• Title/Summary/Keyword: $I_c$

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Insulin-Like Growth Factor-I Induces Androgen Receptor Coactivator Expression in Skeletal Muscle Cells through the p38 MAPK and ERK1/2 Pathways (C2C12 세포에서 insulin-like growth factor-I이 p38 MAPK, ERK1/2 신호전달 경로를 통해 엔드로젠 수용체 coactivator 발현에 미치는 영향)

  • Park, Chan-Ho;Kim, Hye-Jin;Kim, Tae-Un;Lee, Won-Jun
    • Journal of Life Science
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    • v.21 no.2
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    • pp.242-250
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    • 2011
  • Although insulin-like growth factor-I (IGF-I) and androgen receptor (AR) coactivators are well known effectors of skeletal muscle, the molecular mechanism by which signaling pathways integrating AR coactivators and IGF-I in skeletal muscle cells has not been previously examined. In this study, the effects of IGF-I treatment on the gene expression of AR coactivators in the absence of AR ligands and the roles of the p38 MAPK and ERK1/2 signaling pathways in IGF-I-induced AR coactivators induction were examined. C2C12 cells were treated with 250 ng/ml of IGF-I in the presence or absence of specific inhibitors p38 MAPK (SB203580) or ERK1/2 (PD98059). Treatment of C2C12 cells with IGF-I resulted in increased in GRIP-1, SRC-1, and ARA70 protein expression. The levels of GRIP-1, SRC-1, and ARA70 mRNA were also significantly increased after 5min of IGF-I treatment. IGF-I-induced AR coactivator proteins were significantly blocked by pharmacological inhibitors of p38 MAPK and ERK1/2 pathways. However, there was no significant effect of those inhibitors on IGF-I-induced mRNA level of AR coactivators, suggesting that AR coactivators are post-transcriptionally regulated by IGF-I. Furthermore, the present results suggest that IGF-I stimulates the expression of AR coactivators by cooperative activation of the p38 MAPK and ERK1/2 pathways in C2C12 mouse skeletal muscle cells.

Weak Convergence for Nonparametric Bayes Estimators Based on Beta Processes in the Random Censorship Model

  • Hong, Jee-Chang
    • Communications for Statistical Applications and Methods
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    • v.12 no.3
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    • pp.545-556
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    • 2005
  • Hjort(1990) obtained the nonparametric Bayes estimator $\^{F}_{c,a}$ of $F_0$ with respect to beta processes in the random censorship model. Let $X_1,{\cdots},X_n$ be i.i.d. $F_0$ and let $C_1,{\cdot},\;C_n$ be i.i.d. G. Assume that $F_0$ and G are continuous. This paper shows that {$\^{F}_{c,a}$(u){\|}0 < u < T} converges weakly to a Gaussian process whenever T < $\infty$ and $\~{F}_0({\tau})\;<\;1$.

Development of Control System for Insulator Cleaning Robot (애자 청소 로봇 제어 시스템의 개발)

  • Byun, Seung-Hyun;Cho, Byung-Hak;Park, Joon-Young;Lee, Jae-Kyung
    • Proceedings of the KIEE Conference
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    • 2006.07d
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    • pp.1993-1994
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    • 2006
  • 애자 청소 작업은 애자의 절연 저하를 사전에 예방하기 위해 고소 고압의 환경에서 이루어지는 위험한 작업으로 정비작업의 능률과 정밀도가 떨어져 로봇을 이용한 활선 애자 청소 및 진단의 자동화가 요구되어진다. 이러한 요구에 따라 활선 애자 청소 로봇이 개발되고 있다. 본 논문에서는 개발된 애자 청소 로봇 제어를 위해 마스터 슬레이브 구조를 갖는 제어 시스템 구성을 제안하고, 실험을 통해 구현한 제어 시스템의 효용성을 보인다.

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$C^3$I와 스토캐스틱 콘트롤에 관하여

  • 이만형
    • 전기의세계
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    • v.33 no.1
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    • pp.14-25
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    • 1984
  • 전자공업은 방위산업발달에 획기적인 역활을 담당하고 있으며, 특히 전략적 $C^{3}$I (Command, Control, Communication and Intelligence) 개념을 도입하여, 국가방위를 위한 연구가 미국의 여러 대학들과 국방성 산하 연구기관에서 활발히 진행되고 있다. 이 글에서는 $C^{3}$I 에 대한 개략적인 개념을 소개하고, 추계학적 (Stochastic) 관점에서 $C^{3}$I 가 실전을 위하여 어떻게 응용되고 있는 가를 고찰하기 위하여 최근에 발표되고 있는 비선형필터링(Nonliner Filtering), 적응형필터링(Adaptive Filtering), 최적제어 문제들을 소개하고자 한다.

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$C^3$I 추계학적 제어(Stochastic Contorl)의 응용

  • Lee, Man-Hyeong
    • Journal of the Korean Society for Precision Engineering
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    • v.1 no.3
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    • pp.26-40
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    • 1984
  • 전자공업은 방위산업발달에 획기적인 역할을 담당하고 있으며, 특히 전략적 $C^{3}$/I( Command, Control, Communication, and Intelligence) 개념을 도입하여, 국가방위를 위한연구가 미국의 여러 대학들과 방위성 산하 연구기관에서 활발히 진행되고 있다. 이 글에서는 $C^{3}$/I에 대한 개략적인 개념을 소개하고, 추계학적(Stochastic) 관점에서 $C^{3}$/I가 실전을 위해 어떻게 응용되고 있는가를 고찰하기 위하여 최근에 발표되고 있는 비 선형필터링(Nonlinear Filtering), 적응필터링(Adaptive Filtering) 최적제어 문제들을 소개하고자 한다.

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A Study on The Assesment of Power Improvement Effectiveness of Corps Level C4I System Applied to Integrated Fire Operation (지상전술 C4I체계의 통합화력운용간 전투력 상승효과 평가에 관한 연구)

  • 박송기;이재영
    • Journal of the military operations research society of Korea
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    • v.29 no.1
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    • pp.8-27
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    • 2003
  • This paper develops a methodology that can be used to quantify the assesment of power improvement effectiveness of corps level C4I system applied to integrated fire operation by adapting Schuzer's C2 theory. This paper first describes how C4I systers can enhance the battle outcome in three way. : (1) Enhanced unit probability of survival; (2) Enhanced unit's individual effectiveness; improved exchange ratios; (3) Improved task force allocations : increased percentage of assets that can be assigned to a given engagement These enhancements are then show to result from improved probability of detection through information sharing; improved survivability and lethality through battle force coordination; and enhanced force allocation and prepositioning through improved timeliness of information(more advanced warning). It demonstrates that well-designed C4I systems can be shown to represent a significant force multiplier on the outcome of the battle.

Multi Channel Optical Source Controller Design Using $I^2$ C Bus Interface ($I^2$ C Bus interface를 이용한 다채널 광원 제어시스템 설계/구현)

  • 염진수;류광열;허창우
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2002.11a
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    • pp.539-542
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    • 2002
  • 본 논문에서 는 64채널 DWDM(Dense Wavelength Division Multiplexing)용 광원(Optical Source)을 구현하고, 이를 효율적으로 제어하기 위하여 I$^2$C Bus interface를 이용한 제어기를 설계하였다. 채널은 독립적으로 동작될 수 있도록 각각 Laser Diode 구동 회로와 마이크로프로세서, A/D 및 D/A 컨버터로 구성하였으며, 또한 각 채널들은 하나의 I$^2$C Bus를 통해 주 제어기와 연결된다 주 제어기는 RS-232 및 LAN을 통해 틀어오는 사용자의 명령을 I$^2$C Bus를 이용하여 각 채널에 전달하고, 채널로부터 들어오는 정보를 사용자에게 제공한다. RS-232C 및 LAN을 통한 PC와의 전송속도는 57600BPS로 구현하였다.

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A Study on the Development Direction of National University Library - A Case Study of C National University Library - (국립대학교 도서관 발전방향에 관한 연구 - C대학 도서관을 중심으로 -)

  • 서진원
    • Journal of the Korean Society for Library and Information Science
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    • v.35 no.2
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    • pp.133-149
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    • 2001
  • This paper is a case study of Chonbuk National University Library. In the paper I analysed characteristics of the university and change of university libraries. Following that, I suggested the development direction of Chonbuk National University Library. I categorized Chonbuk National University Library program in two - direct service program and indirect service program. Under the categories I subdivided the university library program. After that I explained how the university library program contribute to the development of the university.

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Central Involvement of Benzodiazepine Receptor on the Muscimol-induced Inhibition of Micturition Reflex in Rats (흰쥐의 뮤시몰투여에 의한 배뇨반사억제효과에 대한 벤조디아제핀수용체의 영향)

  • Huh, In-Hoi;Oh, Ho-Jung
    • YAKHAK HOEJI
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    • v.36 no.5
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    • pp.496-505
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    • 1992
  • The correlation between GABA receptors($GABA_A$ and $GABA_B$ receptor) and benzodiazepine receptor on the saline infusion-induced micturition reflex contraction was studied in the female rat. To investigate the effect of ${\gamma}-aminobutyric$ acid(GABA) on the micturition reflex, exogenous GABA(10 mg/kg) and GABA transaminase inhibitor(aminooxyacetic acid; AOAA $1\;{\mu}g$) were administered intravenously(i.v.) and intracerebroventriculary(i.c.v.), respectively. In result, both GABA and AOAA inhibited the saline induced micturition reflex contraction. This AOAA induced inhibition of micturition reflex was blocked by both bicuculine. $GABA_A$ receptor antagonist, and Ro 15-1788, benzodiazepine receptor antagonist. Muscimol, $GABA_A$ receptor antagonist($0.1\;{\mu}g$ i.c.v., $3\;{\mu}g$ intrathecal; i.t., 1 mg/kg i.v.) and baclofen, $GABA_A$ receptor agonist($1\;{\mu}g$ i.c.v., $3\;{\mu}g$ i.t., 1 mg/kg i.v.) also inhibited the bladder contraction. Pretreatment of bicuculline($1\;{\mu}g$ i.c.v.), but not of 5-aminovaleric acid(AVA, $1\;{\mu}g$ i.c.v.), $GABA_B$ receptor antagonist blocked the central inhibition of muscimol. These inhibitory effects were reversed by Ro15-1788 but were potentiated by flurazepam, benzodiazepine receptor antagonist. On the other hand, the inhibitory effects of baclofen were not affected by Ro 15-1788. Diazepam and flurazepam also inhibited the micturition reflex contraction when they were administered $3\;{\mu}g$ i.c.v., $10\;{\mu}g$ i.t., $10\;{\mu}M$, $30\;{\mu}M$ transurethrally, respectively. In conclusion, these results suggest that the micturition reflex is mediated by $GABA_A$, $GABA_B$ receptor and benzodiazepine receptor. The bezodiazepines increase the receptor binding of GABA to the $GABA_A$ receptor, so that the benzodiiazepines show the synergistic effect on the inhibition of the micturition reflex contraction, but not to the $GABA_B$ receptor.

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