• 한국환경보건학회지
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• 제34권1호
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• pp.49-54
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• 2008

The induction of heme oxygenase-1(HO-1) by UV radiation provides a protective defence against oxidative stress, and has been well demonstrated in skin irradiated with UVA, but not UVB. In this study, we show that the induction of cutaneous HO-l can be attributed to UVB radiation. The expression of HO-1 mRNA was assessed in vivo by reverse transcription-polymerase chain reaction (RT-PCR) analysis, and HO-1 enzyme activity was measured in microsomal preparation from irradiated mice. The mRNA level of HO-1 increases in liver and skin from 1d to 3d after UVB $(3KJ/m^2)$ exposure. The results of gene expression were same pattern of HO-1 enzyme activity in skin, but not in liver. HO-1 mRNA in liver resulted in a progressive increase to 4d after UVB exposure, but HO-1 activity in liver increased to 2d. This finding indicates that UVB radiation is an important inducer of HO-1 and increases in HO activity may protect tissue directly or indirectly from oxidative stress.

• 한국세라믹학회:학술대회논문집
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• 한국세라믹학회 2000년도 춘계총회,특별강연,심포지움,연구발표회
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• pp.80.1-80.1
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• 2000

• 한국재료학회:학술대회논문집
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• 한국재료학회 2004년도 춘계학술발표대회 및 제6회 신소재 심포지엄
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• pp.56-56
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• 2004

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2005년도 가을학술대회
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• pp.166-168
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• 2005

The induction of heme oxygenase-1(HO-1) by ultraviolet(UV) radiation provides a protective defense against oxidative stress, and has been well demonstrated in UVA-irradiated skin, but not UVB. In this study in mice, we show that the UVB(290-320nm) radiation can be attributed to the induction of cutaneous heme oxygenase-1. The expression of HO-1 mRNA was assessed in vivo by the reverse transcription-polymerase chain reaction (RT-PCR) analysis, and HO-1 enzyme activity was measured in microsomal preparation from irradiated mice. The mRNA level of HO-1 increases in liver and skin from 24h to 72h after UVB($3KJ/m^3$) radiation. The results of gene expression were same pattern of HO enzyme activity in skin, but not in liver. HO-1 mRNA in liver resulted in a progressive increase to 96h after UVB radiation, but HO activity in liver increased to 48h. This finding indicates that UVB radiation is an important inducer of HO-1 and increases in HO activity may protect tissues directly or indirectly from oxidative stress.

• 대한수학회보
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• 제50권4호
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• pp.1099-1108
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• 2013

We define the Mannheim curve in a 3-dimensional Riemannian manifold, which is a generalization of the Mannheim curve in Euclidean space. In particular, we study the Mannheim curves and their partner curves in 3-dimensional space forms.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송∙미디어공학회 2021년도 추계학술대회
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• pp.245-247
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• 2021

본 작품은 쇼핑의 발달 및 코로나로 인한 언택트 및 비대면 수요의 증가와 더불어 시간과 공간의 제약을 받지 않고 서비스를 이용할 수 있는 장점을 살려 만들었다. 어플리케이션에서 서버와의 연동을 통해 정보를 주고받으면서 웹페이지 안에 3D 모형과 각종 기능을 확인할 수 있고 이를 스마트폰 모바일 기기에서 간편하게 확인이 가능함으로써 다양한 쇼핑 기능들을 시각적으로 확인하고 활용할 수 있다.

• 한국수산과학회지
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• 제8권4호
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• pp.202-207
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• 1975

1975년 6월 7일에서 동년 8월 11일까지 풍양호(4,500H. P), 척양호(3,800H. P.), 동방호(3,000 H. P.), 오대산호(2,600 H. P.), 백경호(850 H. P.), 관악산호(1,000 H..P.) 계 6척의 기관실 소음을 주기관의 회전수에 따라 소음압이 변하는 것과 기관실 체격과 총 마력수에 따른 상관관계등을 조사한 결과를 요약하면 다음과 같다. 1. 각 선박의 총 마력수에 따라 기관실 체적이 비례로 커져가고 있으나 소음관계는 같은 종류의 기관(6기통)을 사용하고 있으므로 소음압이 낮아져 가는 경향을 보이는데 관악산초, 척양호, 동방호는 표준 곡선에 비해 소음압이 3dB정도 높은 경향을 보였고 백경호, 풍양호는 4dB 정도 낮은 경향을 보였다. 2. 각 주기관의 최대 회전수(r.p.m.)가 되기 전의 회전수에서 이미 최대의 소음압을 나타내고 있는데 그 회전수의 백분율은 선박에 따라 약간의 차이는 있으나 $67{\~}75{\%}$인 범위에서 최대소음이 되고 있다. 3. 각 기관실의 최대소음압은 $93.5{\~}105dB$의 범위 였고, stern trawl 선박구조를 가진 어획물 처리장은 81 dB 였는데 풍양호만은 72 dB로서 선원 상호간의 대화는 가능하였다. 4. 관악산호를 제외하고는 각 선박식당의 소음압은 $68{\~}75dB$, 싸롱은 $67{\~}72dB$ 선원실은$67{\~}75dB$ 학생실은$67{\~}72dB$였고 갑판의 소음압은 동방호를 제외하고는 $67{\~}72dB$의 범위였다.

• Biomolecules & Therapeutics
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• 제24권3호
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• pp.268-282
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• 2016

In the present study, we investigated the anti-inflammatory properties of Eucommia ulmoides Oliv. Bark. (EUE) in lipopolysaccharide (LPS)-stimulated microglial BV-2 cells and found that EUE inhibited LPS-mediated up-regulation of pro-inflammatory response factors. In addition, EUE inhibited the elevated production of pro-inflammatory cytokines, mediators, and reactive oxygen species (ROS) in LPS-stimulated BV-2 microglial cells. Subsequent mechanistic studies revealed that EUE suppressed LPS-induced phosphorylation of mitogen-activated protein kinases (MAPKs), phosphoinositide-3-kinase (PI3K)/Akt, glycogen synthase $kinase-3{\beta}$ ($GSK-3{\beta}$), and their downstream transcription factor, nuclear factor-kappa B ($NF-{\kappa}B$). EUE also blocked the nuclear translocation of $NF-{\kappa}B$ and inhibited its binding to DNA. We next demonstrated that EUE induced the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and upregulated heme oxygenase-1 (HO-1) expression. We determined that the significant up-regulation of HO-1 expression by EUE was a consequence of Nrf2 nuclear translocation; furthermore, EUE increased the DNA binding of Nrf2. In contrast, zinc protoporphyrin (ZnPP), a specific HO-1 inhibitor, blocked the ability of EUE to inhibit NO and $PGE_2$ production, indicating the vital role of HO-1. Overall, our results indicate that EUE inhibits pro-inflammatory responses by modulating MAPKs, PI3K/Akt, and $GSK-3{\beta}$, consequently suppressing $NF-{\kappa}B$ activation and inducing Nrf2-dependent HO-1 activation.

• Bulletin of the Korean Chemical Society
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• 제9권4호
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• pp.240-243
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• 1988

Degradation of the 90 K superconductor $YBa_2Cu_3O_{7-{\delta}}$ in water and humid atmosphere were studied and its decomposition products were identified as $BaCO_3$, CuO, $Y_2(CO_3)_3{\cdot}3H_2O$ and $O_2$. XRD analysis, iodometric titration and IR-spectroscopy of the degraded samples suggest that the $YBa_2Cu_3O_{7-{\delta}}$ decomposes in three steps such as the reduction of $Cu^{3+}$ to $Cu^{2+}$, followed by the hydroxylation of $Ba^{2+}$ and $Y^{3+}$ via hydration and finally the formation of carbonates through the uptake of ambient $CO_2$.

• BMB Reports
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• 제48권11호
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• pp.636-641
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• 2015

There are controversial findings regarding the roles of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway on bone metabolism under oxidative stress. We investigated how Nrf2/HO-1 pathway affects osteoblast differentiation of MC3T3-E1 cells in response to hydrogen peroxide (H₂O₂), N-acetyl cysteine (NAC), or both. Exposing the cells to H₂O₂ decreased the alkaline phosphatase activity, calcium accumulation, and expression of osteoblast markers, such as osteocalcin and runt-related transcription factor-2. In contrast, H₂O₂ treatment increased the expression of Nrf2 and HO-1 in the cells. Treatment with hemin, a chemical HO-1 inducer, mimicked the inhibitory effect of H₂O₂ on osteoblast differentiation by increasing the HO-1 expression and decreasing the osteogenic marker genes. Pretreatment with NAC restored all changes induced by H₂O₂ to near normal levels in the cells. Collectively, our findings suggest that H₂O₂-mediated activation of Nrf2/HO-1 pathway negatively regulates the osteoblast differentiation, which is inhibited by NAC.