=0.1, wake interface) to 0.1 (H/W=0.5, skimming flow) times lower than that of the no barrier case, at 10 x/h downwind position; and ranging from 1.0 (H/W=0.1) to 0.4 (H/W=0.5) times lower than that of the no barrier case, at 60 x/h downwind position.

• 대한간호학회지
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• 제29권5호
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• pp.1155-1166
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• 1999

The purpose of this study was to investigate the residents' opinions about community mental health in the Taegu-Kyungpuk area for the future development of a community mental health program and model appropriate for Korea, The subjects were 152 residents in the Taegu - Kyungpuk area. In July 1999, the data was collected using a convenience sample technique. Mental health status was significantly different for the level of occupational advantage(x$^2$＝15.684, p＜.05) and physical health(x$^2$＝39.262, p＜.000). Factor structure for mental health problems with the percentage of variance was as follows. optimistic view(27.518), dark view(10.758), mastery(6.200), discomfiture(6.101) and life style(5.641). Most of the respondents(92.1%) took the mental health problems seriously. The serious aspects of the mental health problem were found to be epilepsy, mental retardation, neurosis and schizophrenia respectively. Concerning about the view of community mental health, most of the respondents answered that the a C.M.H.C. was ‘useful and urgent’ concerning the need for C.M.H,(77.6%). They answered positively on the utilization of C.M.H.C(75.7% ) and preferred the separately new community mental heath center. A psychiatrist was preferred as the key person in charge(44.1%). If community mental health centers were established in a community health center, they answered that the expected major problem would be quality control of care(44.7%). They preferred the psychiatrist's office as the recommended agency for the insane(44.7%). Opinions of the asylum system were found very negative in respect to psychiatric therapy and humanitarianism. The results of this study will help establish a relevant model for this community as the primary site for a community-based mental health model.

• 대한조선학회지
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• 제17권2호
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• pp.17-20
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• 1980

The shearing forces and bending moments acting on the tanker model[1] of $C_B$ 0.82 in regular oblique waves of shallow water are investigated by numerical calculations. The new strip method was adopted. It is concluded that in the shallow water shearing forces and the bending moments acting on the tanker model are higher than those of deep water waves by the present numerical investigations. The wave bending moment at the midship section is roughly twice of deep water value in the shallow of H/T less than 2. in this calculation.

• Clinical and Experimental Pediatrics
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• 제62권3호
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• pp.95-101
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• 2019

Purpose: Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by various insults including pressure overload, cardiac apoptosis appears to result from an exaggerated local production of angiotensin in adult SHRs. Altered expressions of Bcl associated X (Bax), Bcl-2, chemokine receptor (CCR)-2, monocyte chemoattractant protein (MCP)-1, transforming growth factor $(TGF)-{\beta}1$, phosphorylated extracellular signal-regulated kinases (PERK), and connexin 43 proteins, and kallikrein mRNA were investigated to explore the effects of losartan on the SHR model. Methods: Twelve-week-old male rats were grouped as follows: control (C), SHR (hypertension: H), and losartan (L; SHRs were treated with losartan [10 mg/kg/day] for 5 weeks). Western blot and reverse transcription polymerase chain reaction assays were performed. Results: Expression of Bax, CCR-2, MCP-1, $TGF-{\beta}1$, PERK, and connexin 43 proteins, and kallikrein mRNA was significantly increased in the H group compared to that in the C group at weeks 3 and 5. Expression of Bax, CCR-2, MCP-1, $TGF-{\beta}1$, and connexin 43 proteins and kallikrein mRNA was significantly decreased after losartan treatment at week 5. PERK protein expression was significantly decreased after losartan treatment at weeks 3 and 5. Bcl-2 protein expression was significantly decreased in the H group compared to that in the C group at weeks 3 and 5. Conclusion: Losartan treatment reduced expression of Bax, CCR-2, MCP-1, $TGF-{\beta}1$, PERK, and connexin 43 proteins, and kallikrein mRNA in SHRs, along with decreased inflammation and apoptosis.

• 한국수자원학회논문집
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• 제32권4호
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• pp.489-499
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• 1999

본 연구는 분포형 수문 모형인 TOPMODEL의 기본 입력자료인 지형지수, 1n(a/tan {{{{{B}_{}}}}}) 산정을 위한 알고리즘과 수로형성면적(CIT)과 구배멱급수(H)를 고려한 개선된 지형지수 산정 알고리즘의 국내 지형에 대한 적용성을 검토하였다. 대상 유역은 청도천 유역의 한제천 소유역 (18.6km2)과 위천 대표 시험유역의 동곡 소유역(33.6km2)으로, 이 두 유역에 대한 10m, 20m, 30m, 50m, 100m의 수치고도자료(Digital elevation model ; DEM)을 구축하였다. 기존 알고리즘에 대해 수로형성면적의 적용 결과, 수로 격자에 대한 지형지수의 적절한 처리를 통해 개선된 계산 결과를 얻을 수 있었고, 구배멱급수(H)의 적용을 통해 기존의 다방향 흐름(MFD) 알고리즘에 비해 유역 내 협곡 지점에 대한 흐름의 수렴 효과를 얻을 수 있었다. 개선된 알고리즘에 의해 계산된 지형지수 분포는 최대값의 감소로 유출 모의시 과도한 초기 유출 계산 문제를 완화시킬 수 있었다. 기존 알고리즘을 사용한 유출 모의와 비교하여 개선된 알고리즘을 활용한 전체적인 모의 효율은 유사하나 수문정보의 공간 분포 산정은 보다 합리적인 결과를 도출하였다,

• 한국식품영양과학회지
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• 제16권3호
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• pp.85-90
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• 1987

고추가루로부터 acetone을 추출용매(抽出溶媒)로 하여 oleoresin을 제조한 후 capsanthin과 capsaicin의 안정성(安定性)을 검토(檢討)하고, oleoresin-linoleate aqueous model system을 이용하여 ascorbic acid, 금속(金屬), 염류(鹽類), EDTA 등을 첨가하여 capsanthin의 변화(變化)를 측정(測定)한 결과는 다음과 같다. 1. 추출용매(抽出溶媒)로는 acetone이 가장 효과적이었으며, 고추가루로부터 oleoresin의 수율은 14.2%이었다. 2. Capsaicin은 capsanthin에 비하여 고온에서 상당히 안정하였으며 $pH\;3{\sim}8$에서 oleoresin중의 capsanthin과 capsaicin도 비교적(比較的) 안정하였다. 3. Ascorbic acid를 $10^{-3}M$ 첨가시 capsanthin의 산화반응에 prooxidant로서 작용하였으나 $10^{-1}M$ 첨가시에는 antioxidant로서 작용하였다. 4. $Cu^{+2}M$, $Fe^{+3}M$ 이온은 capsanthin의 산화반응(酸化反應)을 촉진시켰으며 농도(濃度)가 높을수록 영향이 컸다. 5. EDTA는 capsanthin에 대하여 항산화(抗酸化) 효과(效果)를 나타내었다.

• Archives of Pharmacal Research
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• 제27권7호
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• pp.806-810
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• 2004

Metformin is a biguanide antihyperglycemic agent often used for the treatment of non-insulin dependent diabetics (NIDDM). In this study, the pharmacokinetics and pharmacodynamics of metformin were investigated in Korean healthy volunteers during a fasting state for over 10 h. In order to evaluate the amount of glucose-lowering effect of metformin, the plasma concentrations of glucose were measured for a period of 10 h followed by the administration of metformin (oral 500 mg) or placebo. In addition, the concentration of metformin in blood samples was determined by HPLC assay for the drug. All volunteers were consumed with 12 g of white sugar 10 minutes after drug intake to maintain initial plasma glucose concentration. The time courses of the plasma concentration of metformin and the glucose-lowering effect were analyzed by nonlinear regression analysis. The estimated $C_{max}$, $T_{max}$, $CL_{t}$/F (apparent clearance), V/F(apparent volume of distribution), and half-life of metformin were 1.42$\{pm}$0.07 $\mu\textrm{g}$/mL, 2.59$\{pm}$0.18h, 66.12$\{pm}$4.6 L/h, 26.63 L, and 1.54 h respectively. Since a significant counterclock-wise hysteresis was found for the metformin concentration in the plasma-effect relationship, indirect response model was used to evaluate pharmacodynamic parameters for metformin. The mean concentration at half-maximum inhibition $IC_{50}$, $k_{in}$, $k_{out}$ were 2.26 $\mu\textrm{g}$/mL, 83.26 $H^{-1}$, and 0.68 $H^{-1}$, respectively. Therefore, the pharmacokinetic-pharmacodynamic model may be useful in the description for the relationship between plasma concentration of metformin and its glucose-lowering effect.

• 한국해안해양공학회지
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• 제9권3호
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• pp.115-124
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• 1997

동일지점에 투하한 여러개 표류부표 사이의 이격거리 관측방법을 사용하여 한국 연안 여러곳에서 와동확산의 분산을 측정하고 ‘확산계수’를 산정하였다. 시간이 경과함에 따라 와동확산의 분산은 ｔ$^{m}$ 에 비례하여 증가 하였는데, 여기서 시간지수승 m은 1.5와 3.5범위의 비정수 값으로 나타났다. 실측된 분산의 시간지수승 관계는 와동확산계수를 상수로 두는 확산모델링 방법에서는 재현되지 않는다. 본 논문에서는 프랙탈 이론을 도입하여 와동확산에 에 따른 분산의 지수승 관계를 시뮬레이트하였다. 본 논문의 프랙탈 확산모델에서는 가우스소음 대신에 프랙탈 가우스소음(fGn)을 와동확산에 따른 임의행보 과정에 적용하였다. 이 모델에서 프랙탈 브라운운동(fBm)으로 표현되는 와동확산의 분산은 시간 ｔ에 대하여 ｔ$^{2H}$와 같이 나타났는데, 여기서 H는 허스트 지수(Hurst exponent)이다. 본 논문의 프랙탈 확산모델은 시간지수승이 1과 2범위인 와동확산 분산을 잘 재현하였지만, 시간지수승이 2가 넘는 경우는 재현되지 않는다. 시간지수승이 2이상인 경우는 평균류의 유속전단(velocity shear)에 기인한다.다.

• 공업화학
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• 제18권3호
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• pp.267-272
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• 2007

$25^{\circ}C$의 순수 물 및 n-부탄올 수용액(0.1 M, 0.2 M 및 0.3 M)에서 양이온 계면활성제인 trimethyltetradecylammonium bromide (TTAB)와 비이온 계면활성제인 polyoxyethylene (23) lauryl ether (Brij 35)의 혼합계면활성제의 임계미셀농도 (CMC)와 반대이온의 결합상수값(B)을 TTAB의 겉보기 몰분율(${\alpha}_1$)의 함수로서 전도도법과 표면장력계법으로 측정하였다. 이와 같이 측정한 CMC 값에 비이상적 혼합미셀화 모델을 적용함으로써 여러 가지 열역학적 함수값($X_i$, ${\gamma}_i$, $C_i$, ${a_i}^M$, ${\beta}$ 및 ${\Delta}H_{mix}$)들을 계산하고 분석하였다. 또한 TTAB/Brij 35 혼합계면활성제의 미셀화에 미치는 n-부탄올의 농도에 따른 열역학 함수값들의 변화를 측정하고 분석하였다.

• 한국항공우주학회지
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• 제33권1호
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• pp.20-25
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• 2005

본 연구에서는 UH-1H 헬리콥터의 축소 로터에 대한 두께소음과 하중소음, 그리고 와류흘림에 의한 광역소음을 각각 수치계산을 통해 얻어내고, 그 크기를 비교하였다. 로터의 후류형상은 Kocurek과 Tangler의 지정후류 방법을 사용하였으며, 팁 마하수 $M_{T}$의 범위는 0.2, 0.4, 0.8로 나누어서 유동장 계산과 그에 따른 소음해석을 시도하였다. 팁 마흐 수 $M_{T}$ = 0.8에서 와류 흘림에 의한 광역 소음은 가청주파수 대역 및 A-가중함수를 고려하였을 때에 상대적으로 저주파수 특성을 갖는 두께소음이나 하중소음에 비해 작은 값을 보이는 것으로 나타났다. 특히 광역소음은 가청주파수를 벗어난 초음파 영역에서 대부분의 음압을 방사하는 것으로 나타났다. 반면 $M_{T}$를 0.4 이하로 하였을 때에는 광역소음이 저주파수 영역으로 이동하면서 이산소음에 비해 더 소음레벨을 보이는 것으로 나타났다. 즉, 저속 회전하는 헬리콥터 로터의 경우에는 광역소음의 고려가 필수적임을 알 수 있다.